• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.7
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• pp.1347-1353
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• 2015

We implemented a 10 Gb/s 4-channel vertical cavity surface emission lasers (VCSEL) driver array in a $0.13{\mu}m$ CMOS process technology. To enhance high current resolution, power dissipation, and chip space area, digital APC/AMC with time division sensing technology is primarily adopted. The measured -3 dB frequency bandwidth is 9.2 GHz; the small signal gain is 10.5 dB; the current resolution is 0.01 mA/step, suitable for the wavelength operation up to 10 Gb/s over a wide temperature range. The proposed APC and AMC demonstrate 5 to 20 mA of bias current control and 5 to 20 mA of modulation current control. The whole chip consumes 371 mW of low power under the maximum modulation and bias currents. The active chip size is $3.71{\times}1.3mm^2$.

• Journal of Digital Convergence
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• v.12 no.11
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• pp.99-112
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• 2014

This study the impact on the real earnings management credit rating (RANK), and looked at the impact on the real earnings management grade credit rating changes (decrease, increase) the effects in detail. firm for a total of 06 years for firm that are listed on the Korea Stock Exchange from 2008 to 2013 for the hypothesis - using the proceeds of the year 2,583 sample were analyzed to study. A regression analysis of the relevance of the credit rating (RANK) and real earnings measured results between the credit rating and a measure of real earnings management ACFO and ADE (+) between AMC (-) IFRS and receive relevant ADE between(+) between AMC (-) if the credit rating (RANK) is increased ACFO and is significantly sound level at 1% showed the relevance of (+) did not significantly ADE (+) 10% of AMC if the credit rating fell ACFO is (-) from AMC show the relevance of positive credit rating is dropped capital letter showed for performing real earnings management of positive even give up the future cash flow in order to reduce the cost.

• Pediatric Infection and Vaccine
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• v.27 no.3
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• pp.147-157
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• 2020

Purpose: We investigated the trend of antibiotic susceptibility of Haemophilus influenzae over 5 consecutive years. Methods: We analyzed the antibiotic susceptibility of H. influenzae isolated from children aged <18 years, who were admitted to the Asan Medical Center Children's Hospital from March 2014 to April 2019. Antibiotic susceptibility of H. influenzae was determined by the disk diffusion test according to the European Committee on Antimicrobial Susceptibility Testing guidelines. Results: Excluding duplicates, 69 isolates were obtained over the past 5 years. The median age of the patients was 5 years (range, 2.8-8.6 years). The antibiotic susceptibility patterns were as follows: ampicillin (AMP)-susceptible/amoxicillin-clavulanate (AMC)-susceptible (AS/ACS; n=15 [21.7%]), AMP-resistant/AMC-susceptible (AR/ACS; n=21 [30.4%]), and AMP-resistant/AMC-resistant (AR/ACR; n=33 [47.8%]). The prevalence of isolates with AR/ACR phenotype tended to increase from 42.1% in 2014-2015 to 54.5% in 2018-2019 (P=0.342). Compared to 2014-2015, the resistance rates to cefuroxime and ceftriaxone in 2018-2019 increased from 31.6% to 77.3% and from 0.0% to 59.1%, respectively (P=0.003 and P<0.001, respectively). Conclusions: Over the last 5 years, H. influenzae isolates with AR/ACR phenotype and ceftriaxone resistance were frequently observed at our institute. The incidence of resistance to cefuroxime and ceftriaxone has increased significantly.

• Tuberculosis and Respiratory Diseases
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• v.58 no.4
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• pp.352-358
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• 2005

Microsatellites are short tandem repeated nucleotide sequences that are present throughout the human genome. Variations in the repeat number or a loss of heterozygosity around the microsatellites have been termed a microsatellite alteration (MA). A MA reflects the genetic instability caused by an impairment in the DNA mismatch repair system and is suggested to be a novel tumorigenic mechanism. A number of studies have reported that MA in the DNA extracted from the plasma occurs at varying frequencies among patients with a non-small cell lung carcinoma (NSCLC). The genomic DNA from 9 subjects with a non-small cell lung cancer (squamous cell cancer 6, adenocarcinoma 2, non-small cell lung cancer1) and 9 age matched non-cancer control subjects (AMC: tuberculosis 3, other inflammatory lung disease 6) and 12 normal control subjects (NC) were extracted from the peripheral blood leukocytes and plasma. Three microsatellite loci were amplified with the primers targeting the Gene Bank sequence D21S1245, D3S1300, and D3S1234. MA in the form of an allelic loss or a band shift was examined with 6% polyacrylamide gel electrophoresis and silver staining. None (0/12) of the NC subjects less than 40 years of age showed a MA in any of the three markers, while 88.9%(8/9) of the AMC above 40 showed a MA in at least one of the three markers (p<0.05). Sixty percent(6/10) of the control subjects with a smoking history showed a MA in one of the three markers, while 9.1%(1/11) of the control subjects without smoking history showed a MA (p<0.05). However, not only did 66.7%(6/9) of lung cancer patients show a MA in at least one of the three markers but so did 88.9%(8/21) of the AMC patients (p>0.05). In conclusion, a MA in the D21S1245, D3S1300, and D3S1234 loci using DNA extracted from the plasma was detected in 66.7% of lung cancer while no MA was found in the young non-smoking control subjects. However, many of the non-cancer control subjects (aged smokers) also showed a MA, which compromised the specificity of the MA analysis as a screening test. Therefore, a further study with a larger sample size will be needed.

• The Magazine of the IEIE
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• v.30 no.8
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• pp.64-64
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• 2003

국내외적으로, 2.3GHz 대역의 휴대 인터넷 서비스와 이동 고속 무선 패킷 데이터 MBWA(Mobile Broadband Wireless Access) 서비스를 위한 기술 개발 및 표준화 작업이 진행중이며, 이들 기술 표준에서는 데이터 속도의 고속화를 달성하기 위하여 AMC(Adaptive Modulation and Coding)를 요구하고 있다. AMC방식 무선 패킷 시스템은 서비스 지역 내에서 SNR(Signal to Noise Ratio)의 값에 연동하여 가변적인 데이터 서비스 속도를 제공하게 되고, 사용자가 서비스 지역을 이동하면서 제공받는 서비스 품질은 물리 채널의 서비스 속도 변화에 대응하여 변화되므로, 서비스 사업자는 서비스 사용자의 속도 품질을 일정하게 유지하고 관리 제어할 수 있도록 하는 서비스 품질 설계 기준이 필요하다. 따라서, 본 기고문에서는 이들 AMC 방식의 고속 무선 패킷 서비스 시스템 기술의 표준화에 병행하여 공중망 무선 패킷 서비스 시스템의 망 구축 설계시 고려되어야 할 가입자 수용용량과 서비스 품질 등을 산정하고 관리하기 위한 파라미터로서 기지국의 평균 데이터 공급 용량 MDT(Mean Data Throughput), 평균속도 공유 패킷 링크 MSPL (Mean Shared Packet Link) 그리고 서비스 Uniformity 지수 UI(Uniformity Index) 등을 제안하고자 한다.

• The Magazine of the IEIE
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• v.30 no.8
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• pp.844-852
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• 2003

국내외적으로, 2.3GHz 대역의 휴대 인터넷 서비스와 이동 고속 무선 패킷 데이터 MBWA(Mobile Broadband Wireless Access) 서비스를 위한 기술 개발 및 표준화 작업이 진행중이며, 이들 기술 표준에서는 데이터 속도의 고속화를 달성하기 위하여 AMC(Adaptive Modulation and Coding)를 요구하고 있다. AMC방식 무선 패킷 시스템은 서비스 지역 내에서 SNR(Signal to Noise Ratio)의 값에 연동하여 가변적인 데이터 서비스 속도를 제공하게 되고, 사용자가 서비스 지역을 이동하면서 제공받는 서비스 품질은 물리 채널의 서비스 속도 변화에 대응하여 변화되므로, 서비스 사업자는 서비스 사용자의 속도 품질을 일정하게 유지하고 관리 제어할 수 있도록 하는 서비스 품질 설계 기준이 필요하다. 따라서, 본 기고문에서는 이들 AMC 방식의 고속 무선 패킷 서비스 시스템 기술의 표준화에 병행하여 공중망 무선 패킷 서비스 시스템의 망 구축 설계시 고려되어야 할 가입자 수용용량과 서비스 품질 등을 산정하고 관리하기 위한 파라미터로서 기지국의 평균 데이터 공급 용량 MDT(Mean Data Throughput), 평균속도 공유 패킷 링크 MSPL (Mean Shared Packet Link) 그리고 서비스 Uniformity 지수 UI(Uniformity Index) 등을 제안하고자 한다.

• Journal of radiological science and technology
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• v.24 no.1
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• pp.5-9
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• 2001

Over-density of pancreatic duct tail part on the endoscopic retrograde pancreatogram results from patient's position and inserted air during the study. The aim of this paper is to decide the filter angle to obtain an uniform density. Endoscopic retrograde pancreatography was performed to 234 patients, and angled wedge filter was used differently. They are $10^{\circ}$ (47), $20^{\circ}$ (45), $30^{\circ}$ (50), and $40^{\circ}$ (50). We also did not use wedge filter to 42 patients. We decided reliance degree in 95%. The statistical difference was p<0.05. The patients' sex rate was 1.8 : 1 between 18 and 87 years old(average age 58 years). Their body girth was 18.71 cm on the average. Of total 234 patients, difference of right and left average density was 0.01 by $30^{\circ}$ wedge filter, -0.08 $40^{\circ}$ wedge filter and 0.27 non-wedge filter. These average values of difference density were very significant statistically, and standard deviation also was close to regular distribution. In conclusion, there is a usefulness of angled wedge filter for increasing diagnostic value of pancreatic duct tall part on the endoscopic retrograde pancreatogram.

• Journal of Advanced Navigation Technology
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• v.7 no.1
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• pp.59-71
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• 2003

The channel scheduler is suggested the radio resource management method in order to provide service with guaranteeing fairness and throughput to the users who use limited wireless channel. Proportional fairness scheduling algorithm is the channel scheduler used in the AMC(Adaptive Modulation and Coding)/TDM system, and this algorithm increases the throughput considering the user's time fairness. In this paper is suggested the channel scheduler combining CDM scheme available in AMC/TDM/CDM system. Unlike the system which only uses TDM which provide the only one user at the same slot, this scheduler can service a lot of users since this uses the CDM scheme with multi-cord channel. At every moment, allocation of transmission power to multi-channel users is problematic because of CDM scheme. In this paper, we propose a water-filling scheduling algorithm to solve the problem. Water-filling fairness(WF2) scheduling algorithm watches the average channel environment. So, this modified method guarantees fairness for each user in terms of power and service time.

• The Journal of Korean Society for Radiation Therapy
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• v.10 no.1
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• pp.94-96
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• 1998

• Journal of Life Science
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• v.29 no.3
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• pp.318-324
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• 2019

Squamous cell carcinoma is the primary tumor type in head and neck cancers, the fifth most common malignant neoplasm world-wide. Survivin, a member of the inhibitor of apoptosis family, is highly expressed in head and neck carcinoma patients and correlated with more aggressive forms. In this study, we investigated whether YM155, a specific survivin inhibitor, could induce apoptosis in head and neck AMC-HN4 cells. YM155 was found to markedly induce apoptosis and cleavage of PARP, a marker of apoptosis. Furthermore, YM155 promoted apoptosis in other cancer cells, such as glioma (U251MG) and renal carcinoma (Caki) cells. In contrast, YM155 had no effect on apoptosis in normal mesangial cells. YM155 significantly induced caspase activation, and pan caspase inhibitor z-VAD-fmk markedly blocked apoptosis, PARP cleavage, and caspase-3 cleavage. Therefore, YM155 was seen to instigate caspase-dependent apoptosis in head and neck AMC-HN4 cells, inducing downregulation of survivin as well as other apoptotic proteins such as c-FLIP and Mcl-1. In addition, the induction of apoptosis and PARP cleavage by YM155 treatment was effectively inhibited in survivin-, c-FLIP- and Mcl-1-over-expressing head and neck AMC-HN4 cells. In conclusion, YM155 is a potent candidate for inducing cell death in head and neck AMC-HN4 cells.