• The Korean Journal of Physiology and Pharmacology
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• v.24 no.2
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• pp.173-183
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• 2020

An in vitro model for ischemia/reperfusion injury has not been well-established. We hypothesized that this failure may be caused by serum deprivation, the use of glutamine-containing media, and absence of acidosis. Cell viability of H9c2 cells was significantly decreased by serum deprivation. In this condition, reperfusion damage was not observed even after simulating severe ischemia. However, when cells were cultured under 10% dialyzed FBS, cell viability was less affected compared to cells cultured under serum deprivation and reperfusion damage was observed after hypoxia for 24 h. Reperfusion damage after glucose or glutamine deprivation under hypoxia was not significantly different from that after hypoxia only. However, with both glucose and glutamine deprivation, reperfusion damage was significantly increased. After hypoxia with lactic acidosis, reperfusion damage was comparable with that after hypoxia with glucose and glutamine deprivation. Although high-passage H9c2 cells were more resistant to reperfusion damage than low-passage cells, reperfusion damage was observed especially after hypoxia and acidosis with glucose and glutamine deprivation. Cell death induced by reperfusion after hypoxia with acidosis was not prevented by apoptosis, autophagy, or necroptosis inhibitors, but significantly decreased by ferrostatin-1, a ferroptosis inhibitor, and deferoxamine, an iron chelator. These data suggested that in our SIR model, cell death due to reperfusion injury is likely to occur via ferroptosis, which is related with ischemia/reperfusion-induced cell death in vivo. In conclusion, we established an optimal reperfusion injury model, in which ferroptotic cell death occurred by hypoxia and acidosis with or without glucose/glutamine deprivation under 10% dialyzed FBS.

• Genomics & Informatics
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• v.19 no.1
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• pp.11.1-11.8
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• 2021

For the novel coronavirus disease 2019 (COVID-19), predictive modeling, in the literature, uses broadly susceptible exposed infected recoverd (SEIR)/SIR, agent-based, curve-fitting models. Governments and legislative bodies rely on insights from prediction models to suggest new policies and to assess the effectiveness of enforced policies. Therefore, access to accurate outbreak prediction models is essential to obtain insights into the likely spread and consequences of infectious diseases. The objective of this study is to predict the future COVID-19 situation of Korea. Here, we employed 5 models for this analysis; SEIR, local linear regression (LLR), negative binomial (NB) regression, segment Poisson, deep-learning based long short-term memory models (LSTM) and tree based gradient boosting machine (GBM). After prediction, model performance comparison was evelauated using relative mean squared errors (RMSE) for two sets of train (January 20, 2020-December 31, 2020 and January 20, 2020-January 31, 2021) and testing data (January 1, 2021-February 28, 2021 and February 1, 2021-February 28, 2021) . Except for segmented Poisson model, the other models predicted a decline in the daily confirmed cases in the country for the coming future. RMSE values' comparison showed that LLR, GBM, SEIR, NB, and LSTM respectively, performed well in the forecasting of the pandemic situation of the country. A good understanding of the epidemic dynamics would greatly enhance the control and prevention of COVID-19 and other infectious diseases. Therefore, with increasing daily confirmed cases since this year, these results could help in the pandemic response by informing decisions about planning, resource allocation, and decision concerning social distancing policies.

• Journal of Internet Computing and Services
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• v.14 no.5
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• pp.69-76
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• 2013

The incidence of globally infectious and pathogenic diseases such as H1N1 (swine flu) and Avian Influenza (AI) has recently increased. An infectious disease is a pathogen-caused disease, which can be passed from the infected person to the susceptible host. Pathogens of infectious diseases, which are bacillus, spirochaeta, rickettsia, virus, fungus, and parasite, etc., cause various symptoms such as respiratory disease, gastrointestinal disease, liver disease, and acute febrile illness. They can be spread through various means such as food, water, insect, breathing and contact with other persons. Recently, most countries around the world use a mathematical model to predict and prepare for the spread of infectious diseases. In a modern society, however, infectious diseases are spread in a fast and complicated manner because of rapid development of transportation (both ground and underground). Therefore, we do not have enough time to predict the fast spreading and complicated infectious diseases. Therefore, new system, which can prevent the spread of infectious diseases by predicting its pathway, needs to be developed. In this study, to solve this kind of problem, an integrated monitoring system, which can track and predict the pathway of infectious diseases for its realtime monitoring and control, is developed. This system is implemented based on the conventional mathematical model called by 'Susceptible-Infectious-Recovered (SIR) Model.' The proposed model has characteristics that both inter- and intra-city modes of transportation to express interpersonal contact (i.e., migration flow) are considered. They include the means of transportation such as bus, train, car and airplane. Also, modified real data according to the geographical characteristics of Korea are employed to reflect realistic circumstances of possible disease spreading in Korea. We can predict where and when vaccination needs to be performed by parameters control in this model. The simulation includes several assumptions and scenarios. Using the data of Statistics Korea, five major cities, which are assumed to have the most population migration have been chosen; Seoul, Incheon (Incheon International Airport), Gangneung, Pyeongchang and Wonju. It was assumed that the cities were connected in one network, and infectious disease was spread through denoted transportation methods only. In terms of traffic volume, daily traffic volume was obtained from Korean Statistical Information Service (KOSIS). In addition, the population of each city was acquired from Statistics Korea. Moreover, data on H1N1 (swine flu) were provided by Korea Centers for Disease Control and Prevention, and air transport statistics were obtained from Aeronautical Information Portal System. As mentioned above, daily traffic volume, population statistics, H1N1 (swine flu) and air transport statistics data have been adjusted in consideration of the current conditions in Korea and several realistic assumptions and scenarios. Three scenarios (occurrence of H1N1 in Incheon International Airport, not-vaccinated in all cities and vaccinated in Seoul and Pyeongchang respectively) were simulated, and the number of days taken for the number of the infected to reach its peak and proportion of Infectious (I) were compared. According to the simulation, the number of days was the fastest in Seoul with 37 days and the slowest in Pyeongchang with 43 days when vaccination was not considered. In terms of the proportion of I, Seoul was the highest while Pyeongchang was the lowest. When they were vaccinated in Seoul, the number of days taken for the number of the infected to reach at its peak was the fastest in Seoul with 37 days and the slowest in Pyeongchang with 43 days. In terms of the proportion of I, Gangneung was the highest while Pyeongchang was the lowest. When they were vaccinated in Pyeongchang, the number of days was the fastest in Seoul with 37 days and the slowest in Pyeongchang with 43 days. In terms of the proportion of I, Gangneung was the highest while Pyeongchang was the lowest. Based on the results above, it has been confirmed that H1N1, upon the first occurrence, is proportionally spread by the traffic volume in each city. Because the infection pathway is different by the traffic volume in each city, therefore, it is possible to come up with a preventive measurement against infectious disease by tracking and predicting its pathway through the analysis of traffic volume.

• The Korean Journal of Applied Statistics
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• v.8 no.1
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• pp.61-74
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• 1995

These days, many kinds of graphical methods have been developed, and it is possible to get information directly from data. Especially, R-code (Cook and Weisberg, 1994) make it possible to draw various kinds of two and three dimensional plots, and to rotate the axis of the plots. But the maximum dimensional of the plot is three, so we can not draw plot of one response variable with more than three explanatory variables. Li(1991, 1992) has developed a method to reduce the dimension of the explanatory variables, so it is possible to draw lower dimensional plots to get information of the full explanatory variables. One of the dimension reduction method developed by Li is pHd. In this paper, we have tried to apply the pHd method for the model with multivariate response.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.10
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• pp.4214-4230
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• 2020

This paper introduces a pilot allocation scheme for massive MIMO systems based on deep convolutional neural network (CNN) learning. This work is an extension of a prior work on the basic deep learning framework of the pilot assignment problem, the application of which to a high-user density nature is difficult owing to the factorial increase in both input features and output layers. To solve this problem, by adopting the advantages of CNN in learning image data, we design input features that represent users' locations in all the cells as image data with a two-dimensional fixed-size matrix. Furthermore, using a sorting mechanism for applying proper rule, we construct output layers with a linear space complexity according to the number of users. We also develop a theoretical framework for the network capacity model of the massive MIMO systems and apply it to the training process. Finally, we implement the proposed deep CNN-based pilot assignment scheme using a commercial vanilla CNN, which takes into account shift invariant characteristics. Through extensive simulation, we demonstrate that the proposed work realizes about a 98% theoretical upper-bound performance and an elapsed time of 0.842 ms with low complexity in the case of a high-user-density condition.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.6B
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• pp.559-568
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• 2002

In this paper, we studied on combining the control of transmission fates and power for the real system where a finite set of transmission rates are used. In [1], the combined control of transmission rates and power was first researched, and suggested the Selective Power Control (SPC) algorithm. However, it can't guarantee the minimum rate to each user and results in frequent changes of rate due to oscillation of the SIR (Signal to Interference Ratio) values. As a main purpose of this paper, we derive a formulation model and propose a distributed iteration algorithm to solve these problems. To evaluate the performance of the proposed algorithm, we carried out numerical analysis and computational experiments. The results indicate that the proposed algorithm achieves better throughput than conventional one by keeping the low average transmission power.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.4
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• pp.1276-1295
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• 2023

Sensor networks are now an essential aspect of wireless communication, especially with the introduction of new gadgets and protocols. Their ability to be deployed anywhere, especially where human presence is undesirable, makes them perfect choices for remote observation and control. Despite their vast range of applications from home to hostile territory monitoring, limited battery power remains a limiting factor in their efficacy. To analyze and transmit data, it requires intelligent use of available battery power. Several studies have established effective routing algorithms based on clustering. However, choosing optimal cluster heads and similarity measures for clustering significantly increases computing time and cost. This work proposes and implements a simple two-phase technique of route creation and maintenance to ensure route reliability by employing nature-inspired ant colony optimization followed by the fuzzy decision engine (FDE). Benchmark methods such as PSO, ACO and GWO are compared with the proposed HRCM's performance. The objective has been focused towards establishing the superiority of proposed work amongst existing optimization methods in a standalone configuration. An average of 15% improvement in energy consumption followed by 12% improvement in latency reduction is observed in proposed hybrid model over standalone optimization methods.

• Journal of Korea Water Resources Association
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• v.41 no.8
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• pp.807-823
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• 2008

This paper presents a technique for estimating discharge rating curve parameters. In typical practical applications, the original non-linear rating curve is transformed into a simple linear regression model by log-transforming the measurement without examining the effect of log transformation. The model of pseudo-likelihood estimation is developed in this study to deal with heteroscedasticity of residuals in the original non-linear model. The parameters of rating curves and variance functions of errors are simultaneously estimated by the pseudo-likelihood estimation(P-LE) method. Simulated annealing, a global optimization technique, is adapted to minimize the log likelihood of the weighted residuals. The P-LE model was then applied to a hypothetical site where stage-discharge data were generated by incorporating various errors. Results of the P-LE model show reduced error values and narrower confidence intervals than those of the common log-transform linear least squares(LT-LR) model. Also, the limit of water levels for segmentation of discharge rating curve is estimated in the process of P-LE using the Heaviside function. Finally, model performance of the conventional log-transformed linear regression and the developed model, P-LE are computed and compared. After statistical simulation, the developed method is then applied to the real data sets from 5 gauge stations in the Geum River basin. It can be suggested that this developed strategy is applied to real sites to successfully determine weights taking into account error distributions from the observed discharge data.

• Journal of Preventive Medicine and Public Health
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• v.36 no.4
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• pp.367-372
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• 2003

Objectives : There are many concerns about ginseng as a cancer chemopreventive substance, but there have been few epidemiological studies on ginseng, This study sought to examine the relationships between ginseng intake and cancer incidence in the Kangwha cohort. Methods ; Between March 1985 and December 1999, 2697 males, aged 55 or over, as of 1985, were followed up for their cancer incidence. The cancer incidence rate, standardized incidence ratio and risk ratios were calculated according to ginseng intake. A Cox proportional hazard model was used to adjust for age at entry, smoking, alcohol intake, hypertension, and body mass index. Results & Conclusions : The ginseng intake group had the same cancer (C00-C97) incidences (Standardized Incidence Ratio: SIR=1.11, 95% Confidence Interval=0.97-1.27) and the same risk ratio (RR=1.09, 95% Confidence Interval=0.85-1.41) as the no-intake group. Analyzing the subjects that had followed up from 1990, however, the ginseng intake group had lower cancer incidences at all sites (RR=0.79, 95% Confidence Interval=0.58-1.09). This was a cohort study to try and evaluate the association between ginseng intake and the incidences of cancer, The results of this study provide no clear conclusions on the cancer preventive effects of ginseng. Therefore, further study is needed in the future.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.2
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• pp.800-813
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• 2021

With the advent of 5G communications, internet of vehicles technology has been widely used in vehicles. Then the dynamic spread of information between vehicles began to come into focus with more research. It is well known that the identification of nodes with great spread influence has always been a hot topic in the field of information spreading. Most of the existing work measures the propagation influence by degree centrality, betweenness centrality and closeness centrality. In this paper, we will identify influential vehicle nodes based on the mobility characteristics of vehicles to explore the information spreading between vehicles in VANETs. Different from the above methods, we mainly explore the influence of the radius of gyration and vehicle kilometers of travel on information spreading. We use a real vehicle trajectory data to simulate the information transmission process between vehicles based on the susceptible-infected-recovered SIR model. The experimental results show that the influence of information spreading does not enhance with increasing radius of gyration and vehicle kilometers of travel. The fact is that both the radius of gyration and the distance travelled have a significant influence on information spreading when they are close to the median. When the value of both is large or small, it has little influence on information spreading. In view of this results, we can use the radius of gyration and vehicle kilometers of travel to better facilitate the transmission of information between vehicles.