• Journal of Pharmaceutical Investigation
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• 제38권6호
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• pp.357-363
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• 2008

Penetration rate of large molecule through skin is very low due to the barrier effect of stratum corneum. Novel microneedle treatment device with roll was designed for transdermal delivery of large molecular drugs such as vaccine and protein drugs. The permeation rates of FITC labelled bovine serum albumin (FITC-BSA) as a model protein were determined using modified Franz diffusion cell and hairless mouse skin which were treated by hydrogel or solution containing FITC-BSA. Fluorescent spectrophotometer was used to analyze the concentration of FITC-BSA. Microscope using fluorescent filter was used to capture the image and location of FITC-BSA in the skin. We confirmed that permeation rate of BSA was increased with the treatment by microneedle and was increased by the increasing frequency of treatment. Furthermore, the permeation rate observed from hydrogel treated skin was significantly higher than that from solution treated skin.

• Journal of the Microelectronics and Packaging Society
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• 제27권2호
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• pp.19-26
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• 2020

Flexible displays have been evolved into curved, foldable, and rollable as the degree of bending increases. Due to the presence of brittle electrodes (e.g. indium-tin oxide (ITO)) that easily cracked and delaminated under severe bending deformation, lowering mechanical stress of the electrodes has been critical issue. Because of this, mechanical stress of brittle electrode in flexible displays has been analyzed mostly in terms of bending radius. On the other hand, in order to make rollable display, various mechanical components such as roller and spring are needed to roll-up or extend the screen for the rollable display apparatus. By these mechanical components, brittle electrode in the rollable display is subjected to the excessive tensile stress due to the retracting force as well as the bending stress by the roller. In this study, mechanical deformation of rollable OLED display was modeled considering boundary conditions of the apparatus. An analytical modeling based on the classical beam theory was introduced in order to investigate the mechanical behavior of the rollable display. In addition, finite element analysis (FEA) was used to analyze the effect of mechanical components in the apparatus on the brittle electrode. Furthermore, a strategy for improving the mechanical reliability of the rollable display was suggested through controlling the stiffness of adhesives in the display panel.

• Journal of the Korean Magnetics Society
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• 제8권5호
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• pp.255-260
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• 1998

Fabrication condition and magnetic properties of ultrathin Co-based amorphous alloy have been investigated. When the ejection gas pressure was lower than 0.05 kgf/$\textrm{cm}^2$ at the roll speed of 55 m/s, ultrathin ribbons with the thickness less than 10 ${\mu}{\textrm}{m}$ were successfully obtained. The ribbon thickness decreased linearly with the decrease in ejection pressure. Moreover the significant decrease in ribbon width was accompanied with the decrease of thickness in the range of ejection pressure to form an ultrathin ribbon. This behavior was attributed to the decrease of effective ejection pressure in the both end-sides of rectangular nozzle due to the larger friction between molten metal and nozzle wall. The effective permeability at low frequency (1 kHz) decreased largely with the decrease in ribbon thickness, while the coercive force increased with the thickness decrease. It was considered that these behaviors were due to the enhancement of surface effect leading to the suppression of wall motion. However effective permeability at high frequency (1 MHz) increased with the decrease in ribbon thickness, and this was ascribed to the easier magnetization rotation owing to the reduction of eddy current.

• Journal of Korea Foundry Society
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• 제22권2호
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• pp.89-96
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• 2002

This study examined the effects of adding Zn to Sn-3.5Ag solder on the microstructure changes and behavior of interface reaction of the solder joint with Cu substrate. The solder/Cu joints were examined with microscope to observe the characteristics of microstructure changes and interfacial reaction layer with aging treatment for up to 120 days at $150^{\circ}C$. Results of the microstructure changes showed that the microstructures were coarsened with aging treatment, while adding 1%Zn suppresses coarsening microstructures. The Sn-3.5Ag/Cu had a fast growth rate of the reaction layer in comparison with the Sn-3.5Ag-1Zn at the aging temperature of $150^{\circ}C$. Through the SEM/EDS analysis of solder joint, it was proved that intermetallic layer was $Cu_6Sn_5$ phase and aged specimens showed that intermetallic layer grew in proportion to $t^{1/2}$, and the precipitate of $Ag_3Sn$ occur to both inner layer and interface of layer and solder. In case of Zn-containing composite solder, $Cu_6Sn_5$ phase formed at the side of substrate and Cu-Zn-Sn phase formed at the other side in double layer. It seems that Cu-Zn-Sn phase formed at solder side did a roll of banrier to suppress the growth of the $Cu_6Sn_5$ layer during the aging treatment.

• Korean Journal of Metals and Materials
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• 제47권7호
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• pp.433-439
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• 2009

Ti and Ti based hydrogen storage alloys have been thought to be the third generation of alloys with a high hydrogen capacity, which makes it difficult to handle because of high reactivity. In order to solve the problem, the activation of a wide range of hysteresis of hydriding/dehydriding and without degradation of hydrogen capacity due to the hydriding/dehydriding cycle have to be improved in order to be aplied. Ti-Cr alloys have a high capacity about 0.8 wt.% in an ambient atmosphere. When the Ti-Cr alloys are added to Nb and Ta elements, they formed a laves phase in the alloy system. The Nb element was expected to make easy diffuse hydrogen in the Ti-Cr storage alloy, which was a catalytic element. In this study, the Ti-Nb-Cr ternary alloy was prepared by melt spinning. As-received specimens were characterized using XRD (X-ray Diffraction), SEM (Scanning Electron Microscopy) with EDX (Energy Dispersive X-ray) and TG/DSC (Thermo Gravimetric Analysis/Differential Scanning Calorimetry). In order to examine hydrogenation behavior, the PCI (Pressure-Composition-Isotherm) was performed at 293, 323, 373 and 423 K.

• Korean Journal of Metals and Materials
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• 제50권5호
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• pp.345-351
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• 2012

A three-point bending test was performed on roll-bonded Mg/Al/STS clad-metal plates under two different testing conditions (Mg layer in tension, or STS in tension) and their mechanical response and fracture behavior were investigated. Bending strength was found to be greater under the condition of Mg layer in tension. Heat treatment at $200^{\circ}C$ increased the bending formability, suggesting the interfacial strength increased at $200^{\circ}C$. Under the condition of Mg in tension, the clad heat-treated at $300^{\circ}C$ and $400^{\circ}C$ fractured in two steps, with the first step associated with the interfacial fracture between Mg and Al, and the second the fracture of the Mg layer. STS/Al layers were found to be bent without complete fracture. Under the condition of STS in tension, the clad heat-treated at $300^{\circ}C$ and $400^{\circ}C$ exhibited a very small load drop at the displacement, which is similar to that of the first load drop associated with the interfacial fracture under the condition of Mg in tension. In this case, no interfacial cracks were found and the complete cut-through fracture of clad was observed at low temperature heat treatment conditions, suggesting excellent interfacial strength. When the heat treatment temperature was higher than $300^{\circ}C$, interfacial cracks were observed. The local stress condition and the position of the interface with respect to the surface were found to have a great influence on the fracture behaviors of clad metals.

• Korean Journal of Metals and Materials
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• 제46권9호
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• pp.593-603
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• 2008

In this study, effects of alloying elements on the sticking occurring during hot rolling of five kinds of ferritic STS430J1L stainless steels were investigated by analyzing high-temperature hardness and oxidation behavior of the rolled steels. Hot-rolling simulation tests were conducted by a high-temperature wear tester which could simulate actual hot rolling. The simulation test results revealed that the sticking process proceeded with three stages, i.e., nucleation, growth, and saturation. Since the hardness continuously decreased as the test temperature increased, whereas the formation of Fe-Cr oxides in the rolled steel surface region increased, the sticking of five stainless steels was evaluated by considering both the high-temperature hardness and oxidation effects. The addition of Zr, Cu, or Si had a beneficial effect on the sticking resistance, while the Ni addition did not show any difference in the sticking. Particularly in the case of the Si addition, Si oxides formed first in the initial stage of high-temperature oxidation, worked as initiation sites for Fe-Cr oxides, accelerated the formation of Fe-Cr oxides, and thus raised the sticking resistance by about 10 times in comparison with the steel without Si content.

• Applied Microscopy
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• 제33권2호
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• pp.105-116
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• 2003

In Vitro fertilization of U. unicinctus eggs observed by immunofluorescence and electron microscopes revealed an overview of the meiotic pattern of the tide animals. The eggs have been fertilized early at germinal vesicle stage, followed by germinal vesicle break down (GVBD), but pre-mitotic aster like structure could not be resolved by the methods employed in this work. The meiotic features, such as rotation-shift movement of spindle fibers, behavior of spermatozoonmonaster in the egg cytoplasm and active spindle fiber of the 1st polar body, have been observed. The antitubulin-FITC fluorescence show the 2nd meiotic apparatus appeared firstly parallel to the tangential line of the oolemma, proceeding the meiosis, its bipolarity is rotated and shifted towards the oolemma. The polar bodysite of the oolemma was not amorphous, but active in a sense of anti-tubulin-FITC reactions during the extrusions of the polar bodies. The immunofluorescence reactions of the spermatozoon centriole appeared at a later stage of the 2nd meiosis. During the time periods, the fertilized spermatozoon resided in the egg cytoplasm. Activating the centrioles, spermatozoon approaches towards the chromosomal materials of the 2nd oocyte. This suggests that spermatozoon centrioles initiate and play a roll to fuse male and female pronuclei.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제16권11호
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• pp.7329-7334
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• 2015

This is to analyze of driver behavioral and the accident characteristics in rollover. The study period was January 2011 to May 2014 and the subject of study was 102 person who were drivers visited the emergency room. Research tool includes a damage information of the vehicle, accident mechanism, damage to the patient clinical information with the injury data from the ROAD Traffic Authority. For data analysis, SPSS 18.0 was used for t-test, ANOVA and Chi-square test. Injury Severity Score average score according to the vehicle type is 6.00 points in the smaller vehicle, at high vehicle 11.78 points, from the other vehicle that showed 14.70 points. Significant differences between the three groups did not show (P=.267). Men did not use a seat belt significantly compared to women(P=.007). Vehicle type and weather, this was no correlation with whether or not use the seat belt(P=.755, P=.793). But showed a tendency to smaller size vehicles drivers do not use a seat belt, the weather could see a little more inclined to use a seat belt rather than a sunny day. Finally, in rollover accidents as in other types of accident it was confirmed that the seat belt has a great influence on the damage.

• Journal of the Korea institute for structural maintenance and inspection
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• 제25권5호
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• pp.32-39
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• 2021

Recently, necessities of steel form for reinforced concrete beam and girder have been emphasized in building structures for the reduction of the construction period and the labor cost. SY Beam was developed for the these purposes and is roll-formed using thin steel plate. On this research, we tried to evaluate and verify the performance and behavior of SY Beam under construction loading stage as like pouring in situ concrete. For the standard shape of SY beam, structural modelling with various steel thicknesses has carried out using MIDAS GEN program. From results of modelling, the width and height of SY Beam were determined 600mm and 400mm respectively. For 3 SY Beams, the loading experiment was performed to measure vertical and horizontal displacement under stacking sand, concrete block, and bundle of rebar. As a result, the vertical deflection showed a tendency to decrease as the thickness increased. In the horizontal displacement, the trend according to the thickness was not clearly observed. From the evaluation on the loading experiment, it is considered that the SY Beam can secure both workability and structural safety. In particular, the SY Beam(1.2mm) hardly generates horizontal displacement, so it has excellent load-bearing capacity. So, we judged that the SY Beam with 1.2mm steel plate has excellent performance and consider to be immediately commercially available.