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In vitro Screening of Medicinal Plants with Estrogen Receptor Modulation Activity (생약의 여성호르몬 수용체 조절 활성 검색)

  • Lee, Chang-Min;Kang, Se-Chan;Oh, Joa-Sub;Choi, Han;Li, Xue-Mei;Lee, Jae-Hyun;Lee, Mi-Hyun;Choung, Eui-Su;Kawk, Joung-Hwan;Zee, Ok-Pyo
    • Korean Journal of Pharmacognosy
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    • v.37 no.1 s.144
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    • pp.21-27
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    • 2006
  • Yeast based estrogenicity assay is the simplest and useful for the assay and the discovery of novel estrogenic substances in natural specimens, The estrogen receptor(ER) modulation activity of 50% EtOH extracts of 101 traditional medicinal herbs was assessed using a recombinant yeast assay system with both a human estrogen receptor expression plasmid and a receptor plasmid. Among them, 14 species proved to be active. Pureariae Flos (flower of Puerraria thunbergiana BENTH.) had the highest estrogenic relative potency$(7.75{\times}10^{-3})$ $(EC_{50}=9.39\;{\mu}g/ml)$. The $EC_{50}$ value of $17{\beta}-estradiol$ used as the positive control was $0.073\;{\mu}g/ml)$ (Relative Potency=1.00). There results demonstrated that some of the traditional medical herb may be useful in the therapy of estrogen replacement.

Generation of Pseudovelocity Section of Block Ⅱ in the Yellow Sea by Seismogram Inversion (탄성파 자료 역산을 통한 황해 2광구 지역의 의속도 단면도의 작성)

  • Kwon Byung-Doo;Jeong Yu-Jeong;Yang Su-Yeong
    • The Korean Journal of Petroleum Geology
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    • v.1 no.1 s.1
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    • pp.29-35
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    • 1993
  • Seismic reflection data can be used to extract information about the velocity structure of the earth. This process is called a velocity inversion of the seismic data. However, it is difficult to recover a broad band reflection coefficient series because the frequency band of seismic trace is limited. The linear programming method has been examined to find the simplest velocity model that has frequency components consistent with the usable frequencies of the seismic trace and interval velocity data. The velocity structure of the earth is displayed in pseudovelocity section. After the linear program had been tested with a synthetic seismic trace, it was applied to the seismic reflection data of the Block Ⅱ in the Yellow Sea. By comparing the pseudovelocity section with sonic logs obtained from the well in the same area, it was possible to define the lithostratigraphy and the boundaries of Cretaceous volcanics and Cretaceous metavolcanics.

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System Structure and Reliability Optimization of VVVF Urban Transit Brake System Through Cost Function Construction (비용함수를 이용한 VVVF 전동차 제동장치의 시스템 구조 및 신뢰도 최적화)

  • Kim, Se-Hoon;Kim, Hyun-Jung;Bae, Chul-Ho;Lee, Jung-Hwan;Lee, Ho-Yong;Suh, Myung-Won
    • Transactions of the Korean Society of Automotive Engineers
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    • v.15 no.3
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    • pp.63-71
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    • 2007
  • During the design phase of a product, reliability and design engineers are called upon to evaluate the reliability of the system, The question of how to meet target reliability for the system arises when estimated reliability or cost is inadequate. This then becomes a problem of reliability allocation and system structure design. This study proposes the optimization methodology to achieve target reliability with minimum cost through construction of the cost function of system. In cost function, total cost means the sum of initial cost, repair cost and maintenance cost. This study constructs optimization problem about system structure design and reliability allocation using cost function. This problem constructed is solved by Multi-island Genetic Algorithm(MIGA), and applies to urban transit brake system. Current brake system of the urban transit is series system. Series system is the simplest and perhaps one of the most common system, but it demands high reliability and maintenance cost because all components must be operating to ensure system operation. Thus this study makes a comparative study by applying k-out-of-n system to brake system. This methodology presented can be a great tool for aiding reliability and design engineers in their decision-makings.

Text Structuring using Centering Theory (중심화 이론을 이용한 텍스트 구조화)

  • Roh, Ji-Eun;Na, Seung-Hoon;Lee, Jong-Hyeok
    • Journal of KIISE:Software and Applications
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    • v.34 no.6
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    • pp.572-583
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    • 2007
  • This paper investigates Centering-based metrics to evaluate ordering of utterances for text structuring. We point out a problem of MIN.NOCB metric which has been regarded as the simplest and best measure to evaluate coherence of ordering within Centering framework, and propose a new Centering-based metric, MAX.CPS as an alternative or supplementary one. This paper introduces a framework which pre-estimates the effectiveness of a metric on a given input ordering, and selects an applicable metric according to the pre-estimation result. Using this framework, we propose a new policy which can generate more optimal ordering within Centering framework. Moreover, we evaluate several kinds of Cf-ranking methods in terms of Centering-based metrics, and find that simply ranking entities by their linear order is generally the most suitable because of characteristics in Korean.

Disaster Vulnerability Analysis for Steep Slope Failure (급경사지 재해도 분석)

  • Choi, Eun-Kyeong;Kim, Sung-Wook;Kim, Sang-Hyun;Park, Dug-Keun;Oh, Jeong-Rim
    • Proceedings of the Korean Geotechical Society Conference
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    • 2009.03a
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    • pp.930-939
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    • 2009
  • Most of steep slope failures occurring in Korea have appeared during the localized heavy rain period, whereas the evaluation model of a disaster vulnerability analysis that has been proposed to date, has been prepared in consideration only of external factors comprising geographical features. This study calculated a wetness index and a contributory area which delivers moisture to the upper slant surface during the rainfall period, and also conducted a disaster vulnerability analysis in consideration of the convergence of surface water as well as the water system created during the occurrence of rainfall by including a curvature that shows a close relevance with the shape of the minute water system that is created temporarily during the occurrence of rainfall and with the convergence and divergence of surface water. When compared with a steep slope failure occurring within a selected model district in order to verify the prepared disaster analysis, a landslide occurring in the model district had emerged in a region in which the disaster vulnerability analysis was high and the density of the minor water system was also high. If these research results are extended nationwide, it is the most effective to use a disaster vulnerability analysis and the density of the minute water system; and it is supposed to be the simplest and the most effective method for preparing a disaster analysis of mountainous land shape such as the model district.

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The internal UV-line-strength relations of early-type galaxies

  • Jeong, Hyun-Jin;Yi, Suk-Young K.;Bureau, Martin;Davies, Roger L.
    • The Bulletin of The Korean Astronomical Society
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    • v.36 no.2
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    • pp.66.2-66.2
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    • 2011
  • The unexpected rising flux of early-type galaxies at decreasing ultraviolet (UV) wavelengths is a long-standing mystery. One important observational constraint is the correlation between UV-optical colours and Mg2 line strengths found by Burstein et al. (1988). The simplest interpretation of this phenomenon is that the UV strength is related to the Mg line-strength. Under this assumption, we expect galaxies with larger Mg gradients to have larger UV colour gradients. By combining UV imaging from GALEX, optical imaging from MDM and SAURON integral-field spectroscopy, we investigate the spatially-resolved relationships between UV colours and stellar population properties of 34 early-type galaxies from the SAURON survey sample. We find that galaxies with old stellar populations show tight correlations between the FUV colours (FUV-V and FUV-NUV) and the Mg b index, $H{\beta}$ index and metallicity [Z/H]. We have also derived logarithmic internal radial colour, measured line strength and derived stellar population gradients for each galaxy and again found a strong dependence of the FUV-V and FUV-NUV colour gradients on both the Mg b line-strength and the metallicity gradients. In particular, global gradients of Mg b and [Z/H] with respect to the UV colour across galaxies are consistent with their local gradients within galaxies, suggesting that the global correlations also hold locally. From a simple model based on multi-band colour fits of UV upturn and UV-weak galaxies, we have identified a plausible range of parameters that reproduces the observed radial colour profiles. In these models, the centers of elliptical galaxies, where the UV flux is strong, are enhanced in metals by roughly 60% compared to UV-weak regions.

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A Study to Guarantee Minimum Bandwidth to TCP Traffic over ATM-GFR Service (ATM-GFR 서비스에서 TCP 트래픽의 최소 대역폭 보장에 관한 연구)

  • 박인용
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.27 no.4C
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    • pp.308-315
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    • 2002
  • Guaranteed frame rate (GFR) service has been defied to provide minimum cell rate (MCR) guarantees for virtual connections (VCs) carrying Internet traffic in ATM networks and allow them to fairly share residual bandwidth. The simplest switch implementation mechanism to support the GFR service in ATM networks consists of the frame-based generic cell rate algorithm (F-GCRA) frame classifier and the early packet discard (EPD)-like buffer acceptance algorithm in a single FIFO buffer. This mechanism is simple, but has foiled to guarantee the same bandwidth as an MCR to a VC that has reserved a relatively large MCR. This paper applies the packet spacing scheme to TCP traffic to alleviate its burstness, so as to guarantee a larger MCR to a VC. In addition, the random early detection (RED) scheme is added to the buffer acceptance algorithm in order to improve fairness in use of residual bandwidth. Simulation results show that the applied two schemes improve a quality of service (QoS) in the GFR service for the TCP traffic.

A study on the eye Location for Video-Conferencing Interface (화상 회의 인터페이스를 위한 눈 위치 검출에 관한 연구)

  • Jung, Jo-Nam;Gang, Jang-Mook;Bang, Kee-Chun
    • Journal of Digital Contents Society
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    • v.7 no.1
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    • pp.67-74
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    • 2006
  • In current video-conferencing systems. user's face movements are restricted by fixed camera, therefore it is inconvenient to users. To solve this problem, tracking of face movements is needed. Tracking using whole face needs much computing time and whole face is difficult to define as an one feature. Thus, using several feature points in face is more desirable to track face movements efficiently. This paper addresses an effective eye location algorithm which is essential process of automatic human face tracking system for natural video-conferencing. The location of eye is very important information for face tracking, as eye has most clear and simplest attribute in face. The proposed algorithm is applied to candidate face regions from the face region extraction. It is not sensitive to lighting conditions and has no restriction on face size and face with glasses. The proposed algorithm shows very encouraging results from experiments on video-conferencing environments.

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Analysis of Empirical Constant of Eddy Viscosity by Zero- and One-Equation Turbulence Model in Wake Simulation

  • Park, Il Heum;Cho, Young Jun;Kim, Tae Yun;Lee, Moon Ock;Hwang, Sung Su
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.20 no.3
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    • pp.323-333
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    • 2014
  • In this paper, the wakes behind a square cylinder were simulated using two kinds of different turbulence models for the eddy viscosity concept such as the zero- and the one-equation model in which the former is the mixing length model and the latter is the k-equation model. For comparison between numerical and analytical solutions, we employed three skill assessments: the correlation coefficient(r) for the similarity of the wake shape, the error of maximum velocity difference(EMVD) for the accuracy of wake velocity and the ratio of drag coefficient(RDC) for the pressure distribution around the structure. On the basis of the numerical results, the feasibility of each model for wake simulation was discussed and a suitable value for the empirical constant was suggested in these turbulence models. The zero-equation model, known as the simplest turbulence model, overestimated the EMVD and its absolute mean error(AME) for r, EMVD and RDC was ranging from 20.3 % to 56.3 % for all test. But the AME by the one-equation model was ranging from 3.4 % to 19.9 %. The predicted values of the one-equation model substantially agreed with the analytical solutions at the empirical mixing length scale $L=0.6b_{1/2}$ with the AME of 3.4 %. Therefore it was concluded that the one-equation model was suitable for the wake simulation behind a square cylinder when the empirical constant for eddy viscosity would be properly chosen.

The Prediction and Analysis of the Power Energy Time Series by Using the Elman Recurrent Neural Network (엘만 순환 신경망을 사용한 전력 에너지 시계열의 예측 및 분석)

  • Lee, Chang-Yong;Kim, Jinho
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.41 no.1
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    • pp.84-93
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    • 2018
  • In this paper, we propose an Elman recurrent neural network to predict and analyze a time series of power energy consumption. To this end, we consider the volatility of the time series and apply the sample variance and the detrended fluctuation analyses to the volatilities. We demonstrate that there exists a correlation in the time series of the volatilities, which suggests that the power consumption time series contain a non-negligible amount of the non-linear correlation. Based on this finding, we adopt the Elman recurrent neural network as the model for the prediction of the power consumption. As the simplest form of the recurrent network, the Elman network is designed to learn sequential or time-varying pattern and could predict learned series of values. The Elman network has a layer of "context units" in addition to a standard feedforward network. By adjusting two parameters in the model and performing the cross validation, we demonstrated that the proposed model predicts the power consumption with the relative errors and the average errors in the range of 2%~5% and 3kWh~8kWh, respectively. To further confirm the experimental results, we performed two types of the cross validations designed for the time series data. We also support the validity of the model by analyzing the multi-step forecasting. We found that the prediction errors tend to be saturated although they increase as the prediction time step increases. The results of this study can be used to the energy management system in terms of the effective control of the cross usage of the electric and the gas energies.