• 제목/요약/키워드: Risk-sensitive

검색결과 418건 처리시간 0.024초

비만치료에 유용한 단순비만지표의 선별 (Assessment of Anthropometric Obesity Indexes by Correlation with Body Composition)

  • 류수민;신승우;김길수;심우진
    • 한방비만학회지
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    • 제6권1호
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    • pp.69-80
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    • 2006
  • Object : Waist circumference(WC), waist-hip ratio(WHR), waist-stature ratio(WSR), and body mass index(BMI) are commonly used for evaluating obesity. This Research were done to determine what is more sensitive obesity indexes(WC, WHR, WSR, BMI) Correlated with body composition such as body fat mass, body fat(%), visceral fat area, and fat free mass. And what is more sensitively correlated obesity indexes with % changes of body composition during weight reduction treatment. Methods : This clinical retrospective research were carried out 127 cases of female obese outpatients with weight reduction treatment during 1 month. Bioelectrical impedence analysis(for body composition) and body size(for anthropometric obesity indexes) were estimated in pre-treatment and post-treatment to evaluate the obesity indexes. Pearson correlation coefficients were used to select useful obesity index. Result & Conclusion : BMI is useful index for diagnosis and evaluation of obesity. WSR is sensitively correlated with visceral fat area and body fat(%). So, WSR is useful index for evaluating abdominal obesity and risk factors of metabolic syndrome. WC is correlated with both body fat mass and fat free mass. WHR is not optimal for diagnosis and evaluation of obesity.

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몬테카를로 모사에 의한 용접 계면에서의 크리프 균열성장 파손 확률 평가 (Evaluation of Creep Crack Growth Failure Probability at Weld Interface Using Monte Carlo Simulation)

  • 이진상;윤기봉
    • Journal of Welding and Joining
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    • 제23권6호
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    • pp.61-66
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    • 2005
  • A probabilistic approach for evaluating failure risk is suggested in this paper. Probabilistic fracture analyses were performed for a pressurized pipe of a Cr-Mo steel reflecting variation of material properties at high temperature. A crack was assumed to be located along the weld fusion line. Probability density functions of major variables were determined by statistical analyses of material creep and creep crack growth data measured by the previous experimental studies by authors. Distributions of these variables were implemented in Monte Carlo simulation of this study. As a fracture parameter for characterizing growth of a fusion line crack between two materials with different creep properties, $C_t$ normalized with $C^*$ was employed. And the elapsed time was also normalized with tT, Resultingly, failure probability as a function of operating time was evaluated fur various cases. Conventional deterministic life assessment result was turned out to be conservative compared with that of probabilistic result. Sensitivity analysis for each input variable was conducted to understand the most influencing variable to the analysis results. Internal pressure, creep crack growth coefficient and creep coefficient were more sensitive to failure probability than other variables.

Laboratory Diagnosis of Invasive Candidiasis

  • Ellepola Arjuna N.B.;Morrison Christine J.
    • Journal of Microbiology
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    • 제43권spc1호
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    • pp.65-84
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    • 2005
  • Invasive candidiasis is associated with high morbidity and mortality. Clinical diagnosis is complicated by a lack of specific clinical signs and symptoms of disease. Laboratory diagnosis is also complex because circulating antibodies to Candida species may occur in normal individuals as the result of commensal colonization of mucosal surfaces thereby reducing the usefulness of antibody detection for the diagnosis of this disease. In addition, Candida species antigens are often rapidly cleared from the circulation so that antigen detection tests often lack the desired level of sensitivity. Microbiological confirmation is difficult because blood cultures can be negative in up to 50% of autopsy-proven cases of deep-seated candidiasis or may only become positive late in the infection. Positive cultures from urine or mucosal surfaces do not necessarily indicate invasive disease although can occur during systemic infection. Furthermore, differences in the virulence and in the susceptibility of the various Candida species to antifungal drugs make identification to the species level important for clinical management. Newer molecular biological tests have generated interest but are not yet standardized or readily available in most clinical laboratory settings nor have they been validated in large clinical trials. Laboratory surveillance of at-risk patients could result in earlier initiation of antifungal therapy if sensitive and specific diagnostic tests, which are also cost effective, become available. This review will compare diagnostic tests currently in use as well as those under development by describing their assets and limitations for the diagnosis of invasive candidiasis.

Phytomonitoring of the Genotoxicity of Environmental Pollutants: An Application to Armenian Nuclear Power Plant

  • Kim, Jin Kyu;Aroutiounian, Rouben M.;Nebish, Anna A.;Kim, Jin-Hong
    • 방사선산업학회지
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    • 제9권4호
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    • pp.181-185
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    • 2015
  • Today the biosafety evaluation, a common problem of vital importance, is based on internationally proved test-systems, standards and techniques. The paradigm of biosafety includes multidisciplinary approach, a combination of physical, chemical and biological tests to monitor the environmental level of pollutants and needs to be improved by modern approaches. The genetic risk of environmental pollutions has long been studied by many researchers. In this study, used was the known sensitive plant test-system, clones of plant Tradescantia (spiderwort) able to detect gene mutations (frequency of mutational events and formation of micronuclei) in combination with chemical and, in some instances, with radiological measurements. In addition, male gametophyte generation of fruit trees was applied as bioindicators of genotoxicity. The obtained results did not show any significant increase along with wind direction. As for the male gametophyte assay, the fertility of the investigated fruit-trees near to NPP did not significantly differ from that of the control point. The influence of the NPP on the male generative system of the investigated taxa of fruit trees for the investigated year was not revealed. The system described needs to be expanded by species of interest (human) as there is a difficulty to transfer the revealed dose correlations to humans. The development of this idea includes various levels: population (epidemiological studies), individual, cellular, molecular (DNA), etc.

인체에서 식품의 혈행 개선 효능 평가 모델 (The Model for Evaluation on Blood Flow of Functional Food in Human Intervention Study)

  • 임예니;권오란;김지연
    • 지질동맥경화학회지
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    • 제7권2호
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    • pp.88-97
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    • 2018
  • The prevalence of atherothrombotic disease continues to rise, presenting an increasing number of challenges to modern society and creating interest in functional foods. Platelet activation, adhesion, and aggregation at vascular endothelial disruption sites are key events in atherothrombotic disease. Physiological challenges such as hyperlipidemia, obesity, and cigarette smoking are associated with vascular changes underlying platelet aggregation and inflammatory processes. However, it is difficult to determine the beneficial response of functional foods in healthy subjects. To address this problem, challenge models and high-risk models related to smokers, obesity, and dyslipidemia are proposed as sensitive measures to evaluate the effects of functional foods in healthy subjects. In this review, we construct a model to evaluate the effects of functional food such as natural products on blood flow based on a human intervention study.

개발비 지출이 기업가치와 신용등급에 미치는 영향 (An Empirical Research on the Firm Value and Credit Rating of Development Expenses)

  • 진동민
    • 아태비즈니스연구
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    • 제9권4호
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    • pp.119-135
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    • 2018
  • Currently, Korean firms are making a lot of effort to invest in research and development (R&D) by spending a lot of development costs in order to cope with the 4th industrial revolution. On the other hand, the capital market of Korea, which is the main source of funding, has caused a lot of cost of capital for firms by its reorganization mainly with safe assets in the experience of foreign exchange crisis at the end of 1997, the sub-prime mortgage crisis in 2007 and the bankruptcy of Lehman Brothers in September 2008. Thus, this study empirically analyzed the effect of development expenses on credit rating and firm value. The credit rating was measured by commercial paper(CP) credit rating which is sensitive for investors in terms of risk because it is issued only by the credit of the firms. Firm value was defined as Tobin's Q, which has been widely used in prior studies. The results of the analysis are summarized as follows; Firstly, development expenses did not affect credit rating. Development expenses are recognized as intangible assets for uncertainty of economic benefits and long-term investment. Thus, it seems that there is no effect of development expenses on CP credit rating as CP credit rating is evaluated by short-term credit rating.

Validation of the Korean Version of the Standardized Swallowing Assessment and the National Institute of Health Stroke Scale Among Acute Stroke Patients

  • Yun, Sukkyung;Kim, Hyemin;Mo, Eunji;Kim, Mingyeong;Kim, Minji;Gil, Chorong;Chang, HeeKyung
    • International Journal of Advanced Culture Technology
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    • 제6권4호
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    • pp.124-130
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    • 2018
  • Proper management and prevention of dysphagia are urgently needed in acute care of stroke patients in Korea. However, no highly sensitive and accessible nurse-led screening tools have been validated within the Korean settings. The purpose of this study was to validate a screening tool led by nurses to identify dysphagia and aspiration risks among acute stroke patients. Registered nurses (RNs) screened 131 residents from a university hospital in South Korea using the Korean version of the Standardized Swallowing Assessment (K-SSA). Results were validated against those from the Gugging Swallowing Screen (GUSS). Compared to results from the GUSS, with 9- and 14-point cutoffs, the K-SSA had a sensitivity of 0.80 and specificity of 0.90 [95% CI 0.806, 0.992] for screening dysphagia and 1.00 sensitivity and 0.94 specificity [95% CI 0.862, 1.000] for screening aspiration risks. The K-SSA demonstrated excellent sensitivity and specificity for screening individuals at risk of dysphagia and aspiration when led by RNs for acute stroke patients.

Nucleic acid-based molecular diagnostic testing of SARS-CoV-2 using self-collected saliva specimens

  • Hwang, Eurim C.;Kim, Jeong Hee
    • International Journal of Oral Biology
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    • 제46권1호
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    • pp.1-6
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    • 2021
  • Since the outbreak of coronavirus disease 2019 (COVID-2019), the infection has spread worldwide due to the highly contagious nature of severe acute syndrome coronavirus (SARS-CoV-2). To manage SARS-CoV-2, the development of diagnostic assays that can quickly and accurately identify the disease in patients is necessary. Currently, nucleic acid-based testing and serology-based testing are two widely used approaches. Of these, nucleic acid-based testing with quantitative reverse transcription-PCR (RT-qPCR) using nasopharyngeal (NP) and/or oropharyngeal (OP) swabs is considered to be the gold standard. Recently, the use of saliva samples has been considered as an alternative method of sample collection. Compared to the NP and OP swab methods, saliva specimens have several advantages. Saliva specimens are easier to collect. Self-collection of saliva specimens can reduce the risk of infection to healthcare providers and reduce sample collection time and cost. Until recently, the sensitivity and accuracy of the data obtained using saliva specimens for SARS-CoV-2 detection was controversial. However, recent clinical research has found that sensitive and reliable data can be obtained from saliva specimens using RT-qPCR, with approximately 81% to 95% correspondence with the data obtained from NP and OP swabs. These data suggest that self-collected saliva is an alternative option for the diagnosis of COVID-19.

Generate Optimal Number of Features in Mobile Malware Classification using Venn Diagram Intersection

  • Ismail, Najiahtul Syafiqah;Yusof, Robiah Binti;MA, Faiza
    • International Journal of Computer Science & Network Security
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    • 제22권7호
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    • pp.389-396
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    • 2022
  • Smartphones are growing more susceptible as technology develops because they contain sensitive data that offers a severe security risk if it falls into the wrong hands. The Android OS includes permissions as a crucial component for safeguarding user privacy and confidentiality. On the other hand, mobile malware continues to struggle with permission misuse. Although permission-based detection is frequently utilized, the significant false alarm rates brought on by the permission-based issue are thought to make it inadequate. The present detection method has a high incidence of false alarms, which reduces its ability to identify permission-based attacks. By using permission features with intent, this research attempted to improve permission-based detection. However, it creates an excessive number of features and increases the likelihood of false alarms. In order to generate the optimal number of features created and boost the quality of features chosen, this research developed an intersection feature approach. Performance was assessed using metrics including accuracy, TPR, TNR, and FPR. The most important characteristics were chosen using the Correlation Feature Selection, and the malicious program was categorized using SVM and naive Bayes. The Intersection Feature Technique, according to the findings, reduces characteristics from 486 to 17, has a 97 percent accuracy rate, and produces 0.1 percent false alarms.

Understanding the Risks on Saudi Arabian's Youth Being Online Without Having Strong Cyber-Security Awareness

  • Alharbi, Nawaf;Soh, Ben;AlZain, Mohammed A;Alharbi, Mawaddah
    • International Journal of Computer Science & Network Security
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    • 제22권7호
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    • pp.131-146
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    • 2022
  • The Internet is becoming a basic need for many individuals globally in this digital age. The youths became more active online than before, with the majority relying on different platforms to communicate and interact with peers. Saudi Arabia is one of the nations where internet usage is high, with an increasing number of active internet users. The youth in Saudi Arabia are engaged in various online platforms. However, they lack adequate knowledge about cybersecurity and the dangers of internet usage, which exposes them to the risk of falling victims to cybercriminals. The most common dangers of internet usage include viruses, malware, phishing, and hacking, compromising users' sensitive information. Increased awareness of these potential threats helps protect Internet users and secure their data. The understanding of the dangers of Internet usage among youths varies across countries. In this regard, our study explores the risks of internet usage among youth in Saudi Arabia compared to the United States, South Africa, and New Zealand.