• 대한감각통합치료학회지
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• 제19권2호
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• pp.12-25
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• 2021

목적 : 감각통합기반의 가족중심코칭이 자폐스펙트럼장애(Autism Spectrum Disorder; ASD)아동의 작업수행도와 만족도에 미치는 효과를 알아보고자 하였다. 연구방법 : 2020년 4월 16일~ 2020년 8월 6일까지 기준에 부합하는 3-6세 ASD 아동 10명과 보호자 10명이 참여하였다. 캐나다 작업수행 평가(Canadian Occupational Performance Measure; COPM)로 아동의 작업 수행도와 만족도를 평가하였고, 목표성취척도(Goal Attainment Scaling; GAS)로 아동의 작업수행을 평가하였다. 실험군은 기존에 받고 있는 감각통합치료와 함께 주 1회 60분, 4주간 가정방문 및 영상통화로 시행되는 목표활동에 대한 개별화된 가족중심코칭을 받았다. 통제군은 기존에 받고있는 감각통합치료와 함께 목표활동에 대한 감각통합기반의 일반적인 상담으로 진행하였다. 중재 전과 후의 집단별 COPM의 수행도와 만족도, GAS 점수 변화를 비교하기 위해 Wilcoxon 부호 순위 검정을 사용하였고, 중재 전후 집단 간의 COPM의 수행도와 만족도, GAS의 점수의 차이를 비교하기 위해 Mann-Whitney U 검정을 사용하였다. 두 집단 간의 효과크기를 확인하기 위해 Cohen's d를 사용하였다. 결과 : 실험군과 통제군 모두 중재 전과 후에 COPM 수행도와 만족도, GAS의 점수에서 통계적으로 유의한 차이를 보였다(p<.05). 집단 간의 중재 전과 후의 COPM 수행도 점수는 통계적으로 유의한 차이를 보이지 않았지만, Cohen's d 값의 결과 COPM 수행도(d=.913)에서 큰 효과를 보였다. COPM 만족도와 GAS 점수는 모두 두 집단 간 통계적으로 유의한 차이를 보였고(p<.05), Cohen's d 값의 결과 COPM 만족도(d=2.768), GAS 점수(d=2.786) 모두 큰 효과를 보였다. 결론 : 감각통합기반의 가족중심코칭이 감각통합기반의 일반적인 상담보다 ASD 아동의 작업 수행도와 만족도에 긍정적인 영향을 미치는 것으로 볼 수 있다.

• 생물정신의학
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• 제2권2호
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• pp.237-247
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• 1995

도파민 $D_3$ 수용체 유전자와 정신분열증 병인과의 연관성을 밝히고자 본 연구에서는 한국에서의 정신분열증환자 66명과 정상대조군 76명에서 다형성의 분포를 PCR을 이용하여 환자대조연구 방법으로 조사하였다. 정신분열증환자에서 대립유전자 1의 빈도는 0.66이었고, 정상 대조군에서는 0.76이었다. 즉, 두군간에 대립유전자 1의 빈도에는 유의한 차이가 없었고, 양성 및 음성 증상군 척도평가에 의한 정신분열증의 양성아형과 음성아형간에도 유의한 차이가 없었다. 정신분열증 환지에서는 전체 66명중 동형 접합체가 43명으로 65.1%. 이형 접합체는 23명으로 34.9%였다. 정상 대조군에서는 전체 76명중 동형접합체가 54명으로 71.1%. 이형접합체는 28.9%였다. 이러한 결과는 이전의 정신분열증과 도파민 $D_3$ 수용체 유전자간의 연관관계를 연구한 외국의 연구결과와 일치하며 도파민 $D_3$ 수용체 유전자가 정신분열증 병인의 원인일 것이라는 가설을 뒷받침하지는 못하였다.

• Journal of Gastric Cancer
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• 제14권2호
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• pp.87-104
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• 2014

Although gastric cancer is quite common in Korea, the treatment outcome is relatively favorable compared to those in western countries. However, there are currently no Korean multidisciplinary guidelines for gastric cancer. Experts from related societies developed guidelines de novo to meet Korean circumstances and requirements, including 23 recommendation statements for diagnosis (n=9) and treatment (n=14) based on relevant key questions. The quality of the evidence was rated according to the GRADE evidence evaluation framework: the evidence levels were based on a systematic review of the literature, and the recommendation grades were classified as either strong or weak. The applicability of the guidelines was considered to meet patients' view and preferences in the context of Korea. The topics of the guidelines cover diagnostic modalities (endoscopy, endoscopic ultrasound, and radiologic diagnosis), treatment modalities (surgery, therapeutic endoscopy, chemotherapy, and radiotherapy), and pathologic evaluation. An external review of the guidelines was conducted during the finalization phase.

• Journal of Korean Neurosurgical Society
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• 제49권6호
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• pp.339-344
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• 2011

Objective : Pituitary apoplexy is one of the most serious life-threatening complications of pituitary adenoma. The purpose of this study is to investigate the visual outcome after early transsphenoidal surgery for the patients with pituitary apoplexy. Methods : We retrospectively reviewed the 31 patients with pituitary apoplexy who were admitted due to acute visual acuity or field impairment and treated by transsphenoidal surgery. Five patients were excluded because of the decreased conscious level. The visual acuity of each individual eye was evaluated by Snellen's chart Visual fields were also checked using automated perimetry. To compare the visual outcome according to the surgical timing, we divided the patients into 2 groups. The first group, 21 of the patients have been undertaken transsphenoidal approach (TSA) within at least 48 hours after admission. The second group included 8 patients who have been undertaken TSA beyond 48 hours. All patients were monitored at least 12 months after surgery. Results : Patients were 21 males and 8 females (M : F=2.6 : 1) with the mean age of 42.4 years. Among the enrolled 29 patients, 26 patients presented with decreased visual acuity and 23 patients revealed the defective visual field respectively. Postoperatively, improvement in the visual acuity was seen in 15 patients (83.3%) who underwent surgery within the first 48 hours of presentation, as compared to those in whom surgery was delayed beyond 48 hours (n=5; 62.5%) (p=0.014). Improvement in the visual field deficits was observed in 15 (88.2%) of patients who had been operated on within the first 48 hours of presentation, as compared to those in whom surgery was delayed beyond 48 hours (n=3; 50.0%) (p=0.037). Conclusion : This study suggests that rapid transsphenoidal surgery is effective to recover the visual impairment in patients with pituitary apoplexy. If there are associated abnormalities of visual acuity or visual fields in patients with hemorrhagic pituitary apoplexy, early neurosurgical intervention within 48 hours should be also required to recover visual impairment.

• Ocean and Polar Research
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• 제41권4호
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• pp.311-318
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• 2019

We analyzed the preliminary survey data (2014-2016) of macrobenthic community biomass (n = 112) from the wind farm area located in the southern part of the west coast of Korea and compared this data with data from the entire west coast (n = 369; 2006-2008). Modal classes from frequency distributions were 6 times higher in the latter (5 vs. 32 g/㎡). The mean and median values of the latter were 1.3 and 1.7 times higher (mean, 20.7 vs. 27.8 g/㎡; median, 17.1 vs. 29.5 g/㎡), and the maximum value was 3.4 times higher. Mood's median test showed significant difference at p-value = 0.01. We estimated the biomass-to-depth relationships from each data set by using Akaike Information Criterion and regarded the non-overlap of the 95% confidence intervals as indicating significant difference. The biomass was different from a 10 m depth below, and 3 times higher in the west coast at around 20 m compared with the maximum depth of the wind farm area. A local event of catastrophic sedimentation ranging from 1 to 2 m was observed in the wind farm during winter surveys. This could be a probable source of the lower biomass, but information on biomass seasonality and a natural experimental approach seem to be needed for the conduct of further studies. This study is meaningful in that it provided the background to assess future changes by understanding the lower level of benthic productivity in the area. We expect this study will contribute to the preparation of measures that can remove or mitigate the source of the lower biomass and improve the productivity of fishery resources in the area.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6569-6572
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• 2013

In cervical cancer, one of the most common malignant tumors in women worldwide, miR-126 has been reported to exhibit decreased expression. However, its role in cervical cancer cell proliferation and drug sensitivity has remained relatively unexplored. Here, we compared the expression of miR-126 in cervical cancer tissues (n = 20) with that in normal cervical tissue (n = 20) using quantitative RT-PCR. The viability of Siha cervical cancer cells was further measured by MTT assay after transfection with miR-126 mimic (Siha-miR-126 mimic) or microRNA mimic negative control (Siha-miR mimic NC) and after treatment with various concentrations of bleomycin (BLM). IC50s were calculated, and the survival rates (SRs) of Siha cells were calculated. miR-126 expression in cervical cancer tissue was significantly decreased compared with that in normal cervical tissue (P < 0.01). The relative SRs of Siha-miR-126 mimic cells were also significantly decreased compared with those of Siha-miR mimic NC cells at 24-96 h after transfection. The IC50 of BLM in Siha-miR-126 mimic cells ($50.3{\pm}2.02{\mu}g/mL$) was decreased compared with that in Siha-miR mimic NC cells ($70.5{\pm}4.33{\mu}g/mL$) at 48 h after transfection (P < 0.05). Finally, the SRs of Siha-miR-126 mimic cells were significantly lower than those of SihamiR mimic NC cells after cultured in medium containing 40 ${\mu}g/mL$ BLM for 24-96 h (P < 0.05). These results suggest that miR-126 is expressed at low levels in cervical cancer. Upregulation of miR-126 inhibited cervical cancer cell proliferation and enhanced the sensitivity to BLM. Thus, miR-126 may represent a novel approach to cervical cancer treatment.

• 한국토양환경학회지
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• 제4권2호
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• pp.87-101
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• 1999

토양세척 기법은 금속-리간드 착물형성을 촉진하여 오염토양으로부터 중금속을 제거하는 효과적인 방법으로 알려져 있다. 본 연구는 폐금속광산 광미와 그 후면 농경지토양의 중금속 오염도 저감에 대한 세척기랩의 적용효과를 검토하기 위해 수행되었다. 실험에 사용된 일부시료에서 구리와 납의 오염도는 토양오염 우려기준 및 대책기준을 초과하였으며 또 다른 시료에서는 카드뮴이 대책기준에 근접하는 오염도를 보였다. 토양시료에 단계적 추출법을 적용하여 실험한 결과에 따르면 광미와 주변토양시료에 존재하는 중금속의 절반 이상이 식물이용가능성 있는 흡착된 형태로 존재함이 밝혀졌다. 또한 단계석 추출법으로 조사한 몇 가지 형태의 중금속 농도와 0.1N HCI 용출실험에서 구한 농도 사이에는 비례관계가 성립하였다. 유기산별 세척능력 비친실험에서 구연산은 위의 세 가지 중금속 모두에 대하여 초산이나 옥살산에 비해 월등한 세척효율을 나타내었다. 그리고, 구연산을 사용하여 토양으로부터 중금속을 세척할 때 세척액의 pH를 5.5이하로 하면 보다 나은 세척효율을 얻을 수 있었다. 구연산 세척법을 이용한 중금속 세척시 효율은 세척액 농도, (세척액/토양)혼합비, 그리고 세척액의 초기 pH에 의존하여 달라졌다. 구연산에 SDS를 같이 투입하여 세척하면 세 가지 중금속 중에서 카드뮴의 세척효율이 가장 크게 개선되었으며 구리 제거율은 변화되지 않았다. 이상에서 알 수 있듯이 구연산 세척기법은 광미와 중금속 오염토양으로부터의 중금속 제거에 적용 가능한 정화방법임이 확인되었다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제38회 동계학술대회 초록집
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• pp.276-276
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• 2010

Localized surface plasmon resonance (LSPR) has been explored recently as a promising approach to increase energy conversion efficiency in photovoltaic devices, particularly for thin film hydrogenated amorphous silicon (a-Si:H) solar cells. The LSPR is frequently excited via an electromagnetic (EM) radiation in proximate metallic nanostructures and its primary con sequences are selective photon extinction and local EM enhancement which gives rise to improved photogeneration of electron-hole (e-h) pairs, and consequently increases photocurrent. In this work, high-dielectric-constant (k) $ZrO_2$ (refractive index n=2.22, dielectric constant $\varepsilon=4.93$ at the wavelength of 550 nm) is proposed as spacing layer to enhance the LSPR for application to the thin film silicon solar cells. Compared to excitation of the LSPR using $SiO_2$ (n=1.46, $\varepsilon=2.13$ at the wavelength of 546.1 nm) spacing layer with Au nanoparticles of the radius of 45nm, that using $ZrO_2$ dielectric shows the advantages of(i) ~2.5 times greater polarizability, (ii) ~3.5 times larger scattering cross-section and ~1.5 times larger absorption cross-section, (iii) 4.5% higher transmission coefficient of the same thickness and (iv) 7.8% greater transmitted electric filed intensity at the same depth. All those results are calculated by Mie theory and Fresnel equations, and simulated by finite-difference time-domain (FDTD) calculations with proper boundary conditions. Red-shifting of the LSPR wavelength using high-k $ZrO_2$ dielectric is also observed according to location of the peak and this is consistent with the other's report. Finally, our experimental results show that variation of short-circuit current density ($J_{sc}$) of the LSPR enhanced a-Si:H solar cell by using the $ZrO_2$ spacing layer is 45.4% higher than that using the $SiO_2$ spacing layer, supporting our calculation and theory.

• 대한족부족관절학회지
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• 제26권2호
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• pp.88-94
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• 2022

Purpose: This study was based on the Korean Foot and Ankle Society (KFAS) member survey and aimed to report the current trends in the epidemiology, diagnosis, and management of acute Achilles tendon rupture (AATR) over the past few decades. Materials and Methods: A web-based questionnaire containing 34 questions was sent to all KFAS members in October 2021. The questions were mainly related to the clinical experience and preferred management of patients with AATR. Answers with a prevalence ≥50% of the respondents were considered a tendency. Results: Seventy-one (12.9%) of the 550 members responded to the survey. The male sex ratio in AATR was answered mean 78%, and the most common age groups were 30~40 years (n=49; 69.0%), and 40~50 years (n=37; 52.1%), in that order. The most common seasons for the occurrence of AATR were spring (37 cases; 52.1%) and autumn (27 cases; 38.0%). Also, sports-related rupture had an average occurrence of 76.2%. The most important clinical factor to determine the type of treatment was the history of previous injuries, and 75.9% of respondents started conservative treatment in the 2010s. The most preferred protocol of conservative treatment was an orthosis capable of ankle range of motion after casting (68.5%), and 53.7% 'satisfied' and 1.9% 'very satisfied' with conservative treatment. The most preferred surgical method was open repair (80.3%), and the Krackow method (60.6%), and 49.3% of treated patients responded 'satisfied' and 45.1% 'very satisfied' with this treatment. Conclusion: This study gives updated information concerning the current trend of epidemiology, diagnosis, and treatment of AATR in Korea. Both consensus and variation in the approach to AATR were identified using this survey study. This study may raise the awareness of various possible approaches toward AATR and should be used to further establish a standard protocol for the management of this injury.

• 한국심리학회지:법
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• 제11권3호
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• pp.349-370
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• 2020

예상치 못한 질문을 통해 효과적인 거짓말 탐지가 가능하다고 알려져 있으나 최근 거짓말 판별에 사용되고 있는 확인 가능한 사실(verifiable details)에 있어 예상치 못한 질문의 효과를 검증한 연구는 많지 않다. 따라서 본 연구에서는 예상치 못한 질문이 진실 진술자와 거짓 진술자가 언급하는 세부정보의 양과 확인 가능한 사실의 수에 미치는 효과를 확인하고자 하였다. 진실 조건의 참가자(40명)는 교내의 카페에 다녀왔고, 거짓 조건의 참가자(40명)는 정해진 장소에서 준비된 과제를 수행한 뒤 카페에 다녀왔다고 거짓말을 하였다. 모든 참가자는 면담에서 2개의 예상한 질문('자세히 말하기', '장소 묘사')과 2개의 예상치 못한 질문('거꾸로 말하기', '증명 요구')에 답하였다. 종속변인은 세부정보의 양과 확인 가능한 사실의 개수였다. 그 결과, 질문 유형과는 관계없이 진실 진술자가 거짓 진술자보다 유의미하게 더 많은 세부정보를 말하였다. 확인 가능한 사실의 개수에 있어서는 진실 진술자와 거짓 진술자 간의 유의미한 차이는 없었다. 그리고 세부정보의 양(71.3%)이 확인 가능한 사실의 수(53.8%)보다 더 정확하게 진실 진술자와 거짓 진술자를 판별하였다. 또한, 거짓 진술자들은 '자세히 말하기' 질문에 비해 '증명 요구' 질문을 받았을 때 더 많은 단어를 말하였으나 세부정보는 더 많이 언급하지 못하였다. 마지막으로 본 연구의 의의와 한계에 대해 논의하였으며 향후 연구 방향에 대해 제언하였다.