• Physical Therapy Rehabilitation Science
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• v.7 no.2
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• pp.54-60
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• 2018

Objective: Persons with chronic stroke fall more often than healthy elderly individuals. The Timed Up and Go test (TUG) is used as a fall prediction tool, but only provides a result for the total measurement time. This study aimed to determine the optimal cut-off values for each of the 6 components of the TUG. Design: Retrospective study. Methods: Thirty persons with chronic stroke participated in the study. TUG evaluation was performed using a wearable miniaturized inertial sensor. Sensitivity, specificity, and predictive values were calculated using the Receiver Operating Characteristic (ROC) curve analysis for the measured values in each section. Optimal values for fall risk classification were determined. Logistic regression analysis was used to investigate the risk of future falls based on TUG. Results: The cut-off values of the 6 sections of the TUG were determined, as follows: sit-to-stand >2.00 seconds (p<0.05), forward gait >4.68 seconds (p<0.05), mid-turn >3.82 seconds (p<0.05), return gait >4.81 seconds (p<0.05), end-turn >2.95 seconds (p<0.05), and stand-to-sit >2.13 seconds (p<0.05). The risk of falling increased by 2.278 times when the mid-turn value was >3.82 seconds (p<0.05). Conclusions: The risk of falls increased by 2.28 times when the value of the mid-turn interval exceeded 3.82 seconds. Therefore, when interpreting TUG results, the predictive accuracy for falls will be higher when the measurement time for each section is analyzed, together with the total time for TUG.

• Korean Journal of Schizophrenia Research
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• v.23 no.2
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• pp.65-70
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• 2020

Objectives: This study aimed to explore whether common genetic variants that confer the risk of schizophrenia have similar effects between Korean and European ancestries using the polygenic risk score (PRS) analysis. Methods: Study subjects included 713 Korean patients with schizophrenia and 497 healthy controls. The Korea Biobank array was used for genotyping. Summary statistics of the most recent genome-wide association study (GWAS) of the European population were used as baseline data to calculate PRS. Logistic regression was conducted to determine the association between calculated PRS of European patients with schizophrenia and clinical diagnosis of schizophrenia in the Korean population. Results: Schizophrenia PRS was significantly higher in patients with schizophrenia than in healthy controls. The PRS at the p-value threshold of 0.5 best explained the variance of schizophrenia (R²=0.028, p=4.4×10^-6). The association was significant after adjusting for age and sex (odds ratio=1.34, 95% confidence interval=1.19-1.51, p=1.1×10^-6). The pattern of the association remained similar across different p-value thresholds (0.01-1). Conclusion: Schizophrenia PRS calculated using the European GWAS data showed a significant association with the clinical diagnosis of schizophrenia in the Korean population. Results suggest overlapping genetic risk variants between the two populations.

• Clinical Nutrition Research
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• v.12 no.4
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• pp.320-335
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• 2023

Literature showed that soluble fiber has beneficial effects on cardiometabolic risk factors and leptin and adiponectin serum levels. Our aim in this meta-analysis was to determine the effect of soluble fiber supplementation on leptin and adiponectin serum levels. A systematic search was conducted using PubMed, Scopus, and ISI Web of Science for eligible trials up to December 2021. A random-effects model was used to pool calculated effect sizes. Our analysis showed that soluble fiber supplementation did not significantly affect adiponectin (standardized mean difference [SMD], -0.49 Hedges's, 95% confidence interval [CI], -1.20, 0.21, p value = 0.167; I² = 95.4, p value < 0.001) and leptin (SMD, -0.8 Hedges's, 95% CI, -1.70, 0.08, p value = 0.076; I² = 94.6, p value < 0.001) concentrations in comparison with placebo. However, in the subgroup, soluble fiber supplementation had a significant improvement in leptin concentration in overweight and obese patients (SMD, -0.22 Hedges's, 95% CI, -0.43, -0.01, p value = 0.048) and a non-significant beneficial effect in adiponectin level in female (SMD, 0.29 Hedges's, 95% CI, -0.13, 0.71, p value = 0.183) and diabetic patients (SMD, 0.32 Hedges's, 95% CI, -0.67, 1.32, p value = 0.526). A non-linear association between soluble fiber dosage and adiponectin (p_{non-linearity} < 0.001) was observed. Soluble fiber supplementation could not change the circulatory leptin and adiponectin levels. However, beneficial effects were seen in overweight and obese leptin, and increases in adiponectin may also be observed in female and diabetic patients. Further studies are needed to confirm this results.

• Journal of Food Hygiene and Safety
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• v.23 no.1
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• pp.80-84
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• 2008

Maximum level of hazardous chemicals in foods can be settled after overall investigation of toxicological database, the representative exposure assessment, risk level on the present exposure level, the need of maximum level establishment, making of maximum level scenario proposed under consumer protection and verification of contamination reduction method and review of application efficiency on maximum level for risk management. The maximum level should be needed when the risk value of specific chemical caused by food ingestion was high and chronic human exposure was predicted continuously unless the maximum level exists. The key role of the risk assessment is to improve the efficiency of the risk management to reduce the present risk level and make the risk management policy scientifically by setting the representative result of the risk assessment.

• Convergence Security Journal
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• v.20 no.2
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• pp.15-28
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• 2020

Smart City is highly anticipated to solve the problems of existing cities and create new added value, but there is also increasing concern about security risks. The negative view of smart city according to security risk awareness is a problem that needs to be improved in order to activate the fourth industrial revolution technology and develop smart city. This study examined risk factors in smart cities based on perceived risk and user resistance theory, and empirically analyzed the relationship with resistance attitudes. According to the empirical analysis with 288 research samples, security, social, and physical risk factors directly affect smart city resistance, while financial, performance, and privacy risk have no significant effect. In addition, it was verified that the security risk can is an antecedent factor for other risk factors, and it was confirmed that it is required to separately discuss the security and privacy risk in the smart city environment. This study shows that it is necessary to prepare policy supports for social interactions as well as security and physical safety issues in order to activate smart city by discussing the risk factors that negatively affect smart city perception from the public's point of view.

• Journal of Navigation and Port Research
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• v.40 no.3
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• pp.147-157
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• 2016

The trend of globalization and the development of the communication-Information technology have led the organization of a complex supply chains which are more vulnerable to risks. The impact of risk on the supply chain can be adverse so importance of risk management on a supply chain has increased. In order to analyze the risk factors of transport system, this study described about the definition of transport risk and investigated the relationship between likelihood index and effect index of each risk factor. We identified risk factors on transport system and measured likelihood index and effect index of each risk factor. Finally, a numerical risk index, which is a value of total transport system, has been resulted by aggregating all indices. In addition, a case study using the proposed method has done on a heavy vehicle transport context with a transport company.

• Journal of radiological science and technology
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• v.35 no.1
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• pp.35-44
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• 2012

The goal of this study is to awaken about risk occurred by CT examination. For radio-technologists working at 'S medical center' located in Seoul, we investigated a recognition about dose and risk CT and normal X-ray examination according by working experience in hospital, experience about CT examination and radiation source. For subjects of investigation, radio-technologists working at 'S medical center' located in Seoul helped us. We collected 131 questionnaires for a test of hypothesis. Cronbach @ coefficients of questionnaires were 0.825988 and 0.767161 and a rejection rate of p-value was below 0.05. SAS 9.1(SAS Institute Inc., Cary, NC, USA.) statistic package was used for hypothesis test. We used Mann-Whitney test, Kruskai-Wallis test, Two sample T-test, Two sample T-test with Bonferroni's Correction and One-way ANOVA methods. P-values of hypothesis about dose of CT and normal X-ray examination were 0.2291 ~ 0.9663. p-values of hypothesis about risk were 0.1924 ~ 1.0000. All of hypothesis is over rejection rate(<0.05). This study shows that radio-technologists of S medical center recognized that CT has higher dose and risk than general X-ray examination.

• Journal of Preventive Medicine and Public Health
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• v.31 no.2 s.61
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• pp.275-284
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• 1998

Activities of enzymes involved in the metabolism of various carcinogenic xenobiotics is one of the most important host factors for cancer occurrence. N-acetyltransferase (NAT) and glutathione S-transferases (GST) are enzymes which .educe the toxicity of activated carcinogenic metabolites. Slow N-acetylation and lack of GST mu (GSTMI) were reported as risk factors of bladder cancer. GST theta (GSTT1), which is another type of GST, was reported to be deleted at higher proportion among Koreans. Since cause of bladder cancer is not fully explained by single risk factor, many kinds of enzymes would be involved in the metabolism of carcinogens excreted in urine. This study was performed to investigate whether the polymorphisms of NAT2, GSTM1 and GSTT1 are risk factors of bladder cancer and to evaluate the effects of their interaction on bladder cancer development. Sixty-seven bladder cancer and 67 age- and sex-matched non-cancer patients hospitalized in Chungbuk National University Hospital from March to December 1996, are the subjects of this case-control study. Questionnaire interview was done and the genotypes of NAT2, GSTM1 and GSTT1 were identified using PCR methods with DNA extracted from venous blood. The effects of the polymorphism of NAT2 and GSTM1 and their interaction on bladder cancer were statistically tested after controlling the other risk factors. The frequencies of slow, intermediate, and rapid acetylators were 3.0%, 38.8%, and 58.2% to. the cases, and 7.6%, 40.9%, and 51.5% for the controls, respectively. The risk of bladder cancer was not associated with the increase of NAT2 activity($\chi^2_{trend}=1.18$, P-value>0.05). GSTM1 was deleted in 68.7% of the cases and 49.3% of the controls ($\chi^2=5.21$, P-value<0.05), and the odds ratio (95% CI) was 2.23 (1.12 - 4.56). GSTT1 deletion, the .ate of which were 26.9% for the bladder cancer patients and 43.3% for the controls, was a significant protective factor against bladder cancer. Smoking history turned out to be insignificant as a risk factor of bladder cancer (OR=1.85, 95% CI: 0.85 - 4.03), and occupation could not be tested because of the extremely small number of occupational history related to the increase of bladder cancer. In multiple logistic analysis controlling the effects of other risk factors, GSTM1 deletion was the only significant risk factor for bladder cancer (OR: 2.56, 95% CI: 1.22-5.36, P-value<0.05), but slow acetylation and GSTT1 deletion were not. These results suggest that GSTM1 deletion may be a significant risk factor of bladder cancer. Since there have been much debates on causal relationship between slow acetylation and GSTT1 deletion, and bladder cancer, further studies are needed.

• The Korean Journal of Applied Statistics
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• v.23 no.4
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• pp.651-668
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• 2010

Various estimators of two risk measures of a specific financial portfolio, Value-at-Risk and Expected Shortfall, are compared for each case of 1-day and 10-day horizons. We use the Korea Composite Stock Price Index data of 20-year period including the year 2008 of the global financial crisis. Indexes of five foreign stock markets are also used for the empirical comparison study. The estimator considering both the heavy tail of loss distribution and the conditional heteroscedasticity of time series is of main concern, while other standard and new estimators are considered too. We investigate which estimator is best for the Korean stock market and which one shows the best overall performance.

• Proceedings of the Korean Geotechical Society Conference
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• 1997.03a
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• pp.161-168
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• 1997

The purpose of this study is to evaluate the possibility of normalization of the distibutions of soil parameters taken from soft ground and the reliability of the safety factors of specific objects on it, including sanitary landfill. Through this study it is found that distributions of soil parameters could be adjusted to appropriate normal distributions as possibility density functions(PDF), and that especially the group of initial cohesions and the coresponding safety factors has a perfect linear correlation. According to those results the PDF to initial cohesion as possibility parameter can not only be tmsformed to the PDF to safety factor but also, conseqently, the reliability of the safety factor(SF) simply based on the mean value of soil parameter(Co) can be calculated or easily picked up from the standrad normal distribution table. It is therefore concluded that even though calculated values of safety factors are over any standard requirements some possibility of risk both to the objects and natural soft ground could be still existing, and also a new standard value for this slope stability control system should be derived just by adjusting old one according to the magnitude of risk possibility.