• 제목/요약/키워드: SCN1A

검색결과 76건 처리시간 0.027초

Heterotrophic nitrification-aerobic denitrification potential of cyanide and thiocyanate degrading microbial communities under cyanogenic conditions

  • Mekuto, Lukhanyo;Kim, Young Mo;Ntwampe, Seteno K.O.;Mewa-Ngongang, Maxwell;Mudumbi, John Baptist N.;Dlangamandla, Nkosikho;Itoba-Tombo, Elie Fereche;Akinpelu, E.A.
    • Environmental Engineering Research
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    • 제24권2호
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    • pp.254-262
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    • 2019
  • The impact of free cyanide ($CN^-$) and thiocyanate ($SCN^-$) on the $CN^-$ (CDO) and $SCN^-$ degraders (TDO) to nitrify and denitrify aerobically was evaluated under alkaline conditions. The CDO's were able to nitrify under cyanogenic conditions, achieving $NH_4{^+}-N$ removal rates above 1.66 mg $NH_4{^+}-N.L^{-1}.h^{-1}$, except when $CN^-$ and $SCN^-$ loading was 15 mg $CN^-/L$ and 50 mg $SCN^-.L^{-1}$, respectively, which slightly inhibited nitrification. The TDO's were able to achieve a nitrification rate of 1.59 mg $NH_4{^+}-N.L^{-1}.h^{-1}$ in the absence of both $CN^-$ and $SCN^-$, while the presence of $CN^-$ and $SCN^-$ was inhibitory, with a nitrification rates of 1.14 mg $NH_4{^+}-N.L^{-1}.h^{-1}$. The CDO's and TDO's were able to denitrify aerobically, with the CDO's obtaining $NO_3{^-}-N$ removal rates above 0.67 mg $NO_3{^-}-N.L^{-1}.h^{-1}$, irrespective of the tested $CN^-$ and $SCN^-$ concentration range. Denitrification by the TDO's was inhibited by $CN^-$, achieving a removal rate of 0.46 mg $NO_3{^-}-N.L^{-1}.h^{-1}$ and 0.22 mg $NO_3{^-}-N.L^{-1}.h^{-1}$ when $CN^-$ concentration was 10 and 15 mg $CN^-.L^{-1}$, respectively. However, when the CDO's and TDO's were co-cultured, the nitrification and aerobic denitrification removal rates were 1.78 mg $NH_4{^+}-N.L^{-1}.h^{-1}$ and 0.63 mg $NO_3{^-}-N.L^{-1}.h^{-1}$ irrespective of $CN^-$ and $SCN^-$ concentrations.

네트워크사회' 만들기: Seattle Community Network의 사례 (Shaping the 'Network Society': A Case Study of Seattle Community Network)

  • 이영희
    • 과학기술학연구
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    • 제6권1호
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    • pp.31-52
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    • 2006
  • 이 연구는 1993년에 미국 서북부에 위치한 중소도시인 시애틀(Seattle)에 기반을 두고 만들어져 지금까지 10년 넘게 유지되어 온, 시애틀 커뮤니티 네트워크(Seattle Community Network)라는 전자적 지역공동체망을 네트워크사회를 구성하는 한 부분으로 보고, SCN이 어떠한 사회적 과정을 거쳐 만들어지고 전개되는가를 심층적으로 분석하는 데 목적이 있다. 오3f은 정보기술의 발전, 특히 인터넷기술의 발전이 네트워크사회가 발전할 수 있는 토양을 어떻게 제공해주는지, 그리고 이러한 전자적 지역 공동체망이 어떠한 사회적 과정을 거쳐 만들어지고 또 정체하게 되는가를 잘 보여주는 대표적인 사례라고 할 수 있다. SCN의 건설은 기술적 필연성의 논리가 아니라 사회적 힘들에 의해 추진되었고, 결국 또한 사회적 힘들의 영향을 받아 정체상태를 맞이하게 되었다. SCN은 정보기술과 네트워크사회에 대한 자본의 지배를 제어하고 정보화가 보다 시민친화적인 방향으로 추진될 수 있도록 시민사회가 나서서 건설한 것이었지만 정보자본주의화의 진전 속에서 결국에는 자본의 거대한 영향력 하에서 더 이상 성장하지 못하고 정체상태를 맞이하게 되었다. 이상의 분석을 통해 우리는 기술결정론이 함의하는 바와는 달리 네트워크사회가 정보기술이 일방적으로 만들어 네는 사회가 아니라 다양한 환경적, 사회적 요인들의 상호작용 속에서 만들어지는 동태적인 성격을 지니는 것임을 알 수 있다.

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Investigation of Soybean Cyst Nematode Heterodera Glycines Type and Evaluation of Resistance on Soybean Varieties and Germplasms in Korea

  • Kim, Myung-Sik;Sung, Mi-Kyung;Kim, Min-Whan;Seo, Hyung-Jin;Kim, Dong-Geun;Chung, Jong-Il
    • 한국작물학회지
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    • 제58권2호
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    • pp.161-168
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    • 2013
  • Soybean cyst nematode (Heterodera glycines Ichinohe) is one of the serious soybean [Glycine max (L.) Merr.] pests in major soybean producing countries. The objective of this study was to investigate of Heterodera glycines type using the five SCN infested soybean field soils and was to evaluate resistance to the soybean cyst nematode HG 2.5.7 type on soybean varieties and germplasms. The five SCN contaminated soil samples were collected from the three provinces on November 2011 in Korea, and eggs were cultured on early spring season in 2012. For the second study, a total fifty nine soybean varieties and germplasms were tested by infestation of HG type 2.5.7 in the greenhouse. Soybean cyst nematode HG types were investigated from five locations, HG 2 (race 1) type at Donghae, HG 2.5 (race 1) type at Jeongseon and Hapcheon, HG type 2.5.7 (race 1 or 5) at Yeongwol, and HG 1.2.7 (race 5) type at Haenam locations in present study. No Korean soybean varieties and germplasms were observed with SCN resistant trait to the HG type 2.5.7. Average SCN female index were calculated with 82.7% in 59 plant materials. Our results could be provided useful information to develop a SCN resistant cultivar in Korea.

가토 신피질 절편에서 PAH$(\rho-aminohippuric\;acid)$ 이동에 미치는 음이온의 영향 (Effects of Anions on PAH Transport in Rabbit Kidney Cortical Slices)

  • 서덕준;이상호;성호경
    • The Korean Journal of Physiology
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    • 제19권1호
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    • pp.49-59
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    • 1985
  • The effects of anions on net accumulation of $(\rho-aminohippuric\;acid)$(PAH) were studied in rabbit kidney cortical slices. Experiments were carried while varying the major anionic composition of the incubation medium(replacement of $Cl^-$ by isethionate and $SCN^-$). The total replacement of $Cl^-$ with isethionate, $SO_4\;^{2-}$ and $SCN^-$ in the incubation medium decreased the 60-min slice-to-medium concentration(S/M) ratio of PAH to 60%, 40% and 50% of control value, respectively. The degree of inhibition in PAH accumulation by the replacement of isethionate and $SCN^-$ was increased with increasing of both preincubation and incubation time. The influence of isethionate and $SCN^-$ on PAH uptake was fully reversible. Both isethionate and $SCN^-$ increased the apparent Km value significantly with no change on the apparent Vmax value, suggesting a competitive inhibition on PAH uptake. And the inhibitory effect of $SCN^-$ on PAH uptake decreased with increase of pH in the incubation medium while that of isethionate increased with increase of pH. Intracellular water content, intracellular electrolyte concentration and oxygen consumption were not influenced by the replacement of $Cl^-$ with isethionate or $SCN^-$ in the incubation medium. These results suggest that both $isethionate^-$ and $SCN^-$ inhibit the PAH uptake by binding to some site necessary for normal PAH transport without affecting the cellular viability.

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혼합정수계획법과 시뮬레이션 기법을 이용한 군 공급사슬망 설계 (Design of military supply chain network using MIP & Simulation model)

  • 이병호;정동화;서윤호
    • 한국국방경영분석학회지
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    • 제34권3호
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    • pp.1-12
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    • 2008
  • 효율적인 공급사슬 망 설계는 공급사슬망 전체의 최적화를 추구하고 이를 통해 장기적이고 전략적인 의사결정을 뒷받침한다. 공급사슬망 설계 문제는 고려 대상이 광범위하고 시스템 조건과 상황에 따라 많은 확률적 요소들을 포함하고 있기 때문에 이를 수리 모델로 표현하더라도 현실을 명확히 반영하기는 어렵다. 본 연구에서는 수리 모델 및 시뮬레이션 기법을 이용한 군 공급사슬망 설계 방법을 제시하였다. 혼합정수계획법이 적용된 수리 모델을 이용하여 총비용을 최소화하는 공급사슬망을 구성하고, 수리 모델의 결과를 시뮬레이션 모델에 반영하여 실험 파라미터의 반복적인 조정을 통해 차량할당 및 경로문제를 해결하였다. 본 연구의 두 모델은 각각 CPLEX와 AutoMod로 실행하였으며, 실제 군 공급사슬망에서 군지사의 임무 제한에 따라 공급사슬망을 재구성하는 실험을 실시하였다. 이 실험을 통하여, 본 연구에서 제시한 방법이 군 공급사슬망 설계 문제해결에 용이하게 적용될 수 있다는 것을 보였다.

한국재래산양 시각교차위핵에 관한 형태학적 연구 (Morphological study on suprachiasmatic nucleus of the Korean native goat)

  • 송승훈;이흥식;이인세;황인구;이충현
    • 대한수의학회지
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    • 제40권4호
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    • pp.665-670
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    • 2000
  • The present study was undertaken to investigate the morphological characteristics of the suprachiasmatic nucleus (SCN) of the Korean native goat by cresyl violet stain. The SCN was located ventrolateral to the third ventricle and dorsal to the optic chiasm. This nucleus was showed carrot form in longitudinal section. Its size was 1.8 mm in length, 0.9 mm in maximum height and 1.6 mm in maximum width. In coronal sections, the SCN shaped very thin plate in rostral part, but it was changed to sweet-potato form in middle part, and ornamental jade form in caudal part. The size of SCN was larger in caudal part than in rostral part. The size of the neuron of SCN was about $10{\mu}m$ in diameter with round or oval shape. The boundary of SCN was not firmly defined in caudal part because the neurons were dispersed into the hypothalamic region. It is concluded that the SCN of the Korean native goat has a morphological characteristics.

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Hypokalemic periodic paralysis: two different genes responsible for similar clinical manifestations

  • Kim, Hun-Min;Hwang, Hee;Cheong, Hae-Il;Park, Hye-Won
    • Clinical and Experimental Pediatrics
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    • 제54권11호
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    • pp.473-476
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    • 2011
  • Primary hypokalemic periodic paralysis (HOKPP) is an autosomal dominant disorder manifesting as recurrent periodic flaccid paralysis and concomitant hypokalemia. HOKPP is divided into type 1 and type 2 based on the causative gene. Although 2 different ion channels have been identified as the molecular genetic cause of HOKPP, the clinical manifestations between the 2 groups are similar. We report the cases of 2 patients with HOKPP who both presented with typical clinical manifestations, but with mutations in 2 different genes ($CACNA1S$ p.Arg528His and $SCN4A$ p.Arg672His). Despite the similar clinical manifestations, there were differences in the response to acetazolamide treatment between certain genotypes of $SCN4A$ mutations and $CACNA1S$ mutations. We identified p.Arg672His in the $SCN4A$ gene of patient 2 immediately after the first attack through a molecular genetic testing strategy. Molecular genetic diagnosis is important for genetic counseling and selecting preventive treatment.

Atom Transfer Radical Polymerization of Hexadecyl Acrylate Using CuSCN as the Catalyst

  • Xu, Wenjian;Zhu, Xiulin;Cheng, Zhenping;Chen, Jianying;Lu, Jianmei
    • Macromolecular Research
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    • 제12권1호
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    • pp.32-37
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    • 2004
  • The atom transfer radical polymerization (ATRP) of hexadecyl acrylate (HDA) was carried out in Ν,Ν-dimethylformamide (DMF) in the presence of CuSCN/Ν,Ν,Ν′,Ν"Ν"-pentamethyldiethylenetriamine (PMDETA). The results indicate that the polymerization is well-controlled: a linear increase of molecular weights occurs with respect to conversion and the polydispersities are relatively low. In particular, the use of CuSCN as the catalyst resulted in faster polymerization rates for hexadecyl acrylate than did those using either CuBr or CuCl; the polydis-persity, however, was larger than those obtained in the cases when CuBr and CuCl were used. In addition, we report the thermodynamic data and activation parameters for the solution ATRP of hexadecyl acrylate.

콩 Cyst 선충 Race 5에 대한 저항성 QTL 탐색 (Identification of Quantitative Trait Loci for Resistance to Soybean Cyst Nematode Race 5)

  • Choi, In-Soo;Kim, Yong-Chul;Kim, Sung-Man;Lee, Chung-Yeol;Park, Hyean-Cheal;Halina T. Skorupska
    • 한국작물학회지
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    • 제42권6호
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    • pp.712-721
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    • 1997
  • 콩 품종 Essex와 PI 437654간 교잡 후 F$_2$유래 F$_3$ 계통들을 재료로 하여 작성된 RAPD 유전자지도상에 cyst 선충 race 5에 대한 저항성 QTLs 분석을 실시한 바 결과를 요약하면 다음과 같다. 1. 회귀분석 결과 26개의 marker들(22 RAPD, 4 RFLP)에서 cyst 선충 race 5 저항성 반응에 대한 유의성이 인정되었다. 2. MAPMAKER /QTL 분석 결과2개의 저항성 QTL들이 탐색되었는데, 이 QTL들은 2개의 linkage groups(LGC-20와 Group 2)에 위치하였다. 3. 탐색된 2개의 QTL들 중 1개는 우성유전, ?고 나머지 하나는 열성유전양상을 나타내었다. 4. 콩 cyst 선충 race 5의 저항성에 대한 유의성이 인정되는 5개의 marker들간 상호작용을 알아보기 위한 다중회귀분석 결과 총 26개의 조합들 중 4개의 marker들(E02$^3$, G$10^1$, W03, pK418C)로 구성된 조합에서 가장 높은 표리적 변이의 값(35.2%)을 나타내었다.

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In Situ Scanning Tunneling Microscope of Cyanide and Thiocyanate Adsorption on Pt(111)

  • Yau, Shueh-Lin;Kim, Youn-Geun;Itaya, Kingo
    • 분석과학
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    • 제8권4호
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    • pp.723-730
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    • 1995
  • Cyclic voltammetry and in situ STM were employed to examine the interfacial structures of a Pt(111) electrode in 0.1 mM KCN (pH9.5) and 0.1 mM KSCN (pH7) solutions. In situ STM atomic resolution revealed well ordered (2${\surd}$3${\times}$2${\surd}$3)$R30^{\circ}$-6CN and ($2{\times}2$)-2SCN structures within the double layer charging region. Six CN adsorbates formed a hollow hexagon, which embraced a coadsorbed $K^+$ cation. In contrast, the coadsorbed $K^+$ cations on the SCN covered Pt(111) were poorly ordered, despite adsorbed SCN formed a long range ordered ($2{\times}2$)-2SCN adlattice. In situ STM revealed the pronounced influence of potential in controlling the structures of compact layers at the proximity of a Pt electrode. Cathodic polarization facilitated the replacement of the coadsorbed cations by protons.

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