• Journal of Haehwa Medicine
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• v.20 no.2
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• pp.79-89
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• 2012

Objective : This study was conducted to evaluate of efficacy and safety of Vanadium Water (VW) on Cancer related Fatigue of Non-advanced Cancer Patients. Methods : Experimental Group Administration. Participants in treatment group consumed three 500 ml/bottle bottles of Jeju Island's VW, which contains 40.2 ${\mu}g/L$ of vanadium, three times a day (morning, afternoon, evening) for 4 weeks (28 days) without any additional treatments for fatigue improvement. The control group participants consumed three 500 ml/bottle bottles of ordinary water (0 ${\mu}g/L$ of vanadium) three times a day for the same period of time without any additional treatments for fatigue improvement. Results : After 4 weeks of VW consumption, total score of Revised Piper Fatigue Scale (RPFS) was reduced 30% and basal score after Fisher's Exact Test resulted statistical borderline significance (p=0.0799) and result of t-test of comparison between two groups' RPFS total score and fatigue cognitive/mood changes resulted statistical significance (p=0.0112). In detail, only 36.4% of control group (N=11) showed improvement while 77.8% of treatment group (N=9) showed fatigue improvement and thyroid hormone level changes. No other lab measures indicated any significant differences between two groups. Conclusion : Daily consumption of 1.5 L of Vanadium water for 4 weeks showed improvement of non-advanced cancer patients' fatigue.

• Structural Engineering and Mechanics
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• v.52 no.5
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• pp.889-901
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• 2014

Very long life fatigue tests were carried out on 16Mn steel base metal and its welded joint by using the ultrasonic fatigue testing technique. Specimen shapes (round and plate) were considered for both the base metal and welded joint. The results show that the specimens present different S-N curve characteristics in the region of $10^5-10^9$ cycles. The round specimens showed continuously decreasing tendency while plate specimens showed a steep decreasing step and an asymptotic horizontal one. The fatigue strength of round specimen was found higher than plate specimen. The fatigue strength of as-welded joint was 45.0% of the base material for butt joint and 40% for cruciform as-welded joint. It was found that fracture can still occur in butt joint beyond $5{\times}10^6$ cycles. The cruciform joint has a fatigue limit in the very long life fatigue regime ($10^7-10^9$ cycles). Fatigue strength of butt as-welded joint was much higher as compared to cruciform as-welded joint. Improvement in fatigue strength of welded joint was found due to UPT. The observation of fracture surface showed crack mainly initiated from welded toe at fusion areas or geometric discontinuity sites at the surface in butt joint and from welded toe in cruciform joint.

• Korean Journal of Veterinary Research
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• v.35 no.2
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• pp.245-254
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• 1995

The density of ATP-sensitive potassium($K_{APT}$) channels, that open as intracellular ATP concentration falls below a critical level, is very high in skeletal muscle surface membrane and those high density may imply that $K_{ATP}$ channels have very important physiological roles. To elucidate a role of $K_{ATP}$ in relation to fatigue, the modulating effects of potassium channel openers and blockers on the fatigue velocity(FV) of mouse extensor hallucis longus muscle(EHL) were investigated in vitro. Twitch contraction was induced by an electrical field stimulation (EFS: 24-48V, 20ms, 0.2-4Hz) and resulting contraction force was isometrically recorded. The twitch forces were gradually decreased to 25% of initial contraction force(ICF) in $37.52{\pm}1.55sec$($mean{\pm}s.e.m.$, n=135), indicating the fatigue phenomena. The mean velocity for development of the fatigue was measured during the period that twitch force decreased to half($FV_{0/0.5}$) and during the period from half to 25%($FV_{0.5/0.25}$) of ICF. The fatigue was induced once every one hour and the tissue response was stable for up to 4 hours. In control condition, ICF was $5.8{\pm}0.12g$ (n=144) and decreased to 50% of ICF with the mean fatigue velocity of $0.182{\pm}0.006g/sec$($FV_{0/0.5}$, n=135) and from 50% to 25% of ICF with $0.084{\pm}0.004g/sec$($FV_{0.5/0.25}$, n=135). Cromakalim($50{\mu}M$) significantly increased $FV_{0.5/0.25}$(n=4). Glibenclamide($IC_{50}>50{\mu}M$), $Ba^{2+}$($IC_{50}=10{\mu}M$), 4-aminopyridine($FV_{0/0.5}$, $IC_{50}=0.5mM$; $FV_{0.5/0.25}$, $IC_{50}=2mM$) decreased both $FV_{0/0.5}$ and $FV_{0.5/0.25}$ concentration-dependently up to 75%. $TEA^+$(30mM), E-4031($10{\mu}M$), tolbutamide(1mM) decreased $FV_{0.5/0.25}$, but apamin(300nM) and $TEA^+$(10mM) showed no significant effects. Our results suggest that activation of the $K_{ATP}$ channels may be major cause of $K^+$ outflux during development of the fatigue and the isolated EHL muscle could be an useful experimental preparation in studying the fatigue phenomena in skeletal muscle. In addition, the possibility of activation of delayed rectifier during the fatigue development remains to be studied further.

• International Journal of Naval Architecture and Ocean Engineering
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• v.3 no.2
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• pp.116-121
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• 2011

The Spectral Fatigue Analysis is representative fatigue life assessment method for vessels. This Analysis is performed generally for the whole vessel and many assessment sites. The spectral fatigue analysis is performed through the process of hydrodynamic response analysis, global structural analysis, local structural analysis and calculation of fatigue damage. In these processes, fatigue damage is affected by many variables. The representative variables are S-N curve data, wave scatter data, wave spectrum, bandwidth effect and etc. In this paper, the effects of these variables to the fatigue damage are analyzed through the spectral fatigue analysis for 170k LNGC.

• Structural Engineering and Mechanics
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• v.44 no.4
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• pp.417-429
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• 2012

Taking the superficial temperature increment as the major fatigue damage indicator, the infrared thermography was used to predict fatigue parameters (fatigue strength and S-N curve) of welded joints subjected to fatigue loading with a high mean stress, showing good predictions. The fatigue damage status, related to safety evaluation, was tightly correlated with the temperature field evolution of the hot-spot zone on the specimen surface. An energetic damage model, based on the energy accumulation, was developed to evaluate the residual fatigue life of the welded specimens undergoing cyclic loading, and a good agreement was presented. It is concluded that the infrared thermography can not only well predict the fatigue behavior of welded joints, but also can play an important role in health detection of structures subjected to mechanical loading.

• Journal of the Korean Society of Safety
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• v.11 no.3
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• pp.154-159
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• 1996

In this thesis, a series of loading tests are conducted in order to investigate the fracture safety of GFRP(Glass Fiber Reinforced Plastics) pipes under fatigue load which are widely used in the developed countries becauses of their natural of anticorrosion and lightweight etc. . Fatigue test is performed by changing number of laminates and loading cycles to examine the flexural strains, the ductility and the fatigue strength for two million repeated loading cycles. From the fatigue test results, it was found that the larger the laminates of GFRP pipes is, the larger the stiffness of GFRP pipes under the fatigue load increases. This phenomenon is true until the fatigue failure. According to the S-N curve drawn by the regression analysis on the fatigue test results, the fatigue strength of percent of the static ultimate strength increases by increasing the laminates of GFRP pipes. The fatigue strength with two million repeated leading cycles in GFRP pipes with the laminates of GFRP pipes varing 15, 25, 35 shows about 75%, 80%, 84% on the static ultimate strength, respectively.

• International Journal of Precision Engineering and Manufacturing
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• v.9 no.4
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• pp.57-62
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• 2008

The aim of this investigation was to extract the fatigue properties at the designated fatigue life of copper foil and observe the mean stress and stress amplitude effects on both the fatigue life and the corresponding surface morphology. Tensile tests were performed to determine the baseline monotonic material properties of the proportional limit and ultimate tensile strength. Constant amplitude fatigue tests were carried out using a feedback-controlled fatigue testing machine. The mean stress and the stress amplitude were changed to obtain the complete nominal stress-life curves. An atomic force microscope was utilized to observe the relationship between the fatigue damage and the corresponding changes in surface morphology. A Basquin's exponent of-0.071 was obtained through the fatigue tests. An endurance limit of 122 MPa was inferred from a Haigh diagram. The specimen surface became rougher as the number of fatigue cycles increased, and there was a close relationship between the fatigue damage and the surface roughness evolution.

• Journal of the Korean Society of Safety
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• v.6 no.2
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• pp.5-13
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• 1991

In this paper, the interfacial stress intensity factors( $K_{i}$＝ $K_1$＋i $K_2$) for the edge interface crack in the dissimilar materials(isotropic-isotropic materials, isotropic-composite materials) were analysed by BEM(Boundary Element Method). The fatigue crack growth behaviour was investigated by load constant fatigue test. From the experimental results, the relationship between da/dN and interfacial stress intensity facto, ( $K_{i}$ or $K_1$) can be expressed by Paris'law for homogeneous materials.s.s.

• Journal of the Korean Society of Safety
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• v.7 no.1
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• pp.20-29
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• 1992

Effects of strain hardening exponents on the retardation behavior of fatigue crack propagation are experimentally investigated. The retardation of fatigue crack propagation seems to be induced by the crack closure at crack tip. The phenomenon of crack closure becomes remarkable with the increment of strain hardening exponent and magnitude of percent peak load. The ratio of crack growth increment(a$\_$d//w$\_$d/) is influenced by a single overloading (a$\_$d/) and estimated plastic zone size (W$\_$d/=2r$\_$y/) is increased according with the increasing of strain ha.dening exponents. The number of retarded crack growth cycles were (N$\_$d/) decreased as the baseline stress intensity factor .ange( K$\_$b/) was increased. Within the limitation of these experimental results obtained under the single overload, an empirical relation between crack retardation ratio (Nd/N＊), strain hardening exponent (n) and percent peak load (％PL) has been proposed as; Nd/N＊＝ exp [PL $.$ PL$.$A(n)＋B(n) ] where, A(n)＝${\alpha}$n＋${\beta}$, B(n)＝${\gamma}$n＋$\delta$, PL＝％PL/100 and ${\alpha}$＝0.78, ${\beta}$＝0.54, ${\gamma}$＝0.58 and $\delta$＝-0.01, It is interesting to note that all these constants are identical for materials such as aluminum(A3203), steel(S4SC), steel(SS41) and stainless steel(SUS316) used in this experimental study.

• Journal of the Korean Society for Railway
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• v.4 no.4
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• pp.138-146
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• 2001

For the purpose of the effective maintenance of surface irregularities of rail, this paper investigates the rail service life to a bending fatigue failure of welding parts of rail on the slab track by the structures laboratory testing to derive S-N curves, a GTDAP(General Track Dynamic Analysis Program) to calculate the stresses and a modified Miner's rule to predict a fatigue life. The useful guides for maintenance of rail welded parts on the slab track are proposed in terms of a grinding period and the depth of rail surface irregularities. This study also proposed the guides for maintenance of rail welded part on the ballast track. The effects of fatigue service lives are compared one another.