• Archives of Pharmacal Research
• /
• 제28권1호
• /
• pp.1-15
• /
• 2005

Cancer is still a major global health concern even after an everlasting strive in conquering this dread disease. Emphasis is now given to chemoprevention to reduce the risk of cancer and also to improve the quality of life among cancer afflicted individuals. Recent progress in molecular biology of cancer has identified key components of the cellular signaling network, whose functional abnormality results in undesired alterations in cellular homeostasis, creating a cellular microenvironment that favors premalignant and malignant transformation. Multiple lines of evidence suggest an elevated expression of cyclooxygenase-2 (COX-2) is causally linked to cancer. In response to oxidative/pro-inflammatory stimuli, turning on unusual signaling arrays mediated through diverse classes of kinases and transcription factors results in aberrant expression of COX-2. Population-based as well as laboratory studies have explored a broad spectrum of chemopreventive agents including selective COX-2 inhibitors and a wide variety of anti-inflammatory phytochemicals, which have been shown to target cellular signaling molecules as underlying mechanisms of chemoprevention. Thus, unraveling signaling pathways regulating aberrant COX-2 expression and targeted blocking of one or more components of those signal cascades may be exploited in searching chemopreventive agents in the future.

• 디지털콘텐츠학회 논문지
• /
• 제11권4호
• /
• pp.545-552
• /
• 2010

개발도상국에 있어서 정보화를 통한 경제력향상은 지역, 국가, 글로벌 경제발전에 기여하는 주요요소이다. 본 논문은 한국의 지역정보화 성공모델을 인도네시아에 적용하는 연구로서, 한 인도네시아 기업 및 정책결정자들과의 IT 교류 활성화를 통하여 연구기반 네트워크를 형성하고 연구 성과를 토대로 국내 지역정보화 및 IT 관련 기업인들의 인도네시아 진출시 주요 정보제공과 비즈매칭의 기회를 제공하고자 한다. 연구적용지역에 있어서는 도시개발 프로젝트를 수행하여 인프라가 어느정도 조성된 인도네시아의 프칼롱안 지역을 선정하였다. 따라서 프칼롱안의 지리적, 인적특성 및 IT 인프라 현황을 조사하고, 한국의 지역정보화 성공모델을 기반으로 현지 상황에 맞춘 인도네시아 프칼롱안 지역정보화 적용방안을 제시한다.

• 한국한의학연구원논문집
• /
• 제17권2호
• /
• pp.63-71
• /
• 2011

Objectives : We studied the ISP(information strategy plan) of oasis spanning 5 years. From this study we aimed at total road map to upgrade the service systematically and to carry out the related projects. If we do it as road map, oasis will be the core infra service contributing to the improvement of TKM(traditional korean medicine) research capability. Methods : We carried out 3 step ISP method composed of environmental analysis, current status analysis and future plan. We used paper, report and trend analysis document as base materials and did the survey to get opinions from users and TKM experts. We limited this study to drawing the conceptual design of oasis. Results : From environmental analysis we knew that China and USA built up the largest TM databases. We did the survey to get the activation ways of oasis. And we did the benchmarking on the advanced services through current status analysis. Finally we determined 'maximize the research value based the open TKM knowledge infra' as oasis' vision. And we designed oasis' future system which is composed of service layer, application layer and contents layer. Conclusion : First TKM related documents, research materials, researcher information and standards are merged to elevate the TKM information level. Concretely large scale TKM information infra project such as TKM information classification code development, TKM library network building and CAM research information offering are carried out at the same time.

• 건축역사연구
• /
• 제20권5호
• /
• pp.47-61
• /
• 2011

This study examined the background and change of building Yeongam eupseong and characteristics and construction method of its spatial structure. The results of this study can be summarized as follows. First, Yeongam eupseong was built for the same purpose of national border defense against the invasion of Japanese army as other Eupseongs were built and it was found first in the literature in the era of King Munjong of Joseon Dynasty with the scale of three gates and 4,369 cheok of castle wall. Such a scale was continued and in particular, according to flat structure, road network and gate position shown in the map, the form and road system of Yeongam eupseong before the 19th century were mostly identical with the current ones. Second, castle wall was built over foundation by using talcum after leveling the foundation soil and castle wall can be divided into outer wall, filling part and inner wall from the section. Outer wall was constructed by inserting and layering pebbles with big irregular stone, filling part was made with talcum and riprap and inner wall with soil in several layers by keeping gradient. This building method showed common features in inserting and layering pebbles for outer wall, use of protruded base and section form compared to Jeollado Eupseong.

• 한국측량학회지
• /
• 제20권4호
• /
• pp.347-357
• /
• 2002

도로와 지하시설물에 대한 정보공유체계구축은 정보공유미흡으로 인한 각종 안전사고방지 및 중복투자방지를 위해서 필요하다. 따라서 본 연구에서는 지자체단위의 정보공유체계 구축방안으로 기본도 일원화(l/l,000수치지형도), 공유항목의 선정, 메타데이터 표준안 설정, 정보공유체계구축안을 제시하였다. 정보공유체계 구축안은 전용망을 이용한 분산형과 인터넷망을 이용한 웹기반형을 제시하였다. 또한 지자체에서 도로기반시설물에 대한 정보공유체계를 구축할 경우 적용할 수 있는 추진방안을 제안하였다.

• Geomechanics and Engineering
• /
• 제37권2호
• /
• pp.135-147
• /
• 2024

A GIS-based landslide susceptibility mapping (LSM) was carried out using frequency ratio (FR), modified frequency ratio (M-FR), analytic hierarchy process (AHP), and modified analytic hierarchy process (M-AHP) methods to identify and delineate the potential failure zones along the Halong - Vandon expressway. The thematic layers of various landslide causative factors were generated for modeling in GIS, including geology, rainfall, distance to fault, distance to road, slope, aspect, landuse, density of landslide, vertical relief, and horizontal relief. In addition, a landslide inventory along the road network was prepared using data provided by the management department during the course of construction and operation from 2017 to 2019, when many landslides were documented. The validation results showed that the M-FR method had the highest AUC value (AUC = 0.971), which was followed by the FR method with AUC = 0.961. The AUC values were 0.939 and 0.892 for the M-AHP and AHP methods, respectively. The generated LSM obtained from M-FR method classified the study area into five susceptibility classes: very low (0), low (0-1), moderate (1-2), high (2-3), and very high (3-4) classes, which could be useful for various stakeholders like planners, engineers, designers, and local public for future construction and maintenance in the study area.

• Spatial Information Research
• /
• 제6권1호
• /
• pp.103-120
• /
• 1998

국가 GIS구축 기본계획에 따르면 1998년부터 2000년까지 지형지번도, 행정구역도, 토지이용현황도, 도로망도, 국토이용계획도, 도시계획도 등 6개 주제도를 수치지도화대상으로 선정하여 우선적으로 수치지도화사업을 추진하는 것으로 되어 있다. 수치지도 제작사업을 추진하기 위해서는 먼저 그에 대한 표준품셈과 제작지침이 마련되어야 한다. 그러나 아직 주제도에 대한 표준품셈이 완전하게 확정되지 않았고, 제작지침도 마련되어 있지 않다. 따라서 이 논문에서는 첫째 6개 주제도를 수치지도화하기 위한 방법을 다각도로 살펴보고 각 주제도별로 가장 바람직한 제작방법을 제시하였다. 둘째 이렇게 제시된 주제도 제작방법과 절차에 따라 안양시 동안구를 대상지역으로 하여 실제로 수치지도를 실험 제작하고 그 결과를 제시하였다. 이 연구결과는 정부가 주제도 제작지침과 주제도 제작사업 추진방안을 마련하는데 골격자료로 활용되었다.

• 한국조경학회지
• /
• 제26권3호
• /
• pp.237-248
• /
• 1998

Landcover has been largely influenced by human activities, especially in recent days. The analysis of the change of land use by urbanized development is useful for determining development plan hereafter. This study aimed to the quantitative analysis about the urban sprawl within 12 years from 1985 to 1996, at Chonan, and for extracting the characteristics of change. For this purpose, this study performed land cover classifications using Landsat TM data . A hybrid classification method was used to classify satellite images into seven types of land cover. Road network digitied from 1:25,000 topographic map was rasterized and overlaid on the landcover map. A result of this study showed that area of forest and paddy decreased due to urban sprawl. Especially from 1993 to 1996, the change of land use progressed rapidly because of merging a city and a country in Chonan. The size of patch in forest had been smaller and irregular form. It is a general progress that size of patch in forest had been smaller and irregular form. It is a general progress that the forest have changed the paddy and bare land paddy and bare land have changed low-density urban or high-density urban. This explained how urbanized Chonan was and applied the suggeston of plan in landuse with the result of this study.

• 한국산학기술학회논문지
• /
• 제19권4호
• /
• pp.34-40
• /
• 2018

본 논문에서는 단안 카메라와 비교적 오차가 큰 GPS-IMU 센서를 이용하여 이동체의 정확한 포즈를 예측하는 고정밀 맵매칭 방법을 제안한다. 제안하는 방법은 카메라로부터 입력 받은 영상을 딥뉴럴 네트워크를 이용하여 의미상으로 분할한 결과와 시맨틱 지도 정보를 비교함으로써 달성된다. 카메라로부터 입력 받은 주행 영상은 시맨틱 분할 알고리즘을 통해서 두 개의 클래스로 분할되며, 시맨틱 지도 정보와 가능한 레이블 페어에 대해 설정된 가중치에 따라 비교 정렬함으로써 현재 이동체의 정확한 포즈를 예측할 수 있도록 한다. 이 과정에서 비교적 오차가 큰 GPS-IMU 센서의 신호는 해 공간의 범위를 효과적으로 줄여준다. 본 논문은 비교적 저렴한 센서를 이용하여 증강현실 및 자율주행 등에 필요한 고정밀 맵매칭이 가능함을 보여준다. 보정 전후의 차량 경로를 지도에 비교 도시하고 시맨틱 지도를 현재 입력 영상에 오버레이 하여 제안한 방법의 효과를 입증하였다. 또한 non-open-sky 환경과 같은 GPS-IMU 수신이 어려운 환경에서도 성능 개선이 있음을 확인하였다.

• 한국환경복원기술학회지
• /
• 제11권3호
• /
• pp.94-106
• /
• 2008

As populations inhabiting in natural ecosystem are fragmented by artificial barriers and habitats are destructed by development, extinction possibility of species is getting higher. It is necessary to design and to manage conservation areas and corridors considering animals' movement and migration for sustainable species diversity in present circumstances. 'Least-cost modeling' is one commonly employed approach in which dispersal costs are assigned to distinct habitat types and the last-costly dispersal paths among habitat patches are calculated using a geographical information system (GIS). This study aims to design ecological corridor using least-cost path method and to apply it to a regional ecological network considering movability of medium-large size mammals. This study was carried out over the metropolitan area, which has been deforested by rapid urbanization. Nevertheless there is connected with Gangwon province, Baekdudaegan mountain range and DMZ, considered where many forest species can migrate to this region. This study employs such an approach to develop least-cost path models for medium-large size mammals, have inhabited for this entire region. Considering those species, two forest areas as a source of species supply and forest areas more than 1,000ha are selected as focal forest areas. Movement and migration paths from species supply sources to focal forest areas are calculated by applying landscape permeability theory using land cover map, road density map and land slope map. Results showed least-cost paths from species supply sources to focal forest areas on two species. Wildcat and roe deer are different in some least-cost paths caused by their landscape permeability but paths show generally same specifics. The result of considering regional distribution of expected movement and migration paths to regional ecological network, low altitude mountains of western metropolitan area are evaluated important area for species connectivity. In national or regional levels ecological connectivity is essential to promote species diversity and to preserve integrated ecosystem. This study concludes that developing least-cost models from similar empirical data could significantly improve the utility of these tools.