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Studies on Preparation of $^{99m}Tc$ Complexes of Methionine Isomers (Methionine 이성질체들의 $^{99m}Tc$ 착물 제조 연구)

  • Awh, Ok-Doo;Chang, Hee-Soon;Lee, Dong-Sun
    • The Korean Journal of Nuclear Medicine
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    • v.26 no.1
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    • pp.140-146
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    • 1992
  • $^{99m}Tc-Methionine$ complexes from enantiomeric and racemic methionines were prepared controlling reaction parameters such as pH and the concentration of stannous chloride. Some radiochromato-graphic systems were also examined to determine the labelling yields of $^{99m}Tc$ complexes. The best resolutions of $^{99m}Tc$ complexes were obtained at ITLC-SA developed with acetone and paper chromatography with n-butanol saturated with 0.3N HCI. In the former system, $HR-{99m}Tc$ and $^{99m}Tc-methionine$ complex remained at origin, while $^{99m}TcO_4^-$ moved with Rf value of 1.0. In latter process, $HR-^{99m}Tc$ stayed at the origin, while $^{99m}TcO_4^-\;and\;^{99m}Tc-methionine$ complexes moved with Rf value of 0.5. By combining of two chromatographic systems, the contents of three $^{99m}Tc$ species were calculated easily. $^{99m}Tc$ Labelling from enantiomeric and racemic methionines had little differences and the optimal condition was found at pH 9.00 and the molar ratio of methionine to stannous chloride of 24:1. The yields of $^{99m}Tc$ complexes from D-, L-, and DL-methionines were 87.6%, 94.1%, and 97.9%, respectively. The results indicated that methionine containing relatively hydrophobic methylthio group $(-SCH_3)$ would be labelled with $^{99m}Tc$ by stannous chloride method.

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Analysis of 1559 Kidney Biopsies : A Single Center Study (1,559례의 소아 신생검에 대한 고찰 : 단일기관 연구)

  • Choi, Yong-Sung;Kim, Sun-Kyoung;Kim, Sung-Do;Cho, Byoung-Soo
    • Childhood Kidney Diseases
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    • v.10 no.2
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    • pp.174-181
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    • 2006
  • Purpose : To analyse the results of the renal biopsies and the clinical diagnoses of patients who had undergone percutaneous kidney biopsies in the department of pediatrics at Kyunghee University Hospital for 22 years from 1984 to 2005. Methods : We retrospectively reviewed the medical records of 1559 patients and analyzed the chief complaints that led to a renal biopsy, age, sex, histopathologic findings and diagnosis. Routine kidney biopsies were performed by automated gun biopsy guided by real time ultrasonography. The diagnoses were made based on the specimen's light microscopy, immunofluorescence microscopy and electron microscopy findings and clinical symptoms and signs. Results : The mean age of the patients was 10 years with the male to female ratio being 1.3:1. The chief complaints that led to a renal biopsy included hematuria only(753 cases, 48.3%), proteinuria only(125 cases, 8.0%) and hematuria combined with proteinuria(537 cases, 34.4%). The most frequent histopathological finding was primary glomerular disease(75.4%) which included IgA nephropathy(30.1%) and mesangial proliferative glomerulonephritis(27.6 %). Systemic disease comprised 11.4% which included Henoch-$Sch\ddot{o}nlein$ nephritis(10.5%) and lupus nephritis(0.8%). Alport syndrome was found in 1.1% of cases which was attributed to hereditary causes. 628 children(40.3%) visited the clinic due to abnormal school urine screening abnormalities and among these, 237 children had mesangial proliferative glomerulonephritis and 234 children who had IgA nephropathy were managed thereafter. Conclusion : IgA nephropathy and mesangial proliferative glomerulonephritis were the two major forms of primary glomerulonephritis found in Korean children who had kidney biopsies from 1984 to 2005.

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Changes of Volatile Flavor Compounds of Seibel Grape Must during Alcohol Fermentation and Aging (Seibel 포도즙 알코올 발효 및 저장 중 휘발성 향기성분의 변화)

  • 고경희;장우영
    • Microbiology and Biotechnology Letters
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    • v.27 no.6
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    • pp.491-499
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    • 1999
  • A great variety of the volatile metabolic by-products was formed in yeast cell during alcohol fermentation. The seibel grape (Vitis labrasca) which was grown in the Southern Korea used for wines. The objective of this research was to identify the volatile flavor compounds during alcohol fermentation and aging at 12$^{\circ}C$. saccharomyces cerevisiae and Schizosaccharomyces pombe were inoculated and fermented in seibel grape must. The volatile flavor compounds of logarithmic, stationary and death phases were extracted, concentrated and identified by gas chromatography/mass spectrometer (GC/MS). The volatile flavor compounds were determined by a Hewlett-Packard 5890 II Plus GC which was equipped with Supelcowax 10 fused silica capillary column (60m$\times$0.32mm$\times$0.25${\mu}{\textrm}{m}$ film thickness) wall coated with polyethyleneglycerol. The scan detection method allowed the comparison of the spectrum from the chromatogram of volatile flavor compounds to those in data Wileynbs base library. Among the volatile compounds collected by ether-hexane extraction method, the evolution of 20 main compounds, such as 9 esters (ethyl butyrate, isoamyl acetate, ethyl caproate, n-hexyl acetate, ethl caprylate, ethyl caprate, diethy succinate, ethyl hexadecanoate, 2-pheneethyl acetate), 4 alcohols (3-methyl-1-butanol, 1-hexanol, 1-heptanol, benzoethanol), 4 ketones and acids (2-octanone, caproic acid, caprylic acid, capric acid), 2 furan and phenol (2,6-bis(1,1-dimethyl ethyl)phenol, 2,3-dihydrobenzofuran) were observed during alcohol fermentation and aging. The production of the esters during alcohol fermentation with S. cerevisiae was higher than those of Sch. pombe. The sensory scores of the aged wine samples in aroma, taste and overall acceptability were not significantly different(p<0.05).

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A Study on Initial Cell Search Parameters in UMTS Terminal Modem (UMTS 단말기 모뎀의 초기 셀 탐색 파라미터의 영향에 대한 연구)

  • 류동렬;김용석;옥광만;최형진
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.28 no.5A
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    • pp.267-275
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    • 2003
  • In UMTS terminal modem uses 3 step search procedure for initial cell search, which comprises 1) slot synchronization, 2) code group identification and frame synchronization, and 3) scrambling-code identification. The performance of initial cell search procedure depends on search parameters like observation time and threshold. The purpose of this paper is to get the optimal observation time and threshold of each step for minimum mean acquisition time. In this paper we induce mean detection time of each step and mean acquisition timefrom the model of 3 step search procedure using state diagram. Also we propose initial cell search algorithm which utilize window search method against initial oscillator error, and select an appropriate observation time and threshold of each step by the analysis of simulation and induced result. It is shown that the mean acquisition time in multipath fading channel can be shorter than 500ms by using the determined observation time and threshold of each step.

1.31 um Uncooled DFB-LD with High Slope Efficiency for G-PON Application (G-PON용 높은 전광변환효율을 갖는 1.31 um 비냉각 DFB-LD)

  • Kim, Jeong-Ho;Pi, Joong-Ho;Kim, Deok-Hyun;Park, Chil-Sung;Ryu, Han-Gwon;Koo, Bon-Jo
    • Korean Journal of Optics and Photonics
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    • v.18 no.5
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    • pp.333-336
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    • 2007
  • A Strained Layer Multiquantum-Well (SL-MQW) distributed feedback laser at a wavelength of 1.31 um operating from $-40^{\circ}C$ to $85^{\circ}C$ without any cooling is grown by metal-organic chemical vapor deposition (MOCVD). Lasers with high slope efficiency are achieved through careful optimization of a SL-MQW active layer, especiallyoptimizing the amount of strain, the well thickness, the barrier thickness, the number of wells, and the active layer width. In this paper, we obtain the slope efficiencies of 0.38[mW/mA] and 0.26 [mW/mA] at $25^{\circ}C$ and $85^{\circ}C$, respectively. Threshold currents are 7.1[mA] and 19.8[mA] at $25^{\circ}C$ and $85^{\circ}C$, respectively.

Fabrication and Measurement of Optical Waveguide using Multi Quantum Well Intermixing (다중양자우물구조의 상호섞임을 이용한 광도파로의 제작 및 측정)

  • Yeo, Deok-Ho;Yoon, Kyung-Hun;Kim, Sung-June
    • Journal of the Korean Institute of Telematics and Electronics D
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    • v.36D no.7
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    • pp.50-55
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    • 1999
  • We have fabricated optical waveguide which utilizes intermixing of InGaAs/InGaAsP multi quantum well separate confinement heterostructure. The waveguide was fabricated by reactive ion etching technique using $CH_4/H_2$ gas mixture, and the width and depth of the waveguide ware $5{\mu}m$ and $1.2{\mu}m$, respectively. The propagation loss of the waveguide was measured by Fabry-Perot interference phenomena using tunable laser. For the waveguide after $800^{\circ}C$, 30s heat treatment, the measured loss was 3.76dB/cm and 3.95dB/cm for TE and TM mode, respectively. This value is very small compared to other waveguide made by IFVD technique. Hence, this technique can applied to integration of waveguide and electronic devices.

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Evaluation of C. Albicans and S. Mutans adherence on different provisional crown materials

  • Ozel, Gulsum Sayin;Guneser, Mehmet Burak;Inan, Ozgur;Eldeniz, Ayce Unverdi
    • The Journal of Advanced Prosthodontics
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    • v.9 no.5
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    • pp.335-340
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    • 2017
  • PURPOSE. Bacterial adhesion on provisional crown materials retained for a long time can influence the duration for which permanent prosthetic restorations can be healthily worn in the oral cavity. The aim of this study was to compare seven different commonly used provisional crown materials with regard to Streptococcus mutans and Candida albicans surface adhesion. MATERIALS AND METHODS. For each group, twenty specimens of the provisional fixed prosthodontic materials TemDent ($Sch{\ddot{u}}tz$), Imident (Imicryl), Tab 2000 (Kerr), Structur Premium (Voco), Systemp (Ivoclar Vivadent), Acrytemp (Zhermack), and Takilon-BBF (Takilon) were prepared (diameter, 10.0 mm; height, 2.0 mm). Surface roughness was assessed by atomic force microscopy. Each group was then divided into 2 subgroups (n=10) according to the microbial suspensions used: S. mutans and C. albicans. The specimens were incubated at $37^{\circ}C$ with S. mutans or C. albicans for seven days. Bacterial adherence on surfaces was assessed using the 2,3-bis[2-methyloxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide (XTT) assay. RESULTS. S. mutans showed maximum adhesion to Structur, followed by Systemp, Acrytemp, Takilon, Tab 2000, Imident, and TemDent (P<.05). The highest vital C. albicans adhesion was noted on Takilon, followed by Imident and Tab 2000; the lowest adhesion was noted on Systemp (P<.05). CONCLUSION. The materials showed significant differences in the degree of bacterial adhesion. C. albicans showed higher surface adhesion than S. mutans on provisional crown and fixed partial denture denture materials.

Health Literacy and Its Associated Factors in Korean-Chinese and Other Asian Immigrant Women in Korea (조선족과 다른 출신국 여성결혼이민자의 건강문해력과 영향 요인 비교)

  • Yang, Sook Ja;Chee, Yeon Kyung;An, Jisook;Park, Min Hee;Jung, Sunok
    • Journal of Korean Public Health Nursing
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    • v.28 no.2
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    • pp.211-227
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    • 2014
  • Purpose: The purpose of this study was to compare health literacy levels of Asian immigrant women and factors associated with health literacy focusing on Korean-Chinese and other Asian immigrants in Korea. Methods: Data were drawn from 258 immigrant women, comprising 56 Korean-Chinese and 202 other immigrants from the Philippines, Vietnam, Japan, Cambodia, Thailand, Uzbekistan, Taiwan, and Han-Chinese. The Rapid Estimate of Adult Literacy in Medicine - Short Form (REALM-SF) was used to assess health literacy, which consisted of seven medical words in Korean (behavior, exercise, menopause, rectal, antibiotics, anemia, and jaundice). Data analysis was performed using descriptive statistics, t-test, ANOVA with $Sch{\acute{e}}ffe$ post hoc test, and hierarchical regression. Results: Korean-Chinese women showed significantly higher levels of health literacy ($M=6.41{\pm}1.07$), compared to their other immigrant counterparts ($M=4.55{\pm}2.15$). While Korean-Chinese women with longer time since immigration (p=.048) reported higher health literacy, for other immigrants, those living with children (p<.001), longer time since immigration (p=.011), and greater Korean language proficiency (p=.004) showed an association with higher health literacy. Conclusion: When providing health care services and health education, health care professionals should consider differences in levels of health literacy and factors associated with health literacy among Korean Chinese and other immigrants.

Improvement of Field Uniformity in the Reverberation Chamber Using Diffusers Filled with Dielectric Material (유전체로 충진된 확산기를 이용한 전자파 잔향실 내의 전자기장 균일도 향상 연구)

  • Kim Hye-Kwang;Rhee Joong-Geun;Lim Wook-Chae
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.16 no.12 s.103
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    • pp.1222-1228
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    • 2005
  • Analysis on the field uniformity inside of a reverberation chamber was done at 2.45 GHz which is an operating frequency of MWO(Microwave Oven). The Schroeder's Quadratic Residue Diffuser was designed for the chamber, and 3 different types of diffusers have been investigated using the finite-difference time-domain(FDTD) method for the field characteristics of each type. Type 2 and 3 diffusers were filled with dielectric material, and the size of these could be designed smaller than Type 1, without degradation of field characteristic. Type 3 diffuser shows better results among the three types of diffusers in view of increased test region and better field uniformity.

Management of IgA vasculitis nephritis (Henoch-Schonlein purpura nephritis) in Children

  • Namgoong, Meekyng
    • Childhood Kidney Diseases
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    • v.24 no.1
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    • pp.1-13
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    • 2020
  • Immunoglobulin (Ig)A vasculitis nephritis (IgAVN), also referred to as Henoch-Schönlein purpura nephritis, is a relatively benign disease in children. However, two 24-year European cohort studies have reported high sustained rates of hypertension, severe proteinuria, and renal dysfunction in patients with IgAVN. Notably, the incidence and exacerbation rates of proteinuria, hypertension, and renal dysfunction during pregnancy were high even in women who recovered from IgAVN before pregnancy. Patients with IgAVN need lifelong care. Trials have been performed to investigate early biomarkers and genes associated with poor prognosis to identify high-risk patients in whom IgAVN may progress to severe renal disease. Urinary IgA/cr, IgM/cr levels, and HLAB35 and angiotensinogen gene expression were shown to be predictors of progression of IgAVN to severe renal dysfunction. The 2019 Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative group published guidelines for pediatric IgAVN, following the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines established in 2012. Compared with the KDIGO guidelines, the SHARE guidelines recommend earlier corticosteroid administration in cases of mild proteinuria (>0.5 g/d). Clinical trials of targeted budesonide delivery to the distal ileum, monoclonal antibody targeting C5, eculizumab and anti-CD20 monoclonal antibody administration, among others are currently underway in patients with IgA nephropathy. It is expected that newer therapeutic agents would become available for IgAVN in the near future. This review summarizes IgAVN with emphasis on recently published literature, including possible preventive strategies, predictive biomarkers for progression of IgAVN, and various treatments.