• Clinical and Experimental Reproductive Medicine
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• v.47 no.4
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• pp.237-244
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• 2020

Endometrial cancer (EC) in young women tends to be early-stage and low-grade; therefore, such cases have good prognoses. Fertility-sparing treatment with progestin is a potential alternative to definitive treatment (i.e., total hysterectomy, bilateral salpingo-oophorectomy, pelvic washing, and/or lymphadenectomy) for selected patients. However, no evidence-based consensus or guidelines yet exist, and this topic is subject to much debate. Generally, the ideal candidates for fertility-sparing treatment have been suggested to be young women with grade 1 endometrioid adenocarcinoma confined to the endometrium. Magnetic resonance imaging should be performed to rule out myometrial invasion and extrauterine disease before initiating fertility-sparing treatment. Although various fertility-sparing treatment methods exist, including the levonorgestrel-intrauterine system, metformin, gonadotropin-releasing hormone agonists, photodynamic therapy, and hysteroscopic resection, the most common method is high-dose oral progestin (medroxyprogesterone acetate at 500-600 mg daily or megestrol acetate at 160 mg daily). During treatment, re-evaluation of the endometrium with dilation and curettage at 3 months is recommended. Although no consensus exists regarding the ideal duration of maintenance treatment after achieving regression, it is reasonable to consider maintaining the progestin therapy until pregnancy with individualization. According to the literature, the ovarian stimulation drugs used for fertility treatments appear safe. Hysterectomy should be performed after childbearing, and hysterectomy without oophorectomy can also be considered for young women. The available evidence suggests that fertility-sparing treatment is effective and does not appear to worsen the prognosis. If an eligible patient strongly desires fertility despite the risk of recurrence, the clinician should consider fertility-sparing treatment with close follow-up.

• Journal of the Korean Geotechnical Society
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• v.37 no.12
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• pp.117-125
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• 2021

The occurrence of ground subsidence and sinkhole in downtown areas, which threatens the safety of citizens, has been frequently reported. Among the various mechanisms of a sinkhole, soil erosion through the damaged part of the sewer pipe was found to be the main cause in Seoul. In this study, a random forest model for predicting the occurrence of sinkholes caused by damaged sewer pipes based on sewage pipe information was trained using the information on the sewage pipe and the locations of the sinkhole occurrence case in Seoul. The random forest model showed excellent performance in the prediction of sinkhole occurrence after the optimization of its hyperparameters. In addition, it was confirmed that the sewage pipe length, elevation above sea level, slope, depth of landfill, and the risk of ground subsidence were affected in the order of sewage pipe information used as input variables. The results of this study are expected to be used as basic data for the preparation of a sinkhole susceptibility map and the establishment of an underground cavity exploration plan and a sewage pipe maintenance plan.

• Journal of the Regional Association of Architectural Institute of Korea
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• v.20 no.6
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• pp.121-129
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• 2018

The present study analyzed what policies are being executed for deteriorated apartments in Japan and what characteristics each policy had in order to examine policy direction and implications for the improvement of vitalization of remodeling business of deteriorated apartments in Korea. The study results are as follows. Japan recognized social problems of deteriorated apartments and pushed forward a national level remodeling actively by preparing financial support of central government and supporting plan by city and province. First, Japan maintained initial performance of buildings through phased maintenance for deterioration of buildings and aimed to reduce environmental load and maintain asset values of buildings through enlarging durability of buildings by responding to lifestyle according to social changes. To this end, they promoted the long life of buildings through the establishment of systematic long term repair plan from the stage of moving in the buildings. Second, in order to reduce the risk of remodeling projects, they prepared an environment where business could be carried out with an easy mind in various aspects by introducing remodeling business registration system and large scale repair construction defect insurance system. Third, they reduced economic burden of main agents of remodeling business with tax preferential treatment and financial support policies. Fourth, they have established remodeling support system based on overall social issues and connected it with social effect that could be obtained through this. The remodeling policies of Japan were carried out in the direction of solving social problems and considering economic aspect rather than just improving individuals' residence environment.

• Fire Science and Engineering
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• v.32 no.6
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• pp.63-68
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• 2018

In this study, to recognize the limitations and problems of fire safety in existing deteriorated buildings in Korea, and to analyze the fire case of Jongno Gooshiwon, the fire life safety assessment was performed and analyzed through fire egress simulation and analyzed the domestic and foreign related codes and regulations. In order to secure the fire safety of existing deteriorated buildings, it is necessary to adopt the systematic introduction and application of fire safety performance evaluation of buildings based on quantitative and objective indicated method for performance maintenance and management for fire life safety.

• Applied Chemistry for Engineering
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• v.32 no.4
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• pp.379-384
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• 2021

A microneedle is a tool that used for drug delivery and diagnosis. Unlike general injections, the microneedle is short in length, enabling effective drug delivery while minimizing pain and risk of infection. Conventionally, microneedles have been manufactured precisely at a nanometer level based on microelectro mechanical systems (MEMS) technology, requiring expensive equipments & maintenance and complicated processes. To address the issues, 3D printing research has been conducted to fabricate microneedles simply, economically, and rapidly. Since 3D printing facilitates to manufacture prototypes and apply feedbacks, it is advantageous for the development and commercialization of microneedle for pharmaceuticals and cosmetics. Therefore, this review will introduce stereolithography (SLA), two-photon polymerization (2PP), dynamic light processing (DLP), continuous liquid interface production (CLIP), and fused deposition modeling (FDM) 3D printing technologies and also highlight research trends for microneedle production using them. Furthermore, the limitation of the current microneedle technology and the direction to be solved in the future will be discussed.

• The Journal of the Korea Contents Association
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• v.22 no.10
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• pp.546-553
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• 2022

This research has focused on identifying a significant cause of the pavement cracks and irregularities of roads in Changwon city which have been constructed using steel slag, an auxiliary-based material. It is important to note that the cracks and irregularities yield logistics inconvenience, the risk of traffic accidents, and increased road maintenance costs. X-ray diffraction analysis tests have been conducted in this study on the sample collected by pavement cutting and excavating the three target roads. It is well known that the primary cause of the expansion of steelmaking slag is the hydration reaction between CaO and MaO. While the reaction of CaO is completed within a few months, that of MgO is pretty slow depending on the firing temperature. The test results reveal that the MgO content of the testing samples is approximately 47% of the total average, and that of CaO is around 14% of the total average. Hence, these results make it possible to be understood that the expansion induced by the slow hydration reaction of MgO results in road uplift in the long term, resulting in the cracks and irregularities of roads.

• Biomolecules & Therapeutics
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• v.31 no.3
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• pp.264-275
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• 2023

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by tremors, bradykinesia, and rigidity. PD is caused by loss of dopaminergic (DA) neurons in the midbrain substantia nigra (SN) and therefore, replenishment of DA neurons via stem cell-based therapy is a potential treatment option. Astrocytes are the most abundant non-neuronal cells in the central nervous system and are promising candidates for reprogramming into neuronal cells because they share a common origin with neurons. The ability of neural progenitor cells (NPCs) to proliferate and differentiate may overcome the limitations of the reduced viability and function of transplanted cells after cell replacement therapy. Achaete-scute complex homolog-like 1 (Ascl1) is a well-known neuronal-specific factor that induces various cell types such as human and mouse astrocytes and fibroblasts to differentiate into neurons. Nurr1 is involved in the differentiation and maintenance of DA neurons, and decreased Nurr1 expression is known to be a major risk factor for PD. Previous studies have shown that direct conversion of astrocytes into DA neurons and NPCs can be induced by overexpression of Ascl1 and Nurr1 and additional transcription factors genes such as superoxide dismutase 1 and SRY-box 2. Here, we demonstrate that astrocytes isolated from the ventral midbrain, the origin of SN DA neurons, can be effectively converted into DA neurons and NPCs with enhanced viability. In addition, when these NPCs are inducted to differentiate, they exhibit key characteristics of DA neurons. Thus, direct conversion of midbrain astrocytes is a possible cell therapy strategy to treat neurodegenerative diseases.

• Structural Monitoring and Maintenance
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• v.10 no.1
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• pp.87-105
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• 2023

Seismic regulations have been updated from time to time to accommodate an increase in seismic hazards. Comparison of seismic fragility of the existing bridges in Indonesia from different historical periods since the era before 1990 will be the basis for seismic assessment of the bridge stock in Indonesia, most of which are located in earthquake-prone areas, especially those built many years ago with outdated regulations. In this study, seismic fragility curves were developed using incremental non-linear time history analysis and more holistically according to the actual strength of concrete and steel material in Indonesia to determine the uncertainty factor of structural capacity, βc. From the research that has been carried out, based on the current seismic load in SNI 2833:2016/Seismic Map 2017 (7% probability of exceedance in 75 years), the performance level of the bridge in the era before SNI 2833:2016 was Operational-Life Safety whereas the performance level of the bridge designed with SNI 2833:2016 was Elastic - Operational. The potential for more severe damage occurs in greater earthquake intensity. Collapse condition occurs at As = F_PGA x PGA value of bridge Era I = 0.93 g; Era II = 1.03 g; Era III = 1.22 g; Era IV = 1.54 g. Furthermore, the fragility analysis was also developed with geometric variations in the same bridge class to see the effect of these variations on the fragility, which is the basis for making bridge risk maps in Indonesia.

• Geomechanics and Engineering
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• v.36 no.5
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• pp.417-426
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• 2024

Shield tunneling method is widely used to build tunnels in complex geological environment. Stability control of tunnel face is the key to the safety of projects. To improve the excavation efficiency or perform equipment maintenance, the excavation chamber sometimes is not fully filled with support medium, which can reduce the load and increase tunneling speed while easily lead to ground collapse. Due to the high risk of the face failure under non-fully support mode, the tunnel face stability should be carefully evaluated. Whether compressive air is required for compensation and how much air pressure should be provided need to be determined accurately. Based on the upper bound theorem of limit analysis, a non-fully support rotational failure model is developed in this study. The failure mechanism of the model is verified by numerical simulation. It shows that increasing the density of supporting medium could significantly improve the stability of tunnel face while the increase of tunnel diameter would be unfavorable for the face stability. The critical support ratio is used to evaluate the face failure under the nonfully support mode, which could be an important index to determine whether the specific unsupported height could be allowed during shield tunneling. To avoid of face failure under the non-fully support mode, several charts are provided for the assessment of compressed air pressure, which could help engineers to determine the required air pressure for face stability.

• The Korean Journal of Air & Space Law and Policy
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• v.28 no.1
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• pp.73-96
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• 2013

ICAO's Universal Safety Oversight Audit Programme (USOAP) was initially launched in January 1995, in response to widespread concerns about the adequacy of aviation safety oversight around the world. The recent reduction in aircraft accidents and effective role that is evaluated on the basis of these results, and in 2013 the existing 'snapshot approach' to 'regular monitoring system (USOAP-Continuous Monitoring Approach)' was converted to. ICAO aviation safety assessment of the state in today's international community 'aviation safety credibility' as objective indicators to judge the enormous impact on the aviation industry, the state is not satisfactory, especially if the results of the evaluation and expansion of code-share airline ban, reduced international air transit passengers, including premium increases business and economic penalties should. In addition, ICAO implementation of the existing laws and regulations(Prescriptive Approach), but based on the Risk-based prevention model, Proactive Approach introduced the concept of aviation safety system, including international aviation safety policy has been to switch paradigms. This new ICAO international aviation safety policy also applies to the Government of the Republic of Korea in line with the aviation safey policies have changed. In particular, the systematic implementation of safety management for the existing laws and regulations in the center of the safety oversight system of risk-based introduction of the concept of proactive safety management, and According to international standards ICAO aviation service providers operate their own Safety Management System was set out in Aviation Law ever. In addition, the aviation safety is at the center of the field of the safety of aircraft operations and maintenance for the promotion is promoting various safety policies. This new paradigm shift in the international aviation safety policy in line with our state in the international community with the most exemplary aviation safety system firmly established itself as a model, the Government will strengthen the competitiveness of our aviation plans to support. To do this, the government, airlines, aviation officials try all the practical effect would be expected.