• Molecular & Cellular Toxicology
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• 제4권3호
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• pp.260-266
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• 2008

Recently, there has been scientific discussion on the utility of -omics techniques such as genomics, proteomics, and metabolomics within toxicological research and mechanism-based risk assessment. Toxicogenomics is a novel approach integrating the expression analysis of genes (genomic) or proteins (proteomic) with traditional toxicological methods. Since 1999, the toxicogenomic approach has been extensively applied for regulatory purposes in order to understand the potential toxic mechanisms that result from chemical compound exposures. Therefore, this article's purpose was to consider the utility of toxicogenomic profiles for improved risk assessment, explore the current limitations in applying toxicogenomics to regulation, and finally, to rationalize possible avenues to resolve some of the major challenges. Based on many recent works, the significant impact toxicogenomic techniques would have on human health risk assessment is better identification of toxicity pathways or mode-of-actions (MOAs). In addition, the application of toxicogenomics in risk assessment and regulation has proven to be cost effective in terms of screening unknown toxicants prior to more extensive and costly experimental evaluation. However, to maximize the utility of these techniques in regulation, researchers and regulators must resolve many parallel challenges with regard to data collection, integration, and interpretation. Furthermore, standard guidance has to be prepared for researchers and assessors on the scientifically appropriate use of toxicogenomic profiles in risk assessment. The National Institute of Toxicological Research (NITR) looks forward to an ongoing role as leader in addressing the challenges associated with the scientifically sound use of toxicogenomics data in risk assessment.

• 한국안전학회지
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• 제29권4호
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• pp.184-190
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• 2014

Decommissioning process of nuclear facilities consist of a sequence of problem solving activities, because there may exist not only working environments contaminated by radiological exposure but also industrial hazards such as fire, explosions, toxic materials, and electrical and physical hazards. Therefore, not a few countries in the world have been trying to develop appropriate counter techniques in order to guarantee safety and efficiency of the process. In spite of that, there still exists neither domestic nor international standard. Unfortunately, however, there are few workers who experienced decommissioning operations a lot in the past. As a solution, it is quite necessary to utilize experts' opinions for risk assessment in decommissioning process. As for an individual hazard factor, risk assessment techniques are getting known to industrial workers with advance of safety technology, but the way how to integrate those results is not yet. This paper aimed to find out an appropriate technique to integrate individual risk assessment results from the viewpoint of experts. Thus, on one hand the whole risk assessment activity for decommissioning operations was modeled as a sequence of individual risk assessment steps which can be classified into two activities, decontamination and dismantling, and on the other, a risk assessment structure was introduced. The whole model was inferred with Fuzzy theory and techniques, and a numerical example was appended for comprehension.

• 한국산업보건학회지
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• 제19권2호
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• pp.88-95
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• 2009

There are many assessment techniques used for occupational risk factors of MSDs in the workplaces. However, because all ergonomic assesment techniques or tools are based on theoretical background derived from workphysiology, biomechanics, psychophysics, industrial hygiene, work system, and etc, it is impossible to compare the assessment techniques. This study was conducted to compare the excess rates of risk factors among ergonomic assessment techniques and to make alternative methods. Site-visits to 6 automobile products and parts company provided data for process repeated work where the produced data was examined for evaluating the relationship between workplace lay-out and work posture by using ergonomic assessment techniques. We evaluated 157 jobs for simple repeated work and 37 jobs for manual materials handling (MMH). In simple repeated work, the exceeded rates of AC were 36.3% in OWAS method and 93.0% in RULA method. The exceeded rate for RULA method was significantly higher than those for OWAS method (p<0.05). In MMH, the exceeded rates of AC were 80.0% in NLE method and 76.5% in WAC method. Statistically significant differences were not identified in the exceeded rates for NLE and MAC methods (p<0.05). The analyzed results among ergonomic assessment techniques (OWAS, RULA, NLE/WAC) were applied to the same work places performing simple repeated work and manual materials handling simultaneously. The applied results showed statistically significant differences (p<0.05) among ergonomic assessment techniques (OWAS, RULA, NLE/WAC). Exceeded rates of four ergonomic assessment techniques in decreasing order was "RULA>NLE>WAC>OWAS". The RULA method was the strongest assessment technique for automobile products and parts company. We discovered that the results could easily be overestimated or underestimated when the ergonomic assessment techniques were not applied correctly during the evaluation process. Therefore, we recommend using at least 2 methods when evaluating and analysing the results.

• 해양환경안전학회지
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• 제18권5호
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• pp.431-438
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• 2012

해상교통환경의 위험도를 평가하기 위한 기술로는 대표적으로 FSA, PAWSA, IWRAP 등이 있으며, 이러한 기술의 개발을 위해서는 해상교통환경에 적합한 위험요소를 선정하고 이에 대한 평가기준이 마련되어야 한다. 기존 기술에서 위험도는 사고의 출현빈도와 이로 인한 영향의 곱으로 정의되어 이에 따라 사고의 출현빈도 및 영향에 해당되는 위험요소들이 각각 구분되어 선정되고 있었다. 그러나, 본 연구는 각 위험요소에 요소별 출현빈도와 영향을 포함하여 이들의 합으로 위험도를 정의함으로써 기존 기술에서 사고의 영향에 해당되었던 위험요소들을 제외하는 한편, 위험요소 분류체계에 관한 기존 연구의 사례 검토를 통하여 위험도를 구성하는 위험요소를 20가지로 추출한 후 유사한 성격에 따라 5가지 카테고리로 분류하였다. 또한, 선정된 각 위험요소에 대하여 관련 통계자료 등을 이용 실용적으로 용이하게 평가할 수 있는 기준을 제시하여, 향후 국내 해상교통환경에 적합한 위험도 평가모델의 개발을 위한 기초를 마련하였다.

• 보건의료기술평가
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• 제1권1호
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• pp.22-26
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• 2013

Objectives: Balancing benefits and risks through the drug life cycle has been discussed for many decades. The objective of this study was to review the processes and tools currently proposed for benefit-risk assessment of medicinal drugs. It aimed to establish scientific and efficient drug safety management system based on the synthetic analysis of benefit-risk evidence. Methods: We conducted a review of exiting literatures published by regulatory agencies or initiatives. Not only quantitative methodologies but also qualitative method were compared to understand their key characteristics for the benefit and risk assessment of drugs. Results: Recently, benefit-risk assessments have more structured approaches to decision making as part of regulatory science. Regulatory agencies such as European Medicines Agency, FDA have prepared plans to apply benefit-risk assessment to regulatory decision making. Also many initiatives such as IMI (Innovative Medicine Initiative) have conducted research and published reports about benefit-risk assessment. For benefit-risk assessment, four kinds of methods are necessary. Frameworks such as BRAT (Benefit Risk Action Team) framework, PrOACT-URL provide guidance for the whole process of decision-making. Metrics are measurements of risk benefit. The estimation techniques are methods to synthesis and combine evidences from various sources. The utility survey techniques are necessary to explicit preferences of various outcome from stakeholders. Conclusion: There is the lack of widely accepted, validated model for benefit-risk assessment. Nor there is an agreement among academia, industry, and government on methods for the quantitative valuation. It is also limited by available evidence and underlying assumptions. Nevertheless, benefit-risk assessment is fundamental to improve transparency, consistency and predictability for decision making through the structured systematic approaches.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1997년도 가을 학술발표회 논문집
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• pp.24-31
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• 1997

Recently, in Korea, demand for establishment of systematic risk assessment techniques for construction projects has increased, especially after the large construction failures occurred during construction such as New Haengju Bridge construction projects, subway construction projects, gas explosion accidents etc. Most of existing risk analysis modeling techniques such as Event Tree Analysis and Fault Tree Analysis may not be available for realistic risk assessment of construction projects because it is very complex and difficult to estimate occurrence frequency and failure probability precisely due to a lack of data related to the various risks inherent in construction projects like natural disasters, financial and economic risks, political risks, environmental risks as well as design and construction-related risks. Therefor the main objective of this paper is to suggest systematic probabilistic risk assessment model and demonstrate an approach for probabilistic risk assessment using advanced Event Tree Analysis introducing Fuzzy set theory concepts. It may be stated that the Fuzzy Event Tree AnaIysis may be very usefu1 for the systematic and rational risk assessment for real constructions problems because the approach is able to effectively deal with all the related construction risks in terms of the linguistic variables that incorporate systematically expert's experiences and subjective judgement.

• 대한안전경영과학회지
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• 제10권4호
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• pp.93-104
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• 2008

A successful fire risk assessment is depends on identification of risk, the analytical process of potential risk, on estimation of likelihood and the width and depth of consequence. Take the influence on enterprise into consideration, Fire risk assessment could carry out along the evaluation of the risk importance, the risk level and the risk acceptance. A large part of the limitation of choosing the risk assessment techniques impose restrictions on expense and time. If it is unnecessary high level risk assessment or Probabilistic Risk Assessment of buildings, in compliance with the Relative Ranking Method, Fire risk indexing and assessing is possible. As working-level technique, AHP method is useful with practical technique.

• 대한인간공학회지
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• 제31권1호
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• pp.143-149
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• 2012

Objective: The aim of this study is to gain an overview of the risk assessment and management system in the shipbuilding industry. Background: The use of risk assessment techniques has grown significantly in recent years. Method: Various references have been reviewed to evaluate risk assessment and management policy. Results: Adapting the risk assessment system has become an important approach not only to prevent industrial accidents but also to enhance the efficiency of works for shipbuilding workers. Conclusion: Risk assessment is an approved technology for operators to address larger hazards, and to ensure risks have been reduced to appropriate levels cost effectively. Application: These results can be used to provide baseline information for risk assessment and management policy.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1997년도 봄 학술발표회 논문집
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• pp.27-34
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• 1997

In this paper, systematic and comprehensive approaches are suggested for the application of quantitative PRA techniques especially for those risk events that cannot be easily evaluated quantitatively In addition, dominant risk events are identified based on their occurrence frequency assessed by both actual survey of construction site conditions and the statistical data related with the probable accidents. Practical FTA(Fault Tree Analysis) and ETA(Event Tree Analysis) models are used for the assessment of the identified risks. When the risk events are lack of statistical data, appropriate Bayesian models incorporating engineering judgement and test results are also introduced in this paper. Moreover, a fuzzy probability technique is used for the quantitative risk assessment of those risk components which are difficult to evaluate quantitatively.

• 한국안전학회지
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• 제29권3호
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• pp.79-84
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• 2014

Human error is one of the major contributors to the accidents. A lot of risk assessment techniques have been developed for prevention of accidents. Nevertheless, most of them were interested in physical factors, because quantitative evaluation of human errors was difficult quantitatively. According to lack of risk assessment techniques about human errors, most of industrial risk assessment for human errors were based on data of accident analysis. In order to develop an effective countermeasure to reduce the risk caused by human errors, a systematic analysis is needed. Generally, risk assessment system is composed of 5 step(classification of work activity, identification of hazards, risk estimation, evaluation and improvement). This study aimed to develop a risk identification technique for human errors that could mainly be applied to industrial fields. In this study, Ergo-HAZOP and Comprehensive Human Error Analysis Technique were used for developing the risk identification technique. In the proposed risk identification technique, Ergo-HAZOP was used for broad-brush risk identification. More critical risks were analysed by Comprehensive Human Error Analysis Technique. In order to verify applicability, the proposed risk identification technique was applied to the work of pile head cutting. As a consequence, extensive hazards were identified and fundamental countermeasures were established. It is expected that much attention would be paid to prevent accidents by human error in industrial fields since safety personnel can easily fint out hazards of human factors if utilizing the proposed risk identification technique.