• Archives of Pharmacal Research
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• v.17 no.5
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• pp.381-382
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• 1994

Administration route dependency on the distribution of PEGylated recombinant human turor necrosis factor binding protein (rhTNFbp-PEG20K dimer) was observed following a subcutaneous (sc) and an intravenous (iv) administrationin rats. ehTNFbp-PEG20K dimer is composed of two rhTNGbp molecules (molecular weight 18, 278 daltons each) joined by polyethylene glycol 2000(PEG30K). The steady state distribution volume of rhTNFbp-PEG20K was 55 m/kg and 359 ml/kg following the i.v. and s.c. administrations, respectively. These results suggest that the distribution of ehTNFbp-PEG20K is limited within the cpillary space after i.v. administration, while rhTNFbp-PEG20K can distribute into a space (35.9% of body weight) which is between extracellylar space and total body water. A lymphatic absorption may paly a role in the distribution of rhTNFbp-PEF20K dimer following the sc administration. The present study suggests that the administration route of a lartge protein molecule should be determined depedning upon target sites.

• Biomolecules & Therapeutics
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• v.8 no.2
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• pp.171-178
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• 2000

To evaluate the pharmacokinetic properties and tissue distribution of a newly developed recombinant human erythropoietin (GC-rhEPO), we analyzed the plasma and tissue levels of erythropoietin by an ELISA after intravenous (IV) and subcutaneous (SC) adminstration to the male rats at the doses of 20, 100, 500 or 2,500 unit/kg. After single IV bolus injection of GC-rhEPO, the plasma concentration was rapidly increased and decreased with two phases with half-lives of 13.4 min and 2.94 hours. AUC was increased dose- dependently but plasma half-lives remained constant regardless of GC-rhEPO doses. Following SC administration, the plasma concentration increased slowly with half-life of 9.2 hours and reached peak at 8 hours. Mean residence time and bioavailability were 18.2 hours and 44%, respectively. After single IV dose of 100 unit/kg, tissue GC-rhEPO level was higher in bone marrow and spleen, while the depletion rate was slower in liver and bone marrow, indicating the higher affinity of GC-rhEPO to bone marrow. Taken together, the experimental results indicate that GC-rhEPO contained the typical pharmacokinetic properties and the tissue distribution patterns inherent to human erythropoietin.

• Horticultural Science & Technology
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• v.18 no.6
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• pp.792-796
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• 2000

The staking cultivation (SC) of oriental melon (Cucumis mela L. var. makuwa Mak.) produced more fruit yield than that of the conventional (creeping) growing. In the SC, preharvest fruit drop rate was high as 47.6% compared to 13.0% of the conventional cultivation. However, the foliar application of aminoethoxyvinylglycine (AVG, $100mg{\cdot}L^{-1}$) at 2 weeks after flowering (20 days before harvest) greatly reduced fruit drops up to 10.9% without causing any effects on ripening and quality of fruits . The AVG application markedly suppressed ethylene production in harvested fruits.

• Clean Technology
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• v.24 no.3
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• pp.157-165
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• 2018

In this study, the removal of $Si_3N_4$ particles from the surface of a silicon wafer was investigated by using supercritical carbon dioxide, the IPA co-solvent and cleaning additive chemicals. First, the solubility of several surfactants and binders in supercritical carbon dioxide solubility and particle dispersibility in the binders were evaluated in order to confirm their suitability for the supercritical cleaning process. Particle removal experiments were carried out with adjusting various process parameters and reaction conditions. The surfactants used in the experiment showed little particle removal effect, producing secondary contamination on the surface of wafers. On the other hand, 5 wt% (with respect to $scCO_2$) of the cleaning additive mixture of trimethyl phosphate, IPA, and trace HF resulted in 85% of particle removal efficiency after $scCO_2$ flowing for 4 minutes at $50^{\circ}C$, 2000 psi, and the flow rate of $15mL\;min^{-1}$.

• Korean Journal of Soil Science and Fertilizer
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• v.33 no.2
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• pp.61-70
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• 2000

Soil erosion in the hilly and mountainous uplands in the Daekwanryong area, Kangwon-Do, were investigated through a field plot experiment. The plot size was 15m long and 2.5m wide with the average slope of 12.5 percents. Soil erodibility factor (K), surface coverage (SC), soil aggregate percentage and wind erodibility (I) were evaluated in the mountainous soils under different management practices for corn and potato cultivations. Soil erodibility factor (K) was greater in upper part than in lower part of the plots. Surface coverage (SC) values ranged from 0.01 to 0.84 depending on the amounts of crop residues. Soils having a greater crop residue in surface were less subjected to soil erosion. SC values after corn harvest were 0.4 to 0.8, while those after potato harvest were 0.4 to 0.5, indicating potato might be better than corn for erosion control. Soil aggregate percentages of the experimental plots ranged from 49.7 to 79.8%. Those were higher in potato-cultivated plots with higher surface coverage, organic fertilizer treatment and contour tillage. Soil aggregate percentage of potato-cultivated plots was significantly correlated to crop residue coverage after harvest. The dried soil aggregate percentage, showing the ranges of 26.4 to 56.4%, were higher in the plots with the increased crop residue incorporation. Wind erodibility (I) of the soil was decreased with increasing surface coverage. When soil had 26.4% of the dried aggregate percentage, wind erodibility was estimated to be $183Mgha^{-1}$ which was equivalent to soil loss of $0.5Mg\ha^{-1}day^{-1}$.

• Proceedings of the Korea Contents Association Conference
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• 2006.11a
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• pp.124-128
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• 2006

The purpose of this study was to develop a scale of social capital in participant sports. To achieve the purpose of this study Socal Capital Scale by Fukuyama(1996), Shane(2005), Kim(2003), Park & Kim(2000), Jung & Shim(2004) was translated and modified to use in participant sports. Throughout the research procedures including back translation, expert meeting, pre-test, sampling, data analysis. Result of this study are as follows First, SCSPS(social capital scale in participant sports) was consisted with four sub-domains such as social network, norms, trust, information share, and position improvement. Second, based on outputs form SEM, it was indicated that model used to develop SCSPS had relatively good fit with significant scores of model indices. Finally, reliability and validity of the scale also showed relatively high scores.

• Analytical Science and Technology
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• v.13 no.3
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• pp.304-308
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• 2000

The iodide was recovered from a simulated spent fuel to the sodium bisulfite aqueous solution. It was discussed that the trace iodide (below 1 ppm) was determined without the matrix effect of 0.1 M sodium bisulfite and 1 mM $HNO_3$ in aqueous solution by ion chromatography with UV detection. AS4A-SC (DIONEX) column and UV-absorption spectrophotometer were used. The UV-absorption spectra of sodium bisulfite, nitric acid and iodide were obtained, and then 230 nm was selected as an absorption wavelength for iodide determination. 0.1 M NaCl eluent was optimum condition. In this condition the calibration curve of iodide was obtained on the range of about 0-1,000 ppb. The linear coefficient was 0.99993 and the detection limit was 5 ppb. The relative standard deviation was 1.26%.

• Restorative Dentistry and Endodontics
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• v.25 no.2
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• pp.180-192
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• 2000

One bottle system was recently developed in order to simplify the clinical skills and save chair time after continuous improvements on dentin bonding agents. There has been many studies to measure the bond strength of one bottle systems but no actual work has been done on micromorphologic study of resin-dentin interdiffusion zone after one bottle system application. To evaluate the bonding patterns of various commercially available one bottle systems to dentin, observation of resin-dentin interdiffusion zone under TEM was performed. Caries-free human third molars within one month of extractions were chosen for the experiments. The molars were sectioned 1mm above the cementoenamel junction and got rid of the root portions. Crown portions of the teeth were sectioned parallel to occlusal surface so that dentin discs of 1mm in thickness were remained. 7 one bottle systems and 1 two bottle system were applied according to manufacturer's instructions and followings were the results. 1. In every experimental groups, cross bandings of collagen fiber were distinguishable and tight bon dings between the bonding agents and dentin were observed. 2. Hybrid layer was clearly observed in ONE-STEP$^{(R)}$, Prime & Bond$^{(R)}$ 2.1, Syntac$^{(R)}$ SC, MAC-BOND II groups but it was not clear in Single Bond, D-Liner Dual PLUS, ONE COAT BOND groups. 3. Electron-density of hybrid layer was uniform in pattern in MAC-BOND II, Prime & Bond$^{(R)}$ 2.1 groups but not so uniform in ONE-STEP$^{(R)}$ group. 4. Electron-dense amorphous phase in most superior layer of the resin-dentin interdiffusion zone was characteristically observed in Single Bond, Syntac$^{(R)}$ SC, ONE COAT BOND groups. It can be concluded that bondings between the dentin bonding agents and dentin can be various in pattern according to their chemical compositions and the condition during applications.

• Journal of The Korean Society of Agricultural Engineers
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• v.66 no.4
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• pp.1-15
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• 2024

In recent years, climate change has been responsible for unusual weather patterns on a global scale. Droughts, natural disasters triggered by insufficient rainfall, can inflict significant social and economic consequences on the entire agricultural sector due to their widespread occurrence and the challenge in accurately predicting their onset. The frequency of drought occurrences in South Korea has been rapidly increasing since 2000, with notably severe droughts hitting regions such as Incheon, Gyeonggi, Gangwon, Chungbuk, and Gyeongbuk in 2015, resulting in significant agricultural and social damage. To prepare for future drought occurrences resulting from climate change, it is essential to develop long-term drought predictions and implement corresponding measures for areas prone to drought. The Intergovernmental Panel on Climate Change (IPCC) Sixth Assessment Report outlines a climate change scenario under the Shared Socioeconomic Pathways (SSPs), which integrates projected future socio-economic changes and climate change mitigation efforts derived from the Coupled Model Intercomparison Project 6 (CMIP6). SSPs encompass a range of factors including demographics, economic development, ecosystems, institutions, technological advancements, and policy frameworks. In this study, various drought indices were calculated using SSP scenarios derived from 18 CMIP6 global climate models. The SSP5-8.5 scenario was employed as the climate change scenario, and meteorological drought indices such as the Standardized Precipitation Index (SPI), Self-Calibrating Effective Drought Index (scEDI), and Standardized Precipitation Evapotranspiration Index (SPEI) were utilized to analyze the prediction and variability of future drought occurrences in South Korea.

• Proceedings of the IEEK Conference
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• 2000.06a
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• pp.57-60
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• 2000

In this paper, we proposed new scheme to reduce the Peak-to-Average Power Ratio (PAPR) in Orthogonal Frequency Division Multiplexing (OFDM) system OFDM system is highlighted for multi-media communication system, however it has large PAPR. To reduce the PAPR in OFDM system, several techniques have been proposed such as clipping, coding and so on Our proposed method is a case of block coding and proposed system be termed Sub-Coding OFDM (SC-OFDM) system We also compare the performance between conventional and our proposed OFDM system by computer simulation.