• Phonetics and Speech Sciences
• /
• v.6 no.2
• /
• pp.163-174
• /
• 2014

Korean L2 speakers have many problems learning the pronunciation of English words. One of these problems is vowel epenthesis. Vowel epenthesis is the insertion of vowels into or between words, and Korean learners of English typically do this between successive consonants, either within clusters, or across syllables, word boundaries or following final coda consonants. The aim of this study was to investigate whether individual differences in vowel epenthesis are more closely related to the perception and production of segments (vowels and consonants) and prosody or if they are relatively independent from these processes. Subjects completed a battery of production and perception tasks. They read sentences, identified vowels and consonants, read target words likely to have epenthetic vowels (e.g., abduction) and demonstrated stress recognition and epenthetic vowel perception. The results revealed that Korean second-language learners (L2) have problems with vowel epenthesis in production and perception, but production and perception abilities were not correlated with one another. Vowel epenthesis was strongly related to vowel production and perception, suggesting that problems with segments may be combined with L1 phonotactics to produce epenthesis.

• Journal of Power Electronics
• /
• v.15 no.4
• /
• pp.1026-1034
• /
• 2015

In this paper, a unified control strategy using the current space vector modulation (CSVM) technique is proposed and applied to a bidirectional three-phase DC/AC converter. The operation of the converter changes with the direction of the power flow. In the charging mode, it works as a buck type rectifier; and during the discharging mode, it operates as a boost type inverter, which makes it suitable as an interface between high voltage AC grids and low voltage energy storage devices. This topology has the following advantages: high conversion efficiency, high power factor at the grid side, tight control of the charging current and fast transition between the charging and discharging modes. The operating principle of the mode analysis, the gate signal generation, the general control strategy and the transition from a constant current (CC) to a constant voltage (CV) in the charging mode are discussed. The proposed control strategy has been validated by simulations and experimental results obtained with a 1kW laboratory prototype using supercapacitors as an energy storage device.

• Plant Resources
• /
• v.3 no.1
• /
• pp.93-97
• /
• 2000

As indicated by Chinese letters “沙赫” (sha-ji) is the ripe fruit of Seabuckthron(Hippophae rhamnoides Linneus) family Flaeagnaceae is one of ancient natural medicine used by the Tibetan and Mongolian nationallites with ancient methods to treat desease. It is an effectiv Traditional Tibetan medicine. Bud only now are they beginning to be understood in the world of modern medicine. Hippophae was written in the book of Traditional Tibetan Medicine - “Somalaza” (8th century), “Sibuyidian” (1840) and “Jingzhubencao” (Qing Dynasty). The “Sibuyidien” was trnslated in to the Russian and published at 1903 in the Russian. Then the Russian bigan to study on Hippophae and they have achieved great successes. The Chinese scientists began to study on the chemical constituent and medical action with modern technique at 1952. With more than 40 years painstaking eport they have conceived and used a wide variety of experimental screening systems, achieved successes. Finally they with one's own tests has keen verified that the crude drug being various kind of bioactive substance could inhibits tumor, increase immunity, wipe out free radical, prevent disease of cardiovascular system, have anti-radiation, anti-inflammeutory effects. At 1977 the Hippophae rhamnoides was written in Chinase Pharmacopoeia.

• Parasites, Hosts and Diseases
• /
• v.55 no.5
• /
• pp.505-512
• /
• 2017

Toxoplasma gondii cathepsin C proteases (TgCPC1, 2, and 3) are important for the growth and survival of T. gondii. In the present study, B-cell and T-cell epitopes of TgCPC1 were predicted using DNAstar and the Immune Epitope Database. A TgCPC1 DNA vaccine was constructed, and its ability to induce protective immune responses against toxoplasmosis in BALB/c mice was evaluated in the presence or absence of the adjuvant ${\alpha}-GalCer$. As results, TgCPC1 DNA vaccine with or without adjuvant ${\alpha}-GalCer$ showed higher levels of IgG and IgG2a in the serum, as well as IL-2 and $IFN-{\gamma}$ in the spleen compared to controls (PBS, pEGFP-C1, and ${\alpha}-GalCer$). Upon challenge infection with tachyzoites of T. gondii (RH), $pCPC1/{\alpha}-GalCer$ immunized mice showed the longest survival among all the groups. Mice vaccinated with DNA vaccine without adjuvant (pCPC1) showed better protective immunity compared to other controls (PBS, pEGFP-C1, and ${\alpha}-GalCer$). These results indicate that a DNA vaccine encoding TgCPC1 is a potential vaccine candidate against toxoplasmosis.

• Journal of information and communication convergence engineering
• /
• v.10 no.1
• /
• pp.85-90
• /
• 2012

A 40-MS/sec 10-bit pipelined analog to digital converter (ADC) with a 1.2 Vpp differential input signal is proposed. The implemented pipelined ADC consists of eight stages of 1.5 bit/stage, one stage of 2 bit/stage, a digital error correction block, band-gap reference circuit & reference driver, and clock generator. The 1.5 bit/stage consists of a sub-ADC, digital to analog (DAC), and gain stage, and the 2.0 bit/stage consists of only a 2-bit sub-ADC. A bootstrapped switch with a constant resistance is proposed to improve the linearity of the input switch. It reduces the maximum VGS variation of the conventional bootstrapped switch by 67%. The proposed bootstrapped switch is used in the first 1.5 bit/stage instead of a sample-hold amplifier (SHA). This results in the reduction of the hardware and power consumption. It also increases the input bandwidth and dynamic performance. A reference voltage for the ADC is driven by using an on-chip reference driver without an external reference. A digital error correction with a redundancy is also used to compensate for analog noise such as an input offset voltage of a comparator and a gain error of a gain stage. The proposed pipelined ADC is implemented by using a 0.18-${\mu}m$ 1- poly 5-metal CMOS process with a 1.8 V supply. The total area including a power decoupling capacitor and the power consumption are 0.95 $mm^2$ and 51.5 mW, respectively. The signal-to-noise and distortion ratio (SNDR) is 56.15 dB at the Nyquist frequency, resulting in an effective number of bits (ENOB) of 9.03 bits.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.16 no.1
• /
• pp.70-79
• /
• 2016

This paper proposes a low-power range-scaled 14b 30 MS/s pipeline-SAR composite ADC for high-performance CIS applications. The SAR ADC is employed in the first stage to alleviate a sampling-time mismatch as observed in the conventional SHA-free architecture. A range-scaling technique processes a wide input range of 3.0VP-P without thick-gate-oxide transistors under a 1.8 V supply voltage. The first- and second-stage MDACs share a single amplifier to reduce power consumption and chip area. Moreover, two separate reference voltage drivers for the first-stage SAR ADC and the remaining pipeline stages reduce a reference voltage disturbance caused by the high-speed switching noise from the SAR ADC. The measured DNL and INL of the prototype ADC in a $0.18{\mu}m$ CMOS are within 0.88 LSB and 3.28 LSB, respectively. The ADC shows a maximum SNDR of 65.4 dB and SFDR of 78.9 dB at 30 MS/s, respectively. The ADC with an active die area of $1.43mm^2$ consumes 20.5 mW at a 1.8 V supply voltage and 30 MS/s, which corresponds to a figure-of-merit (FOM) of 0.45 pJ/conversion-step.

• Journal of IKEEE
• /
• v.14 no.1
• /
• pp.8-16
• /
• 2010

This paper presents a design of the successive approximation ADC(SA-ADC) applicable to a midium-low speed analog-front end(AFE) for the maximum 15MS/s CCD image processing. SA-ADC is effective in applications ranging widely between low and mid data rates due to the large power scaling effect on the operating frequency variations in some other way of pipelined ADCs. The proposed design exhibits some distinctive features. The "differential capacitor-coupling scheme" segregates the input sampling behavior from the sub-DAC incorporating the differential input and the sub-DAC output, which prominently reduces the loading throughout the signal path. Determining the MSB(sign bit) from the held input data in advance of the data conversion period, a kind of the signed successive approximation, leads to the reduction of the sub-DAC hardware overhead by 1 bit and the conversion period by 1 cycle. Characterizing the proposed design in a 3.3 V $0.35-{\mu}m$ CMOS process by Spectre simulations verified its validity of the application to CCD analog front-ends.

• Journal of Ginseng Research
• /
• v.45 no.2
• /
• pp.334-343
• /
• 2021

Background: Gut microbiota mainly function in the biotransformation of primary ginsenosides into bioactive metabolites. Herein, we investigated the effects of three prebiotic fibers by targeting gut microbiota on the metabolism of ginsenoside Rb1 in vivo. Methods: Sprague Dawley rats were administered with ginsenoside Rb1 after a two-week prebiotic intervention of fructooligosaccharide, galactooligosaccharide, and fibersol-2, respectively. Pharmacokinetic analysis of ginsenoside Rb1 and its metabolites was performed, whilst the microbial composition and metabolic function of gut microbiota were examined by 16S rRNA gene amplicon and metagenomic shotgun sequencing. Results: The results showed that peak plasma concentration and area under concentration time curve of ginsenoside Rb1 and its intermediate metabolites, ginsenoside Rd, F2, and compound K (CK), in the prebiotic intervention groups were increased at various degrees compared with those in the control group. Gut microbiota dramatically responded to the prebiotic treatment at both taxonomical and functional levels. The abundance of Prevotella, which possesses potential function to hydrolyze ginsenoside Rb1 into CK, was significantly elevated in the three prebiotic groups (P < 0.05). The gut metagenomic analysis also revealed the functional gene enrichment for terpenoid/polyketide metabolism, glycolysis, gluconeogenesis, propanoate metabolism, etc. Conclusion: These findings imply that prebiotics may selectively promote the proliferation of certain bacterial stains with glycoside hydrolysis capacity, thereby, subsequently improving the biotransformation and bioavailability of primary ginsenosides in vivo.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.13 no.4
• /
• pp.139-149
• /
• 2003

In this paper a hardware design of area-efficient hash processor which implements MD5 algorithm using hardware sharing and carry-save addition schemes is described. To reduce area, the processor adopts hardware sharing scheme in which 1 step operation is divided into 2 substeps and then each substep is executed using the same hardware. Also to increase clock frequency, three serial additions of substep operation are transformed into two carry-save additions and one carry propagation addition. The MD5 hash processor is designed using 0.25 $\mu\textrm{m}$CMOS technology and consists of about 13,000 gates. From timing simulation results, the designed MD5 hash processor has 465 Mbps hash rates for 512-bit input message data under 120 MHz operating frequency.

• Journal of Microbiology and Biotechnology
• /
• v.25 no.11
• /
• pp.1819-1826
• /
• 2015

Poly(ε-ʟ-lysine) (ε-PL) is a novel bioactive polymer secreted by filamentous bacteria. Owing to lack of a genetic system for most ε-PL-producing strains, very little research on enhancing ε-PL biosynthesis by genetic manipulation has been reported. In this study, an effective genetic system was established via intergeneric conjugal transfer for Streptomyces albulus PD-1, a famous ε-PL-producing strain. Using the established genetic system, the Vitreoscilla hemoglobin (VHb) gene was integrated into the chromosome of S. albulus PD-1 to alleviate oxygen limitation and to enhance the biosynthesis of ε-PL in submerged fermentation. Ultimately, the production of ε-PL increased from 22.7 g/l to 34.2 g/l after fed-batch culture in a 5 L bioreactor. Determination of the oxygen uptake rate, transcriptional level of ε-PL synthetase gene, and ATP level unveiled that the expression of VHb in S. albulus PD-1 enhanced ε-PL biosynthesis by improving respiration and ATP supply. To the best of our knowledge, this is the first report on enhancing ε-PL production by chromosomal integration of the VHb gene in an ε-PL-producing strain, and it will open a new avenue for ε-PL production.