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The Serum Level of Insulin Growth Factor-1 and Insulin Growth Factor Binding Protein-3 in Children with Henoch-Schönlein Purpura

  • Kim, Hee Jin;Jung, Su Jin;Lee, Jun Ho
    • Childhood Kidney Diseases
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    • v.20 no.1
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    • pp.23-28
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    • 2016
  • Purpose: We investigated whether serum levels of insulin growth factor-1 (IGF-1) and insulin growth factor binding protein-3 (IGFBP-3) are valuable in predicting clinical outcomes or are correlated with other laboratory findings in children with Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP). Methods: We examined 27 children who were consecutively admitted to our hospital with HSP between January 2011 and February 2012. Blood tests (C-reactive protein, white blood cell count, platelet count, erythrocyte sedimentation rate, albumin, immunoglobulin A, complement C3, antineutrophil cytoplasmic antibody, IGF-1, IGFBP-3) and urine tests were performed upon admission. IGF-1 and IGFBP-3 were resampled in the recovery phase. Controls included 473 children whose IGF-1 and IGFBP-3 were sampled for evaluating their growth, at the outpatient department of pediatric endocrinology in our hospital. IGF-1 and IGFBP-3 were compared between the HSP children and controls, and between the acute and recovery phases in HSP children. The ability of these values to predict clinical outcomes including renal involvement was analyzed using bivariate logistic regression analysis (BLRA). Results: IGF-1 and IGFBP-3 were not different between the HSP children and controls ($148.7{\pm}117.6$ vs. $69.2{\pm}96.9$, P=0.290: $3465.9{\pm}1290.9$ vs. $3597.2{\pm}1,127.6$, P=0.560, respectively). There was no significant difference in IGF-1 or IGFBP-3 between acute and recovery phases. Based on the BLRA, no variable, including IGF-1 and IGFBP-3, could predict clinical outcomes including the presence of nephritis Conclusion: We concluded that IGF-1 and IGFBP-3 do not predict clinical outcomes of HSP, including renal involvement, in this study.

Nursing Ethics Values of Nursing Students (간호대학생의 간호윤리 가치관)

  • Kim, Mi-Hwa
    • The Journal of the Convergence on Culture Technology
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    • v.5 no.1
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    • pp.59-66
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    • 2019
  • This study was to investigate the effect of deontology and utilitarianism on the ethical values of nursing students and to provide basic data. Data collection was conducted from May 14 to June 1, 2018 in 180 students of a university nursing student in Daegu who explained their research and agreed to the study. The collected data were analyzed using the SPSS 21.0 program. In order to confirm the difference between the subjects' demographic characteristics and nursing-related characteristics, the independent t-test and ANOVA were used, and the post-test was conducted using the $Sch{\acute{e}}ffe$ post-test. The ethical values of the nursing students were $97.51{\pm}8.96$ out of 150, indicating that they were inclined toward the position of deontology. The first grade students were more dominant, and the higher the grade, the more inclined toward utilitarianism. It is necessary to develop education to establish ethical values so that ethical decision making can be done through philosophical thinking when various nursing dilemma situations in the clinical field are based on the results.

Life History of Retired Female Teachers: Analysis Methods of F. Schütze (퇴직 여교사의 생애: F. Schutze 방법으로 분석)

  • Han, Eun-Hwa;Lee, Hyun-Sim;Lee, Geon-Uk
    • 한국노년학
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    • v.36 no.4
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    • pp.959-979
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    • 2016
  • This study was performed to explore the life experience as a teacher was dissolved in life aimed at elementary school female teachers. The selection of the four-year teaching career more than 35 years, from January to November 2015 and retired teacher retirement not more than three years to 2015, five people in the study participants were conducting research. Research method was approached narrative interview method of qualitative research, Sch?tze of biographical research methods utilized in exploring how narratives. Results from this study showed the biographical curve through the 'biographical statement', 'experience the life of a female teacher','difficulties experienced in the reality of female teachers', 'reward as a teacher', divided into the categories' 'post-retirement life adaptation types'. These findings are in accordance with the retirement teacher pointed out the lack of social adaptation programs, such as training or preparation for life after retirement, With the increasing need for pre-retirement training is to prepare for life after retirement were suggestions that the government offers programs and information about the life after retirement is necessary.

Behavior of Model Pile Embedded in Expansive Soil with Magnesia Oxide-Based Refractories (MgO계 내화물이 함유된 팽창성 지반에서의 모형말뚝 거동 분석)

  • Yoon, Boyoung;Kim, Mintae
    • Journal of the Korean Geotechnical Society
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    • v.39 no.11
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    • pp.33-40
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    • 2023
  • This study explores the performance of pile foundations in highly expansive soil, incorporating magnesium oxide-based refractory materials. A controlled model chamber, housing a fixed pile, was utilized to induce ground expansion through fused magnesia (FM). The investigation focused on measuring the vertical displacement of FM-sand mixtures and the axial load on the pile in relation to depth and time. The study varied the amount of FM content (FMc) at 30%, 50%, and 70%. The upward movement exhibited an augmentation with increasing FMc, tapering off with depth as accumulation progressed toward the mixture surface. Compression and tensile forces were both evident along the pile for FMc at 30% and 50%, while only a tensile force was observed at an FMc of 70%. These results offer valuable insights for the analysis of pile behavior within FM-sand mixtures.

Evaluation of Ventilation Effectiveness Before and After Kitchen Renovation in Schools of Gyeongsangnam-do (경남지역 학교 급식조리실 개선 전후 환기성능 평가)

  • Jongwon Son;Taehyeung Kim;Hyunchul Ha;Byounghoon Kim;Kritana Prueksakorn
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.34 no.1
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    • pp.35-47
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    • 2024
  • Objectives: Many cases of lung cancer have been reported by school kitchen workers as occupational cancer. Twenty-eight schools in Gyeongsangnam-do Province were selected to evaluate the effect of improved kitchen ventilation systems. Ventilation characteristics before and after renovation were compared and design techniques were identified. Methods: In the design stage for kitchen ventilation systems, expert intervention was used to improve the designs. Ventilation characteristics and air quality were evaluated before and after the renovations. Hood face velocity and fan flow rate were measured and the smoke visualization technique was used to evaluate the capability of protecting worker's breathing zone. The concentrations of PM0.3 were measured at points not adjacent to cooking equipment because these concentrations fluctuate greatly. Results: Mean hood face velocity increased from 0.29 m/s before renovation to 0.7m/s after renovation. The concentrations of PM0.3 showed a roughly 95% reduction. Concentrations of CO showed more than a 75% reduction. Smoke visualization showed greater protection of workers' breathing zone. Conclusions: Advanced design techniques for school kitchen ventilation systems were applied to renovate old kitchen ventilation systems. The performance of the new kitchen ventilation systems was nearly excellent. Further improvement of design techniques is still needed, however.

Discrete Element Method (DEM) Analysis of Soil Plug Formation in Impact-Driven Open-ended Piles (이산요소해석법을 활용한 개단말뚝의 관내토 거동 분석)

  • Kim, Youngsang;Kim, Mintae
    • Journal of the Korean Geotechnical Society
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    • v.40 no.4
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    • pp.145-154
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    • 2024
  • This study used the discrete element method (DEM) to model the driving process of open-ended piles and investigate the behavior of soil plug during pile penetration. The developed DEM model was verified by comparing model pile test results and numerical analysis, particularly using a contact model considering rolling resistance between soil particles. The study successfully simulated soil compression inside the pile by adjusting the relative density and penetration velocity, and it was confirmed that the soil plug tended to be more compressed as the initial penetration velocity decreased. Soil plug length measurements, plug length ratio, and incremental filling ratio were analyzed and validated against experimental results. The developed DEM model aims to reduce trial and error in further studies by detailing the modeling and verification process.

Intestinal Ultrasonographic and Endoscopic Findings in Pediatric Patients with Henoch-Sch$\"{o}$nlein Purpura and Gastrointestinal Symptoms (위장관 증상을 동반한 Henoch-Sch$\"{o}$nlein Purpura 환아의 장관 초음파 소견 및 내시경 소견)

  • Noh, Yun-Il;Ryu, Min-Hyuk;Jung, Chul-Zoo;Lee, Dong-Jin;Kwon, Jung-Hyeok
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.4 no.2
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    • pp.181-190
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    • 2001
  • Purpose: The aim of this study is to investigate the usefulness of intestinal ultrasonography (US) and upper gastrointestinal endoscopy in the early diagnosis of Henoch-Sch$\"{o}$nlein purpura (HSP) with the gastrointestinal (GI) symptoms preceding the emergence of the skin lesion. Methods: The clinical, intestinal US and upper gastrointestinal endoscopic records of 85 patients (88 cases) with GI symptoms relating to HSP presenting between January 1999 and April 2001 were reviewed. Results: 1) GI symptoms were observed in 52 cases (59%) and skin, joint, renal and scrotal manifestations were observed in 88 (100%), 64 (73%), 15 (17%), 3 cases (3%) respectively. 2) Out of 52 cases with GI symptoms, abdominal pain was observed in all cases (100%). Positive stool occult blood, nausea and vomiting, abdominal tenderness, melena or tarry stool, diarrhea, hematemesis, rebound tenderness and rigidity were observed in 28 (50%), 17 (33%), 17 (33%), 12 (23%), 6 (12%), 4 (8%), 1 (2%) and 1 case (2%) respectively in order of frequency. 3) Intestinal US examination was performed in 27 cases with HSP and GI symptoms (52 cases). Out of 27 sonographic examinations 22 showed abnormal findings. Thickening of the duodeno-jejunal wall was observed in 16 cases (73%). Free peritoneal fluid, enlarged mesenteric lymph node, ileus and abnormal gall bladder were seen in 8 (36%), 8 (36%), 4 (18%) and 1 case (5%) respectively. In three cases of HSP without GI symptoms, those changes were absent. 4) In all of five cases with HSP and GI symptoms, endoscopic study showed mucosal edema and multiple hemorrhagic erosions especially at the second portion of the duodenum. Biopsy specimens from the duodenum of 2 cases out of 5 endoscopic examinations showed acute inflammatory infiltrates in the mucosa with hemorrhage. 5) Both intestinal US and endoscopic studies were performed in 4 cases with HSP and GI symptoms simultaneously. Out of 4 those cases, 3 cases showed the thickened duodeno-jejunal wall on the intestinal US, which suggested erosive hemorrhagic duodenitis by endoscopic findings. Conclusion: The typical but nonpathognomonic intestinal US findings including the thickening of the duodeno-jejunal wall and upper gastrointestinal endoscopic findings including hemorrhagicerosive duodenitis, in children with GI symptoms, should be considered a manifestation of HSP, even in the absence of skin lesion.

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Die $Luftfrachtersatzbef{\ddot{o}}rderung$ (항공화물대체운송(航空貨物代替運送)에 관한 법적(法的) 문제(問題))

  • Jeon, Sam-Hyeon
    • The Korean Journal of Air & Space Law and Policy
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    • v.9
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    • pp.327-349
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    • 1997
  • Luftfrachtersatzverkehr ist der Transport von Luftfrachtgut von Flughafen zu Flughafen unter einem Luftfrachtbrief im $Oberfl{\ddot{a}}chentransport$ urn die erste und/oder letzte Teilstrecke einer als Gesamtstrecke vereinbarten $Luftfrachtbef{\ddot{o}}rderung$. These Strecken $f{\ddot{u}}hren$ von nationalen oder intemationalen $Flugh{\tilde{a}}fen$ zurn Zentralflughafen ($_"Hub"$) der Luftverkehrsgesellschaft bzw. in urngekehrter Richtung vom Zentralflughafen hin zu den einzelnen nationalen oder intemationalen $Flugh{\ddot{a}}fen$. Die Vorteile des Luftfrachtersatzverkehrs sind offenkundig, daher auch sein $st{\ddot{a}}ndiges$ Anwachsen. Allerdings bestand bei den Luftverkehrsgesellschaften jahrelang eine $gro{\ss}e$ Unsicherheit, wie dieser Luftverkehr, der eben nicht in der Luft $durchgef{\ddot{u}}hrt$ wird, rechtlich zu qualifizieren sei. Stellte die $Bef{\ddot{o}}rderung$ von $Luftfrachtg{\ddot{u}}tem$ auf der $Stra{\ss}e$ einen Bruch des $Luftbef{\ddot{o}}rderungsvertrages$ dar, so wie im Schadensfall die $Gesch{\ddot{a}digten$, Absender oder $Empf{\ddot{a}}nger$ des betreffenden Gutes, der Luftverkehrgesllschft auf Art. 18 Abs. 3 oder Art. 31 Warschauer Abkommen(WA) berufen? Folge dieser Unsicherheit war, $da{\ss}$ ${\ddot{u}}ber$ lange Jahre hinweg die Luftverkehrsgesellschaften sich scheuten, diese Frage einer gerichtlichen $Kl{\ddot{a}}rung$ $zuzuf{\ddot{u}}hren$, Eher war man geneigt, sich mit dem Anspruchsgegner $au{\ss}ergerichtlich$ zu vergleichen, selbst wenn dies bedeutete, $da{\ss}$ man sich nicht auf die $Haftungsbeschr{\ddot{a}}nkungen$ des Art. 22 WA berufen konnte, als ein Urteil zu erstreiten, welcher $m{\ddot{o}}glicherweise$ der Praxis der $Luftfrachtersatzbef{\ddot{o}}rderung$ einen - rechtlichen - Riegel vorgeschoben $h{\ddot{a}}tte$. Diese Unsicherheit ist jedoch durch die Entscheidung die erste und wohl auch bislang einzige $h{\ddot{o}}chstrichterliche$ Entscheidung zur $Luftfrachtersatzbef{\ddot{o}}rderung$ nicht nur in Deutschland, sondem soger in Europa. Die Luftverkehrsgesellschaften $k{\ddot{o}}nnen$ mit dieser Entscheidung gut leben. Bei emer $vertragsgem{\ddot{a}}{\ss}en$ $Luftfrachtersatzbef{\ddot{o}}rderung$ haftet der $Luftfrachtf{\ddot{u}}hrer$ $f{\ddot{u}}r$ $Sch{\ddot{a}}den$ $anl{\ddot{a}}{\ss}lich$ der mit dem Luftfahrzeug $ausgef{\ddot{u}}hrten$ Teilstrecke nach den Vorsschriften des Warschauer Abkommens und $f{\ddot{u}}r$ $Sch{\ddot{a}}den$ $anl{\ddot{a}}{\ss}lich$ der mit einem $Oberfl{\ddot{a}}chenbef{\ddot{o}}rderungsmittel$ $ausgef{\ddot{u}}hrten$ Teilstrecke nach den Vorschriften, welche $f{\ddot{u}}r$ das $tats{\ddot{a}}chlich$ eingesetzte ransportmittel $einschl{\ddot{a}}gig$ sind. Bei unbekanntem Schadensort haftet der $Luftfrachtf{\ddot{u}}hrer$ nach dem jeweils $sch{\ddot{a}}rfsten$ der in Betracht kommenden Rechte. Bei emer vertragwidrigen $Luftfrachtersatzbef{\ddot{o}}rderung$ haftet der $Luftfrachtf{\ddot{u}}hrer$ nach dem Recht des vereinbarten $Bef{\ddot{o}}rderungsmittels$, da sich auf dieses Recht der Vertragspartner des $Luftfrrachtf{\ddot{u}}hrers$ eingerichtet hatte. Der $Luftfrachtf{\ddot{u}}frer$ haftet aber auch nach dem Recht des $tats{\ddot{a}}chlich$ eingesetzten $Bef{\ddot{o}}rderungsmittels$, da er sich in dessen Haftungsordnung durch die einseitige Wahl des $Bef{\ddot{o}}rderungsmittels$ selbst hineingestellt hat. Bei unbekanntem Schadensort haftet der $Luftfrachtf{\ddot{u}}hrer$ nach dem jeweils $sch{\ddot{a}}rfsten$ der in Betracht kommenden Rechte.

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The Effect of Long-term Steroid Therapy Combined with Azathioprine in Henoch-$Sch{\ddot{o}}nlein$ Nephritis (Henoch-$Sch{\ddot{o}}nlein$(HS) 신염에서 장기 스테로이드와 Azathioprine의 병합치료 효과)

  • Moon, Kyoung-Sang;Jin, So-Young;Kim, Eun-Mi
    • Childhood Kidney Diseases
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    • v.2 no.2
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    • pp.118-124
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    • 1998
  • Purpose : There is no specific treatment guidelines for Henoch-$Sch{\ddot{o}}nlein$(HS) nephritis. Therefore we performed this study to observe the effect of long term steroid therapy combined with azathioprine Methods : Treatment protocols; 1) Steroid pulse therapy: methylprednisolon 30 mg/kg/dose, maximum 1 gm, intravenolisly 6 times for alternate day. 2) Oral steroid was given 2 mg/kg/day for 1 month, 1 mg/kg/day for following 1 month and alternate day oral steroid combined with azathioprine 2 mg/kg/day for 2 years. Results : Time period from HSP to onset of HS nephritis was between 2 weeks to 5 months with mean $7.4{\pm}7.4$ weeks. Clinical remission were seen in 4 cases out of 5 ($80\%$). Mean time period with disappearance of proteinuria and microscopic hematuria were $5{\pm}2.4$ month and $13.3{\pm}2.9$ month respectively. On pathologic findings by ISKDC, 3 cases were grade IIIb, 2 cases were grade IV in first kidney biopsies and showed pathologic improvement in follow up tidneybiopsiesafterlyearstreatment. Conclusion : As there is no definitive treatment for HS nephritis so far, our study of long term oral steroid therapy with azathioprine was effective in clinical and histologic aspect. Therefore further study in HS nephritis with in a large group will be needed in the future.

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Comparison of Clinical Outcome According to the Duration of Corticosteroid Therapy in Childhood Henoch-$Sch{\ddot{o}}nlein$ Purpura: a Bicentric Study (소아 Henoch-$Sch{\ddot{o}}nlein$ purpura에서 스테로이드 치료 기간에 따른 임상적 결과의 비교)

  • Lee, Su-Jin;Shin, Jae-Il;Lee, Chong-Guk;Kim, Kee-Hyuck
    • Childhood Kidney Diseases
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    • v.12 no.2
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    • pp.170-177
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    • 2008
  • Purpose : The aim of this study was to evaluate whether the incidence of relapse or nephritis might be influenced by the duration of corticosteroid therapy in children with Henoch-Schonlein purpura(HSP). Methods : We retrospectively analyzed 186 children with a diagnosis of HSP in two major hospitals in Ilsan, Korea from the years 2000 to 2003. To evaluate whether renal involvement or relapse might be influenced by the duration of corticosteroid therapy in children with HSP, one pediatric nephrologist from hospital A, maintained corticosteroid therapy for at least 2 weeks(Group A, n=94). The other from hospital B used only during the symptomatic period(Group B, n=92). Results : There were no significant differences in age, sex, body weight, white blood cell count, hemoglobin, hematocrit, platelet count, serum protein and albumin levels between the two groups. The incidence of abdominal pain or arthralgia also did not differ between two groups. However, the duration of steroid therapy was significantly longer in Group A than in Group B and the cumulative dose of prednisolone was also higher in Group A than in Group B. The development of nephritis was more frequent in Group A. Conclusion : The longer duration of steroid use was not associated with the decreased rate of nephritis. Therefore, corticosteroids should be used carefully in a selected group of HSP children, and be tapered rapidly after control of the acute symptoms.