• 대한치과의사협회지
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• 제54권2호
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• pp.155-162
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• 2016

Radiographs can help in the diagnosis and treatment planning, but the exposure to ionizing radiation may elevate the risk of developing cancer in a person's lifetime. The objective of this review is to briefly summarize 1) radiation risk, especially cancer risks associated with diagnostic imaging, 2) linear, non-threshold (LNT) hypothesis, 3) the risks of radiation exposure to a fetus, and 4) the campaign of Image Gently. The individual risk of radiation-related cancer from any single medical imaging procedure is extremely small and it is not likely to be cancer risk at doses lower than 100 mGy, but patients may be harmed by avoiding diagnostic imaging due to fear of radiation hazard. Dentists need to understand the radiation doses delivered by various radiographic techniques and the acceptable exposure thresholds to effectively advise the patient and to reduce the unnecessary radiation

• Toxicological Research
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• 제28권3호
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• pp.173-178
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• 2012

This study investigated the human health risks of trichloroethylene from Industrial Complex A. The excessive carcinogenic risks for central tendency exposure were $1.40{\times}10^{-5}$ for male and female residents in the vicinity of Industrial Complex A. The excessive cancers risk for reasonable maximum exposure were $2.88{\times}10^{-5}$ and $1.97{\times}10^{-5}$ for males and females, respectively. These values indicate that there are potential cancer risks for exposure to these concentrations. The hazard index for central tendency exposure to trichloroethylene was 1.71 for male and female residents. The hazard indexes for reasonable maximum exposure were 3.27 and 2.41 for males and females, respectively. These values were over one, which is equivalent to the threshold value. This result showed that adverse cancer and non-cancer health effects may occur and that some risk management of trichloroethylene from Industrial Complex A was needed.

• Communications for Statistical Applications and Methods
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• 제25권1호
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• pp.91-97
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• 2018

In this paper, we show that there exists an optimal investment policy for the surplus in a risk model, in which the surplus is continuously invested to other business at a constant rate a > 0, whenever the level of the surplus exceeds a given threshold V > 0. We assign, to the risk model, two costs, the penalty per unit time while the level of the surplus being under V > 0 and the opportunity cost per unit time by keeping a unit amount of the surplus. After calculating the long-run average cost per unit time, we show that there exists an optimal investment rate $a^*$>0 which minimizes the long-run average cost per unit time, when the claim amount follows an exponential distribution.

• 대한지역사회영양학회지
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• 제16권1호
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• pp.145-154
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• 2011

The purpose of this study was to evaluate the relationship between taste perceptions and risk factors for health of Korean elderly living in rural areas. Recognition thresholds for four basic tastes, drug consumption, BMI, fasting blood glucose, serum total cholesterol, serum triglyceride, systolic blood pressure, and diastolic blood pressure were assessed in 176 males and 312 females aged between 50 and 88 years. For the recognition threshold of the four basic tastes, alcohol drinking did not influence their sensitivities, but the alcohol drinking group preferred a higher pleasant concentration of NaCl than did the non-alcohol drinking group. However, smoking significantly decreased sensitivities of the four basic tastes. For the pleasant concentration of NaCl, the smoking group tended to prefer a higher concentration than the non-smoking group. Drug consumption, fasting blood glucose, serum total cholesterol, and serum triglycerides did not have a significant correlation to the sensitivity of the four basic tastes and preference of salty solution. Systolic blood pressure and diastolic blood pressure may have been positively correlated with the pleasant concentration of NaCl but did not correlate with the recognition thresholds of NaCl and sucrose. Further, systolic blood pressure was negatively correlated with the recognition thresholds of caffeine, whereas diastolic blood pressure was negatively correlated with the recognition thresholds of caffeine and citric acid. The finding that the risk factors for health correlated with taste perception has diagnostic and practical implications for health promotion for the elderly.

• Industrial Engineering and Management Systems
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• 제15권1호
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• pp.63-76
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• 2016

Multiperiod portfolio selection problem attracts more and more attentions because it is in accordance with the practical investment decision-making problem. However, the existing literature on this field is almost undertaken by regarding security returns as random variables in the framework of probability theory. Different from these works, we assume that security returns are uncertain variables which may be given by the experts, and take absolute deviation as a risk measure in the framework of uncertainty theory. In this paper, a new multiperiod mean absolute deviation uncertain portfolio selection models is presented by taking transaction costs, borrowing constraints and threshold constraints into account, which an optimal investment policy can be generated to help investors not only achieve an optimal return, but also have a good risk control. Threshold constraints limit the amount of capital to be invested in each stock and prevent very small investments in any stock. Based on uncertain theories, the model is converted to a dynamic optimization problem. Because of the transaction costs, the model is a dynamic optimization problem with path dependence. To solve the new model in general cases, the forward dynamic programming method is presented. In addition, a numerical example is also presented to illustrate the modeling idea and the effectiveness of the designed algorithm.

• Toxicological Research
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• 제34권4호
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• pp.291-296
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• 2018

Chemical carcinogenesis is a multistep process. Genotoxic carcinogens, which are DNA-reactive, induce DNA adduct formation and genetic alterations in target cells, thereby generating mutated cells (initiation). Subsequently, preneoplastic lesions appear through clonal proliferation of the mutated cells and transform into tumors (promotion and progression). Many factors may influence these processes in a dose-dependent manner. Therefore, quantitative analysis plays an important role in studies on the carcinogenic threshold of genotoxic carcinogens. Herein, we present data on the relationship between key carcinogenic events and their deriving point of departure (PoD). Their PoDs were also compared to those of the carcinogenesis pathway. In an experiment, the liver of rats exposed to 2-amino-3,8-dimethylimidazo-(4,5-f)quinoxaline (MeIQx) was examined to determine the formation of MeIQx-DNA adducts, generation of mutations at LacI transgene, and induction of preneoplastic glutathione S-transferase placental form (GST-P)-positive foci and tumors (benign and malignant). The PoDs of the above key events in the carcinogenicity of MeIQx were increased as the carcinogenesis advanced; however, these PoDs were lower than those of tumor induction. Thus, the order of key events during tumor induction in the liver was as follows: formation of DNA adducts ${\ll}$ Mutations ${\ll}$ GST-positive foci (preneoplasia) ${\ll}$ Tumor (adenoma and carcinoma). We also obtained similar data on the genotoxic and carcinogenic PoDs of other hepatocarcinogens, such as 2-amino-3,8-dimethylimidazo(4,5-f)quinoline. These results contribute to elucidating the existence of a genotoxic and carcinogenic threshold.

• 한국수자원학회논문집
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• 제52권3호
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• pp.173-185
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• 2019

한반도는 지형학적 요건으로 인하여 태풍과 관련된 재난이 매년 발생하여 막대한 피해를 유발하고 있다. 태풍 내습시 폭풍해일과 집중호우가 동시에 발생한다면 해안지역의 침수피해는 더욱 증가할 것으로 사료된다. 이러한 관점에서 태풍과 폭풍해일의 상호의존성을 정량적으로 규명하는 것은 해안지역의 재해분석에 필수적이다. 본 연구에서는 Bayesian 기법을 기반으로 절점기준을 초과하는 임계값의 초과확률을 산정하기 위하여 Poisson 분포와 Generalized-Pareto 분포를 이용한 Poisson-GP 폭풍해일 빈도해석 기법을 개발하였다. 본 연구를 통하여 개발된 Poisson-GP 폭풍해일 빈도해석 기법은 설계해수면의 불확실성을 정량적으로 제시하였으며 해안지역의 폭풍해일 관련 방재기술 향상에 기여할 것으로 판단된다.

• 한국항해항만학회지
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• 제28권1호
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• pp.9-16
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• 2004

본 연구는 선박충돌회피 알고리즘에 대하여 검토하고, 이를 개선하려는 의도로 수행되었다. 선박충돌회피 알고리즘에 대한 연구는 지금까지 많이 수행되었는데, 이런 연구에서 채용하고 있는 핵심 이론을 내용에 따라 구분하면 위험도계산법과 위험지역 설정법으로 각각 나뉠 수 있다. 그 두 가지 이론은 각각의 장점과 단점을 가지고 있으며, 또한 그 한계성을 포함하고 있다. 이번 연구는 두 가지 이론의 한계점을 극복하기 위한 방안을 제시한다. 제시된 모델은 위험도 계산법을 기초로 하고 있으며, 위험도계산법에서 가장 문제시 되어온 임계값 설정 문제를 해결하기 위하여, 사용자가 항해 환경 등에 따라 적절히 그 설정값을 선택할 수 있는 기능을 제시하고 있다. 또한 두 가지 이론의 상호 관계를 규명하기 위해서 위험도 계산법의 시뮬레이션을 인용하여, 본선 주위에 위험구역을 도식해 봄으로써, 위험지역설정과 그 차이를 비교하여, 양자간의 이해를 돕는 수단으로 활용하였다. 마지막으로 위험도 계산법의 경우, 특히 TCPA, DCPA를 사용하여 위험도계산을 할 경우, 두 선박이 선미에서 너무 접근하는 문제점이 발생하는데, 이런 문제의 해결책의 하나로, 위험지역 설정법을 부분적으로 적용한 새로운 모델을 제시하고 그 효용성을 검증하였다.

• 한국산업보건학회지
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• 제22권1호
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• pp.73-81
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• 2012

Object: The aim of this study is to suggest a list of priority chemicals for the Hazard & Risk Evaluation of Chemicals (HREC) controlled by the Industrial Safety and Health Act (ISHA). Method: Screening assessment was done for 642 chemicals whose exposure threshold limit values were set by the Ministry of Employment and Labor (MOEL). Hazard data were collected from Korea Occupational Safety & Health Agency (KOSHA) and/or other toxicity database. Exposure data were obtained from KOSHA internal database. The hazard and exposure scores of chemicals were listed by order of priority in accordance with GHS classification and exposure index data. Result: From the result of screening risk assessment for 642 chemicals, we extracted a list of 13 priority chemicals for HREC performed by the ISHA. A priority list of 27 chemicals which have carcinogen, mutagen and/or reproductive toxicity but not controlled by the ISHA was suggested for additional evaluation as "chemicals for special management".

• 한국방재안전학회논문집
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• 제14권2호
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• pp.1-11
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• 2021

최근 우리나라에서는 기후변화로 인하여 기상재해의 위험성이 증가하고 있고 특히 강우로 인한 피해가 계속해서 강조되고 있다. 현재의 기상예보가 정량적 강우를 제시해주지만 피해 정도를 예상하는 데에는 여러 가지 어려움이 존재한다. 그래서 피해에 따른 영향을 파악하기 위해서는 유역별 한계강우량이 필요하다. 강우로 인한 피해는 지역별로 상이하게 일어나고 있고 각 유역의 특성인자가 고려된 분석은 한계가 존재한다. 또한 강우가 올 때마다 수문모델을 통한 강유-유출분석에는 시간이 많이 소모되고 단순 강우 데이터만 사용하여 분석되는 경우가 많다. 본 연구는 GIS데이터를 이용하였고 2개의 수문모델을 커플링하여 침수를 유발하는 한계유출량으로부터 한계강우량을 산정하였다. 산정결과는 실제사례와 비교하여 결과를 검증하였고 대체로 위험지역에 대해 피해가 난 것으로 분석되었다. 향후 본 연구를 통해 사전에 침수위험지역에 대해 대비를 할 수 있을 것이고 머신러닝 분석방법을 추가한다면 정확도가 높아질 것으로 예상된다.