• Title/Summary/Keyword: Route life time

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Rapid Typing of Clinical Strains of Mycobacterium tuberculosis by IS6110-based Outward PCR

  • Kim, Yeun;Lee, Uen-Ho;Park, Young-Kil;Bai, Gill-Han;Cho, Sang-Nae;Lee, Hye-Young
    • Biomedical Science Letters
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    • v.10 no.2
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    • pp.163-169
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    • 2004
  • Worldwide, tuberculosis remains one of the leading infectious diseases, accounting for nearly 3 million deaths and more than 8 million new cases annually. DNA typing of Mycobacterium tuberculosis is important for the control of tuberculosis, since it can be used to track transmission route of tuberculosis, source of internal laboratory contaminations, and to answer questions on the nature of tuberculosis infections such as reactivation or exogenous reinfection of disease. At present, IS6110-based RFLP is the choice of method for typing large numbers of clinical isolates of M. tuberculosis, since it has the highest resolution power. However, RFLP requires long time, high cost and qualified experts, so only reference level laboratories can use the RFLP technique. In order to have an optional molecular typing method suitable for the clinical settings, this study evaluated the use of one of PCR-based typing methods, IS6110-based outward PCR for typing clinical isolates of M. tuberculosis. In brief, the results from this study showed that IS6110-based RFLP is useful to discriminate diverse clinical isolates of M. tuberculosis as well as to identify clinical isolates that belong to the same family or cluster groups that have been previously classified by RFLP analysis. In addition, the banding profiles resulted from IS6110-based outward PCR seemed to represent genomic characteristics of M. tuberculosis, since strains belong to the K-family generated unique band that is not present in any other strains but present only in the genome of K-family strains. The IS6110-based outward PCR was also shown to be useful with DNAs isolated directly from liquid cultures indicating this method can be suitable for typing M. tuberculosis in clinical settings.

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A Study on Optimal Planning of Sustainable Rural Road Path based on Infrastructure for Green-Tourism and Public Service (그린투어리즘 및 공공서비스 기반의 지속가능한 농촌도로노선의 최적계획에 관한 연구)

  • Kim, Dae-Sik;Chung, Ha-Woo
    • Journal of Korean Society of Rural Planning
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    • v.11 no.1 s.26
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    • pp.1-8
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    • 2005
  • The purpose of this study is to develop a simulation model of rural road path for infrastructure of green-tourism and public service in rural areas. This study makes an objective function for moving cost minimization considering car travel time according to road characteristics, which can route the optimal shortest road paths between the center places and all rear villages, based on GIS coverages of road-village network for connecting between center places and rural villages as input data of the model. In order to verify the model algorithm, a homogeneous hexagonal network, assuming distribution of villages with same population density and equal distance between neighborhood villages on a level plane area, was tested to simulate the optimal paths between the selected center nodes and the other rear nodes, so that the test showed reasonable shortest paths and road intensity defined in this study. The model was also applied to the actual rural area, Ucheon-myun, which is located on Hoengsung-gun, Kangwon-do, with 72 rural villages, a center village (Uhang, 1st center place) in the area, a county conte. (Hoengsung-eup, 2nd center place), and a city (Wonju, 3rd center place), as upper settlement system. The three kinds of conte. place, Uhang, Hoengsung-eup, and Wonju, were considered as center places of three scenarios to simulate the optimal shortest paths between the centers and rural villages, respectively. The simulation results on the road-village network with road information about pavement and width of road show that several spans having high intensity of road are more important that the others, while some road spans have low intensity of road.

Deep Brain Photoreceptors and Photoperiodism in Vertebrates

  • Oishi, Tadashi;Haida, Yuka;Okano, Keiko;Yoshikawa, Tomoko;Kawano, Emi;Nagai, Kiyoko;Fukada, Yoshitaka;Tsutsui, Kazuyoshi;Tamotsu, Satoshi
    • Journal of Photoscience
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    • v.9 no.2
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    • pp.5-8
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    • 2002
  • Photoperiodism is an important adaptive phenomenon in various physiological parameters including reproduction to cope with seasonal changes. Involvement of extraretinal photoreceptors in the photoperiodism in non-mammalian vertebrates has been well established. In addition, circadian clock system is known to be involved in the photoperiodic time measurement. The pathway consists of light-input system, time measurement system (circadian clock), gonadotropin releasing hormone (GnRH) production in the hypothalamus, luteinizing hormone (LH) and follicle stimulating hormone (FSH) production in the pituitary, and final gonadal development. Recently, several laboratories reported photopigments newly cloned in the pineal, eyes and deep brain in addition to already known visual pigments in the retina. These are pinopsin, parapinopsin, VA-opsin, melanopsin, etc. All these photopigments belong to the opsin family having retinal as the chromophore. However, the function of these photopigments remains unknown. I reviewed the studies on the location of the photopigments by immunocytochemistry. I also discussed the results on the action spectra for induction of gonadal development in relation with the location of the photoreceptors. Various physiologically active substances distribute in the vertebrate brain. Such substances are GnRH, GnIH, neuropeptide Y, vasoactive intestinal peptide, c-Fos, galanin, neurosteroids, etc. I summarized the immunhistochemical studies on the distribution and the photoperiodic changes of these substances and discussed the route from the deep brain photoreceptor to GnRH cells.

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Source-based Multiple Gateway Selection Routing Frotocol in Ad-hoc Networks (애드 흑 네트워크에서 소스 기반 다중 게이트웨이 선출 라우팅 프로토콜)

  • Lee Byung-Jin;Yoo Sang-Jo
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.30 no.8A
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    • pp.679-687
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    • 2005
  • A mobile ad-hoc network (MANET) is one consisting of a set of mobile hosts capable of communicating with each other without the assistance of base stations. It is necessary to use bandwidth effectively because MANET has limited bandwidth. In this paper, we propose SMGS (source based multiple gateway selection routing protocol). In SMGS, each node estimates its expected life time (ELT) and if its ELT is larger than that of current gateway it becomes a candidate node. When a source node establishes a path, in each grid the candidate node will take the route request and be a gateway node for the each source node. The node that is expected to stay the longest time in the grid is selected so that we can reduce frequent gateway handoff, packet loss, and handoff delay.

Comparisons in Pharmacokinetic Profiles of New Platinum Coordination Complexes, KBP31705-C127 and KBP30603-901 with Cisplatin and Carboplatin (신규 백금착물 항암제 KBP31705-C127, KBP30603-901의 Cisplatin 및 Carboplatin과의 약동력학적 동태 비교)

  • 정인숙;이주선;허수정;김진숙;진창배;김동현;김명배;박경수;손연수
    • Biomolecules & Therapeutics
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    • v.4 no.4
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    • pp.349-353
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    • 1996
  • The present study examined pharmacokinetic profiles of KBP31705-Cl27 and KBP30603-901, new platinum coordination complexes synthesized as anticancer candidates, in comparison with two well-known platinum-containing anticancer agents, cisplatin and carboplatin in rats. Under sodium pentobarbital anesthesia of male Sprague-Dawley rats, urinary bladder, and femoral artery and vein were catheterized for urine collection, blood sampling and drug injection, respectively Following i.v. administration of cisplatin (2 mg/kg), KBP31705-C127 (2 mg/kg), carboplatin (20 mg/kg) or KBP30603-901 (20 mg/kg), blood samples were collected at 2, 4, 6, 8, 10, 15, 20, 30, 45, 60 and 120 minutes. Urine samples were collected at 1-hr interval for 4 hr. Platinum concentrations in plasma and urine were measured using an inductively coupled plasmamass spectrometer. The plasma concentration-time curves were biphasic for all drugs during the time period studied. Compared with cisplatin, KBP31705-C127 showed similar decay patters in the alpha- and betaphases with slightly lower plasma concentrations. Urinary platinum excretion for cisplatin and KBP31705-C 127 was 56 and 52% of the administered dose in 4 hr, respectively. With regard to carboplatin and KBP 30603-901, a similar decay pattern was also observed in the alpha-phase. The half life of KBP30603-901 in the beta-phase, however, was much longer than that of carboplatin, which was consistent with the urinary excretion results that 46 and 59% of the administered dose were excreted in the urine in 4hr, respectively. The results suggest that platinum coordination complexes are primarily excreted via the renal route and KBP30603-901 can elicit longer duration of action due to slower renal excretion compared to carboplatin.

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Development and Application of Hygiene Safety Quotient (HSQ) and Nutrition Quotient (NQ) Management Web & App Program for Efficient Foodservice Management of Children's Foodservice Facilities (어린이 급식소의 효율적인 급식관리를 위한 위생·안전지수·영양지수 관리 웹 & 앱 프로그램 개발 및 적용)

  • Jung, Dajung;Kang, Hyunjoo
    • Journal of the Korean Dietetic Association
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    • v.26 no.3
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    • pp.221-233
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    • 2020
  • The Center for Children's Foodservice Management periodically visited children's foodservice facilities for hygiene, safety and nutrition management, and the 'HSQ (Hygiene Safety Quotient) and NQ (Nutrition Quotient) Management Web & App Program' was developed and applied to improve the health, safety, and nutrition management status of children's foodservice facilities. The HSQ is a comprehensive hygiene and safety index consisting of six categories from the hygiene and safety checklist for children's foodservice facilities provided by the Ministry of Food and Drug Safety. The NQ is a nutrition index for foodservice facilities consisting of five categories from the nutrition checklist. First, this program can be used to efficiently understand the actual conditions of children's foodservice. Foodservice facilities are provided with the result report prepared by the center without restrictions on time or place. Second, it can be used as "a channel for comfortable communication with foodservice facilities". Foodservice facilities are provided with a route where questions and resolutions can be communicated to the center. Third, it is easy to compare and review the results of foodservice facilities by institution and number of visits while downloading the results data at the same time, as the result report is written based on hygiene, safety, and nutrition visits. Through such programs, it is believed that standardized work and integrated management will improve the work efficiency of the center's employees. It is also thought that these programs will promote healthier life-styles in children by establishing a safe food environment for children's foodservice.

Naval Ship Evacuation Path Search Using Deep Learning (딥러닝을 이용한 함정 대피 경로 탐색)

  • Ju-hun, Park;Won-sun, Ruy;In-seok, Lee;Won-cheol, Choi
    • Journal of the Society of Naval Architects of Korea
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    • v.59 no.6
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    • pp.385-392
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    • 2022
  • Naval ship could face a variety of threats in isolated seas. In particular, fires and flooding are defined as disasters that are very likely to cause irreparable damage to ships. These disasters have a very high risk of personal injury as well. Therefore, when a disaster occurs, it must be quickly suppressed, but if there are people in the disaster area, the protection of life must be given priority. In order to quickly evacuate the ship crew in case of a disaster, we would like to propose a plan to quickly explore the evacuation route even in urgent situations. Using commercial escape simulation software, we obtain the data for deep neural network learning with simulations according to aisle characteristics and the properties and number of evacuation person. Using the obtained data, the passage prediction model is trained with a deep learning, and the passage time is predicted through the learned model. Construct a numerical map of a naval ship and construct a distance matrix of the vessel using predicted passage time data. The distance matrix configured in one of the path search algorithms, the Dijkstra algorithm, is applied to explore the evacuation path of naval ship.

The Effects of Intention Inferences on Scarcity Effect: Moderating Effect of Scarcity Type, Scarcity Depth (소비자의 기업의도 추론이 희소성 효과에 미치는 영향: 수량한정 유형과 폭의 조절효과)

  • Park, Jong-Chul;Na, June-Hee
    • Journal of Global Scholars of Marketing Science
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    • v.18 no.4
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    • pp.195-215
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    • 2008
  • The scarcity is pervasive aspect of human life and is a fundamental precondition of economic behavior of consumers. Also, the effect of scarcity message is a power social influence principle used by marketers to increase the subjective desirability of products. Because valuable objects are often scare, consumers tend to infer the scarce objects are valuable. Marketers often do base promotional appeals on the principle of scarcity to increase the subjective desirability their products among consumers. Specially, advertisers and retailers often promote their products using restrictions. These restriction act to constraint consumers' ability th take advantage of the promotion and can assume several forms. For example, some promotions are advertised as limited time offers, while others limit the quantity that can be bought at the deal price by employing the statements such as 'limit one per consumer,' 'limit 5 per customer,' 'limited products for special commemoration celebration,' Some retailers use statements extensively. A recent weekly flyer by a prominent retailer limited purchase quantities on 50% of the specials advertised on front page. When consumers saw these phrase, they often infer value from the product that has limited availability or is promoted as being scarce. But, the past researchers explored a direct relationship between the purchase quantity and time limit on deal purchase intention. They also don't explored that all restriction message are not created equal. Namely, we thought that different restrictions signal deal value in different ways or different mechanism. Consumers appear to perceive that time limits are used to attract consumers to the brand, while quantity limits are necessary to reduce stockpiling. This suggests other possible differences across restrictions. For example, quantity limits could imply product quality (i.e., this product at this price is so good that purchases must be limited). In contrast, purchase preconditions force the consumer to spend a certain amount to qualify for the deal, which suggests that inferences about the absolute quality of the promoted item would decline from purchase limits (highest quality) to time limits to purchase preconditions (lowest quality). This might be expected to be particularly true for unfamiliar brands. However, a critical but elusive issue in scarcity message research is the impacts of a inferred motives on the promoted scarcity message. The past researchers not explored possibility of inferred motives on the scarcity message context. Despite various type to the quantity limits message, they didn't separated scarcity message among the quantity limits. Therefore, we apply a stricter definition of scarcity message(i.e. quantity limits) and consider scarcity message type(general scarcity message vs. special scarcity message), scarcity depth(high vs. low). The purpose of this study is to examine the effect of the scarcity message on the consumer's purchase intension. Specifically, we investigate the effect of general versus special scarcity messages on the consumer's purchase intention using the level of the scarcity depth as moderators. In other words, we postulates that the scarcity message type and scarcity depth play an essential moderating role in the relationship between the inferred motives and purchase intention. In other worlds, different from the past studies, we examine the interplay between the perceived motives and scarcity type, and between the perceived motives and scarcity depth. Both of these constructs have been examined in isolation, but a key question is whether they interact to produce an effect in reaction to the scarcity message type or scarcity depth increase. The perceived motive Inference behind the scarcity message will have important impact on consumers' reactions to the degree of scarcity depth increase. In relation ti this general question, we investigate the following specific issues. First, does consumers' inferred motives weaken the positive relationship between the scarcity depth decrease and the consumers' purchase intention, and if so, how much does it attenuate this relationship? Second, we examine the interplay between the scarcity message type and the consumers' purchase intention in the context of the scarcity depth decrease. Third, we study whether scarcity message type and scarcity depth directly affect the consumers' purchase intention. For the answer of these questions, this research is composed of 2(intention inference: existence vs. nonexistence)${\times}2$(scarcity type: special vs. general)${\times}2$(scarcity depth: high vs. low) between subject designs. The results are summarized as follows. First, intention inference(inferred motive) is not significant on scarcity effect in case of special scarcity message. However, nonexistence of intention inference is more effective than existence of intention inference on purchase intention in case of general scarcity. Second, intention inference(inferred motive) is not significant on scarcity effect in case of low scarcity. However, nonexistence of intention inference is more effective than existence of intention inference on purchase intention in case of high scarcity. The results of this study will help managers to understand the relative importance among the type of the scarcity message and to make decisions in using their scarcity message. Finally, this article have several contribution. First, we have shown that restrictions server to activates a mental resource that is used to render a judgment regarding a promoted product. In the absence of other information, this resource appears to read to an inference of value. In the presence of other value related cue, however, either database(i.e., scarcity depth: high vs. low) or conceptual base(i.e.,, scarcity type special vs. general), the resource is used in conjunction with the other cues as a basis for judgment, leading to different effects across levels of these other value-related cues. Second, our results suggest that a restriction can affect consumer behavior through four possible routes: 1) the affective route, through making consumers feel irritated, 2) the cognitive making route, through making consumers infer motivation or attribution about promoted scarcity message, and 3) the economic route, through making the consumer lose an opportunity to stockpile at a low scarcity depth, or forcing him her to making additional purchases, lastly 4) informative route, through changing what consumer believe about the transaction. Third, as a note already, this results suggest that we should consider consumers' inferences of motives or attributions for the scarcity dept level and cognitive resources available in order to have a complete understanding the effects of quantity restriction message.

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An Analysis on Shortest Path Search Process of Gifted Student and Normal Student in Information (정보영재학생과 일반학생의 최단경로 탐색 과정 분석)

  • Kang, Sungwoong;Kim, Kapsu
    • Journal of The Korean Association of Information Education
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    • v.20 no.3
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    • pp.243-254
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    • 2016
  • This study has produced a checker of the shortest path search problem with a total of 19 questions as a web-based computer evaluation based on the 'TRAFFIC' questions of PISA 2012. It is because the computer has been settled as an indispensable and significant instrument in the process of solving the problems of everyday life and as a media that is underlying in assessment. Therefore, information gifted students should be able to solve the problem using the computer and give clear enough commands to the computer so that it can perform the procedure. In addition, since it is the age that the computational thinking is affecting every sectors, it should give students new educational stimuli. The relationship between the rate of correct answers and the time took to solve the problem through the shortest route search process showed a significant correlation the variable that affected the problem solving as the difficulty of the question rises due to the increase of nodes and edges turned out to be the node than the edge. It was revealed that information gifted students went through algorithmic thinking in the process of solving the shortest route search problem. And It could be confirmed cognitive characteristics of the information gifted students such as 'ability streamlining' and 'information structure memory'.

Safety Evaluation of Evacuation in a Dormitory Girls' High School based on PAPS (PAPS에 기반한 여자고등학교 기숙사생의 피난 안전성 평가)

  • Jeon, Seung-duk;Kong, Ha-sung
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.1
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    • pp.469-481
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    • 2022
  • This study is for increasing evacuation safety by analyzing RSET(the required safe escape time) through the arrangement of personnel by floor and by room while evacuating in a Girls' High School Dormitory. For this study, PAPS(Physical Activity Promotion System) results that have not been studied so far were analyzed and reflected in evacuation simulations on the premise that individual student's physical strength can affect evacuation. Based on the PAPS results, four scenarios were applied. In addition, evacuation simulation using the pathfinder program was conducted in two situations: the evacuation route was assigned or not. Scenario 4 was the fastest at 168.5 seconds of RSET in assigning evacuation routes among scenarios. As a result of this study, the arrangement of students focusing on improving their academic ability and student life guidance excluding student physical strength has problem. In order to solve this problem, it is effective to place C group students(low grade on PAPS) on low floors and A group students(high grade on PAPS) on high floors and to assign evacuation routes in each room. In the future, the following ways need to be more studied. A study on how to increase evacuation safety through practical evacuation training, the way of assessing evacuation safety reflecting the lifestyle and physical strength of girls, the evacuation route assignment according to the fire occurrence point, and the method to secure evacuation routes in the event of a fire near stairs or entrances should be conducted.