Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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In Vitro Chemosensitivity Test of SK-302B on Human Colon Carcinoma Cell Lines

  • Kim, Soo-Kie (Department of Microbiology, Wonju College of Medicine, Yonsei University) ;
  • Ahn, Chan-Mug (Department of Basic Sciences 1,2 Institute of Basic Medical Sciences, Wonju College of Medicine, Yonsei University) ;
  • Kim, Tae-Ue (Department of Medical Technology, College of Health Science, Yonsei University) ;
  • Choi, Sun-Ju (Department of Microbiology ,Wonju College of Medicine, Yonsei University) ;
  • Park, Yoon-Sun (Department of Microbiology ,Wonju College of Medicine, Yonsei University) ;
  • Shin, Woon-Seob (Department of Microbiology ,Wonju College of Medicine, Yonsei University) ;
  • Koh, Choon-Myung (Department of Microbiology, Wonju College of Medicine, Yonsei University)
  • Published : 1996.08.01
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Abstract

SK-302B, an antibiotic purified from soil Streptomyces sp. 302, was structurally identified as echinomycin (C/sub 50/H/sub 66/N/sub 11/S/sub 2/). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.

Keywords

References

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