• 항공우주시스템공학회지
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• 제2권3호
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• pp.1-6
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• 2008

The tilt rotor aircraft has the flight characteristics which takes off vertically like a helicopter and flies forward like an airplane. Especially, the transition process from a helicopter to an airplane mode requires not only the mixing of control inputs but also the stability and controllability augmentation system(SCAS) in order to keep the safe flight because there are compound flight dynamic characteristics of a helicopter and an airplane including non-linearity, uncertainty. This paper describes the design of SCAS in a lateral motion for the tilt rotor aircraft based on the $H_{\infty}$ control method, which was performed from mathematical model with weighting matrix based on the relationship between the $H_{\infty}$ norm and the sensitivity function. Through simulation analysis for the controller designed on the $H_{\infty}$ control theory, it was shown that this method may be applied to the control design of the tilt rotor aircraft.

• 한국항공운항학회:학술대회논문집
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• 한국항공운항학회 2006년도 춘계학술대회 논문집
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• pp.71-74
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• 2006

• 제어로봇시스템학회논문지
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• 제11권3호
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• pp.233-239
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• 2005

This paper presents the design and evaluation of a tiltrotor attitude controller. The implemented response type of the command augumentation system is Attitude Command Attitude Hold. The controller architecture can alleviate the need for extensive gain scheduling and thus has the potential to reduce development time. The control algorithm is constructed using the feedback linearization technique. And an on-line adaptive architecture that employs a neural network compensating the model inversion error caused by the deficiency of full knowledge tiltrotor aircraft dynamics is applied to augment the attitude control system. The use of Lyapunov stability analysis guarantees boundedness of the tracking error and network parameters. The performance of the controller is evaluated against ADS-33E criteria, using the nonlinear tiltrotor simulation code for Bell TR301 developed by KARI. (Korea Aerospace Research Institute)

• Journal of Genetic Medicine
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• 제12권2호
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• pp.118-122
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• 2015

Noninvasive prenatal test (NIPT) is a novel screening method for the diagnosis of fetal chromosomal aneuploidies. NIPT is based on technology that detects cell-free fetal DNA in maternal plasma and analyzes it with massively parallel sequencing technology to determine whether the fetus is at risk of trisomy 21, trisomy 18, trisomy 13 or sex chromosome abnormalities (SCAs). NIPT has been reported to have sensitivity of 99% and a false positive rate of less than 1% for detecting trisomy 21 and trisomy 18. Although extension of the application of NIPT to other SCAs has been attempted, there are concerns in extending NIPT to SCAs because of maternal or fetal mosaicism, undetected maternal SCAs, and multiple pregnancies. Recently, we assessed a pregnancy with the rare Turner syndrome mosaicism 45, X/47, XXX, which was reported as 45, X with NIPT. We present the case here and briefly review the current literatures on NIPT in testing for fetal monosomy X. To the best of our knowledge, this is the first report of the 45, X/47, XXX mosaicism in Korea to be reported as 45, X by NIPT with whole genome sequencing. This case report will provide valuable information for counseling women who want to undergo NIPT.

• 한국항공우주학회지
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• 제40권3호
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• pp.251-257
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• 2012

무인기 및 유인기의 자동비행제어기는 다양한 비행성 규정, 안정도 여유 및 시간응답 특성에 대한 요구조건을 만족할 수 있도록 설계되어야 한다. 기존의 제어기 설계과정은 많은 시간과 시행오차를 수반하기 때문에 최적화 알고리즘을 활용하면 다양한 요구조건들을 충족시키는 제어기를 효율적으로 설계할 수 있다. 본 논문에서는 통합 최적화 제어설계 프로그램인 CONDUIT을 소형 무인기의 횡운동 SCAS 설계에 적용하여 그 효용성을 제시하였다. 최적화를 통해 설계된 롤 자세각 및 방위각 제어기는 시간응답특성만을 고려하여 설계한 기본제어기와 성능을 비교하고 분석하여, 최적화 기법을 적용한 제어기의 성능이 우수하고 다양한 비행성 요구조건을 충족시킬 수 있음을 확인하였다.

• Journal of Genetic Medicine
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• 제4권1호
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• pp.22-37
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• 2007

The autosomal dominant spinocerebellar ataxias (SCAs) are a group of neurodegenerative diseases, clinically and genetically heterogeneous, characterized by degeneration of spinocerebellar pathways with variable involvement of other neural systems. At present, 27 distinct genetic forms of SCAs are known: SCA1-8, SCA10-21, SCA23, SCA25-28, DRPLA (dentatorubral-pallidoluysian atrophy), and 16q-liked ADCA (autosomal dominant cerebellar ataxia). Epidemiological data about the prevalence of SCAs are restricted to a few studies of isolated geographical regions, and most do not reflect the real occurrence of the disease. In general a prevalence of about 0.3-2 cases per 100,000 people is assumed. As SCA are highly heterogeneous, the prevalence of specific subtypes varies between different ethnic and continental populations. Most recent data suggest that SCA3 is the commonest subtype worldwide; SCA1, SCA2, SCA6, SCA7, and SCA8 have a prevalence of over 2%, and the remaining SCAs are thought to be rare (prevalence <1%). In this review, we highlight and discuss the SCA7. The hallmark of SCA7 is the association of hereditary ataxia and visual loss caused by pigmentary macular degeneration. Visual failure is progressive, bilateral and symmetrical, and leads irreversibly to blindness. This association represents a distinct disease entity classified as autosomal dominant cerebellar ataxia (ADCA) type II by Harding. The disease affectsprimarily the cerebellum and the retina by the moderate to severe neuronal loss and gliosis, but also many other central nervous system structures as the disease progresses. SCA7 is caused by expansion of an unstable trinucleotide CAG repeat in the ATXN7 gene encoding a polyglutamine (polyQ) tract in the corresponding protein, ataxin-7. Normal ATXN7 alleles contain 4-35 CAG repeats, whereas pathological alleles contain from 36->450 CAG repeats. Immunoblott analysis demonstrated that ataxin-7 is widely expressed but that expression levels vary among tissues. Instability of expanded repeats is more pronounced in SCA7 than in other SCA subtypes and can cause substantial lowering of age at onset in successive generations termed ‘anticipation’ so that children may become diseased even before their parents develop symptoms. The strong anticipation in SCA7 and the rarity of contractions should have led to its extinction within a few generations. There is no specific drug therapy for this neurodegenerative disorder. Currently, therapy remains purely symptomatic. Cellular models and SCA7 transgenic mice have been generated which constitute valuable resources for studying the disease mechanism. Understanding the pathogenetic mechanisms of neurodegeneration in SCAs should lead to the identification of potential therapeutic targets and ultimately facilitate drug discovery. Here we summarize the clinical, pathological, and genetic aspects of SCA7, and review the current understanding of the pathogenesis of this disorder. Further, we also review the potential therapeutic strategies that are currently being explored in polyglutamine diseases.

• 수산경영론집
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• 제2권1_2호
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• pp.1-5
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• 1971

• 항공우주기술
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• 제6권2호
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• pp.1-7
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• 2007

40% 축소형 스마트 무인기의 자율비행을 위한 자세 및 자세각속도 제어기를 설계하였다. 19개 설계점에서 축약된 시스템 운동방정식을 유도하였다. 운동방정식으로부터 설계요구 조건인 시간 응답을 만족 할 수 있는 제어기 이득을 해석적인 방법으로 선정하였다. 각 설계 점마다 구동기 및 통신 시간 지연을 고려한 안정도 여유를 구하였다 또한, 슬라이딩 모드 제어이론을 적용한 강건 제어기를 설계하여 선형 제어기와 성능 비교를 하였다. 설계된 제어기를 비선형 모델에 적용한 응답 결과로부터 제어 로직의 성능 및 적용 가능성을 평가하였다.

• 한국산학기술학회논문지
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• 제11권12호
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• pp.5191-5198
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• 2010

지하철 이용수요와 토지이용, 개발밀도, 환승교통체계, 접근성과 같은 다양한 역세권 특성의 관계를 규명하기 위한 많은 연구들이 추진되어 왔으나, 역세권내 보행 가로망 구조와 지하철 이용수요간의 관계에 관한 분석은 미비한 실정이다. 본 연구는 부산광역시 79개 지하철 역세권내 가로망의 구조를 공간구문론(Space syntax)을 이용하여 평가하였으며, 역세권내 가로망 구조의 접근성을 포함한 다양한 역세권 특성이 지하철 이용수요에 미치는 영향을 실증분석을 하였다. 분석결과 역세권 가로망 구조를 대변할 수 있는 공간지표인 통합도, 연결도, 명료도 중 역세권 가로망의 접근 편의성을 나타내는 통합도가 높을수록 지하철 이용수요가 증가하는 것으로 나타났다. 또한 역세권 토지이용형태와 개발밀도를 각각 반영하는 집객시설 집중도와 용적률이 높을수록 지하철 이용수요가 증가하는 것으로 나타났다. 따라서 부산광역시의 지하철 역세권 구조를 대중교통 중심의 개발 체계로 개선하기 위해서는 역세권내 보행가로의 접근성을 향상시킬 수 있는 가로 설계와 통행 목적성이 강한 도시시설물을 압축 고밀의 건축물에 조성하기 위한 노력들이 추진되어야 할 것으로 판단된다.

• 한국항해항만학회지
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• 제44권2호
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• pp.65-72
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• 2020

Mankind has been using ships for more than 5,000 years and has developed a range of related technologies. However, despite such a long history, compared to aircraft with a history of approximately one century, the pace of progress has been markedly slow. Even though technological progress of ships or the installation of various navigation equipment have been achieved, seaborne collisions have occurred quite frequently. This study analyzed the TCAS( Traffic Collision Avoidance System) that has contributed to the prevention of collisions with other transport methods including aircraft to suggest a collision avoidance system that can be deployed for ships. To apply the technologies applied to aircraft that move in 3D to ships that move in 2D, the difference in the operational environment between the two modes was analyzed to identify elements that need to be applied to ships. The suggested display of data on the collision prevention system is one that manipulates the augmented reality display device used in automobiles that over the past few years has undergone rapid development. Based on the presentation of technological elements that need to be considered when adopting the SCAS or the Seaborne Collision Avoidance System as suggested in this study, the authors hope to contribute to the prevention of collisions.