• Restorative Dentistry and Endodontics
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• 제25권4호
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• pp.606-618
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• 2000

Dental pulp infection is most commonly caused by extensive dental caries, and some bacterial species invade root canals; bacterial components and products are thought to be associated with the pathogenesis of periapical periodontitis. A principle driving force behind pulpal disease response appears to lie in the host immune system's to bacteria and their products. We examined the production of interleukin $1{\beta}$ (IL-$1{\beta}$) and tumor necrosis factor ${\alpha}$(TNF-${\alpha}$) from human peripheral mononuclear cells, lymphocytes and monocytes stimulated by heat-killed Acitnobacillus actinomycetemcomitans (ATCC 29523), Porphyromonas gingivalis (ATCC 33277) and Prevotella intermedia (ATCC 25611), and also by their sonicated bacterial extracts (SBE), respectively. The effects of three strains of heat-killed bacteria and their SBEs on the morphology of cultured blood cell lines HL-60 (KCLB 10240) and J774A.1 (KCLB 40067) were observed under the inverted microscope. Ultrastructural changes of J774A.1 exposed to heat-killed P. intermedia and its SBE were investigated using transmission electron microscopy. Production of IL-$1{\beta}$ was reduced in human peripheral mononuclear cells after stimulation by sonic bacterial extracts of A. actinomycetemcomitans, P. gingivalis, and P. intermedia. Heat-killed and sonic extract of P. gingivalis inhibited the production of TNF-${\alpha}$ in peripheral mononuclear cells. Production of TNF-${\alpha}$ was inhibited in peripheral monocytes after stimulation by sonic extracts of A. actinomycetemcomitans, P. gingivalis, and P. intermedia. HL-60 and J 774A.1 cells showed granular degeneration after treatment with heat-killed and sonic extracts of A. actinomycetemcomitans, P. gingivalis, and P. intermedia Chromatin margination and shrinkage were observed in 774A.1 treated with heat-killed P. intermedia. Cell wall structure and organelles were destroyed and vacuoles were formed in cytoplasm in J774A.1 treated with P. intermedia sonic extract. These results suggest that A actinomycetemcomitans, P gingivalis and P intermedia may have an important role in the formation and progression of pulpal diseases via both modulation of production of IL-$1{\beta}$ and TNF-${\alpha}$ from blood mononuclear cells and cytopathic effects.

• 한국산림과학회지
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• 제88권3호
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• pp.309-319
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• 1999

본 연구는 산림 시업에 따른 풍치 관리 정보를 파악하고자 수행하였다. 대상 임분은 현재 산림무육작업 요구도가 높은 낙엽송 인공림을 대상으로 하였다. 촬영된 임분 사진의 모의조작을 통하여 산림작업별로 구분된 35매의 임분 경관이 이용되었다. 각 경관은 신뢰성 검정을 통해 얻은 3개 집단, 전체 593명의 평가 자료를 이용하여 분석하였다. 시각 선호도 평가는 1 - 10 point 평점값을 이용하였다. 이들 평점값의 보정은 RMRATE의 SBE 분석 프로그램을 통해 실시되었다. 시각 선호도와 이미지 척도와의 관련 정도를 비교하기 위해 13매의 간벌 임분을 대상으로 어의 구별척을 이용하여 공간 이미지를 측정하였다. 일반적으로 무육 전의 자연 임분 보다는 작업 후의 쾌적하고 질서 정연한 임분을 높게 선호하고 있었다. 시각 선호도는 나지 면적과 폐잔재 면적이 증가할수록 감소하였으며 임목 밀도, 지하고, 지피식생과 높은 관련이 있었다. 소규모 개별지의 벌구 모양은 곡선보다는 직선 모양을 선호하고 있었다. 시각 선호도는 응답자의 사회경제적 변수에 따라 유의적 차이가 있었다. 연구 결과들은 산림풍치관리를 위한 시업 수행 방법을 제시하고 있다.

• 말소리와 음성과학
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• 제9권2호
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• pp.69-76
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• 2017

The current study investigated whether Korean learners' English-learning environments, especially target English accent (General American English (GAE) vs. Southern British English (SBE)) and English-language experience affected their production of English vowels. Thirty six EFL learners, 27 ESL-US learners, and 33 ESL-UK learners produced 8 English vowels with a bVt frame (beat, bit, bet, bat, bought, bot, boat, boot). The learners' productions were acoustically analyzed in terms of F1 and F2 frequencies. The overall results revealed that the learners' target accent had an effect on their production of some English vowels. The EFL and ESL-US learners' (especially, female learners') production of bought, bot, boat, and boot, which show characteristic differences between the GAE and SBE accents, was closer to that of the native American English (AE) speakers than the native British English (BE) speakers. In contrast, the ESL-UK learners' production of bought and bot demonstrated the opposite pattern. Thus, the impact of target accent was not demonstrated across the board. The effect of the learners' different English-language experience was also rather limited. This was because the EFL learners' production was not much different from the ESL-US learners' production, in spite of the ESL-US learners' residence in the US for more than 9 years. Furthermore, the Korean learners, irrespective of their different English-language experience, tended to produce bit and bat with lower F1 than the native AE and BE speakers, thus resulting in bit and bat to be produced similarly to beat and bet, respectively. This demonstrates the learners' persistent L1 effects on their English vowel production despite the learners' residence in the English speaking countries or their high English proficiency.

• Composites Research
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• 제36권6호
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• pp.416-421
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• 2023

Multifunctional composite materials capable of both load-carrying and energy functions are promising innovative candidates for the advancement of contemporary technologies owing to their relative feasibility, cost-effectiveness, and optimized performance. Carbon fiber (CF)-based structural batteries utilize the graphitic inherent structure to enable the employment of carbon fibers as electrodes, current collectors, and reinforcement, while the matrix system is an ion-conduction and load transfer medium. Although it is possible to enhance performance through the modification of constituents, there remains a need for a systematic design methodology scheme to streamline the commercialization of structural batteries. In this work, a bi-phasic epoxy-based ionic liquid (IL) modified structural battery electrolyte (SBE) was developed via thermally initiated phase separation. The polymer's morphological, mechanical, and electrochemical characteristics were studied. In addition, the interfacial shear strength (IFSS) between CF/SBE was investigated via microdroplet tests. The results accentuated the significance of considering IFSS and matrix plasticity in designing composite structural batteries. This approach is expected to lay the foundation for realizing smart structures with optimized performance while minimizing the need for extensive trial and error, by paving the way for a streamlined computational design scheme in the future.

• 대한본초학회지
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• 제39권4호
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• pp.19-28
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• 2024

Objectives : Ephedrae Herba has been used in the East Asian traditional medicine, for treatment of asthma, cold and influenza. Silymarin is an effective antioxidant and its anti-fibrogenic, anti-inflammatory, and hepatoprotective properties have been reported. This study was performed to explore an anti-fibrogenic potential of Ephedrae Herba extract (EHE) + silymarin on immortalized human hepatic stellate cell line, LX-2 cells. Methods : We studied the anti-fibrogenic effects of EHE + silymarin on transforming growth factor β1 (TGF-β1) signaling pathway in LX-2 cells. Cell viability was measured using the MTT assay. mRNA levels were detected by real-time PCR. TGF-β1 signaling-related proteins expression were detected by Western blot. Results : Silymarin 30 ㎍/mL and EHE 100 ㎍/mL showed cytotoxicity on LX-2 cells. Therefore, the concentrations of silymarin and EHE were studied at 10 ㎍/mL, respectively. Silymarin significantly reduced PAI-1 protein expression, Smad binding element (SBE) luciferase activity, and mRNA (PAI-1, MMP2 and 9) expression compared to TGF-β1. EHE significantly reduced SBE luciferase activity and mRNA (PAI-1, MMP2 and 9) expression compared to TGF-β1. More importantly, EHE + silymarin significantly reduced all parameters compared to TGF-β1, and also significantly reduced compared to EHE alone and silymarin alone. Conclusion : The results indicate that EHE + silymarin has anti-fibrogenic effect in LX-2 cells induced by TGF-β1. Additionally, EHE + silymarin shows more effective anti-fibrogenic effect than EHE alone and silymarin alone.

• 한국환경성돌연변이발암원학회지
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• 제21권1호
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• pp.44-50
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• 2001

To identify nongenotoxic carcinogen determined as negative by ICH guideline-recommended standard genotoxicity test battery; Ames test, chromosome aberration assay, mouse lymphoma $tk^{+/-}$ assay, in vivo micronucleus assay, we picked bisphenol A as a model compound. In this study, we applied in vitro BalB/c 3T3 cell transformation assay and Syrian hamster embryo (SHE) cell transfarmation assay. Bisphenol A was treated upto $769.2 ug/m{\ell}$ in BalB/c 3T3 cells and upto $125 ug/m{\ell}$ in SHE cells. bisphenol A didn't induced morphological transformation both with one stage treatment protocol and with two stage treatment protocol. But, treated far 48 hr, Bisphenol A induced morphological transformation significantly in SHE cells.

• KIEAE Journal
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• 제11권2호
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• pp.45-57
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• 2011

As climate change and environmental degradation become more evident, the public's concern and knowledge on sustainable development requires planners to have regards to social impacts and long term economic viability, as well as environmental impacts. The main objective of this study is to analyze existing sustainability assessment tools for single detached houses. The most widely used oversea tools are selected. From analysis on the existing assessment tools, "Impact Estimator" by Athena Institute, "Bees 4.0" by NIST, "CASBEE for Home" by JSBC, "Envest for Housing" by Energy Saving Trust, "LISA" by Center for Sustainable Technology, "SBTool" by iiSBE (International Initiative for Sustainable Built Environment), it can be seen that the current sustainability assessment programs are in need of much improvement. The selected programs are analyzed on scope of program setting & running, data input & output, assessment categories, and strength & weakness. This study is to supplement the existing sustainability assessment tools for single detached houses, and provide information for the development of web-based program to assist architects or home owners to plan sustainable houses in Korea in the schematic design stage.

• 생약학회지
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• 제45권1호
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• pp.55-61
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• 2014

Microwaves are non-ionizing electromagnetic waves of frequency between 300MHz to 300GHz and positioned between the X-ray and infrared rays in the electromagnetic spectrum. In recent years, the use of microwave for extraction of ingredient from plant material has shown remarkable research interest and potential. Scutellaria radix has been used as a traditional medicine for a variety of diseases. It has been reported to exert beneficial health effects, such as anti-bacterial, antiviral, anti-inflammatory, and free-radical scavenging. Oxidative stress or the accumulation of reactive oxygen species (ROS) leads neuronal cellular death and dysfunction, and it contributes to neuronal degenerative disease such as Alzheimer's disease, Parkinson's disease and stroke. In this study, we aimed to compare the neuroprotective and antioxidant effect of Scutellaria radix extracted by different methods using hot-water extraction (SBE-DW) or microwave extraction (SBE-DW-MW). As a result, we first examined HPLC analysis of hot-water and microwave extracts of Scutellaria radix. The hot-water and microwave extracts of Scutellaria radix showed the discernible difference patterns of HPLC analysis. Microwave-water extracts of Scutellaria radix increased DPPH radical scavenging activity more than hot-water extraction. Microwave-water extracts of Scutellaria radix also showed neuroprotective effects and ROS inhibition against glutamate-induced oxidative stress in mouse hippocampal HT22 cells, but hot-water extraction not showed. In addition, the phosphorylation of MAPKs induced by glutamate insult was prevented by microwave-water extracts of Scutellaria radix. Thus, these results suggested that microwave extraction can be utilized for improving the extraction efficiency and biological activity of Scutellaria radix.

• 지식경영연구
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• 제21권3호
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• pp.141-160
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• 2020

본 연구에서는 한국 화장품의 구매의도에 대한 소셜미디어 마케팅 활동의 효과를 실증적으로 검증하고자 한다. 소셜미디어의 사용이 증가함에 따라 기업이 소비자와 브랜드를 연결하는 마케팅 방식이 변하고 있다. 따라서 소셜미디어 마케팅 활동이 소비자의 소셜브랜드 참여, 브랜드 자산 및 구매의도에 미치는 영향을 실증적으로 분석할 필요가 있다. 본 연구의 목적은 한국 화장품 회사들의 소셜미디어 마케팅 활동이 브랜드 자산과 소셜브랜드 참여를 통해 소비자의 화장품 구매의도에 미치는 영향을 실증적으로 분석하는 것이다. 선행 연구를 통해 소셜미디어 마케팅 활동을 포함한 구성개념들을 정의하고 설문문항을 개발하였다. 총 332개의 설문지를 수집하여 이중 불성실하게 작성된 설문지를 제외한 219개의 설문데이터를 사용하여 분석을 수행하였다. 분석결과 5개의 소셜미디어 마케팅 활동은 브랜드자산, 소셜브랜드 참여 그리고 구매의도에 긍정적인 영향을 미치는 것으로 나타났다. 본 연구를 통해 화장품 회사들은 소셜미디어를 활용한 마케팅 활동을 강화하고 이를 통한 브랜드자산의 축적과 사용자의 소셜브랜드 참여를 유도하는 것이 중요하다는 점을 확인할 수 있었다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2004년도 하계종합학술대회 논문집(1)
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• pp.43-46
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• 2004

In this paper, we present a carrier phase estimation algorithm for LDPC coded systems. LDPC coded system can not achieve the ideal performance if phase offset is introduced by channel. However, the estimation of phase offset is very hard since the operating point of LDPC is very low SNR. To solve this problem, the algorithm using the tentative soft decision value and based on Maximum Likelihood (ML), was proposed in [2]. But this algorithm has problem which works only under constant phase offset. If phase offset is time variant, it has a severe degradation in performance. To solve this problem. we propose two types of estimators. symbol by symbol estimator: Unidirectional estimator (UDE) and hi-directional estimator (BDE), and sub-block estimator (SBE).