• Communications of the Korean Mathematical Society
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• v.9 no.3
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• pp.687-700
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• 1994

Throughout this paper we will let H denote the complete Heyting algebra ($H, \vee, \wedge, *$) with order reversing involution *. 0 and 1 denote the supermum and the infimum of $\emptyset$, respectively. Given any set X, any element of $H^X$ is called H-fuzzy set (or, simply f.set) in X and will be denoted by small Greek letters, such as $\mu, \nu, \rho, \sigma$. $H^X$ inherits a structure of H with order reversing involution in natural way, by definding $\vee, \wedge, *$ pointwise (sam notations of H are usual). If $f$ is a map from a set X to a set Y and $\mu \in H^Y$, then $f^{-1}(\mu)$ is the f.set in X defined by f^{-1}(\mu)(x) = \mu(f(x))$. Also for $\sigma \in H^X, f(\sigma)$ is the f.set in Y defined by $f(\sigma)(y) = sup{\sigma(x) : f(x) = y}$ ([4]). A preorder R on a set X is reflexive and transitive relation on X, the pair (X,R) is called preordered set. A map $f$ from a preordered set (X, R) to another one (Y,T) is said to be preorder preserving (inverting) if for $x,y \in X, xRy$ implies $f(x)T f(y) (resp. f(y)Tf(x))$. For the terminology and notation, we refer to [10, 11, 13] for category theory and [7] for H-fuzzy semitopogenous spaces.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.153.2-154
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• 2003

Pathophysiological elevation of intracellular calcium concentration ([$Ca^{2+}$]$_i$) in the neuron has been considered as an important responsible factor in the neuronal cell damages. However, the mechanism of increase of [$Ca^{2+}$]$_i$ through ryanodine receptor (RyR), the relationship between [$Ca^{2+}$]$_i$ level and cell damages have not been fully demonstrated. (omitted)

• Journal of applied mathematics & informatics
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• v.27 no.3_4
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• pp.749-755
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• 2009

In this paper, we investigate the invariant interval, periodic character, semicycle and global attractivity of all positive solutions of the equation $Y_{n+1}\;=\;\frac{p+qy_{n-k}}{1+y_n+ry_{n-k}}$, n = 0, 1, ..., where the parameters p, q, r and the initial conditions $y_{-k}$, ..., $y_{-1}$, $y_0$ are positive real numbers, k $\in$ {1, 2, 3, ...}. It is worth to mention that our results solve the open problem proposed by Kulenvic and Ladas in their monograph [Dynamics of Second Order Rational Difference Equations: with Open Problems and Conjectures, Chapman & Hall/CRC, Boca Raton, 2002]

• Proceedings of the Korea Information Processing Society Conference
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• 2008.05a
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• pp.84-87
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• 2008

본 논문에서는 Q.Wang & R.K.Ward 가 제안한 WTHE(weighted and thresholded histogram equalization)방법의 enhancement parameters를 주어진 영상의 히스토그램 분포에 따라 적응적으로 제공하는 방법을 제안한다. WTHE는 영상의 히스토그램을 weight와 threshold를 이용하여 변형한 후 히스토그램 평활화(histogram equalization : HE)방법을 수행 함으로써 화질을 개선하는 방법이다. 이 방법은 두 가지 parameters 제어로 기존의 히스토그램 평활화 방법의 단점인 과도한 밝기 변화와 불필요한 artifacts를 줄일 수 있다. 본 논문에서는 WTHE 방법을 좀 더 간편하면서 다양한 분야에 적용하기 위해서 입력 영상에 따라 달라지는 parameters 값을 자동으로 제공하는 적응형 WTHE(Adaptive WTHE : AWTHE) 방법을 제안하고, 제안된 방법의 성능을 실험으로 제시한다.

• The Journal of the Korea Contents Association
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• v.22 no.5
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• pp.656-666
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• 2022

The purpose of this study is to evaluate the effect on the grit, learning reality, and learning satisfaction for nursing students using the flipped learning teaching method. We developed a flipped learning educational program using ADDIE model for nursing students and evaluated the program effect. As a result of this study, the grit (t=-3.07, p=.003), the learning presence (t=-4.87, p<.001) and the learning satisfaction (t=-5.18, p<.001) significantly increased after flip learning method application. The Grit shown to have a significant positive correlation with learning presence (r = .47, p<.001), and learning satisfaction (r = .26, p<.005). The learning presence shown to have a significant positive correlation with learning satisfaction (r = .548, p<.001). The flipped learning teaching method may improve the grit, learning reality, and learning satisfaction. Various efforts will be needed to lay the foundation for flipped learning teaching methods in the field of nursing education in the future.

• Bulletin of the Korean Mathematical Society
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• v.20 no.1
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• pp.45-49
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• 1983

If R is ring and M is a right (or left) R-module, then M is called a faithful R-module if, for some a in R, x.a=0 for all x.mem.M then a=0. In [4], R.E. Johnson defines that M is a prime module if every non-zero submodule of M is faithful. Let us define that M is of prime type provided that M is faithful if and only if every non-zero submodule is faithful. We call a right (left) ideal I of R is of prime type if R/I is of prime type as a R-module. This is equivalent to the condition that if xRy.subeq.I then either x.mem.I ro y.mem.I (see [5:3:1]). It is easy to see that in case R is a commutative ring then a right or left ideal of a prime type is just a prime ideal. We have defined in [5], that a chain of right ideals of prime type in a ring R is a finite strictly increasing sequence I$_{0}$.contnd.I$_{1}$.contnd....contnd.I$_{n}$; the length of the chain is n. By the right dimension of a ring R, which is denoted by dim, R, we mean the supremum of the length of all chains of right ideals of prime type in R. It is an integer .geq.0 or .inf.. The left dimension of R, which is denoted by dim$_{l}$ R is similarly defined. It was shown in [5], that dim$_{r}$R=0 if and only if dim$_{l}$ R=0 if and only if R modulo the prime radical is a strongly regular ring. By "a strongly regular ring", we mean that for every a in R there is x in R such that axa=a=a$^{2}$x. It was also shown that R is a simple ring if and only if every right ideal is of prime type if and only if every left ideal is of prime type. In case, R is a (right or left) primitive ring then dim$_{r}$R=n if and only if dim$_{l}$ R=n if and only if R.iden.D$_{n+1}$ , n+1 by n+1 matrix ring on a division ring D. in this paper, we establish the following results: (1) If R is prime ring and dim$_{r}$R=n then either R is a righe Ore domain such that every non-zero right ideal of a prime type contains a non-zero minimal prime ideal or the classical ring of ritght quotients is isomorphic to m*m matrix ring over a division ring where m.leq.n+1. (b) If R is prime ring and dim$_{r}$R=n then dim$_{l}$ R=n if dim$_{l}$ R=n if dim$_{l}$ R<.inf. (c) Let R be a principal right and left ideal domain. If dim$_{r}$R=1 then R is an unique factorization domain.TEX>R=1 then R is an unique factorization domain.

• Molecules and Cells
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• v.26 no.3
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• pp.265-269
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• 2008

Calumenin, a multiple EF-hand $Ca^{2+}$ binding protein is located in the SR of mammalian heart, but the functional role of the protein in the heart is unknown. In the present study, an adenovirus gene transfer system was employed for neonatal rat heart to examine the effects of calumenin over-expression (Calu-OE) on $Ca^{2+}$ transients. Calu-OE (8 folds) did not alter the expression levels of DHPR, RyR2, NCX, SERCA2, CSQ and PLN. However, Calu-OE affected several parameters of $Ca^{2+}$ transients. Among them, prolongation of time to 50% baseline ($T_{50}$) was the most outstanding change in electrically-evoked $Ca^{2+}$ transients. The higher $T_{50}$ was due to an inhibition of SERCA2-mediated $Ca^{2+}$ uptake into SR, as tested by oxalate-supported $Ca^{2+}$ uptake. Furthermore, co-IP study showed a direct interaction between calumenin and SERCA2. Taken together, calumenin in the cardiac SR may play an important role in the regulation of $Ca^{2+}$ uptake during the EC coupling process.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.52-52
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• 2003

Junctate is a newly identified integral ER/SR membrane $Ca^{2+}$ binding protein, which is an alternative splicing form of the same gene generating aspartyl $\square$-hydroxylase and junctin. To elucidate the functional role of junctate in heart, transgenic (TG) mice overexpressing mouse cardiac junctate-1 under the control of mouse $\square$$^{~}$ myosin heavy chain promoter were generated. Overexpression of junctate in mouse heart resulted in cardiac hypertrophy, increased fibrosis, bradycardia, arrhythmias and impaired contractility. Overexpression of junctate also led to down-regulation of SERCA2, calsequestrin, calreticulin and RyR, but to up-regulation of NCX and PMCA. The SR $Ca^{2+}$ content decreased and the L-type $Ca^{2+}$ current density and the action potential durations increased in TG cardiomyocytes, which could be the cause for the bradycardia in TG heart. The present work has provided an important example of pathogenesis leading to cardiac hypertrophy and arrhythmia, which was caused by impaired $Ca^{2+}$ handling by overexpression of junctate in heart.n heart.

• Journal of Microbiology and Biotechnology
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• v.33 no.10
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• pp.1268-1280
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• 2023

Echinacoside (ECH) is a naturally occurring phenylethanoid glycoside, isolated from Echinacea angustifolia, and this study aimed to analyze its effect on thermogenesis and its interaction with dopaminergic receptors 1 and 5 (DRD1 and DRD5) in 3T3-L1 white adipocytes and mice models. We employed RT-PCR, immunoblot, immunofluorescence, a staining method, and an assay kit to determine its impact. ECH showed a substantial increase in browning signals in vitro and a decrease in adipogenic signals in vivo. Additionally, analysis of the iWAT showed that the key genes involved in beiging, mitochondrial biogenesis, and ATP-dependent thermogenesis were upregulated while adipogenesis and lipogenesis genes were downregulated. OXPHOS complexes, Ca²⁺ signaling proteins as well as intracellular Ca²⁺ levelswere also upregulated in 3T3-L1 adipocytes following ECH treatment. This was collectively explained by mechanistic studies which showed that ECH mediated the beiging process via the DRD1/5-cAMP-PKA and subsequent downstream molecules, whereas it co-mediated the α1-AR-signaling thermogenesis via the DRD1/5/SERCA2b/RyR2/CKmt pathway in 3T3-L1 adipocytes. Animal experiments revealed that there was a 12.28% reduction in body weight gain after the ECH treatment for six weeks. The effects of ECH treatment on adipose tissue can offer more insights into the treatment of obesity and metabolic syndrome.

• Clinical and Experimental Reproductive Medicine
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• v.30 no.4
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• pp.269-280
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• 2003

Objective: We reported the overcoming effect of $Ni^{2+}$ on the in vitro 2-cell block of mouse embryos. In this study, we aim to investigate whether $Ni^{2+}$ should induce intracellular $Ca^{2+}$ transient in the mouse embryos. Materials and Methods: Embryos were collected at post hCG 32hr from the oviduct of the ICR mouse and cultured in M2 medium omitted phenol red. Intracellular $Ca^{2+}$ was checked by using a confocal laser scanning microscope and fluo-3AM by using various intracellular $Ca^{2+}$ antagonists. Results: In 1mM $Ni^{2+}$ treated medium which contained $Ca^{2+}$(1.71mM), 75.7% of the embryos showed $[Ca^{2+}]i$ transient about 200 sec later. In the $Ca^{2+}$-free medium, 69.8% of the embryos showed $[Ca^{2+}]i$ transient. In U73122, phospholipaseC(PLC) inhibitor (5uM, 10min) pretreated group, 33.3% of the embryos showed $[Ca^{2+}]i$ transient. Heparine, inositol 1, 4, 5-triphosphate receptor(IP3R) antagonist preinjected embryos showed no response with 1mM $Ni^{2+}$. In danthrolene treatment, ryanodine receptor(RyR)-antagonist, 43% embryos showed $[Ca^{2+}]i$ transient but they showed delayed response about 340sec in the presence of $Ca^{2+}$. Conclusions: Summing up the above results, $Ni^{2+}$ seems to induce $Ca^{2+}$-release from the $Ca^{2+}$-store even in the $Ca^{2+}$-free medium. IP3 receptors of the mouse 2-cell embryos might have an essential role for the intracellular $Ca^{2+}$ increase by $Ni^{2+}$.