• Title/Summary/Keyword: SHP-2

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A Study of School Doctor Program for Dysmenorrhea in Korean Medicine (월경통 한의 교의 사업에 관한 연구)

  • Song, Lak Gu;Sung, Hyun Kyung;Go, Ho Yeon;Park, Jang Kyung
    • The Journal of Pediatrics of Korean Medicine
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    • v.32 no.4
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    • pp.87-102
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    • 2018
  • Objectives This study aims to investigate the effect of the Korean medicine in treating dysmenorrhea as a part of school health program (SHP) and satisfaction rate of the participated students in this program. With this study, we tried to contribute to the development of health promotion program of Korean medicine. Methods As part of the 'Korean Medicine Health Promotion Project', we conducted a dysmenorrhea program at one of many high schools in Eumseong-gun. From April to June 2018, we conducted the promotion program a total of 7 times and analyzed the questionnaire regarding satisfaction and the monthly experience of menstruation. Results The study participants' grade distribution was $2^{nd}$ grade 32, $3^{rd}$ grade 23 with a total 55 students. Mean dysmenorrhea VAS was $6.07{\pm}2.10$, and the mean number of visits to the dysmenorrhea program was $3.61{\pm}1.47$. There were no significant differences in the average number of visits between grades. Overall satisfaction was $4.06{\pm}0.97$, teacher satisfaction was $4.29{\pm}1.10$, and lecture satisfaction was $4.18{\pm}0.95$. Dysmenorrhea decreased but was not statistically significant. Conclusions Korean medicine is appropriate for the health promotion program. With cooperation and support from local schools, it will be very possible to carry out a successful business. It is also necessary to organize the program according to the viewpoint of youth and to interact with the students.

Technical feasibility study for power generation from a potential mini hydro site nearby Shoolini University

  • Pundir, Anil;Kumar, Anil
    • Advances in Energy Research
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    • v.2 no.2
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    • pp.85-95
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    • 2014
  • Small Hydro-Power (SHP) is an environmental friendly technology. Usually hydro power generation projects are viewed as constructing large dams and reservoirs but available new research and engineering techniques have helped hydro power generation without large dams and without large reservoirs. In India, there are several water installations, irrigation dams, canals, streams or running rivers not tapped to generate power. In these cases the existing system and facilities can help in generating power with less investment and time. This area is yet unexplored. Harnessing a stream for hydroelectric power is a major undertaking for the energy crises and the global issues to go green. In this technical note a potential site for mini hydro power plant nearby Shoolini University is identified and examined for the economic feasibility.

Chicken novel leukocyte immunoglobulin-like receptor subfamilies B1 and B3 are transcriptional regulators of major histocompatibility complex class I genes and signaling pathways

  • Truong, Anh Duc;Hong, Yeojin;Lee, Janggeun;Lee, Kyungbaek;Tran, Ha Thi Thanh;Dang, Hoang Vu;Nguyen, Viet Khong;Lillehoj, Hyun S.;Hong, Yeong Ho
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.5
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    • pp.614-628
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    • 2019
  • Objective: The inhibitory leukocyte immunoglobulin-like receptors (LILRBs) play an important role in innate immunity. The present study represents the first description of the cloning and structural and functional analysis of LILRB1 and LILRB3 isolated from two genetically disparate chicken lines. Methods: Chicken LILRB1-3 genes were identified by bioinformatics approach. Expression studies were performed by transfection, quantitative polymerase chain reaction. Signal transduction was analyzed by western blots, immunoprecipitation and flow cytometric. Cytokine levels were determined by enzyme-linked immunosorbent assay. Results: Amino acid homology and phylogenetic analyses showed that the homologies of LILRB1 and LILRB3 in the chicken line 6.3 to those proteins in the chicken line 7.2 ranged between 97%-99%, while homologies between chicken and mammal proteins ranged between 13%-19%, and 13%-69%, respectively. Our findings indicate that LILRB1 and LILRB3 subdivided into two groups based on the immunoreceptor tyrosine-based inhibitory motifs (ITIM) present in the transmembrane domain. Chicken line 6.3 has two ITIM motifs of the sequence LxYxxL and SxYxxV while line 7.2 has two ITIM motifs of the sequences LxYxxL and LxYxxV. These motifs bind to SHP-2 (protein tyrosine phosphatase, non-receptor type 11) that plays a regulatory role in immune functions. Moreover, our data indicate that LILRB1 and LILRB3 associated with and activated major histocompatibility complex (MHC) class I and ${\beta}2-microglobulin$ and induced the expression of transporters associated with antigen processing, which are essential for MHC class I antigen presentation. This suggests that LILRB1 and LILRB3 are transcriptional regulators, modulating the expression of components in the MHC class I pathway and thereby regulating immune responses. Furthermore, LILRB1 and LILRB3 activated Janus kinase2/tyrosine kinase 2 (JAK2/TYK2); signal transducer and activator of transcription1/3 (STAT1/3), and suppressor of cytokine signaling 1 genes expressed in Macrophage (HD11) cells, which induced Th1, Th2, and Th17 cytokines. Conclusion: These data indicate that LILRB1 and LILRB3 are innate immune receptors associated with SHP-2, MHC class I, ${\beta}2-microglobulin$, and they activate the Janus kinase/signal transducer and activator of transcription signaling pathway. Thus, our study provides novel insights into the regulation of immunity and immunopathology.

Durable Press Finish of Cotton via Dual Curing Using UV Light and Heat

  • Jang, Jinho;Yoon, Ki-Cheol;Ko, Sohk-Won
    • Fibers and Polymers
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    • v.2 no.4
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    • pp.184-189
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    • 2001
  • Continuous photografting/crosslinking of polyethyleneglycol dimethacrylate oligomers onto cotton using a water-soluble benzophenone photoinitiator was investigated. Photografting increased with increasing irradiation dose, oligomer concentration and photoinitiator concentration. Maximum grafting efficiency of DM 400 and 600 were 83% and 79%, respectively. the photografting increased the wrinkle resistance of cotton implying surface crosslinking of cotton. bothsurface crosslinking and bulk crosslinking of cotton were accomplished via dual curing of a mixed formulation containing both a thermally curable component (BTCCA/SHP) and a UV-curable component. The wrinkle resistance of the crosslinked cotton was found to be higher when cured by thermal curing due to the facile post-polymerization of the UV active component. The presence of crosslinks in the dually crosslinked cotton was verified with FT-IR and thermogravimetric analysis.

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Ultrasonic image diagnosis using pattern recognition (패턴인식을 이용한 초음파 화상의 진단)

  • Choi, K.C.;Kim, S.I.;Lee, D.S.
    • Proceedings of the KOSOMBE Conference
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    • v.1991 no.11
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    • pp.57-60
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    • 1991
  • A new approach to texture classification for ultrasound liver diagnosis using run difference matrix was developed. The run difference matrix consists of the gray level difference along with distance. From this run difference matrix, we defined several parameters such as LDE, LDEL, NUF, SMO, SMG, SHP etc. and three vectors namely DOD, DGD and DAD. Each parameter value calculated in fatty cirrhotic, chronic hepatitic and normal liver mage was plotted in two dimensional plane. We compared our results with run length method. There are several advantages of run difference matrix method over the run lengths. 1) It is more sensitive to small difference of gray level distribution. 2) The parameters provide more statistically significant value. Images were classified with the extracted parameters to each diseases using neural networks. In preliminary clinical exprements, this approach showed satisfying results.

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LAND COVER CHARACTERISTICS OF MOUNTAIN REGIONS IN NORTH KOREA (북한 산악지역의 개간지 및 산림 특성에 관한 연구)

  • Cha, Su-Young;Park, Chong-Hwa
    • Proceedings of the KSRS Conference
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    • 2008.03a
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    • pp.109-112
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    • 2008
  • 현재 북한 토지피복 특성 중의 하나인 과도한 산지의 농지로의 전용은 홍수 등 자연재해를 일으키는 원인이 되고 있지만 북한에 대한 참조자료의 부족으로 피해규모나 상황에 대한 이해가 부족하다. 본 연구는 북한 양강도 산간지역을 대상으로 개간농지와 산림의 토지피복특성을 가을시기(2005 년 10 월 25 일) Quickbird (<0.6m) 위성영상의 육안분석과 분광특성을 이용하여 정확한 토지피복분류에의 기초 정보를 제공하는 것을 목적으로 한다. 토지피복 유형별 Training area 의 ROI(Region of Interest)의 면적은 2500pixel 로 하였고, 이것을 다시 .shp 파일로 변환하여 GoogleEarth 에서 표고 및 경사 등 보다 자세한 지형지물을 확인하였다. Quickbird 영상의 NDVI 분석을 통해 0.2 정도에서 식생과 농경지로 구분하는 임계값(Threshold)을 추정할 수 있었지만 늦게까지 추수를 끝내지 않은 농작물이나 이모작 농작물의 경우는 산림과 혼재되어 나타나고 있었다. 또한, 산림의 북사면은 수역 다음으로 낮은 NDVI 값을 나타내어 지형의 영향이 나타나고 있음을 알 수 있었다.

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A Study on the Evaluation of Synthetic Seakeeping Performance of a Ship Using Real Time Weather Data (실시간 기상정보를 이용한 선박의 종합내항성능 평가에 관한 연구)

  • Kim, Soon-Kap;Lee, Sang-Min;Lee, Choong-Ro
    • Journal of the Korean Institute of Navigation
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    • v.22 no.2
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    • pp.23-32
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    • 1998
  • There is a limitation for a ship which is sailing on sea to gather weather and seastate informations. To make up for this weakness, land organizations can gather wider variety of information and evaluate the seakeeping performanceon ship. And supply this information to the ship. In this study, calculated the response amplitude of shp motions with the weather information provided in real time, the nominal speed loss with obtaining increase of resistance caused by wave and stochastic process of the seakeeping performance elements. And the results have been achieved to develop a system which can evaluate the synthetic seakeeping performance. Using this system, the results have been studied to determine the feasibility of using simulation in actural operation onboard ship.

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A D-Band Balanced Subharmonically-Pumped Resistive Mixer Based on 100-nm mHEMT Technology

  • Campos-Roca, Y.;Tessmann, A.;Massler, H.;Leuther, A.
    • ETRI Journal
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    • v.33 no.5
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    • pp.818-821
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    • 2011
  • A D-band subharmonically-pumped resistive mixer has been designed, processed, and experimentally tested. The circuit is based on a $180^{\circ}$ power divider structure consisting of a Lange coupler followed by a ${\lambda}$/4 transmission line (at local oscillator (LO) frequency). This monolithic microwave integrated circuit (MMIC) has been realized in coplanar waveguide technology by using an InAlAs/InGaAs-based metamorphic high electron mobility transistor process with 100-nm gate length. The MMIC achieves a measured conversion loss between 12.5 dB and 16 dB in the radio frequency bandwidth from 120 GHz to 150 GHz with 4-dBm LO drive and an intermediate frequency of 100 MHz. The input 1-dB compression point and IIP3 were simulated to be 2 dBm and 13 dBm, respectively.

An Study on the Erosion Characteristics of Tube CN98 (CN98 포신의 마모특성 연구)

  • Kim, Jae-Kab
    • Journal of the Korea Institute of Military Science and Technology
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    • v.9 no.2 s.25
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    • pp.42-52
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    • 2006
  • Tube erosion can be defined as a phenomenon for an increment of bore diameter, a declination of accuracy and utility of tube by firing. This study introduces the characteristics of tube life for the 155 mm K9 SHP Using a tube history book with bore measurement data and firing data of standard charge, this study analyzed the EFC vs Tube life and EFC with heat transfer effect formula as a consideration of continuous firing vs tube life. The results were compared with Firing Table(FT 155-K9-1) after the analysis. Also, this study suggests that CN98 tube can be rifled as 1000 EFC through the severe condition with continuous firing.

Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects

  • Miao, Longxing;Yang, Yijun;Li, Zhongwen;Fang, Zengjun;Zhang, Yongqing;Han, Chun-chao
    • Journal of Ginseng Research
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    • v.46 no.2
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    • pp.206-213
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    • 2022
  • Ginsenoside Rb2 is an active protopanaxadiol-type saponin, widely existing in the stem and leave of ginseng. Rb2 has recently been the focus of studies for pharmaceutical properties. This paper provides an overview of the preclinical and clinical pharmacokinetics for Rb2, which exhibit poor absorption, rapid tissue distribution and slow excretion through urine. Pharmacological studies indicate a beneficial role of Rb2 in the prevention and treatment of diabetes, obesity, tumor, photoaging, virus infection and cardiovascular problems. The underlying mechanism is involved in an inhibition of oxidative stress, ROS generation, inflammation and apoptosis via regulation of various cellular signaling pathways and molecules, including AKT/SHP, MAPK, EGFR/SOX2, TGF-β1/Smad, SIRT1, GPR120/AMPK/HO-1 and NF-κB. This work would provide a new insight into the understanding and application of Rb2. However, its therapeutic effects have not been clinically evaluated. Further studies should be aimed at the clinical treatment of Rb2.