• Journal of Pharmaceutical Investigation
• /
• v.23 no.3
• /
• pp.179-186
• /
• 1993

In vitro dissolution test and pharmacokinetic study in human volunteers were conducted to evaluate the pharmacokinetic characteristics of 150 mg furbiprofen sustained-release capsule (FPSR-150). As a reference product, 50 mg flurbiprofen conventional-release capsule (FPCR-50) was used. Dissolution tests of two products were run using the paddle method in 450 : 540 (v/v %) mixture of simulated gastric and intestinal fluids (K.P. VI) by adjusting medium pH according to time. FPCR-50 was dissolved very rapidly, and it took about 1.5 hr for FPCR-50 to be dissolved over 90%, whereas 15 hr for FPSR-150. Also, in pharmacokinetic study, ten healthy male volunteers were administered one capsule of FPSR-150 or two capsules of FPCR-50 (FPCR-l00) with randomized two period cross-over study. Significant differences between FPCR-l00 and FPSR-150 were found in mean times to reach peak concentration, mean resident times and mean terminal phase halflives, while not in AUC/Dose (Student's t-test). In ANOVA for AUC/Dose to compare the bioavailabilities of two FP products, there was no significant difference. From the comparison of the simulated steady-state plasma concentration-time curves following multiple medications of FPCR-50 (3 capsules a day, dosing interval=8 hrs) and FPSR-150 (1 capsule a day) based on the above results obtained from single doses of two FP products, it was noted that the medication of FPSR-150 is more useful in clinical application rather than FPCR-50.

• The Bulletin of The Korean Astronomical Society
• /
• v.39 no.2
• /
• pp.114-114
• /
• 2014

We present our activities linking to planning of possible forms of large program to study on circumstellar H2O and SiO maser sources with KaVA. A great advantage of KaVA for the stellar maser observations is the combination of the unique capability of the multi-frequency phase referencing technique of KVN and the dual-beam astrometry of VERA with the KaVA's relative dense antenna configuration. We have demonstrated this advantage through the test observations conducted by the KaVA Evolved Stars Sub-working Group since 2012 March. Snapshot KaVA imaging is confirmed to be possible in integration time of 0.5 hour at the 22 GHz band and 1.0 hour at the 43 GHz band in typical cases. This implies that large snapshot imaging surveys towards many H2O and SiO stellar masers are possible within a reasonable machine time (e.g., scans on ~100 maser sources within 200 hours). This possibility enables us to select the maser sources, which are suitable for future long-term (10 years) intensive (biweekly-monthly) monitoring observations, from 1000 potential target candidates selected from dual-frequency band (K/Q-bands) KVN single-dish observations. The output of the survey programs will be used for statistical analysis of the structures of individual stellar maser clumps and the spatio-kinematical structures of circumstellar envelopes with accelerating outflows. The combination of astrometry in milliarcsecond(mas) level and the multi-phase referencing technique yields not only trigonometric parallax distances to the masers but also precise position reference for registration of different maser lines. The accuracy of the map registration affects interpretation of the excitation mechanism of the SiO maser lines and the origin of the variety of the maser actions, which are expected to reflect periodic behaviors of the circumstellar envelope with stellar pulsation. Currently we are checking the technical feasibility of KaVA operations for this combination. After this feasibility test, the long-term monitoring campaign program will run as one of KaVA's legacy projects.

• Physical Therapy Rehabilitation Science
• /
• v.4 no.1
• /
• pp.32-37
• /
• 2015

Objective: This study was conducted to test the effects of mobile texting and gaming on gait with obstructions under different illumination levels. Design: Cross-sectional study. Methods: Twelve healthy adults aged 20 to 36 years (mean 23.5 years) were tested under six different conditions. All participants used touchscreen smartphones. Testing conditions included: 1) Walking with an obstruction under a bright illumination level; 2) walking with an obstruction with a low level of illumination; 3) walking with an obstruction while texting under a bright illumination level; 4) walking with an obstruction while texting with a low level of illumination; 5) walking with an obstruction while gaming under a bright illumination level; and 6) walking with an obstruction while gaming with a low level of illumination. All participants were asked to text the Korean national anthem by their own phone and play Temple Run 2 using an iPhone 5. Gait variances were measured over a distance of 3 m, and the mean value after three trials was used. A gait analyzer was used to measure the data. Results: Compared to normal gait with obstruction, gait speed, step length, stride length, step time, stride time, cadence while texting and gaming showed significant differences (p<0.05). Differences between the illumination levels included gait speed, step length, stride length, and step time (p<0.05) with no significant differences in stride time and cadence. Conclusions: Dual-tasking using a smartphone under low levels of illumination lowers the quality of gait with obstructions.

• The Korean Journal of Applied Statistics
• /
• v.18 no.2
• /
• pp.253-269
• /
• 2005

One of the basic assumptions of the regression models is that the parameter vector does not vary across sample observations. If the parameter vector is not constant for all observations in the sample, the statistical model is changed and the usual least squares estimators do not yield unbiased, consistent and efficient estimates. This study investigates the regression model with some or all parameters vary across partitions of the whole sample data when the model permits different response coefficients during unusual time periods. Since the usual test for overall homogeneity of regressions across partitions of the sample data does not explicitly identify the break points between the partitions, the testing the equality between subsets of coefficients in two or more linear regressions is generalized and combined with the test procedure to search the break point. The method is applied to find the possibility and the turning point of the structural change in the long-run unemployment rate in the usual static framework by using the regression model. The relationships between the variables included in the model are reexamined in the dynamic framework by using Vector Autoregression.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.16 no.5
• /
• pp.494-502
• /
• 2011

Bimodal tram is designed to run on a dedicated path in automatic mode using a magnetic track system in order to realize a combination of the accessibility of a bus and the constant regularity of a railroad. This paper presents design and test results of the series hybrid propulsion system of the bimodal tram on both test track and public road, which uses CNG (Compressed Natural Gas) engine and Lithium polymer battery pack. This paper describes the real-time data measuring equipment for the series hybrid propulsion system of the bimodal tram. Using this measurement equipment, the performance of the prototype vehicle's driving on test track and public road was verified and the fuel consumption and the efficiency of CNG engine have been investigated.

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.38 no.3
• /
• pp.304-315
• /
• 2001

In this paper, we peformed the real-time implementation of AMR(Adaptive Multi-Rate) speech coding algorithm which is adopted for IMT-2000 service using TMS320C6201, i.e., a Texas Instrument´s fixed-point DSP. With the ANSI C source code released from ETSI, optimization is performed to make it run in real-time with memory as small as possible using the C compiler and assembly language. Implemented AMR speech codec has the size of 32.06 kWords program memory, 9.75 kWords data RAM memory, and 19.89 kWords data ROM memory. And, The time required for processing one frame of 20 ms length speech data is about 4.38 ms, and it is short enough for real-time operation. It is verified that the decoded result of the implemented speech codec on the DSP is identical with the PC simulation result using ANSI C code for test sequences. Also, actual sound input/output test using microphone and speaker demonstrates its proper real-time operation without distortions or delays.

• Journal of Pharmaceutical Investigation
• /
• v.38 no.2
• /
• pp.135-142
• /
• 2008

The present study describes the evaluation of the bioequivalence of two atorvastatin tablets, Lipitor $Tablet^{(R)}$ (Pfizer, reference drug) and Atorva $Tablet^{(R)}$ (Yuhan, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Forty-nine healthy male Korean volunteers received each medicine at the atorvastatin dose of 40 mg in a $2{\times}2$ crossover study with a two weeks washout interval. After drug administration, serial blood samples were collected at a specific time interval from 0-48 hours. The plasma atorvastatin concentrations were monitored by an high performance liquid chromatography -tandem mass spectrometer (LC-MS/MS) employing electrospray ionization technique and operating in multiple reaction monitoring (MRM) and positive ion mode. The total chromatographic run time was 4.5 min and calibration curves were linear over the concentration range of 0.1-100 ng/mL for atorvastatin. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48hr) was calculated by the linear log trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were complied trom the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Atorva $Tablet^{(R)}$ / Lipitor $Tablet^{(R)}$ were ${\log}\;0.9413{\sim}{\log}\;1.0179$ and ${\log}\;0.831{\sim}{\log}\;1.0569$, respectively. These values were within the acceptable bioequivalence intervals of ${\log}\;0.8{\sim}{\log}\;1.25$. Based on these statistical considerations, it was concluded that the test drug, Atorva $Tablet^{(R)}$ was bioequivalent to the reference drug, Lipitor $Tablet^{(R)}$.

• Tunnel and Underground Space
• /
• v.23 no.3
• /
• pp.180-191
• /
• 2013

The purpose of this research was to find an optimal quarrying for marble by analyzing the applicability and the work efficiency of a chain saw machine newly introduced in the underground Baekwoon mine. From the test results of the physical properties of Baekwoon marble, which affects the efficiency of rock cutting, it was found to have similar physical characteristics as the ones which are now being produced in the other areas in Korea. And especially it shows isotropic property, which can be thought to be advantageous as a dimensional stone. To check the long-term quality of the marble as a stone material, several tests such as corrosion resistance test and abrasion test were carried out. It was found to be vulnerable to acid rain with decrease of weight and seismic wave velocity after applying artificial rain at pH 5.6 for 50 times. The percentage of wear from abrasion test was 22.67%. The working time and cutting speed of the chain saw machine were recorded and analyzed during the test-run at the quarry. The overall work cycle was assorted into 9 unit operations and the operating time per each unit was drawn. The operating times for the two cutting patterns, which could be possibly applicable to the work site, were compared. The results indicated that the pattern B, that the cutting sequence was set to minimize the movement of the machine, showed 6% less working hours than the pattern A, which first cuts the outer boundary. With cutting pattern analysis, the ore body in the Baekwoon mine was 3 dimensionally modeled and a quarrying plan considering the existing conditions of the marble was suggested.

• Proceedings of the IEEK Conference
• /
• 2005.11a
• /
• pp.569-572
• /
• 2005

This paper proposed the design and implementation of a DSP platform for the various multimedia streaming. The DSP platform synchronizes with host PC to configure DSP and to transmit multimedia streaming through PCI. The suggested DSP platform decodes high-capacity video/audio data using the suggested high-speed FIFO, CPLD and memory interface. The buffer control techniques is proposed in other to avoid the under/over-run of the audio/video data during the audio/video decoding. For the DSP platform test, host PC transmits program stream(PS) that consists of the MPEG-2 video MP@ML and 5.1ch AC3 audio data (Coyote.mov file, half hour running time) to DSP platform. The DSP platform plays continuously back the high sound-quality audio and high-definition video at once.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.39 no.3
• /
• pp.327-335
• /
• 2015

In this paper, we propose an independent cooling control (ICC) scheme for high strength and atmosphere corrosion resisting steel to obtain the desired temperature and properties along the longitudinal direction of the steel in the run-out table (ROT) process. A temperature model of the independent process is developed to divide the ROT into front and back sections. The control concept uses field data, problem analysis, and a time-temperature transformation diagram. The effectiveness of the proposed control is verified using simulation results under a temperature disturbance by the transformation in the middle of the ROT. The results of a hot strip mill field test show that the temperature control performance is significantly improved by the proposed control scheme.