• 한국산학기술학회논문지
• /
• 제3권3호
• /
• pp.221-226
• /
• 2002

Medicare에서는 급증하는 진료비 증가를 통제하고 양질의 의료서비스를 제공하기 위하여 일종의 예산통제시스템인 SGR을 도입하여 시행하고 있다. SGR에 대한 비판이 있긴 하나 진료비 급증을 통제하는데 나름대로 기여한 것으로 평가받고 있다. 본 연구에서는 노인인구증가, 급여율 증가 등으로 의료비가 급증하고 있는 우리나라의 현 상황에서 Medicare의 SGR의 의미, 문제점을 살펴보고 수가계약제가 시행되고 있는 우리의 경우 성공적으로 SGR을 적용하기 위한 전제 조건 등을 살펴본다.

• Molecules and Cells
• /
• 제38권5호
• /
• pp.390-395
• /
• 2015

Degradation of chlorophyll (Chl) by Chl catabolic enzymes (CCEs) causes the loss of green color that typically occurs during senescence of leaves. In addition to CCEs, STAYGREEN1 (SGR1) functions as a key regulator of Chl degradation. Although sgr1 mutants in many plant species exhibit a staygreen phenotype, the biochemical function of the SGR1 protein remains elusive. Many recent studies have examined the physiological and molecular roles of SGR1 and its homologs (SGR2 and SGR-LIKE) in Chl metabolism, finding that these proteins have different roles in different species. In this review, we summarize the recent studies on SGR and discuss the most likely functions of SGR homologs.

• 한국미생물·생명공학회지
• /
• 제44권4호
• /
• pp.563-570
• /
• 2016

S. griseus wild type에서 dasA 유전자의 과발현에 의해 유도된 기저균사의 ectopic sporulation 관련 유전자를 알아보기 위해서, empty vector가 삽입된 균주와 dasA가 과발현된 균주의 전사체를 DNA microarray법으로 비교하였다. DNA microarray 결과를 토대로 dasA 유전자 과발현 균주에서 2배이상 발현량이 증가되었으며 p-value가 0.05 미만(p-value < 0.05)인 유전자들 중에서 false positive 를 제외시키는 작업을 통하여 최종적으로 4개의 유전자(SGR794, SGR2469, SGR3656, SGR3657)와 3개의 cluster (SGR795-797, SGR2377-2378, SGR6997-6998)를 선발하였다. 이들의 전사량은 low resolution Sl nuclease mapping 법을 통하여 dasA 유전자 과발현 균주에서 증가된 것을 확인하였다.

• 한국지반환경공학회 논문집
• /
• 제14권1호
• /
• pp.53-60
• /
• 2013

본 연구에서는 대표적인 물유리계 공법인 SGR 공법과 SMI 공법을 실내시험으로 공학적 특성을 비교한 것으로, 각 조건별 양생기간과 양생조건에 따라서 내구성, 강도 및 차수특성, 환경 영향성을 비교 분석하였다. 그 결과 내구성의 경우 SGR 공법은 SMI 공법에 비해 최대 23배 정도 체적변형이 발생하였고, 환경에 미치는 영향은 두 시료 모두 안전한 것으로 나타났다. 차수특성의 경우 SMI 공법은 최대 24% 정도 감소하였으나 SGR의 경우 체적변형이 급격하게 발생하여 간극이 커져 투수계수가 커지는 경향을 나타냈으며, 강도특성은 SMI 공법이 SGR 공법 보다 호모겔의 경우 약 11.0배, 샌드겔의 경우 약 3.9배 정도 높게 나타났다. 이러한 주원인은 SMI 공법은 SGR 공법 보다 용출현상으로 인한 체적변형이 적게 나타났기 때문으로 판단된다.

• 혜화의학회지
• /
• 제17권1호
• /
• pp.95-104
• /
• 2008

This study was designed to investigate the Effects of Smilacis Glabrae Rhizoma(SGR) on the gout. After pretreatment of SGR(50, 500mg/kg) for 5days, the Effects of SGR was evaluated on changes Joint value increase ratio, Serum albumin, Serum globulin, glutamate dxalacetate transminase(AST), glutanate pyruvate transminase(ALT), blood urea nitrogen(BUN), Serum creatitine, Serum uric acid, xanthine oxidase activity, WBC, Erythrocyte Sedimentation Rate(ESR), platelet. The results were obtained as follows ; Joint valueincrease ratio was decreased in 50mg/kg, 500mg/kg SGR taken group, but changes were not significantly different with the control group. AST, ALT were not significantly different in all SGR taken groups compared with the control group. Serum BUN, creatinine were significantly decreased in 500mg/kg SGR taken group compared with control group. ESR was significantly decreased in all SGR taken groups compared with the control group. WBC, platelet were significantly decreased in 500mg/kg SGR taken group compared with control group. Serum uric acid was not significantly different in all SGR taken groups compared with the control group. Xanthine oxidase activity was significantly decreased in 500mg/kg SGR taken group compared with control group. From above results, it may be concluded that SGR can be used for treatment and prevention of gout.

• 대한본초학회지
• /
• 제33권2호
• /
• pp.45-52
• /
• 2018

Objectives : Smilacis Glabrae Rhizoma (SGR) has been used in traditional medicine for treating diseases related to inflammation and cancer. However, the protective effect of SGR has not been reported in the study of acute pancreatitis (AP). Therefore, this study was performed to evaluate the protective effects of SGR water extract on cerulein-induced AP. Methods : AP was induced by intraperitoneal injection of supramaximal concentrations of stable cholecystokinin analogue cerulein ($50{\mu}g/kg$) 6 times at intervals of one hour in mice. SGR water extract (0.01, 0.05, or 0.1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of cerulein. The mice were sacrificed at 6 h after the final injection of cerulein. Pancreas and lung were rapidly removed for histochemical examination and myeloperoxidase (MPO) assay. In addition, polymerase chain reaction (PCR) was performed to examine mRNA levels of proinflammatory cytokines such as interleukin(IL)-6, $IL-1{\beta}$ and Tumor necrosis $factor(TNF)-{\alpha}$. Results : Administration of SGR water extract significantly inhibited pancreatic weight to body weight ratio. In addition, SGR treatment inhibited the histological damages and increase of MPO activity in both pancreas and lung during AP. Also, mRNA levels of IL-6 but not $IL-1{\beta}$and $TNF-{\alpha}$ were inhibited by SGR water extract against AP. Conclusion : Our results revealed that pre-treatment of SGR water extract reduces the severity of cerulein-induced AP. Therefore, this study suggest that SGR could be used as a drug or agent to prevent AP.

• Food Science and Biotechnology
• /
• 제16권2호
• /
• pp.238-242
• /
• 2007

Square root models were developed for predicting the kinetics of growth of Listeria monocytogenes in sesame leaves as a function of temperature (4, 10, or $25^{\circ}C$). At these storage temperatures, the primary growth curves fit well ($R^2=0.898$ to 0.980) to a Gompertz equation to obtain lag time (LT) and specific growth rate (SGR). The square root models for natural logarithm transformations of the LT and SGR as a function of temperature were obtained by SAS's regression analysis. As storage temperature ($4-25^{\circ}C$) decreased, LT increased and SGR decreased, respectively. Square root models were identified as appropriate secondary models for LT and SGR on the basis of most statistical indices such as coefficient determination ($R^2=0.961$ for LT, 0.988 for SGR), mean square error (MSE=0.l97 for LT, 0.005 for SGR), and accuracy factor ($A_f=1.356$ for LT, 1.251 for SGR) although the model for LT was partially not appropriate as a secondary model due to the high value of bias factor ($B_f=1.572$). In general, our secondary model supported predictions of the effects of temperature on both LT and SGR for L. monocytogenes in sesame leaves.

• 천문학회보
• /
• 제40권2호
• /
• pp.38.4-39
• /
• 2015

We have been monitoring Sgr A*, the radio source at the center of our galaxy, continuously since G2 encounter was predicted. KaVA is a powerful High resolution imaging array at K and Q band, and it has a excellent uv-coverage for Sgr A*. Together with 1-Gbps recording, our observations have provided high-quality images of Sgr A* at Q-band. Our images reveal a scatter-broadened, elliptical Gaussian structure of the source. We found no significant flux or structural variation of Sgr A* in 2013-2014, which is consistent with recent simulations by Kawashima et al. Continuous monitoring in the coming few years would be able to capture the possible flux increase in the source caused by G2, which will lead to better understanding of the accretion process around supermassive black holes.

• 한국산학기술학회논문지
• /
• 제4권2호
• /
• pp.57-62
• /
• 2003

미국에서 시행중인 SGR을 도입하기 위해서는 우선 건강보험진료비의 증가요인에 대한 분석이 선행되어야 한다. 진료비의 증가요인을 찾고 각 요인에 대한 기여율이 주어진 경우 이 요소들을 보다 쉽게 나타내 줄 수 있는 GDP나 MEI를 이용하여 수가조정률을 구할 수 있다 그러나 문제는 과연 GDP나 MET의 변화에 따라 수가조정률이 어느 정도 이루어지는지에 대한 연구가 부족하다. 본 연구에서는 건강보험진료비 증가요인에 대한 개념적인 식을 구성한 뒤 GDP나 MEI가 증가요인들에 대한 대리변수가 될 수 있다는 점을 알 수 있었고 이 요소들의 변화가 수가변화에 어느 정도 영향을 미치는지를 살펴보았다. 그 결과 우리나라에서는 GDP변화율이 심해 미국에 비해 환산지수 변화가 클 수 있다는 점을 발견할 수 있었다.

• 대한본초학회지
• /
• 제25권1호
• /
• pp.23-31
• /
• 2010

Objectives : The purpose of this study was to compare the anticancer effects of Smilacis Chinae Rhizoma (SCR) and Smilacis Glabrae Rhizoma (SGR) on stomach cancer SNU-1 cells. Methods : The cell proliferation, apoptosis and cytokine level from the extracts were examined in order to compare the anticancer effects of SCR and SGR on SNU-1 cells. Results : SCR had greater anticancer effects than SGR in terms of the inhibition of cell proliferation and apoptosis in the SNU-1 cells. SCR decreased TGF-$\beta$ and SGR increased IL-2 in SNU-1 cells. SCR decreased more TGF-$\beta$ and increased more TNF-$\alpha$ compared to SGR. Conclusions : There were few significant differences according to the concentration and fraction, but a greater anticancer effect of SCR was shown as compared with SGR.