• KSBB Journal
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• v.23 no.1
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• pp.44-47
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• 2008

Anthracycline antibiotics doxorubicin (DXR) is clinically important cancer therapeutic agent produced by Streptomyces peucetius. DXR result by further metabolism of rhodomycin D (RHOD) and require a deoxy-sugar component for their biological activity. In this study, production of TDP-L-daunosamine and its attachment to ${\varepsilon}$-rhodomycinone (RHO) to generate RHOD has been achieved by bioconversion in Streptomyces venezuelae that bears eleven genes. S. peucetius seven genes (dnmUTJVZQS) were transformed by plasmid and S. venezuelae two genes desIII, IV and two more S. peucetius drrA, B genes were integrated into chromosomal DNA. To generate the feeding substrate RHO, 6L S. peucetius grown on agar plate was harvested, extracted with organic solvent and then purified using preparative HPLC. Recombinant S. venezuelae grown on agar plate containing RHO was harvested and its n-butanol soluble components were extracted. The glycosylated product of aromatic polyketide RHO using heterologous host S. venezuelae presents the minimal information for TDP-L-daunosamine biosynthesis and its attachment onto aglycone. Moreover, the structure of auxiliary protein, DnrQ, was predicted by fold recognition and homology modeling in this study. This is a general approach to further expand of new glycosides of antitumor anthracycline antibiotics.

• Korean Journal of Ecology and Environment
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• v.40 no.1
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• pp.72-81
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• 2007

The purpose of this study was to develop a multi-metric Lentic Ecosystem Health Assessment (LEHA) model and apply model to dataset sampled from Daechung Reservoir in September 2005. The metrics were composed of 11 parameters such as physical, chemical and biological variables. The metric attributes of $M_1{\sim}M_8$ followed after the model of biological integrity using fish assemblages that previously adapted in lotic ecosystems, while the metrics of $M_9{\sim}M_{11}$ were added on the basis of literature. The metric of $M_9$ reflected habitat conditions in the littoral zone and the metric of $M_{10}$ reflected chemical conditions of the reservoir. For the application of regression analysis of long-transformed conductivity [$Log_{10}$(Cond)] against $COD_{Mn}$, based on 150 sampling sites at Korean reservoirs, showed that the variation of conductivity was explained 77.4% [$COD_{Mn}=4.42{\times}Log_{10}(Cond)-5.43;\;R^2=0.774$, p<0.01, n=150] by the variation of $COD_{Mn}$. The metric of $M_{11}$ was based on Tropic State Index (TSI), based on chlorophyll-${\alpha}$ concentrations (Chl-${\alpha}$). Analysis of TSI $(Chl-{\alpha})$ showed that above 50 was estimated "1", $40{\sim}50$ was estimated "3" and below 40% was estimated '5'. Overall, velues of LEHA in the reservoir averaged 30.5, indicating a "fair${\sim}$poor condition", which is judged by the criteria of U.S. EPA (1993). More studies such as metric numbers and attributes should be done for the application of the model.

• The Journal of Korean Medicine
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• v.45 no.1
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• pp.150-164
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• 2024

Objectives: This study aimed to investigate the levels of brain iron deposition in Parkinson's disease (PD) patients using Quantitative Susceptibility Mapping (QSM) and to determine whether distinctions compared to the general population exist. Furthermore, we examined potential variations in iron deposition among different PD subtypes. Methods: Structural brain imaging was conducted on 75 participants at Gangdong Kyung Hee University Hospital between August 2017 and May 2020. PD patients were categorized into Tremor Dominant (TD) and Postural Instability and Gait Difficulty (PIGD) subtypes. Voxel-based morphometry and QSM were employed to compare voxel-wise magnetic susceptibility across the entire brain between Normal Controls (NC) and PD groups. Subsequently, QSM values were compared between TD and PIGD groups. Results: QSM values were compared among 46 PD patients and 23 normal controls, as well as between TD (n=22) and PIGD (n=24) groups. Voxel-based QSM analysis revealed no significant differences between groups. Similarly, ROI-based QSM analysis showed no significant distinctions. Conclusions: No significant variations were observed between the PD patient group, NC group, or PD subtypes. This study systematically compared QSM values across a broad range of brain regions potentially linked to PD pathology. Additionally, the subdivision of the PD group into TD and PIGD subtypes for QSM-based iron deposition analysis represents a meaningful and innovative approach.

• Journal of KIISE
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• v.42 no.5
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• pp.591-600
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• 2015

SLA (Service Level Agreement) is an essential factor that must be guaranteed to provide a reliable and consistent service to user in cloud computing environment. Especially, a contract between user and service provider with SLA is important in an environment using a cloud service brokerage. The cloud computing is classified into IaaS, PaaS, and SaaS according to IT resources of the various cloud service. The existing SLA is difficult to reflect the quality factors of service, because it only considers factors about the physical Network environment and have no methodological approach. In this paper, we suggested a method to specify the quality characteristics of software and proposed a mechanism and structure that can exchange SLA specification between the service provider and consumer. We defined a meta-model for the SLA specification in the SaaS level, and quality requirements of the SaaS were described by the proposed specification language. Through case studies, we verified proposed specification language that can present a variety of software quality factors. By using the UDDI-based mediation process and architecture to interchange this specification, it is stored in the repository of quality specifications and exchanged during service binding time.

• Molecules and Cells
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• v.26 no.4
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• pp.338-343
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• 2008

An embryonic stem cell is a powerful tool for investigation of early development in vitro. The study of embryonic stem cell mediated neuronal differentiation allows for improved understanding of the mechanisms involved in embryonic neuronal development. We investigated expression profile changes using time course cDNA microarray to identify clues for the signaling network of neuronal differentiation. For the short time course microarray data, pattern analysis based on the quadratic regression method is an effective approach for identification and classification of a variety of expressed genes that have biological relevance. We studied the expression patterns, at each of 5 stages, after neuronal induction at the mRNA level of embryonic stem cells using the quadratic regression method for pattern analysis. As a result, a total of 316 genes (3.1%) including 166 (1.7%) informative genes in 8 possible expression patterns were identified by pattern analysis. Among the selected genes associated with neurological system, all three genes showing linearly increasing pattern over time, and one gene showing decreasing pattern over time, were verified by RT-PCR. Therefore, an increase in gene expression over time, in a linear pattern, may be associated with embryonic development. The genes: Tcfap2c, Ttr, Wnt3a, Btg2 and Foxk1 detected by pattern analysis, and verified by RT-PCR simultaneously, may be candidate markers associated with the development of the nervous system. Our study shows that pattern analysis, using the quadratic regression method, is very useful for investigation of time course cDNA microarray data. The pattern analysis used in this study has biological significance for the study of embryonic stem cells.

• Journal of the Korean Operations Research and Management Science Society
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• v.17 no.1
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• pp.117-117
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• 1992

Pubilc utility industries including the electric utility industry are facing a new stream of privatization com-petition with the private sector and deregulation. The necewssity to solve now and in the future power supply and demand problems has been increasing through the sophisticated generation expansion plan(GEP) approach con-sidering not only KEPCo's supply-side resources but also outside resources such as non-utility generation(NUG) demand-side management (DSM). Under the environmental situation in the current electric utility industry a new approach is needed to acquire multiple resources competitively. This study presents the development of a modified electric generation expansion analysis system(EGEAS) model with avoided cost based on the existing EGEAS model which is a dynamic program to develope an optimal generation expansion plan for the electric utility. We are trying to find optimal GEP in Korea's case using our modified model and observe the difference for the level of reliabilities such as the reserve margin(RM) loss of load probability(LOLP) and expected unserved energy percent(EUEP) between the existing EGEAS model and our model. In addition we are trying to calculate avoided cost for NUG resources which is a criterion to evaluate herem and test possibility of connection calculation of avoided cost with GEP implementation using our modified model. The results of our case study are as follows. First we were able to find that the generation expansion plan and reliability measures were largely influenced by capacity size and loading status of NUG resources, Second we were able to find that avoided cost which are criteria to evaluate NUG resources could be calculated by using our modified EGEAS model with avoided cost. We also note that avoided costs were calculated by our model in connection with generation expansion plans.

• Journal of the Korean Home Economics Association
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• v.43 no.9 s.211
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• pp.27-40
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• 2005

The purpose of this study was to examine the relationship between male consumers' clothing shopping orientation and sex role identity. Since shopping, especially clothing shopping has been traditionally considered a female job, it was expected that male consumers' sex role identity would influence how they approach the task of clothing shopping. Data were collected through an Internet survey firm from men aged between 20 and 40 years(N=199). The major results are as follows: 1. Based on the six clothing shopping orientation factors identified tv factor analysis, the respondents were categorized into 5 distinct groups: Self-Directed Shoppers, Planners, Brand-Oriented Shoppers, Convenience Shoppers, and Impulsive High-Involvers. 2. Five sex role factors were identified by factor analysis: two masculinity factors (strong and reticent) and three femininity factors(gentle, meticulous, and affable). Among these factors, 'gentle' was considered the most ideal, followed in order by 'strong,' 'meticdous,' 'affable,' and 'reticent.' 3. The results of MANOVA showed that the clothing shopping orientation groups statistically differed in their perceived sex role identity as well as in their ideal sex role identity. Overall, Self-Directed Shoppers and Impulsive High-Involvers scored higher in both perceived masculinity and femininity than the other groups. Convenience Shoppers and Planners were high in femininity but low in masculinity. The Brand-Oriented Shoppers were low in both masculinity and femininity. The results indicate that Korean males who are in their 20s and 30s consider androgyny as a desirable state. In addition, those who are high in androgyny are more likely to be highly involved in clothing shopping.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.23 no.2
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• pp.34-34
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• 1987

Friction welding has emerged as a reliable process for high-production commercial application with significant economic and technical advantages. But nondestructive test in friction weld was not clearly developed. Therefore the experimental verification is necessary in order to understand the characteristics of the pulse echo effects according to various change in welding conditions. This paper presents a new attempt to detect the bond strength of friction welds by ultrasonic. Instead of looking for a flaw or cracks at the interface, the new approach evaluates the coefficient by reflection which provides a single quantitative indicator involving the acoustic energy reflected at the interface. The objective of this study is to find the relationship between the reflection coefficients and the weld strength. Results of the bar-to-bar friction welding of aluminum to copper and stainless steel and such relationship investigation are presented and interpreted.

• Journal of KIISE:Computer Systems and Theory
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• v.26 no.12
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• pp.1485-1492
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• 1999

대규모 시스템 명세의 올바름을 검증하기 위한 유한 상태 LTS에 기반을 둔 CTL논리 적용에 있어 가장 큰 문제점은, 시스템 내부의 병렬 프로세스간의 상호작용으로 인한 상태폭발이다. 그러나 Modal mu-calculus 논리를 시스템 안전성 및 필연성 특성 명세에 사용하면, 행위에 의한 순환적 정의가 가능하므로 상태폭발 문제가 해결 가능하다. 본 논문에서는 LTS로 명세화된 통신 프로토콜 시스템 모델의 안전성 및 필연성 특성을 모형 검사 기법에 의해 검증함에 있어, 시제 논리로 사용된 Modal mu-calculus 안전성 및 필연성 논리식과 CTL 의 안전성 및 필연성 논리식의 극한값이 동일함을 두 논리식을 만족하는 상태 집합이 같다는 것을 보임으로써 증명한다. 증명된 결과는 I/O FSM 모델로 표현된 통신 프로토콜의 안전성 및 필연성 검사를 위해 이론적인 기반으로서, 컴퓨터를 이용한 모형검사 기법에 효과적인 방법으로 응용이 가능하다.Abstract In applying CTL-based model checking approach to correctness verification of large state transition system specifications, the major obstacle is the combinational explosion of the state space arising due to interaction of many loosely coupled parallel processes. If, however, the modal mu-calculus viewed as a CTL-based logic with recursion, is used to specify the safety and liveness property of a given system, it is possible to resolve this problem. In this paper, we discuss the problem of verifying communication protocol system specified in LTS, and prove that a logic expression specifying safety and liveness in modal mu-calculus is semantically identical to the maximum value of the expression in CTL. This relation is verified by the proof that the sets of states satisfying the two logic expressions are equivalent. The proof can be used as a theoretical basis for verifying safety and liveness of communication protocols represented as I/O FSM model.

• Korean Journal of Cognitive Science
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• v.4 no.2
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• pp.29-51
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• 1994

This paper presents a new approach to describing the meanings of English relative clauses with the theoretical framework of Conceptual Structure Theory (henceforth CST)which builds on the pionerring work of Sowa.And this paper aims at proposing some extensions to his work. CST describes the conceptual structrures of sentences with conceptual graphs(henceforth CG). which have begun to be used as an intermediate language in natural language processing and machine translation of computer.CGs are composed of concept types and conceptual relation types. They are a system of logic for semantic representation of sentences. This paper focuses on showing the differences of the CGs according to the functions of English relative clauses. English relative clauses are divided into restrictive and nonrestrictive uses.And this paper describes a restrictive clause with a CG including a expression.which derives from the viewpoint of Montague-semantics and Nom-S Analysis.This paper deals mainly with the relative clauses of double restroction as an example of restrictive relative clauses.The description of a nonrestrictive relative clause does not need any-expression, for it doesn's involve the meaning of set.And this paper links the CG of an appositive relative clause,which is a kind of nonrestrictive clauses,to the concept of the antecedent in the main clause.The description of a nonrestrictive relative clause with adverbial meaning is strated with two CGs for the main clause and the relative clause.They are linked with an appropriate intersentential conceptual relation type according to the contextual realtions between them.This paper also presents a CG of a sentential relative clause,which gives a comment on the main clause.