• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1200-1203
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• 2005

Kami-Okchun-San(OCS) is known as an effective herbal medicine on Type 2 diabetes. We peformed to investigate acute toxicity of OCS on ICR mice. ICR mice in acute toxicity experiment were administered orally with dosages of 3,200mg/kg (low dosage group), 4,000mg/kg (middle dosage group), 5,000mg/kg (high dosage group) per single time, respectively. Body weights, clinical signs, motalities and histopathological finding were observed daily for 14 days according to the Regulation of Korean Food and Drug Administration(1999. 12. 22). Single oral administration of OCS with different dosages, no animals died of the test drug. Autopsy of animal revealed no abnormal gross findings. Therefore, LD50 value of OCS for ICR mice was more than 5,000mg/kg on oral route. Normally increasing changes were observed in body weight, drinking water and food intake in every dosage group. Hematological parameters were also observed normally in all animals. No histopathological lesions were observed in both control and treated animals. Above data suggest that no toxic dose level of OCS in ICR mice is considered to be more than 5,000mg/kg. Therefore, it was concluded that OCS have no effect on acute toxicity and side effect in ICR mice.

• Korean Journal of Heritage: History & Science
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• v.42 no.4
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• pp.50-73
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• 2009

Recently old stone walls were designated as registered cultural properties that meant an extension of categories about cultural properties from a spot area to whole area. Moreover given the changing situation of residential pattern, which is due to rapid social change, this designation can be seen as a significant measure to keep as intact as possible traditional landscapes in agricultural and fishing villages. In this paper, I analyze the symbol system and meaning of old stone walls and attempt to pick out the cultural elements which are related to them. These days we have made efforts to various aspects for which make traditional cultural resources into cultural contents. But many studies had done before emphasized aspects for beauty only. Especially existing studies about an old stone wall was mainly focused on architectural interpretation and tourist route. So we need to build a plot around oral research and need a creative approach for sharing with tourists. Cultural contents combine the original form, potential and capabilities with media by detecting original form of culture and finding out the worth and meaning. In this paper examined the probability of using by investigating a stone wall in Sang-hak Village that is related with recovering of places to live in contemporary society and finding cultural contents. I suggest more creative ways to make cultural properties into tourist resources by considering the possibilities of place marketing using storytelling, based on an analysis of data gathered.

• Journal of the Korean Society of Marine Environment & Safety
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• v.28 no.2
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• pp.370-376
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• 2022

Smart ships related studies are being conducted in various fields owing to the development of technology, and an engine room patrol robot that can patrol the unmanned engine room is one such study. A patrol robot moves around the engine room based on the information learned through artificial intelligence and checks the machine normality and occurrence of abnormalities such as water leakage, oil leakage, and fire. Study on engine room patrol robots is mainly conducted on machine detection using artificial intelligence, however study on movement and control is insufficient. This causes a problem in that even if a patrol robot detects an object, there is no way to move to the detected object. To secure maneuverability to quickly identify the presence of abnormality in the engine room, this study experimented with whether a patrol robot can determine the shortest path by applying the A* algorithm. Data were obtained by driving a small car equipped with LiDAR in the ship engine room and creating a map by mapping the obtained data with SLAM(Simultaneous Localization And Mapping). The starting point and arrival point of the patrol robot were set on the map, and the A* algorithm was applied to determine whether the shortest path from the starting point to the arrival point was found. Simulation confirmed that the shortest route was well searched while avoiding obstacles from the starting point to the arrival point on the map. Applying this to the engine room patrol robot is believed to help improve ship safety.

• Spatial Information Research
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• v.20 no.2
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• pp.117-127
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• 2012

The purpose of this study is to develop the auto-building algorithm of the Geometric Network Model(GNM), a topology model including geometric information because of the need to reflect the features' geometric characteristic into the topology model, which is for development of indoor 3D virtual model enabling queries. As the critical algorithm, the Straight Medial Axis Transformation(SMAT) algorithm is proposed in order to automatically extract the medial axis of features. The SMAT algorithm is generalized from the existing S-MAT algorithm and a range of target features where applicable is extended from simple polygons to weakly simple polygons which mean the polygons containing the inner ring inside. The GNM built automatically is finally printed out as the .csv file for easy access and w ide application in other systems. This auto-building algorithm of the GNM is available for plenty of cases such as finding a shortest path, guiding a route in emergency situation, and semantic analysis.

• Clean Technology
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• v.22 no.3
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• pp.196-202
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• 2016

In this study, ceria- based catalysts were prepared for dimethyl carbonate (DMC) synthesis and reaction conditions were evaluated for finding the optimal reaction route. In order to find optimal catalysts for DMC synthesis, calcination temperature and Cu(II) impregnation amount were evaluated. The oxidative carbonylation using methanol, carbon monoxide and oxygen and the direct synthesis using methanol and carbon dioxide were introduced for producing DMC. Following the law of Le Chatelier, the dehydration reaction was applied for enhancing the reactivity (methanol conversion) as removing water during the reaction. 2-cyanopyridine, as a chemical dehydration agent, was used. In the case of the oxidative carbonylation, methanol conversion rate increased from 15.1% to 38.7% and the DMC selectivity increased from 0% to 98.8%. In the case of the direct synthesis, methanol conversion rate increased from 1.0% to 77.8% and the DMC selectivity increased from 41.2% to 100.0%.

• Korean Journal of Animal Reproduction
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• v.19 no.1
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• pp.55-63
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• 1995

The putative totipotency germ cells has a relative abundance of alkaline phosphatases. Thus, histological staining of AP activity offers a new route to isolate totipotent cells and also provides insights into culture systems of these cells. Furthermore, the AP staining technique is simple and fast, requires only the napthol AS/MS substrate in combination with trapping diazonium salts such as fast red or fast blue. However, our unexpected finding was that AP staining of mouse ES cells were detected in the undifferentiaed epiblast-derived cells as well as several types of differentiating cells. This findings are different from results of Talbot et al. (1993) reported usefulness of the AP staining and implies that histological staining of AP may not by useful to determine undifferentiaed state or totipotency of ES cells. Thus, we have investigated the patterns of AP expression by RT-PCR in order to identify a marker of undifferentiated ES/primordial germ (PG) cells. In RT-PCR analysis, embryonic (E)-AP was detected only in undifferentiated ES cells, but intestinal(I)-AP was not detected in all of the examined ES and PG cells. In addition, nonspecific (NS)-AP wasdetected in undifferentiated PG cell from day 7, 5 to 13 of gestation. Histological activity of AP in ES cells was completely suppressed by addition of L-phenylalanine (Phe), L-homoarginine (Har), and L-phenylalanylglycylglycine (PheGlyGly) as an inhibitor, but RT-PCR showed the same results as in the absence of an inhibitors. Our findings suggested that expression of E-AP and NS-AP may use as a marker to determine the undifferentiated status in ES and PG cells.

• Journal of Global Scholars of Marketing Science
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• v.9
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• pp.129-151
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• 2002

Today, shipping companies have shown the positive volition to the finding of chanced market through the development of new route with the new recognition and enhancement of competitiveness on the quality management in order to cope with the sharply-changing environment of shipping industry. Accordingly, this study is an empirical study which attempts the general and situational approach in order to clarify what TQM source, Activities and performance affect the enterprises and how it is different upon the step of quality management activities in the object of the incidental business related to the oceangoing and costal transportation, and marine and the groups related to the marines, subdividing the area of offering the shipping service.

• Spatial Information Research
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• v.18 no.3
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• pp.63-72
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• 2010

The vehicle routing problem with simultaneous pick-up and delivery (VRPSPD) is a variant of the vehicle routing problem (VRP) that customers require simultaneously a pick-up and delivery service. The main objective of VRPSPD is to minimize a cost of routes satisfying many constraints. Traditional VRPSPD have been dealt with a static environment. The static environment means that a routing data and plan cannot be changed. For example, it is difficult to change a vehicle's routing plan so that a vehicle serves the pick-up demands of new customers during the delivery service. Therefore, traditional approach is not suitable for dynamic environments. To solve this problem, we propose a novel approach for finding efficient routes using a real-time re-routing heuristics based on the Location Based Service (LBS). Our re-routing heuristics can generate a new route for vehicle that satisfies a new customer's demand considering the current geographic location of a vehicle. Experimental results show that our methodology can reduce the traveling cost of vehicles comparing with other previous methods.

• Archives of Plastic Surgery
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• v.33 no.5
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• pp.621-626
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• 2006

Purpose: Erythropoietin is traditionally known to regulate erythropoiesis, but recently its protective effect against ischemia-reperfusion injury has been studied mainly in cardiovascular and neuronal systems. This study was planned to investigate the effects of recombinant human erythropoietin on ischemia-reperfusion injury in rat TRAM flap model. Methods: Superiorly based TRAM flap was elevated and ischemic insult was given for four hours. Thirty minutes before reperfusion, single dose recombinant human Erythropoietin(5000IU/kg) was injected via intraperitoneal route in the treatment group. At 24 hours postoperatively, systemic neutrophil count, tissue myeloperoxidase activity, malonyldialdehyde amount, nitric oxide content, tissue water content and histologic finding of inflammation was evaluated. On 10 days postoperatively, flap survival rate, angiogenesis and change in hematocrit level was evaluated. Results: Tissue nitric oxide level was significantly higher and myeloperoxidase activity was significantly lower in the treatment group 24 hours after reperfusion. Tissue water content was significantly lower in the treatment group. Perivascular neutrophil infiltration and intravascular adhesion was marked in the control group. Mean flap survival after ten days was 69% in the treatment group, and 47% in the control group, demonstrating a significant difference. Neovascularization in the treatment group also outnumbered the control group. No significant hematocrit rise was noted ten days after erythropoietin administration. Conclusion: Recombinant human Erythropoietin improved flap survival in ischemia-reperfusion injured rat TRAM flaps, at least partially owing to suppressed inflammation, increased nitric oxide, and enhanced angiogenesis.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.4 no.1 s.6
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• pp.1-13
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• 2005

For integrated transit networks operated with diverse transit modes, it is difficult to find related literatures on the provision of multiple travel time routes information. This study proposes a methodology on how to select K number of least time transit routes in the integrated transit network with two modes, bus and subway. In the Proposed method, three constraints usually (will be) encountered for decision by users-(1) service time constraints of travel modes, (2) maximum payment fare constraints under the integrated distance based fare system, and (3) maximum number of transfer constraints - are taken into consideration in the searched routes. The experimental studies shows that the proposed method properly provides K number of least time routes. In addition, it somehow proves that by combinatorially considering three constraints the proposed method can be evaluated as to enlarge the quality as well as the diversity of route information demanded by users.