• Journal of Nutrition and Health
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• 제50권1호
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• pp.32-40
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• 2017

소아기의 과체중 혹은 비만은 성인기의 만성질환의 onset 위험을 증가시키는 대사이상을 야기하므로 관련된 obesogenic 환경 (나트륨 섭취 등)을 제어할 필요가 있다. 본 연구에서는 소아기의 과도한 소금섭취가 신장의 재흡수 기능을 조절하는 SLC12A3기능장애로 이어져 고혈압 및 비만을 야기하는지를 확인하고자 하였다. 서울 구로구에 소재한 8~9세 초등학생 752명 (남학생: 379명 여학생: 373명)을 대상으로 BMI가 85 percentiles이상을 비만군으로, 이하를 정상군으로 분류하였다. SLC12A3 rs11643718 유전자형은 GG (wild)와 GA + AA로 분류하여 신체계측, 혈액검사, 식이조사 등을 비교분석하였다 대상자의 남아가 여아보다, 비만군이 정상군보다 신체지수, 혈액지수, 식사섭취량이 여아보다 높았다. 남녀 모두 비만군에서 높은 TG와 낮은 HDLc를 보여주었지만 비만한 남아는 혈압에, 비만한 여아는 인슐린저항성에 더 민감한 반응을 보였다. 비록 남녀차이는 있지만 비만군 및 정상군 모두에서 SLC12A3의 GA + AA형이 GG형보다 혈압과 체중이 높았다. GG 유전자형을 가지고 있는 소아는 혈중 LDLc, FBS, insulin등이 높거나 식이 콜레스테롤섭취가 증가할수록 비만이 될 위험도가 증가하였고 엽산의 섭취가 증가할수록 비만위험도는 감소하였다. 반면, GA + AA 유전자형을 가지고 있는 소아는 고나트륨 (> 4,000 mg/day)섭취시 비만위험도 (odd ratio)가 15.57배 증가하였고 남아 (22.84배)에서 더욱 위험도가 높았다. HDLc의 경우는 유전자형에 관계없이 증가할수록 비만위험도가 감소하였다. 결론적으로 SLC12A3 (rs11643718) 유전자의 A allele를 가진 형이 나트륨에 특이적으로 반응하여 과체중위험을 증가시키는 것으로 생각된다.

• 한국정보시스템학회지:정보시스템연구
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• 제14권2호
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• pp.1-23
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• 2005

Theoretically, both of fund transfer and balance inquiry which are typical Internet banking services are influenced by the beliefs on the use of Internet banking such as perceived risk and convenience, which have been shown as in the other studies. However, the use of fund transfer can be more sensitive than that of balance inquiry by the beliefs on Internet banking use since the former is not only more risk involved but also more complicated in using than the latter. The objective of this study is to analyze the relationship between the use of two Internet banking services-fund transfer and balance inquiry-and the beliefs on Internet banking use-security risk, convenience and social Influence. For this purpose, we provide the research model for explaining the difference between balance inquiry and fund transfer in the degree of influencing by security risk, convenience and social influence and test it empirically by collecting data from surveying for 206 internet banking users. In result, we show validity of the suggested model by Partial Least Square(PLS) approach.

• 융합경영연구
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• 제12권2호
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• pp.1-10
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• 2024

Purpose: This study conducted an empirical study to estimate the loss aversion rate of individual investors in the Seoul condominium market. Research design, data and methodology: A survey was conducted with Seoul residents ranging from 30's to 60's with various backgrounds. Descriptive statistical analysis and a paired sample t-test were conducted using SPSS 27.0 statistical package. Results: The results of the t-test showed that Seoul residents are indeed more sensitive to loss than gains, as pointed out in various researches related to behavioral economics. Also, the loss aversion rate associated with KRW 50 million risk was found to be 2.14. Finally, the same question was asked with KRW 100 million risk, doubled associated risk of previous question, using the same scenario, and it's been verified that the loss aversion rate increases as the associated risk or stake increases. The loss aversion rate with double risk is 2.26 which is about 5% higher than the one with KRW 50 million risk. Conclusions: This study can help many groups of people in society who need to establish rewards and punishment policies within any organization. In particular, incorporating human cognitive biases, such as loss aversion can help the South Korean government shape more effective reward and punishment policies when building rewards and punishments using taxes.

• 한국환경성돌연변이발암원학회지
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• 제24권3호
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• pp.137-142
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• 2004

Dioxin-like compounds are ubiquitous environmental polltants that could be accumulated in biological system and toxic to human and wildlife. Given this issue, it is important to develop a reliable dioxin detection methods for a rational risk assesment of dioxin-like compounds. In this study, we tried to set up and validate a sensitive, reliable risk assessment of dioxin-like compounds. In this study, we tried to set up and validate a sensitive, reliable and rapid bioassay model, CALUX bioassay as a screening tool for routine measurement of dioxin-like conpounds in environmental matrices. For the valisation of CALUX bioassay, firstly, we performed dose-response assay for 2,3,7,8-TCDD, most potent dioxin-like compound, using two different methods CALUX and EROD assay. Induction of luciferase activity and CYPIA catalyzed EROD activity were dose-dependently induced by 2,3,7,8-TCDD, with initial induction at 0.1 pM and maximal induction at 1 nM. In order t determine whether the CALUX bioassay could predict the effects of dioxin-like compounds, 2,3,7,8-TCDD dose-response from CALUX was compared with that from EROD assay. The correlation coefficient ($r^2$) was found to be 0.89, indicating a good correlation between two different methods and the possibility of CALUX bioassay as a useful dioxin detecting method.

• 대한세포병리학회지
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• 제18권1호
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• pp.1-12
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• 2007

Approximately 70% of cervical cancers are caused by HPV types 16/18 and thus the implementation of vaccination programmes with vaccines against HPV types 16/18 will have a major impact on the incidence of cervical cancer worldwide. However, this reduction will not be seen until several decades after full implementation of such vaccination programmes since the vaccines must be given to young adolescents before exposure to the virus and women who are already sexually active are not likely to be protected. Both GSK and Merck insist that even vaccinated women must continue to participate in regular cervical screening by the most sensitive method available since the vaccine can only give protection against up to 70% of cervical cancers. It is unlikely that the current vaccines will be modified to include additional high risk HPV types in the foreseeable future. While HPV testing is highly sensitive, it is not recommended for women under 30 years of age nor for vaccinated women. Additionally, HPV testing has poor specificity. The Digene Hybrid Capture 2 test is licensed for use only in conjunction with a cytology test, not as a stand-alone test, and the high risk panel has recognised cross reactivity with low risk HPV types. None of the other HPV test methods currently commercially available are FDA approved and all must be internally validated before use. This makes comparison of test results between laboratories difficult. The most sensitive and specific screening test currently available for women of all ages is the Cytyc ThinPrep System consisting of the ThinPrep Pap Test (TPPT) and the ThinPrep Imaging System (Imager). The TPPT was the first LBC system approved by the US FDA in 1996 and there are about 4,000 processors in use worldwide. The Imager was FDA approved in 2003 and over 350 systems are in routine use, mainly in the US. 40% of TPPT in the US are processed on Imager. There is clear evidence in peer reviewed literature that the Imager increases laboratory productivity by 100% and growing evidence that Imager detects more high grade SIL than the conventional smear or manual evaluation of TPPT. This aspect is particularly important since the number of cytological abnormalities will decrease as vaccination programmes are implemented. Cytotechnologists will see fewer and fewer abnormal smears and their skills will be put at risk. By doubling throughput, Imager will allow cytotechnologists to maintain their skills.

• 대한가정학회지
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• 제40권1호
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• pp.179-194
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• 2002

This study investigates the incidence and risk factors of adolescents' unwanted sexual behavior for a sample of 769 adolescent males and females. Seven percent of the sample experienced unwanted sexual behavior. Female adolescents were more likely to be victims of unwanted sexual behavior Adolescents with an unwanted sexual behavior, as compared to those without, were more likely to have experienced pregnancy, to drink alcohol, to be sensitive to romantic circumstances, to love his/her parker, to have fathers with higher education, to have lower family income, to have friends with similar norms and attitudes, to be more experienced sexually, not to have both biological parent, to have parents who did not monitor their behavior closet, to get partner's pressure to get sexually involved, and to have higher devotion level toward parker or their relationship.

• Nutrition Research and Practice
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• 제6권3호
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• pp.246-253
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• 2012

The Framingham risk score (FRS) has been used to assess the risk of a cardiovascular event and to identify patients for risk factor modifications. Therefore, the purpose of this study was to evaluate the relationship of the FRS with dietary intake and inflammatory biomarkers. We conducted a cross-sectional study of 180 men ($49.2{\pm}10.2$ years) with MS. Serum levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), and adiponectin were examined. Participants were asked to complete the food frequency questionnaire (FFQ) using the previous 1 year as a reference point. The absolute cardiovascular disease (CVD) risk percentage over 10 years was calculated to estimate the FRS, which was classified as low risk (< 10%), intermediate risk (10-20%), and high risk (> 20%). Mean intake of polyunsaturated fatty acids was lower in subjects who had > 20% FRS than in subjects who had < 10% FRS ($3.7{\pm}1.9$ g/day vs. $4.7{\pm}1.9$ g/day; P < 0.05). Significant differences in the Index of Nutritional Quality of protein, phosphorus, iron, vitamin A, vitamin $B_1$, niacin, vitamin $B_6$, and vitamin C were observed between the > 20% FRS group and the < 10% FRS group (P < 0.05). IL-6 concentrations were significantly lower in subjects with a < 10% FRS than in subjects who were 10-20% FRS or > 20% FRS ($0.91{\pm}0.26$ vs. $1.48{\pm}033$ vs. $2.72{\pm}0.57$ pg/mL, respectively; P < 0.05). IL-6 and dietary intake of polyunsaturated fatty acids together explained 6.6% of the variation in FRS levels in a stepwise multiple regression model. Our results provide some evidence that dietary intake in the higher CVD risk group was inferior to that in the lower risk group and that dietary fat intake and IL-6 were associated with FRS and MS in Korean men.

• The Plant Pathology Journal
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• 제36권5호
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• pp.406-417
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• 2020

Early warning services for crop diseases are valuable when they provide timely forecasts that farmers can utilize to inform their disease management decisions. In South Korea, collaborative disease controls that utilize unmanned aerial vehicles are commonly performed for most rice paddies. However, such controls could benefit from seasonal disease early warnings with a lead time of a few months. As a first step to establish a seasonal disease early warning service using seasonal climate forecasts, we developed the EPIRICE Daily Risk Model for rice blast by extracting and modifying the core infection algorithms of the EPIRICE model. The daily risk scores generated by the EPIRICE Daily Risk Model were successfully converted into a realistic and measurable disease value through statistical analyses with 13 rice blast incidence datasets, and subsequently validated using the data from another rice blast experiment conducted in Icheon, South Korea, from 1974 to 2000. The sensitivity of the model to air temperature, relative humidity, and precipitation input variables was examined, and the relative humidity resulted in the most sensitive response from the model. Overall, our results indicate that the EPIRICE Daily Risk Model can be used to produce potential disease risk predictions for the seasonal disease early warning service.

• Earthquakes and Structures
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• 제19권6호
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• pp.471-484
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• 2020

Previous earthquakes show that, structural safety evaluations should include the evaluation of nonstructural components. Failure of nonstructural components can affect the operational capacity of critical facilities, such as hospitals and fire stations, which can cause an increase in number of deaths. Additionally, failure of nonstructural components may result in economic, architectural, and historical losses of community. Accelerations and random vibrations must be under the predefined limitations in structures with high technological equipment, data centers in this case. Failure of server equipment and anchored server racks are investigated in this study. A probabilistic study is completed for a low-rise rigid sample structure. The structure is investigated in two versions, (i) conventional fixed-based structure and (ii) with a base isolation system. Seismic hazard assessment is completed for the selected site. Monte Carlo simulations are generated with selected parameters. Uncertainties in both structural parameters and mechanical properties of isolation system are included in simulations. Anchorage failure and vibration failures are investigated. Different methods to generate fragility curves are used. The site-specific annual hazard curve is used to generate risk curves for two different structures. A risk matrix is proposed for the design of data centers. Results show that base isolation systems reduce the failure probability significantly in higher floors. It was also understood that, base isolation systems are highly sensitive to earthquake characteristics rather than variability in structural and mechanical properties, in terms of accelerations. Another outcome is that code-provided anchorage failure limitations are more vulnerable than the random vibration failure limitations of server equipment.

• Safety and Health at Work
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• 제11권4호
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• pp.385-396
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• 2020

Teachers are facing various job demands with psychosocial aspects being fundamental due to the nature of the occupation. Although teachers' work is associated with different psychosocial health risks, little is known on how to identify and tackle those. Thus, a systematic literature search as per the PRISMA statement was conducted via MEDLINE (PubMed), PSYNDEX (PubPsych), and ScienceDirect. Two reviewers independently screened 2261 titles and abstracts and 169 full-texts. According to the inclusion criteria established a priori, articles from peer-reviewed journals (English or German) on psychosocial risk management in teachers were incorporated. Despite a comprehensive and sensitive search, only four publications could be identified, outlining a process to implement risk management and different assessment tools. Taken together, data presented in the articles were scarce. Recommendations for process steps and the assessment of psychosocial risks can be derived from the findings. To implement effective psychosocial risk management in the teaching profession, further research is needed, though. Effective and practicable approaches, which are accepted by the target group, should be further developed and investigated. Relevant causes of occupational strain in the teaching profession must be identified and assessed reliably. Low-threshold interventions should be implemented, and the outcome must be evaluated afterward.