• Proceedings of the Korean Society of Applied Pharmacology
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.19-29
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• 1996

The neurological manifestations of AIDS include dementia, encountered even in the absence of opportunistic superinfection or malignancy. The AIDS Dementia Complex appears to be associated with several neuropathological abnormalities, including astrogliosis and neuronal injury or loss. How can HIV-1 result in neuronal damage if neurons themselves are only rarely, if ever, infected by the vitus\ulcorner In vitro experiments from several different laboratiories have lent support to the existence of HIV- and immune-related toxins. In one recently defined pathway to neuronal injury, HIV-infected macrophages/microglia as well as macrophages activated by HIV-1 envelope protein gp120 appear to secrete excitants/neurotoxins. These substances may include arachidonic acid, platelet-activating factor, free radicals (NO - and O$_2$), glutamate, quinolinate, cysteine, cytokines (TNF-${\alpha}$, IL1-B, IL-6), and as yet unidentified factors emanating from stimulated macrophages and possibly reactive astrocytes. A final common pathway for newonal suscepubility appears to be operative, similar to that observed in stroke, trauma, epilepsy, and several neurodegenerative diseases, including Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis. This mechanism involves excessive activation of N-methyl-D-aspartate (NMDA) receptor-operated channels, with resultant excessive influx of Ca$\^$2+/ leading to neuronal damage, and thus offers hope for future pharmacological intervention. This chapter reviews two clinically-tolerated NMDA antagonists, memantine and nitroglycerin; (ⅰ) Memantine is an open-channel blocker of the NMDA-associated ion channel and a close congener of the anti-viral and anti-parkinsonian drug amantadine. Memantine blocks the effects of escalating levels of excitotoxins to a greater degree than lower (piysiological) levels of these excitatory amino acids, thus sparing to some extent normal neuronal function. (ⅱ) Niuoglycerin acts at a redox modulatory site of the NMDA receptor/complex to downregulate its activity. The neuroprotective action of nitroglycerin at this site is mediated by n chemical species related to nitric oxide, but in a higher oxidation state, resulting in transfer of an NO group to a critical cysteine on the NMDA receptor. Because of the clinical safety of these drugs, they have the potential for trials in humans. As the structural basis for redox modulation is further elucidated, it may become possible to design even better redox reactive reagents of chinical value. To this end, redox modulatory sites of NMDA receptors have begun to be characterized at a molecular level using site-directed mutagenesis of recombinant subunits (NMDAR1, NMDAR2A-D). Two types of redox modulation can be distinguished. The first type gives rise to a persistent change in the functional activity of the receptor, and we have identified two cysteine residues on the NMDARI subunit (#744 and #798) that are responsible for this action. A second site, presumably also a cysteine(s) because <1 mM N-ethylmaleimide can block its effect in native neurons, underlies the other, more transient redox action. It appears to be at this, as yet unidentified, site on the NMDA receptor that the NO group acts, at least in recombinant receptors.

• Journal of the Korean Chemical Society
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• 제31권2호
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• pp.133-142
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• 1987

Stereoselectivities of (4+2) cycloaddition reactions of cyclopentadiene with the methyl-substituted allenic acids and esters were investigated by application of $\pi$-nonbonded interaction ($\pi$-NBI) theory. 2-FMO method has been found to be adequate for determination of endo selectivities of diene(LUMO)-dienophile (LUMO) interaction in the thermal reactions and diene (HOMO)-dienophile (LUMO) interaction in the Lewis acid catalyzed reactions. $\pi$-isoconjugate diene structure was formed by through-bond interaction of allene moiety with methyl group in the cumulated diene system; the methyl substituent acts as a conjugative chain and causes inter-level narrowing effect of the FMO's. In dienophiles which do not form $\pi$-isoconjugate diene system, methyl group acts merely as an electron donating group. In thermal reactions, the stereoselectivities are controlled by $\pi$-nonbonded secondary orbital interaction ($\pi$-NSOI) of methyl substituent, which behaves similarly as an ethylene molecule.

• Archives of design research
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• 제18권4호
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• pp.297-302
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• 2005

A house in the traditional Korean living had a shape without shape containing all the acts, emotions, and reason of a human being and was an integrated whole creating a life by involving in all the diverse acts. In this vein, a good house for the Asian people should emotion to make the residents healthy rather than comfortable and have its own life constantly changing, exercising, and creating and circulating ch'i(氣). This study presents a house design plan with the focus on the circulation of ch'i(氣) in order to create a space for a healthy body and free spirit. By approaching ch'i from the two aspects of spirit and body, the ways were examined to make a house be full of ch'i and breathe itself as if it were alive along with humans. And the case of Jungam's design process was illustrated.

• The Journal of the Korea Contents Association
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• 제17권6호
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• pp.571-579
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• 2017

The main purpose of this research is to investigate the impact of compensation on job satisfaction. The study is designed to determine whether perceived internal equity acts as a mediation role in affecting the relationship between compensation and job satisfaction. This study also aims to explore the role of supervisor support in affecting employees' perception of equity toward the compensation. A total of 157 samples was obtained for the data analysis as a quantitative approach. The results of the data analyses revealed that both extrinsic and intrinsic rewards are positively correlated with job satisfaction. The results also showed that perceived internal equity acts as a mediating role in predicting variables of compensation and job satisfaction. The supervisor support does not moderate the relationship between compensation and perceived internal equity. It is suggested that management's efforts must be made in compensation management in order to increase employees' job satisfaction and to improve employees' perception of equity.

• The Journal of the Korea Contents Association
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• 제17권11호
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• pp.541-553
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• 2017

Maker education rooted on Maker Movement refers to constructivist learning approach in which students as makers participate in producing visible outcomes through self-directed inquiry and creative hands-on activities in a real life context to solve their personal or social problems. The Maker education, therefore, stresses cultivation of 'maker mindset' in the process-oriented learning environments, pursuing evaluation aspects different from those in the existing educational system. In this context, this study aimed to explore an evaluation framework for the Maker education which reflects the Maker mindset: First, a literature review was conducted to search for the evaluation framework of the maker education which consists of the category of 5 ONs (Minds-on, Hands-on, Hearts-on, Social-on, Acts-on) representing intellectual, physical, emotional, interpersonal and practical aspects, respectively; Second, a Delphi survey for content validity was carried out to confirm the adequacy of the 5 ONs category along with sub-elements for each category. Finally, this study presented the evaluation framework for the Maker education, which is expected to be used as feedback rather than a measuring tool for the process and environments of the Maker education.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제15권9호
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• pp.5495-5501
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• 2014

Individuals with a left frontal brain injury show significant impairments in their speech ability. The aims of the present study were (1) to assess and compare the ability of speech acts comprehension and executive function between individuals with a left frontal brain injury and normal individuals, and (2) to investigate the correlation of speech act comprehension ability factors. The study's subjects were 18 individuals with a left frontal brain injury and 18 normal control adults of the same age, gender, and educational age. The following results were obtained. First, the group of individuals with a left frontal brain injury had lower speech act comprehension, executive function than the normal control group. Second, the speech act comprehension ability of the individuals with a left frontal brain injury showed a high correlation with the executive function.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• 제2권1호
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• pp.99-114
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• 2007

Objectives : The purpose of this study was to introduce the Chuna Manual Therapy (CMT) using Bong (a type of stick which is called 'bong') as a part of Oriental Medicine. Methods : We searched several traditional methods of CMT using Bong, either individual contact to specialist of CMT using Bong or referred to publications, and summarized briefly for introduction. Authors also made a comparative study between existing CMT and CMT using the bong. Results & Conclusions : The indications of Bong CMT are regarded as acute or chronic pain syndrome, whiplash associated disorders, facet syndrome, vertebral misalignment, chronic fatigue syndrome, obesity and also lower extremity length difference caused by malalignment of vertebrae and pelvic bone. The Meridian Muscle Therapy by pressing down using the Bong can be carried out on the imbalances of the muscle by shortening and lengthening contraction. CMT with Bong is considered more effective than other existing CMT in terms of effectiveness. In the case of pelvic correction which needs a tremendous amount of force, it can reduce the force required effectively. This fact can be inferred by the theory of composition and decomposition of force during the transmission of power. We can perform Bong CMT feeling less fatigued subsequently than general CMT. Pressing down with flexed fingers to grip bong acts on the contraction of flexor digiti and extensor digiti muscle, this protects the $doctor^{\circ}{\emptyset}s$ wrist joints from injury. The bong which acts as a tool between the doctor and the patient, while being given treatment, absorbs and spreads out the direct impact from the patient to the doctor. CMT with Bong is able to apply to both existing massage therapies with the hand. The bong appliance can be used in all applications, particularly, but not limited to; Orthopedic and Manual Correction Therapy, Meridian Muscle Pressing, Exercise Therapy, and Meridian Point Manual Pressing Therapy. CMT with Bong belongs to the category of oriental rehabilitation and Chuna manual medicine.

• Journal of the Korea Society of Computer and Information
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• 제25권11호
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• pp.195-200
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• 2020

Korea enacted the Protection of Public Interest Reporters Act in March 2011 to protect whistleblowers from acts of infringement of public interest in the private sector. Most acts of infringement of the public interest are carried out secretly within the organization, which is known to the outside world by reports from members of the organization who are well aware of the problems within the organization. However, whistleblowers are at a disadvantage due to reporting and are reluctant to report. In addition, measures are needed to strengthen institutional mechanisms such as confidentiality, protection of personal information, responsibility, and prohibition of disadvantageous measures to effectively protect reporters due to lack of practical protective measures. Therefore, practical protection measures for whistleblowers are needed in line with the purpose of protecting whistleblowers, and measures to expand the corresponding compensation system will also be needed. Therefore, in this study, we would like to review the main contents of the current system for protecting whistleblowers in Korea and suggest reasonable improvement measures for protecting whistleblowers.

• Journal of Cadastre & Land InformatiX
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• 제45권1호
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• pp.1-15
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• 2015

Korea's Spatial Information Policy has been institutionalized based by "National Spatial Data Infrastructure Act", "Act on Land Survey, Waterway Survey and Cadastral Records", "Spatial Data Industry Promotion Act". In year 2015, These acts were modified with new names and contents. It is critical that the definition of spatial information ought to be generalized. In addition, it is of paramount importance to review factors those contribute to the systematic development on coherent relation between Spatial Information Act and other acts. Examples of improvement area may include: Categorization of Spatial Information Concept, Systematization of Spatial Data Related Legislation, and Enhancement of Organization Specializing in Spatial Information. Furthermore, Legislation & Policy case of Germany, France and the United States were used as a basis for improvement.

• The Journal of the Korea Contents Association
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• 제15권5호
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• pp.179-190
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• 2015

This study discusses on the influential factors of satisfaction in communication by focusing on the political communication phenomenon that is revealed in our society. The acts of political communication and its communication satisfaction are examined by exploring individuals' political inclination and their media usage which are the main influential factors of political communication. An interview survey was conducted on a thousand adults over the age of nineteen who are residing in sixteen cities and provinces nationwide. As a result, a high rate of online media usage was observed among people with progressive political inclination. It showed that the political communication acts of 'writing/communicating' which indicates ons actively posting their personal opinions, has a positive influence on communication satisfaction. On the other hand, the usage of offline media was dominant over people with conservative and neutral political inclination. A passive act of 'reading/watching,' which is to observe other people's opinions, was shown by most of the interviewees. Therefore, it was able to discuss that in order for a harmonious flow of political communication among our society, the understanding of citizens' political characteristic must be preceded and the differentiated political communication using media must be raised accordingly.