• Quality Improvement in Health Care
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• v.23 no.2
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• pp.57-66
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• 2017

Purpose:The purpose of this study was to identify the patient's characteristics influencing patient's comprehensibleness of doctor's explanation. Methods: This study was conducted as a secondary data analysis using the raw data of The 6th Korea National Health and Nutrition Examination Survey (KNHANES VI) conducted in 2015. The survey sampled 22,948 adults, and 4,469 of them were included in this analysis. Multiple regression analysis was performed to determine the patient's characteristics influencing patient's comprehensibleness of doctor's explanation. Results: The patient's comprehensibleness of doctor's explanation were more higher as age (t=5.65, p<.001), female (t=4.40, p<.001), subjective good health status (t=3.48, p=.001) were higher. On the other hand, the patient's comprehensibleness of doctor's explanation were more higher education level (t=-6.80, p<.001), not-recent outpatient experience (t=-6.04, p<.001), pain/discomfort (t=-2.64, p=.008), anxiety/depression (t=-2.58, p=.010) were lower. Conclusion:It is necessary to be provided the patients who are higher education level, pain/discomfort and anxiety/depression with applying the doctor's detailed explanation and intervention programs.

• Communications of the Korean Mathematical Society
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• v.35 no.1
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• pp.185-199
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• 2020

In this paper, we introduce the definitions of s_p-convergent sequence in fuzzy metric spaces and fuzzy normed spaces. We investigate relations of convergence, s_p-convergence, s_∞-convergence and st-convergence in fuzzy metric spaces and fuzzy normed spaces. We also study s_p-convergence, s_∞-convergence and st-convergence using the sub-sequence of convergent sequence in fuzzy metric spaces and fuzzy normed spaces. Stationary fuzzy normed spaces are defined and investigated. We finally define s_p-closed sets, s_∞-closed sets and st-closed sets in fuzzy metric spaces and fuzzy normed spaces and investigate relations of them.

• Communications of the Korean Mathematical Society
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• v.39 no.3
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• pp.785-802
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• 2024

Given M a monoid with a neutral element e. We show that the solutions of d'Alembert's functional equation for n × n matrices Φ(pr, qs) + Φ(sp, rq) = 2Φ(r, s)Φ(p, q), p, q, r, s ∈ M are abelian. Furthermore, we prove under additional assumption that the solutions of the n-dimensional mixed vector-matrix Wilson's functional equation $$\begin{cases}f(pr, qs) + f(sp, rq) = 2\phi(r, s)f(p, q),\\Φ(p, q) = \phi(q, p),{\quad}p, q, r, s {\in} M\end{cases}$$ are abelian. As an application we solve the first functional equation on groups for the particular case of n = 3.

• Tuberculosis and Respiratory Diseases
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• v.45 no.5
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• pp.975-983
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• 1998

Purpose: Frequent deletion of 3p in numerous cancer including lung cancer suggests the presence of tumor suppressor gene. 3p has been analysed by RFLP and PCR-LOH of microsatellite locus. In this study, we observed the deletion of 3p in Korean NSCLC by PCR-LOH of 4 microsatellite loci and investigated the clinical significance. Method: 62 surgically resected NSCLC DNA and normal lung DNA have been analysed by PCR-LOH at three dinucleotide[D3S1228 (3p14.1-14.3), D3S1067 (3p14.3-21.1), D3S1029 (3p21.1-21.3)] and one tetranucleotide[D3S1537 (3p 22-24.2)] repeat microsatellite loci. Results: Among 59 informative cases, 3p deletion by PCR-LOH at four microsatellite loci was found in 31 patients(52.5%). 3p deletion were found in 55% of squamous cell lung cancer and 47% of adenocarcinoma patients. No significant difference has been found in clinical parameters such as staging, smoking and survival according to the status of 3p deletion. Conclusion: Deletions in 3p have played an important role in Korean NSCLC though no clinical significance was detected.

• Korean Journal of Human Ecology
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• v.17 no.2
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• pp.305-313
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• 2008

This subject investigated visual evaluation of preference and fitness level of set-in sleeve in sleeve types(form)and studied suitable sleeve type at silhouette and targeted female students in twenties. The results of study were as follows: 1. Visual evaluation factors in set-in sleeve of sleeve types were selected 6 factors; the 1st factor is decorativeness, the 2nd factor is attractiveness, the 3rd factor was activeness, the 4th factor was feminine, the 5th factor was charming and 6th factor was a figural element. Decorativeness and attractiveness factors in visual evaluation of sleeve types were the most important level. 2. The visual evaluation differences of sleeve types in set-in sleeve were as follows; in the 1st factor, S and P2 were the most decorative sleeve type. in the 2nd factor, S, P2 and P3 are the most attractive sleeve type. in the 3rd factor, B and P3 were the most active sleeve type. in the 4th factor, L was the most feminine sleeve type. in the 5th factor, P1, L and P3 were charming sleeve type. in the 6th factor, P3 was evaluated that it shows narrowened shoulder sleeve types. 3. The analysis result of preference and wearing level in each sleeve types were as follows. 20's female university students like to wear S, P1, P2 and P3 sleeve types and the most favorite sleeve types are S, P2 and P3. 4. The analysis result of silhouette set-in sleeve in sleeve types; S, B and P2 in H-type silhouette, P2, S and P1 in A-type silhouette, B and P3 in O-type silhouette, L and P3 in X-types silhouette were show the most suitable sleeve types.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4589-4594
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• 2014

The mammalian target of rapamycin (mTOR) signaling pathway is upregulated in the pathogenesis of many cancers, including colorectal cancer (CRC). DEPTOR is an mTOR inhibitor whose expression is negatively regulated by mTOR. However, the role of DEPTOR in the development of CRC is not known. The aim of this study was to investigate the expression of DEPTOR and mTORC1 activity (P-S6) in a subset of CRC patients and determine their relation to tumor differentiation, invasion, nodal metastasis and disease-free survival. Here, Immunohistochemical expression of P-S6 (S235/236) and DEPTOR were evaluated in 1.5 mm tumor cores from 90 CRC patients and in 90 samples of adjacent normal mucosa by tissue microarray. The expression of P-S6 (S235/236) was upregulated in CRC, with the positive rate of P-S6 (S235/236) in CRC (63.3%) significantly higher than that in control tissues (36.7%, 30%) (p<0.05). P-S6 (S235/236) also correlated with high tumor histologic grade (p=0.002), and positive nodal metastasis (p=0.002). In contrast, the expression level of DEPTOR was correlated with low tumor histological grade (p=0.006), and negative nodal metastasis (p=0.001). Interestingly, P-S6 (S235/236) expression showed a significant negative association with the expression of DEPTOR in CRC (p=0.011, R= -0.279). However, upregulation of P-S6 (S235/236) (p=0.693) and downregulation of DEPTOR (p=0.331) in CRC were not significantly associated with overall survival. Thus, we conclude that expression of DEPTOR negatively correlates with mTORC1 activity and tumor progression in CRC. DEPTOR is a potential marker for prognostic evaluation and a target for the treatment of CRC.

• Biomolecules & Therapeutics
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• v.27 no.6
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• pp.522-529
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• 2019

M1/M2 polarization of immune cells including microglia has been well characterized. It mediates detrimental or beneficial roles in neuroinflammatory disorders including cerebral ischemia. We have previously found that sphingosine 1-phospate receptor subtype 1 ($S1P_1$) in post-ischemic brain following transient middle cerebral artery occlusion (tMCAO) can trigger microglial activation, leading to brain damage. Although the link between $S1P_1$ and microglial activation as a pathogenesis in cerebral ischemia had been clearly demonstrated, whether the pathogenic role of $S1P_1$ is associated with its regulation of M1/M2 polarization remains unclear. Thus, this study aimed to determine whether $S1P_1$ was associated with regulation of M1/M2 polarization in post-ischemic brain. Suppressing $S1P_1$ activity with its functional antagonist, AUY954 (5 mg/kg, p.o.), attenuated mRNA upregulation of M1 polarization markers in post-ischemic brain at 1 day and 3 days after tMCAO challenge. Similarly, suppressing $S1P_1$ activity with AUY954 administration inhibited M1-polarizatioin-relevant $NF-{\kappa}B$ activation in post-ischemic brain. Particularly, $NF-{\kappa}B$ activation was observed in activated microglia of post-ischemic brain and markedly attenuated by AUY954, indicating that M1 polarization through $S1P_1$ in post-ischemic brain mainly occurred in activated microglia. Suppressing $S1P_1$ activity with AUY954 also increased mRNA expression levels of M2 polarization markers in post-ischemic brain, further indicating that $S1P_1$ could also influence M2 polarization in post-ischemic brain. Finally, suppressing $S1P_1$ activity decreased phosphorylation of M1-relevant ERK1/2, p38, and JNK MAPKs, but increased phosphorylation of M2-relevant Akt, all of which were downstream pathways following $S1P_1$ activation. Overall, these results revealed $S1P_1$-regulated M1/M2 polarization toward brain damage as a pathogenesis of cerebral ischemia.

• The Korean Journal of Food And Nutrition
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• v.26 no.2
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• pp.234-241
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• 2013

The purpose of this research was to suggest a category and level of national examination for dietitian's license and provide basic data for the development of national examination question by analyzing the current states on the curriculum of national examination for the dietitian's license and correlation with the current states on curriculum and national examination for the dietitian's license. The higher the current states on curriculum, the lower absentee rate and failing rate of the national examination for the dietitian's license. The higher the current states on curriculum, the higher pass rate of the national examination for the dietitian's license. Also, the current states on curriculum were positive relationship with correct answer rates. The higher the educational system, the higher the current states on curriculum. The educational system was negative relationship with the current states on curriculum of 'public health', 'advanced nutrition', 'food science', 'principles of culinary', and 'food sanitary law (p<0.05)'. The correct answers rates of 'institutional foodservice' were significantly positive relationship with the current states on curriculum of 'institutional foodservice (p<0.01)', 'foodservice organization (p<0.01)', 'food sanitation (p<0.05)', and 'practice in foodservice institutions (p<0.01)'. The pass rate was significantly positive relationship with the correct answer rates of 'institutional foodservice (p<0.01)', 'physiology (p<0.01)', 'biochemistry (p<0.01)', 'food sanitary law (p<0.01)', 'food science and preparation (p<0.05)', 'nutrition education (p<0.01)', 'nutrition (p<0.01)', and 'total score (p<0.05)'.

• Journal of the Korean Mathematical Society
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• v.54 no.2
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• pp.575-598
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• 2017

This paper introduces and studies a generalization of the classical Struve function of order p given by $$_aS_{p,c}(x):=\sum\limits_{k=0}^{\infty}\frac{(-c)^k}{{\Gamma}(ak+p+\frac{3}{2}){\Gamma}(k+\frac{3}{2})}(\frac{x}{2})^{2k+p+1}$$. Representation formulae are derived for $_aS_{p,c}$. Further the function $_aS_{p,c}$ is shown to be a solution of an (a + 1)-order differential equation. Monotonicity and log-convexity properties for the generalized Struve function $_aS_{p,c}$ are investigated, particulary for the case c = -1. As a consequence, $Tur{\acute{a}}n$-type inequalities are established. For a = 2 and c = -1, dominant and subordinant functions are obtained for the Struve function $_2S_{p,-1}$.

• The Korean Journal of Mycology
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• v.26 no.4 s.87
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• pp.551-561
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• 1998

Plasma membrane from the fungal cells (Aspergillus phoenicis, Rhizopus acidus, Candida albicans) treated with sodium benzoate (S.B), potassium sorbate (P.S) and calcium propionate (C.P) during the cultivation were separated. The contents and patterns of plasma membrane proteins compared with those of the control. The growth of A. phoenicis was decreased by the average 64.0% in the S.B treatment. That of R. acidus was inhibited by the average 69.0% in the P.S treatment. Also, That of C. albicans was showed the deminution of the average 59.5% in the S.B treatment. The contents of protein involved in the plasma membrane of the each fungal cells were inhibited the average 41.0%, 41.7% and 59.5% in the S.B treatment, respectively. In case of A. phoenicis, the changes in the protein pattern involved in the plasma membraneshowed the aspect similar to the control on the 1st day and 2nd day of cultivation in the treatment group, but $116\;KD{\sim}97\;KD$ band almost disappeared in the 5th day of cultivation, and $45\;KD{\sim}29\;KD$ band was uncleared through the cultivation. In S.B treatment group R. acidus was showed the loss of $116\;KD{\sim}97\;KD$ band from the middle stage of cultivation and P.S, and C.P treatment group were started the loss at the early stage and completely lost at the 36 hours of cultivation. In C. albicans, $116\;KD{\sim}97\;KD$ band were started the loss at the early stage to compare with the control and $66\;KD{\sim}45\;KD$ band were dimmed at the 96 hours of cultivation. Especially, the C.P treatment group were perfectly lost at the 96 hours of cultivation.