• 대한통합의학회지
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• 제12권3호
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• pp.121-130
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• 2024

Purpose : This study was conducted to investigate the effect of neck stabilization exercises using a stick on the pain, headache, and quality of life of adult patients with chronic non-specific neck pain. Methods : The participants of this study were 28 adult patients with chronic non-specific neck pain. The subjects were assigned to the experimental group (n=15, neck stabilization exercises using a stick after conservative physical therapy) and the control group (n=13, conservative physical therapy) according to the order of participation in the study and the intervention methods. The intervention was conducted three times a week for four weeks. The neck stabilization exercises using a stick consisted of isometric exercises of the muscles around the neck and strengthening exercises of the muscles around the scapula. The visual analog scale (VAS) and headache impact test (HIT-6) were used to measure the pain and headache, and the SF 36 health questionnaire (SF-36) was used to measure the quality of life. Results : In the comparison of VAS, HIT-6, and SF-36, there were significant differences between before and after the intervention in both the experimental and control groups (p<.05). The pre-post comparisons between the two groups according to the experiment showed significant differences between the experimental group and the control group (p=.001). However, the experimental group showed greater changes than the control group. Conclusion : Through this study, it was confirmed that neck stabilization exercises using a stick have positive effects on reducing the neck pain and headaches and improving the quality of life of adult patients with chronic neck pain. Therefore, it is considered that neck stabilization exercises using a stick can be used as an effective exercise method for the treatment and prevention of patients with chronic neck pain in the future.

• Radiation Oncology Journal
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• 제23권1호
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• pp.51-60
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• 2005

목적 : 분자 표적의 선택적 억제가 방사선 세포 살상 효과를 증진시키는 것으로 알려져 있으므로 선택적 COX-2 억제제와 EGF 수용체 차단제를 HeLa 세포주에 처리한 후 방사선 효과의 상승작용을 알아보고자 하였다. 대상 및 방법 : 자궁경부암 세포주인 HeLa세포에서 EGF 수용체 차단제 AG 1478, 선택적 COX-2 억제제 NS 398과 방사선을 복합 투여하여 세포성장 억제 분석(cell graph inhibition assay)과 세포사멸 분석(apoptosis assay)을 시행하였고, 방사선 감수성 변화를 살펴보기 위해 세포생존 분석(clonogenic survival assay)을 시행하였다. 방사선 감수성 인자로는 2 Gy에서의 세포생존분획($SF_2$)과 linear-quadratic model을 이용한 dose enhancement ratio (DER)를 사용하였다. 방사선 감수성에 대한 작용기전 분석을 위해 flow cytometry로 세포주기 분석(cell cycle analysls)을 시행하였고, western blot 분석을 통하여 bcl-2와 bax 단백질의 발현 변화를 살펴보았다. 결과 : HeLa세포에 NS 398과 AG 1478을 방사선과 함께 복합 투여한 실험 군에서 세포사멸 정도가 가장 높게 나타났다($8.49\%$ vs. $22.70\%$). 세포주기 분석 결과, 방사선과 복합 약물 처리군에서 $G_0/G_l$ 세포주기 정체와 5 세포 분획 소실이 나타났으며 이러한 변화는 72시간 이후까지 지속되었다 세포생존 분석 결과로는 방사선과 AG 1478군에서 $SF_{2}0.68{\pm}0.07$, DER 1.12를 보인 반면, 방사선과 복합약물처리군에서는 $SF_{2}0.12{\pm}0.01,\;DER\;3.00$으로 나타났다. Western blot분석에서는 방사선과 복합약물처리군에서 bcl-2와 bax 단백질 발현이 모두 감소하는 양상을 보였다. 결론 : 신호전달 체계를 억제하는 분자 표적 약제인 선택적 COX-2 억제제와 EGF 수용체 차단제를 방사선과 복합투여함으로써 HeLa세포의 방사선 감수성이 증가됨을 확인하였다.

• 한국수정란이식학회지
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• 제33권1호
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• pp.1-11
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• 2018

Cellular cyclic adenosine-3' 5'-monophosphate (cAMP) modulator is known as meiotic inhibitor and can delays spontaneous maturation in IVM experiment. Among many cAMP modulators, the role of Pituitary adenylate cyclase activating polypeptide (PACAP) on IVM isn't known. The purpose of this study is to improve the maturation of oocytes derived from follicles ${\leq}3mm$ in diameter through PACAP as meiotic inhibitor during pre-in vitro maturation (pre-IVM). First, we checked PACAP and its receptors in cumulus cells and, to establish the optimal phase and concentration of PACAP for pre-IVM, we conducted chromatin configuration assessments. As a result, the rate of GV (Germinal Vesicle) according to duration of pre-IVM was significantly decreased 12 h and 18 h after IVM (87.1 and 84.1%, respectively) compared to 0 h (99.4%). When COC was cultured for 18 h, the GV rate in the $1{\mu}M$ of PACAP treatment group (82.1%) was significantly higher than any other PACAP treatment groups (60.5, 64.1, 74.4 and 69.9 %, respectively). So, we divided into four groups as follows; MF (the conventional IVM group, obtained from follicle from 3 to 6 mm in diameter), SF (the conventional IVM group, obtained from follicle ${\leq}3mm$ in diameter), Pre-SF(-)PACAP (IVM group including 18 h pre-IVM without $1{\mu}M$ of PACAP, obtained from follicle ${\leq}3mm$ in diameter) and Pre-SF(+)PACAP (IVM group including 18 h pre-IVM with $1{\mu}M$ of PACAP, obtained from follicle ${\leq}3mm$ in diameter). To examine the effect of PACAP during pre-IVM, we investigated analysis of nuclear maturation, intracellular glutathione (GSH) and reactive oxygen species (ROS) levels. In cumulus cells, PACAP receptors, ADCYAP1R1 and VIPR1 were detected but were not detected in oocytes. After IVM, the Pre-SF(+)PACAP had the highest Metaphase II rate (91.7%) among all groups (P<0.05). The GSH levels in the MF and Pre-SF(+)PACAP were significantly higher than in the other groups (P<0.05) and ROS levels was no significant difference among all groups. In conclusion, these results indicated that even though the oocytes were derived from SF, pre-IVM application of PACAP improved meiotic and cytoplasmic maturation by regulating intracellular oxidative stress.

• 과학과기술
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• 제27권12호통권307호
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• pp.39-43
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• 1994

초인간 6백만불의 사나이가 하나의 과학소설(SF)에 등장하는 가공인물이 아니라 현실로 다가오고 있다. 현대의학의 눈부신 발전에 힘입어 병들거나 고장난 인체부위를 인공장기나 다른 사람의 장기로 갈아끼우는 본격적인 인간개조시대가 열리고 있기 때문이다. 6배만불의 사나이는 가능한 것일까? 인공장기 연구개발 현황과 문제점을 총점검해 본다.

• Korean Journal of Acupuncture
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• 제28권3호
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• pp.233-244
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• 2011

Objectives : To evaluate the effectiveness of direct moxibustion in patients with failed back surgery syndrome (FBSS). Methods : 5 patients (3 females and 2 males) with FBSS underwent direct moxibustion on ouch points (阿是穴) for 10 to 15 weeks (once a week). The effectiveness of the treatment was evaluated with NRS (numerical rating scale), ODI (Oswestry disability index), BDI (Beck depression inventory) score, SF-36 (short form 36 health survey) score and PSQI (Pittsburgh sleep quality index) before and after the treatment. Results : Within observation period, average value changed from 10.0 to 4.2 in NRS of pain, from 37.0 to 20.6 in ODI, from 20.6 to 12.0 in BDI score, 42.2 to 62.6 in SF-36 score, and from 8.6 to 5.2 in PSQI. Conclusions : Direct moxibustion on FBSS patients showed more or equivalent effectiveness when compared to conventional FBSS treatment modalities.

• 전기학회논문지
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• 제56권12호
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• pp.2122-2126
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• 2007

A special PM-Tube(Photo Multiplier Tube) that is using the photoelectric effect has been designed and manufactured to measure the radiation energy of arc in a gas circuit breaker(GCB). The PM-Tube, LLG(liquid light guides), ND(neutral density) filter, and a model gas circuit breaker have been combined for the reception and the transmission of the light and a simplified synthetic test facility with the arc energy measuring system has been established. In the case of $SF_6$ gas pressure $5kg.f/cm^2$ and arc length 20mm, the radiation energy increases with the arc current but it tend to be saturated in the above 20kA. Under the arc current 20kA, the total radiation energy has the biggest value around 8kA and was not exceeded 40% of the total arc energy.

• 척추신경추나의학회지
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• 제6권1호
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• pp.35-42
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• 2011

Objective : The purpose of this study is evaluated the effects of Oriental treatments to symptoms and quality of life in the patients with herniated cervical disc being suggested operation. Methods : 20 patients diagnosed with herniated cervical disc by MRI in hospital were treated by oriental medical treatments. Symptoms of the patients were assessed by analogue scale(VAS) and SF-36. Results : After 12 weeks treatments, the VAS of symptoms of herniated cervical disc and the score of SF-36 were significantly improved. Conclusions : It could be suggested that oriental medical treatments were effective for the patients with herniated cervical disc being suggested operation. Further study of the effect of oriental medical treatments on herniated cervical disc is needed.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제54권12호
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• pp.532-539
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• 2005

The demand of Gas Insulated Transformer(GIT) using $SF_6$ gas as insulating and cooling medium is being increased dramatically in the underground substation of urban area because it has the advantages of non-flammable and non-explosive, etc. This paper describes the structural features and advantages of the gas insulated transformer compare to an oil immersed transformer, and presents a brief overview of the consideration and technology which apply to $SF_6$ gas insulated transformer.

• 기본간호학회지
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• 제16권4호
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• pp.490-496
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• 2009

Purpose: The purpose of this study was to examine the validity of a single item scale by comparing a single item scale of health related quality of life to subscopes of the multi-item scales in the Medical Outcome Study Short Form-36 (SF-36), and Minnesota Living with Heart Failure Questionnaire (MLHFQ). Method: The data from 103 patients with heart failure were analyzed. The statistics program SPSS 12.0 used for descriptive statistics. Results: Significant correlations were found between the single item scale and subscopes of SF-36, for physical functioning (r= .42), role physical (r= .22), general health perception (r= .46), vitality (r= .40), social functioning (r= .20) and mental health (r= .51), but not for body pain (r= .12) and role emotional (r= .06). Physical (r= -.41), emotional (r= -.49) and total scores (r= -.49) of MLHFQ were significantly related to the single item scale. Conclusion: The single item scale of health related quality of life showed low to moderate correlation with multi-item scales. Even though the single item scale was correlated with several subscopes of multi-item scales, the correlation was not high, so we have to use caution when using the single item scale instead of multi-item scales.

• 사상체질의학회지
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• 제23권3호
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• pp.330-339
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• 2011

1. Objectives: The purpose of this study is to find the association between personality pattern and quality of life according to Sasang Constitution. 2. Methods: The 529 subjects whose constitutions had been confirmed by the experts on the base of drug response were recruited. Personality questionnaire was composed of 15 personal characteristics items measuring the influence of yin/yang and health estimating instrument was SF-12 evaluating the quality of life. Two-way ANOVA was conducted to analyze the Sasang Constitutional difference according to personality pattern. 3. Results: There were 5 different items in PCS(physical component summary), 7 different items in MCS(mental component summary). The individual scores of 3 items - give up easily/stand, decide easily/hard and be exited easily/rationalwere different according to the Sasang Constitution. 4. Conclusions: We suggest that psychological factors may affect the health state, especially might affect the health state of Sasang Constitution differently.