• Journal of Environmental Health Sciences
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• v.40 no.1
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• pp.55-62
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• 2014

Objectives: $^{32}P$-postlabeling assay is the most sensitive method of detecting DNA adduct formation. However, it is limited by a low sample throughput and use of radioisotopes (RI). In this study, we modified it to minimize these limitations and applied it to Z. platypus exposed to Benzo(a)pyrene (BaP) in order to investigate DNA adduct formation (effect biomarker for pollutants) in Z. platypus for assessing risk of waterborne BaP exposure. Methods: DNA hydrolysis was performed only with Micrococcal nuclease (MNase), RI reduction test was performed and the overlapping steps between thin layer chromatography (TLC) and radioisotope high-performance liquid chromatography (RI-HPLC) were omitted. The application of a modified method to Z. platypus exposed to BaP was performed. Results: The results revealed that the amount of RIs used can be reduced roughly 10-fold. Because the analysis time was shortened by 8.5 hours, the sample throughput per hour was increased compared with the previous method. The results of applying modified $^{32}P$-postlabeling assay to Z. platypus, DNA adduct formation in Z. platypus showed dose-dependency with the BaP concentration. Only BPDE-dGMP was detected as a DNA adduct. Conclusion: These results demonstrate that the modified $^{32}P$-postlabeling assay is a suitable method for detecting DNA adduct formation in Z. platypus exposed to waterborne BaP and will be useful in risk assessment of carcinogenic effect in aquatic environment due to BaP.

• Journal of Preventive Medicine and Public Health
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• v.36 no.1
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• pp.47-53
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• 2003

Objectives : I used a case-crossover design to investigate the association between air pollution, and hospital admissions for asthmatic children under the age of 15 years in Seoul, Korea Methods : I estimated the changes in the levels of hospitalization risk from theinterquartile (IQR) increase in each pollutant concentrations, using conditional logistic regression analyses, with controls for weather information. Results : Using bidirectional control sampling, the results from a conditional logistic regression model, with controls for weather conditions, showed the estimated relative risk of hospitalization for asthma among children to be 1.04 (95% confidence interval (CI), 1.01-1.08) for particulate matter with an aerodynamic diameter less than or equal to 10m (IQR=40.4ug/m3); 1.05 (95% CI, 1.00- 1.09) for nitrogen dioxide (IQR=14.6ppb): 1.02 (95% CI,0.97-1.06) for sulfur dioxide (IQR=4.4ppb): 1.03 (95% CI, 0.99-1.08) for ozone (IQR=21.7ppb): and 1.03 (95% CI, 0.99-1.08) for carbon monoxide f10R=1.0ppm). Conclusions : This empirical analysis indicates the bidirectional control sampling methods, by design, would successfully control the confounding factors due to the long-term time trends of air pollution. These findings also support the hypothesis that air pollution at levels below the current ambient air quality standards of Korea is harmful to sensitive subjects, such as asthmatic children.

• Journal of Nutrition and Health
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• v.31 no.1
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• pp.62-71
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• 1998

As stomach cancer is very prevalent in Koreans, various factors, especially dietary factors, related to stomach cancer incidence were examined in a case-control study. The study population consisted of 105 individual s diagnosed for stomach cancer in two general hospitals and 124 control subjects, matched for age and sex, in Seoul. Data for general characteristics, family history, smoking and alcohol consumption, personality , dietary habits and food preference were obtained by self-administered questionnaire and personal interview. Heredity was found to be one of the most important factors causing stomach cancer. In addition, genetic inheritance tended to differ between the sexes. The male patients showed significantly higher incidence of their father's relatives than mother's relatives but the female patients showed higher incidence of their mother's relatives that father's relatives. Smoking was significantly related to stomach cancer. It was also found that the cases drank alcohol more frequently and in much greater quantity than the controls. Personality was related to the incidence of stomach cancer. The cases tended to be more sensitive , impatient, and anxious to do things quickly. With regards to dietary habits, the male cases had meals significantly more irregularly than the male controls. The relative risk of preferencefor salty food and ramen showed to be significantly very high. The male cases consumed carbonated beverages and instant foods, low intake of green yellow vegetables, smoking of cigarettes and drinking of alcohol may contribute to the risk of stomach cancer.

• Journal of Preventive Medicine and Public Health
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• v.45 no.3
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• pp.188-195
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• 2012

Objectives: This study was conducted to examine the association between health condition and leaving the labor market among middle-aged and older adults in South Korea. Methods: Data was obtained from individuals aged 45 years and older participating in the 2006 and 2008 Korean Longitudinal Study of Ageing. We used various health measures including chronic diseases, comorbidities, traffic accident injuries, disabilit of instrumental activities of daily living, depressive symptoms, and self-rated health. The odds ratios of job loss, and retirement, versus employment were calculated using multinomial logistic regression by each health measure. Results: In our cross-sectional and longitudinal analysis, health problems related to physical disabilities had the greatest effect on leaving the worksite. A shift in health condition from good to poor in a short period was a predictor of increased risk of unemployment but a persistent pattern of health problems was not associated with unemployment. Women with health problems showed a high probability of retirement, whereas among men, health problems instantly the possibility of both job loss and retirement. Conclusions: Health problems of middle aged and older workers were crucial risk factors for retirement and involuntarily job loss. Especially functional defect and recent health problems strongly and instanty affected employment status.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.891-894
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• 2014

This study is aimed to investigate the role of paired boxed gene 1 (PAX1) methylation analysis by methylation-sensitive high-resolution melting (MS-HRM) in the detection of high grade lesions in atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H) and compared its performance with the Hybrid Capture 2 (HC2) human papillomavirus (HPV) test. In our study, 130 cases with a diagnosis of ASC-H from the cervical cytological screening by Thinprep cytologic test (TCT) technique were selected for triage. Their cervical scrapings were collected and evaluated by using PAX1 methylation analysis (MS-HRM) and high-risk HPV DNA test (HC2), followed by colposcopy and cervical biopsy. Chi-square test were used to test the differences of PAX1 methylation or HPV infection between groups. In the detection of CIN2+, the sensitivity, specificity, the PPV, NPV and the accuracy of PAX1 MS-HRM assay and high-risk HPV (HR-HPV) tests were respectively 80.6% vs 67.7%, 94.9% vs 54.5%, 83.3%, vs 31.8%, 94.0% vs 84.4%, and 91.5% vs 57.7%. The PAX1 MS-HRM assay proved superior to HR-HPV testing in the detection of high grade lesions (CIN2+) in ASC-H. This approach could screen out the majority of high grade lesion cases of ASC-H, and thus could reduce the referral rate to colposcopy.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.9
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• pp.179-189
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• 2020

The paper empirically examines the bank-specific determinants of loan growth in the Vietnamese banking system for the period from 2007 to 2019. We approach the CAMELS framework and employ the dynamic panel regression to determine the effects of each CAMELS factor on bank lending. To ensure the robustness of results, we also use alternative definitions of the variables and different specifications with and without full sets of CAMELS components. With these settings, we display multiple important results. (i) We find that a large capital buffer tends to boost bank lending expansion faster. (ii) High asset quality might positively contribute to high loan growth; in other words, banks subject to high credit risk are discouraged from making loans. (iii) Less efficiently managed banks are more likely to adopt an aggressive lending strategy, highlighting the moral hazard incentives of Vietnamese banks. (iv) More profitable banks with excellent competitive advantages could expand their lending activities to a larger extent. (v) Liquidity is positively related to the loan growth of banks. (vi) Perceived interest rate risk tends to suppress loan growth since interest-rate-sensitive banks might be concerned about the adverse effects of unpredictable adverse changes in interest rates in the future.

• Toxicological Research
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• v.32 no.1
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• pp.15-20
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• 2016

Physiologically based pharmacokinetic (PBPK) modeling can provide an effective way to utilize in vitro and in silico based information in modern risk assessment for children and other potentially sensitive populations. In this review, we describe the process of in vitro to in vivo extrapolation (IVIVE) to develop PBPK models for a chemical in different ages in order to predict the target tissue exposure at the age of concern in humans. We present our on-going studies on pyrethroids as a proof of concept to guide the readers through the IVIVE steps using the metabolism data collected either from age-specific liver donors or expressed enzymes in conjunction with enzyme ontogeny information to provide age-appropriate metabolism parameters in the PBPK model in the rat and human, respectively. The approach we present here is readily applicable to not just to other pyrethroids, but also to other environmental chemicals and drugs. Establishment of an in vitro and in silico-based evaluation strategy in conjunction with relevant exposure information in humans is of great importance in risk assessment for potentially vulnerable populations like early ages where the necessary information for decision making is limited.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.49 no.4
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• pp.177-184
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• 2000

In this paper, we proposes a method for assessing the effect of voltage sag in power distribution systems using fuzzy model. The proposed method is based on the reliability data of distribution system and specified computer business equipment manufacturer association(SCBEMA) curve that express the representative power acceptability curve by voltage sag for each customer type. The SCBEMA curves are made by using the CBEMA curves obtained from the experiment for the customers sensitive equipment. In order to transform SCBEMA curves to the differential damage by voltage sag, a fuzzy model is used. The proposed fuzzy model is composed to reflect two parameters of customers damage by voltage sag. One is the duration and magnitude of voltage sag and the other is the different risk due to the customer types. The Monte Carlo simulation method and the historical reliability data in KEPCO ae used for case studies.

• Nuclear Engineering and Technology
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• v.51 no.3
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• pp.894-903
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• 2019

An approach for collapse risk assessment is proposed to evaluate the vulnerability of electric cabinet in nuclear power plants. The lognormal approaches, namely maximum likelihood estimation and linear regression, are introduced to establish the fragility curves. These two fragility analyses are applied for the numerical models of cabinets considering various boundary conditions, which are expressed by representing restrained and anchored models at the base. The models have been built and verified using the system identification (SI) technique. The fundamental frequency of the electric cabinet is sensitive because of many attached devices. To bypass this complex problem, the average spectral acceleration $S_{\bar{a}}$ in the range of period that cover the first mode period is chosen as an intensity measure on the fragility function. The nonlinear time history analyses for cabinet are conducted using a suite of 40 ground motions. The obtained curves with different approaches are compared, and the variability of risk assessment is evaluated for restrained and anchored models. The fragility curves obtained for anchored model are found to be closer each other, compared to the fragility curves for restrained model. It is also found that the support boundary conditions played a significant role in acceleration response of cabinet.

• Safety and Health at Work
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• v.10 no.3
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• pp.314-320
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• 2019

Background: Sitting posture may be related to risk factors, including inadequate weight-bearing support, particularly when maintained for long periods. Considering that body weight is loaded in a closed support system composed of the seat, backrest, floor and working surface, the aims of the present study were to describe the development of an ergonomic sitting workstation to continuously record weight-bearing at the seat, chair, backrest, work surface, and floor and to test its measurement properties: reproducibility, criterion-related validity, and sensitivity. Methods: Rigid bodies (1 to 30 kg) and participant weights were recorded to evaluate the workstation measurement properties. Results: Rigid body tests showed variation values less than 0.050 kg on reproducibility test and errors below 5% of measured value on criterion validity tests. Participant tests showed no statistically significant differences between repeated measures ($p{\geq}0.40$), errors were less than 2% of participant weights an sensitivity presented statistically significant changes (p = 0.007). Conclusion: The sitting workstation proposed showed to be reliable, valid and sensitive for use in future ergonomic studies to evaluate the sitting posture.