• 대한한의학회지
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• 제30권5호
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• pp.26-41
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• 2009

Objectives: The experiment was to estimate the value of Saengmaegsan as a therapeutic anti-aging agent with an analysis of ingredients and their bio-activating effects by enzymologic methods. Methods: We analyzed anti-aging effects of the ingredients of Saengmaegsan being Liriope Platyphylla, Schizandrae Chinensis, and Schizandrae Chinensis. Results: In Liriope Platyphylla and Schizandrae Chinensis, reducing sugar concentration was shown at the highest level. Of mineral contents, K+ and Na+ were the highest in Saengmaegsan and each ingredient also, and then Ca++ and Al. The amount of polyphenol showed was in order Schizandrae Chinensis > Saengmaegsan > Panax Ginseng > Liriope Platyphylla. The electron donating ability of Schizandrae Chinensis doubled that of Saengmaegsan and Panax Ginseng, at the same time that one per 1 ml in Saengmaegsan was significantly found the greatest level as compared to each single ingredient. SOD-like activity was high in Saengmaegsan and Schizandrae Chinensis. SOD-like activity of Saengmaegsan was higher than in single components. Nitric oxide inhibition in pH 1.2 was high in Saengmaegsan and Schizandrae Chinensis, and for per 1 ml it showed the same pattern as above. In pH 3.0 the result was not different from in pH 1.2. Xanthine oxidase inhibition was high in Schizandrae Chinensis and for per 1 ml showed the greatest activity in Liriope Platyphylla. Tyrosinase inhibition in Omija was the most noticeable, and for per 1 ml was Liriope Platyphylla more than any others. Conclusions: With this analysis of ingredients, it is proven that Saengmaegsan and each component fosters antioxidation. On the whole, the composite prescription Saengmaegsan was superior to each individual component.

• 동아시아식생활학회지
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• 제19권3호
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• pp.369-374
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• 2009

This study analyzed and examined the anti-oxidant properties of Saengmaegsan chocolate, and blood glucose levels were examined according to the Saengmaegsan chocolate intake. The total carbohydrate content of the chocolate was 57.8%, crude fat was 31.5%, crude ash was 1.6%, and crude protein was 4.0%. In Saengmaegsan chocolate. Furthermore, total polyphenol content of Saengmaegsan chocolate was 191.52 mg/100 g and DPPH scavenging activity was 87.06%. The radical scavenging activity of the Saengmaegsan chocolate was higher than that of normal milk chocolate. Also, blood glucose levels were significantly lower, by Saengmaegsan chocolate intake, than by normal milk chocolate intake. These results indicate that Saengmaegsan chocolate can be used as a safe and is clinically applicable as a supplementation of in diet therapy for both healthy and diabetic persons.

• 대한한의학회지
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• 제19권2호
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• pp.100-111
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• 1998

This study is designed to investigate the effects of Saengmaegsan extract on cultured myocardial cell sheets affected by oxygen tension change. The results were as follows : 1. Saengmaegsan meaningfully restored the cellular activity decrease in the cultured myocardial cells affected by high oxygen tension. 2. Saengmaegsan meaningfully lessened the degree of total protein decrease in the myocardial cells caused by high oxygen tension. 3. Saengmaegsan meaningfulJy refrained from syntetic decrease of 4-hydroxyproline in both low oxygen tension group and high oxygen tension group.

• 대한한방내과학회지
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• 제20권1호
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• pp.153-166
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• 1999

SAENGMAEGSAN(SMS) has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. The effect of SMS on the vascular system is not known. The purpose of this study was to determine the effect of SMS on blood pressure, regio-nal cerebral blood flow(rCBF). 1. Blood pressure did not change by SMS in rats. 2. rCBF was increased by SMS in a dose-dependent manner. 3. Pretreatment with propranolol. methylene blue and indomethacin significantly inhibited SMS induced increase in rCBF. These results suggest that SMS causes a diverse response of blood pressure, regional cerebral blood flow (rCBF) and pial arterial diameter. The increase in rCBF is also mediated by prostaglandins. cyclic GMP and adrenergic ${\beta}$receptor.

• 동아시아식생활학회지
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• 제15권5
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• pp.606-612
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• 2005

This study was performed to provide basic data that predict the application of Saengmaegsan(SMS) as medicinal food. SMS has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. We examined the effects of SMS on physiological function in isolated abdominal aorta and femoral artery from rabbit and measured the changes of regional cerebral hood flow(rCBF), which was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Spargue-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. The contraction forces by injection of norephinephrine in isolated abdominal aorta and femoral artery were significantly decreased in each concentration of SMS treatment compared with control. rCBF was increased by SMS in a dose-dependent manner. These results suggest that SMS causes a diverse response of rCBF and arterial diameter. These mechanism in rCBF increase may be mediated by prostaglandis, cyclic GMP and adrenergic $\beta-receptor$. Also mechanism in artery contraction decrease is also mediated by prostaglandis and cyclic GMP. These results indicate that SMS can be nsed as a safe and clinically applicable as a supplementation of diet therapy for cerebral cardiovascular disease patients.

• 한국식품영양과학회지
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• 제44권3호
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• pp.393-400
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• 2015

본 연구는 생맥산 농축액을 기호도가 높고 먹기 편리한 젤리에 첨가하여 젤라틴 젤리를 제조한 후 품질 특성 및 항산화성 분석을 실시하였다. 생맥산 젤리의 pH는 생맥산 농축액의 첨가량이 증가할수록 유의적으로 낮아졌고(P<0.05), 산도는 유의적으로 높아졌다(P<0.05). 가용성 고형물 함량은 대조군이 $46.8^{\circ}Brix$였고, 환원당은 생맥산 농축액 첨가군이 대조군에 비하여 높았다(P<0.05). 색도에서 명도값(L값)과 황색도(b값)는 대조군에 비해 생맥산 농축액의 첨가량이 많아질수록 감소하였으며(P<0.05), 적색도(a값)는 증가하였다(P<0.05). 경도와 씹힘성은 생맥산 농축액 첨가군이 대조군에 비하여 유의적으로 감소하였다(P<0.05). 부서짐성은 대조군에서 가장 높게 나타났으며 생맥산 농축액 첨가량이 증가할수록 점차 낮아지는 경향을 보였다. 탄력성은 생맥산 농축액 첨가량이 증가할수록 점차 증가하는 경향을 보였다. 탄성은 대조군에 비해 생맥산 농축액 첨가군이 높았다. DPPH radical 소거능 및 hydroxyl radical 소거능 측정 결과 생맥산 농축액 첨가량이 증가할수록 항산화 활성이 증가하였다. 총 phenol 함량의 경우 생맥산 농축액 첨가량이 증가할수록 높았다. 관능검사에서 강도 특성 및 기호도 평가결과, 전체적인 기호도에서 생맥산 농축액 농도 50% 첨가군이 가장 높은 점수를 받았다. 위와 같은 결과들을 종합해보면 젤리 제조 시 생맥산으로 인해 항산화능이 우수할 것으로 기대되며, 기호도 검사와 강도 검사를 고려할 때 생맥산 25~50% 첨가군이 가장 적합한 것으로 결정되었다.