• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2005년도 추계 종합학술대회 논문집
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• pp.239-246
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• 2005

본 연구는 직무만족에 영향을 미치는 여러 가지 요인 중에서 특히 역할갈등을 주요요인으로 설정하고 역할갈등의 유발요인을 규명함으로써, 역할 갈등을 해소하고 직무만족을 더욱 증대시키는 분석적 토대를 마련하고자 하는 것이 연구의 목적이다.

• 가정간호학회지
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• 제20권1호
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• pp.33-43
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• 2013

Purpose: The aim of this study was to investigate the perceptions of nurses regarding their roles in social welfare facilities, including role expectation, role performance, and role conflict and its influencing factors. Methods: Data were collected by administering a structured questionnaire to 92 nurses working in 5 types of social welfare facilities. Descriptive statistics, paired t test, Pearson correlation coefficient, and multiple linear regression analyses were performed using the SPSS Win 18.0 program. Results: The mean score of role expectation ($4.44{\pm}0.41$) was significantly higher(t =17.50, p<.001) than that of role performance ($3.46{\pm}0.005$). The biggest mean difference between role expectation and role performance was found in "research activities" ($2.92{\pm}0.81$). The mean score of role conflict was $2.89{\pm}0.66$, with the highest mean score found in "conflict caused when one nurse takes up two or more roles" ($3.31{\pm}0.69$). The influencing factors on role conflict were the difference between role expectation and role performance(${\beta}=.45$, p<.001), and facility size (${\beta}=-.37$, p<.001), which accounts for 51.5% incidence of role conflict controlling nurses' age, career, position, and working periods in social welfare facilities (F=17.13, p<.001). Conclusion: The nurses working in the social welfare facilities perceived some restrictions on their role performance compared with their role expectation, this difference being a major factor influencing their role conflict. Therefore, future studies need to investigate interventions to minimize this effect.

• 한국직업건강간호학회지
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• 제6권2호
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• pp.136-143
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• 1997

The purpose of this study was to analyze relationship between the role conflict and self-reported climacteric symptoms in the middle-aged industrial female workers. The data were collected by self-reported questionnaire from Nov. 1 to Nov. 30, 1996. The subjects were 201 women whose age, between 40 and 59 years. The analysis of data was t-test, ANOVA, $Scheff{\grave{e}}$ test, Pearson correlation coefficient analysis, Stepwise multiple regression analysis. The results were as follows : 1. 54.8% of the respondents had their climacteric symptom in middle life. 2. Age and religion affected significantly self-reported climacteric symptoms(F=4.2, P=.007 ; t=-2.1, P=0.42). 3. A comparison between two groups, with high and low rate of self-reported climacteric symptoms, indicated that for middle-aged industrial female workers when role conflict is high, climacteric symptoms is high(t=7.8, P=.000). 4. The relationship between self-reported climacteric symptoms and role conflict was positively significant(r=.5, P=.000). 5. The role conflict as a spouse affected significantly self-reported climacteric symptoms(F=52.6, P=.000). Role conflict the role as a spouse was explained 21% of self-reported climacteric symptoms. In conclusion, role conflict is the dominant factor in influencing self-reported climacteric symptoms.

• 가정과삶의질연구
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• 제28권3호
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• pp.129-137
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• 2010

This study investigated the relationships among collectivism, role conflict, and the organizational commitment of teachers in kindergartens and childcare centers. The subjects were 190 teachers who worked in a kindergarten or a childcare center in Daegu and in Gyoungbuk Province. Questionnaires were used to investigate collectivism, role conflict, and organizational commitment by self-reports from teachers. The collected data were analyzed by factor analysis, Pearson's correlation, and stepwise multiple regression using SPSS Win 15.0. The results were as follows. (1) Collectivism was positively associated with the organizational commitment of the teachers. (2) Role conflict was negatively associated with the organizational commitment of the teachers. Among the different types of role conflict, teaching profession conflict, co-worker conflict, and administration conflict were negatively associated with organizational commitment. (3) Role conflict was a better predictor of organizational commitment than collectivism. Additionally, administration conflict as a type of role conflict was a better predictor of organizational commitment than collectivism.

• 한국콘텐츠학회논문지
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• 제18권11호
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• pp.594-610
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• 2018

본 연구에서는 임파워링 리더십이 리더-구성원 교환관계(LMX: Leader-Member Exchange), 리더신뢰, 역할 내 행동에 미치는 영향을 살펴보고, 임파워링 리더십과 역할 내 행동의 관계에 있어서 LMX와 리더신뢰의 매개역할을 검증하였다. 양산, 울산, 경주의 중소기업 종사자를 대상으로 설문조사를 하였으며 289명을 대상으로 자료를 수집하였다. 전반적인 기술통계분석과 탐색적 요인분석을 위해 SPSS 18.0을 사용하였다. AMOS 18.0을 사용하여 연구변수의 타당성을 파악하기 위한 확인적 요인분석과 연구가설을 검증하고자 공분산 구조분석을 실시하였다. 연구결과 첫째, 임파워링 리더십은 LMX, 리더신뢰에 유의한 영향을 미치는 것으로 나타났다. 둘째, 임파워링 리더십은 역할 내 행동에 유의한 영향을 미치지 않는 것으로 나타났다. 셋째, LMX은 리더신뢰와 역할 내 행동에 유의한 영향을 미치는 것으로 나타났다. 넷째, 리더신뢰는 역할 내 행동에 유의한 영향을 미치는 것으로 나타났다. 마지막으로 임파워링 리더십과 역할 내 행동 간의 관계에서 LMX와 리더신뢰가 매개역할을 하는 것으로 나타났다. 본 연구 결과에 근거하여 조직구성원의 역할 내 행동을 높이기 위해서 리더의 임파워링 리더십을 통한 LMX과 리더신뢰를 강화시켜야 함을 시사하고 있다.

• Reproductive and Developmental Biology
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• 제29권2호
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• pp.101-108
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• 2005

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a well-known inducer of apoptotic cell death in many tumor cells. 1RAIL is expressed in human placenta, and cytotrophoblast cells express 1RAIL receptors. However, the role of TRAIL in human placentas and cytotrophoblast cells is not. well understood. In this study a trophoblast cell line, JEG-3, was used as a model system to examine the effect of TRAIL. on key intracellular signaling pathways involved in the control of trophoblastic cell apoptosis and survival JEG-3 cells expressed receptors for 1RAIL, death receptor (DR) 4, DR5, decoy receptor (OcR) 1 and DeR2. Recombinant human TRAIL (rhTRAIL) did not have a cytotoxic effect determined by MIT assay and did not induce apoptotic cell death determined by poly-(ADP-ribose) polymerase cleavage assay. rhTRAIL induced a rapid and transient nuclear translocation of nuclear $factor-{\kappa}B(NF-{\kappa}B)$ determined by immunoblotting using nuclear protein extracts. rhTRAIL rapidly activated extracellular signal-regulated protein kinase (ERK) 1/2 as determined by immnoblotting for phospho-ERK1/2. However, c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (p38MAPK) and Akt (protein kinase B) were not activated by rhTRAIL. The ability of 1RAIL to induce $NF-{\kappa}B$ and ERK1/2 suggests that interaction between TRAIL and its receptors may play an important role in trophoblast cell function during pregnancy.

• IMMUNE NETWORK
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• 제24권1호
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• pp.10.1-10.17
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• 2024

In this review, we will explore the intricate roles of cytokines and vascular endothelial growth factors in autoimmune diseases (ADs), with a particular focus on rheumatoid arthritis (RA) and multiple sclerosis (MS). AD is characterized by self-destructive immune responses due to auto-reactive T lymphocytes and Abs. Among various types of ADs, RA and MS possess inflammation as a central role but in different sites of the patients. Other common aspects among these two ADs are their chronicity and relapsing-remitting symptoms requiring continuous management. First factor inducing these ADs are cytokines, such as IL-6, TNF-α, and IL-17, which play significant roles in the pathogenesis by contributing to inflammation, immune cell activation, and tissue damage. Secondly, vascular endothelial growth factors, including VEGF and angiopoietins, are crucial in promoting angiogenesis and inflammation in these two ADs. Finally, placental growth factor (PlGF), an emerging factor with bi-directional roles in angiogenesis and T cell differentiation, as we introduce as an "angio-lymphokine" is another key factor in ADs. Thus, while angiogenesis recruits more inflammatory cells into the peripheral sites, cytokines secreted by effector cells play critical roles in the pathogenesis of ADs. Various therapeutic interventions targeting these soluble molecules have shown promise in managing autoimmune pathogenic conditions. However, delicate interplay between cytokines, angiogenic factors, and PlGF has more to be studied when considering their complementary role in actual pathogenic conditions. Understanding the complex interactions among these factors provides valuable insights for the development of innovative therapies for RA and MS, offering hope for improved patient outcomes.

• Archives of Pharmacal Research
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• 제22권2호
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• pp.108-112
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• 1999

Recombinant murine stem cell factor (rmSCF) or recombinant murine nerve growth factor (rmNGF) induced the morphological change of large numbers of rat peritoneal mast cells (RPMC). We investigated the role of phosphatidylinositol $3^{l}-kinase$ (PI3-kinase) in receptors-mediated morphological change in RPMC. Exposure of RPMC to PI3-kinase inhibitor, wortmannin, before the addition of rmSCF and rmNGF antagonized those factors-induced morphological change. These results suggest that the PI3-kinase is involved in the signal transduction pathway responsible for morphological change following stimulation of rmSCF and rmNGF and that wortmannin blocks these responses.

• Tuberculosis and Respiratory Diseases
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• 제85권3호
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• pp.221-226
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• 2022

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation due to chronic airway inflammation and destruction of the alveolar structure from persistent exposure to oxidative stress. The body has various antioxidant mechanisms for efficiently coping with such oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) is a representative system. Dysregulation of the Nrf2-ARE pathway is responsible for the development and promotion of COPD. Furthermore, COPD severity is also closely related to this pathway. There has been a clinical impetus to use Nrf2 for diagnostic and therapeutic purposes. Therefore, in this work, we systematically reviewed the clinical significance of Nrf2 in COPD patients, and discuss the value of Nrf2 as a potential COPD biomarker.

• 한국의류학회지
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• 제22권4호
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• pp.460-468
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• 1998

The purpose of this study were 1) to identify the differences between homosexual and heterosexual men in clothing behaviors(fashion leadership, preference for up-to-date style and sexual attractiveness), lifestyle and sex-role attitudes, and 2) to investigate the relation- ships between clothing behaviors and lifestyle and sex-role attitudes. The data was collected via self-administered questionnaires from 183 adult men(88 homosexual, 95 heterosexual men) living in Seoul, and was analyzed by factor analysis, t-test, correlations and multiple regressions. The result of this study were as follows: 1. Two factors of fashion leadership. were identified: fashion opinion leadership and fashion innovativeness. Four factors of lifestyle were identified: appearance awareness, self-confidence, authoritativeness, and achievement. 2. The result of t-test between homosexual and heterosexual men in clothing behaviors and psychological characteristics, homosexual men showed higher scores in fashion innovativeness, fashion opinion leadership, preference for up-to-date style, and appearance awareness of lifestyle characteristics. 3. From the result of analyzing the effects of psychological characteristics on 4 variables of clothing behaviors, appearance awareness of lifestyle characteristics was found to be the most influential factor for all the clothing behavior variables in both groups.