• Journal of Microbiology and Biotechnology
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• 제11권4호
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• pp.656-662
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• 2001

Angiogenesis is known as a crucial process in the growth and spreading of tumor cells. Accordingly, the effective inhibition of this process would appear to be a promising way to cure angiogenesis-related diseases, including cancer. This study demonstrates that acalycixenolide E (AX-E) from the marine organism Acalycigorgia inermis exhibits a potent anti-angiogenic activity both in vitro and in vivo. AX-E inhibits the bFGF-induced proliferation of HUVECs in a dose dependent manner, along with the bFGF-induced migration, invasion, and tube formation of HUVECs. Moreover, AX-E potently inhibits the in vivo neovascularization of the chorioallantoic membranes (CAMs) of growing chick embryos. interestingly, AX-E suppresses the expression of metalloproteases 2 and 9, yet shows no effect on their activities. The novel chemical structure and potent anti-angiogenic activity of AX-E will be of great value in elucidating the molecular mechanism of angiogenesis as well as in the development of a novel anti-angiogenic drug.

• 한국인터넷방송통신학회논문지
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• 제9권1호
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• pp.103-107
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• 2009

본 논문은 WLAN(Wireless Local Area Network)용 이중대역 칩 안테나를 설계 제작하였고, 외장형 AP(Access Point) 안테나와 달리 작은 LAN카드에 내장된다. 안테나의 사이즈에 제한이 있으므로 가능한 유전율이 높은 유전체를 이용하였으며, 수급의 문제, 가격의 문제, 특성의 문제 등을 종합적으로 고려했을 때, 세라믹의 상대 유전율은 9.8, 두께는 3.5mm와 5mm를 사용하였다. 설계 제작된 세라믹 안테나는 IEEE 802.11.a,g 그리고 b까지 트리플 모드로 사용할 수 있을 뿐 아니라 광대역에서 사용할 수 있다. 사용가능한 주파수 밴드는 2.4~2.5GHz & 4.9~5.85GHz의 광대역 특성을 가지며, 전 주파수 대역에서 비교적 일정한 성능을 갖는다.

• Progress in Superconductivity
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• 제11권1호
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• pp.72-77
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• 2009

Low temperature scanning laser microscopy (LTSLM) can be used for a two-dimensional display of bolometric response arising from the localized excitation of a sample by the focused laser beam. In this study, the distribution of critical temperature ($T_c$) and critical current density ($J_c$) in YBCO coated conductor were analyzed using LTSLM. For improving the temperature stability, we have modified the system into a double-shielding type. Through the modification, the temperature stability was successfully improved from ${\pm}10mK\;to\;{\pm}2mK$. The superconducting properties of YBCO coated conductors were measured for the sample of a narrow bridge type using wet etching process. The spatial non-uniformity of the ac voltage response, ${\delta}V(x)$, which is proportional to ${\partial}\rho(x,J_B)/{\partial}T$ in the transition temperature region could be observed and displayed in a two-dimensional image.

• 대한기계학회논문집B
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• 제24권10호
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• pp.1285-1293
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• 2000

In port fuel injection system of SI engines, injected fuel is impinged onto the surface of intake valves and port-wall, and then formed the wall flow under the cold start operation. Wall flows entrained into the cylinder result in the unsteady and nonuniform mixture formation. Therefore, the spray impingement to the wall is considered as having negative influences such as lowering combustion efficiency and causing unburned hydrocarbon emissions. This study investigates the spray characteristics of the wall impinging air-assist spray in suction air flow. A PDPA was used to analyze the flow characteristics under the different conditions such as impingement angle and supplied air. Experimental data concerning the impinging sprays has been obtained in the vicinity of the wall. Measured droplets divided into the pre-impinging droplets which denote as the positive normal velocities and post-impinging droplets that describe as the negative normal velocities for the suction flow. Their velocities, size distributions and SMD are comparatively analyzed before and after the impingement.

• 대한기계학회논문집B
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• 제32권1호
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• pp.39-46
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• 2008

The loss coefficient of the butterfly valve which allows partial opening of the valve at closed position and is applicable to the small-sized pipe system with the diameter of 1 inch was measured for the variation of the valve disk blockage ratio. Two different types of the valve disk configuration to adjust the blockage ratio were considered. One was the solid type valve disk of which the diameter was changed into the smaller size rather than the pipe diameter, and the other was the perforate type valve disk on which some holes were perforated. The results from two types of valve disk were compared to identify their characteristics in the loss coefficient distributions. The loss coefficient and the controllable angle of the valve disk were decreased exponentially with the decrease of the blockage ratio. In addition, the perforate valve disk had the effect on the higher loss coefficient rather than the solid type valve disk.

• International Journal of Automotive Technology
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• 제1권2호
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• pp.95-100
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• 2000

The droplet and the turbulent characteristics of a counterflowing internal mixing pneumatic nozzle mainly focused. The measurements were made using a Phase Doppler Particle Analyzer under the different air pressures. The nozzle with tangential-drilled holes at an angle of 30 to the central axis has been designed. The spatial distributions of velocities, fluctuating velocities, droplet diameters and SMD were quantitatively and qualitatively fluctuating velocities were substantially higher than the radial and the tangential ones. This implies that the disintegration process is enhanced with the higher air pressure. The larger droplets were detected near the spray centerline at the upstream while the smaller ones were generated at the downstream. This was attributed to the lower rates of spherical particles which were not subject to instantaneous breakup. However, substantial increases in SMD from the central part tower spray periphery were predictable in downstream regions.

• 대한기계학회논문집B
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• 제23권1호
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• pp.92-103
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• 1999

The fuel spray behavior in the intake port of an electronic control port irijection gasoline engine has a strong influence on engine performance, exhaust emission and fuel consumption. Thus, in this study, fuel spray behavior and flow characteristics of the air assist gasoline spray injected into a suction flow in a simulated rectangular intake port have boon investigated. Macro-behavior of spray characteristics was investigated by means of visualization and the measurements of SMD and velocity were made by PDPA. For analysis the flow field with droplets size, droplets are classified five droplets size groups. As a result, the normal distance of suction flow increasing, the relatively large droplets distribution and SMD increase because small droplets easily follow suction flow. Near impinging wail, after impinging against the wall, secondary atomized small droplets of D < $30{\mu}m$ bound from the wall. And the increasement of suction flow progress to the large droplets of D > $100{\mu}m$ distribution. Therefore, SMD are apparently increased near impinging wall, Z/d = 9.0.

• 대한기계학회논문집B
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• 제27권4호
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• pp.484-495
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• 2003

This study investigates the flow characteristics of fuel droplets between twin spray for the 4-hole injector used a 4-valve gasoline engine. The injectors for this study were the three types of 4-hole gasoline injector in which orifice diameter was 0.24mm. The spray behavior of twin spray was investigated by means of visualization employed stroboscope. A PDPA system was employed to simultaneously measure the size and velocity of fuel droplets. The 3 dimensional mean velocities. droplet size distributions, SMD and joint probability density function of velocity and droplet size are analyzed at the center of the spray and the center region of twin spray. As a result, the configurations of injector exit such as orifice interval and length of outlet, are very important factors that affect the flow characteristics of fuel droplets at the center region of twin spray.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집B
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• pp.758-763
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• 2001

This paper presents twin spray characteristics of two impinging F-O-O-F type injectors in which fuel and oxidizer impinge on each other to atomize under the various conditions. The droplet size and velocity in the impinging spray flow field were measured using a PDPA. The droplet size and velocity were investigated at mixture ratios of 1.5, 2.0, 2.47 and 3.0 for four injectors in which two single F-O-O-F injectors were arranged at intervals of 20.8, 31.2, 41.6 and 62.4mm respectively. In general, the arithmetic mean diameter, SMD and standard deviation of droplet size in the interaction area (X=0 and Y=0mm) were smaller. The axial velocity in the interaction area was slightly higher. Considering the behavior of impinged droplets using the We number calculated by using the axial velocity instead of the relative velocity in line C in Fig. 1(b) for four injectors, it is consumed that the We number over 500 had the possibility to disintegrate, and the We number below 500 had it to cohere after impingement of twin spray. The results of this study can be used for the design of a nozzle for liquid propellant rockets.

• Natural Product Sciences
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• 제20권4호
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• pp.269-273
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• 2014

Activity guided phytochemical examination of the rhizome of Phragmites communis has led to the isolation of two phenolic acids and two lignans. Structures of these compounds were elucidated as methyl gallate (1), ${\rho}$ -hydroxy cinnamic acid (2), (+) -lyoniresinol (3), (+)-lyoniresinol-9'-O-${\beta}$-D-glucopyranoside (4) by comparisons with previously reported spectral data. To investigate the melanogenesis inhibitory effects of these compounds, the melanin level and tyrosinase activity were examined in B16F10 melanoma cell. Each compound inhibited both tyrosinase activity and melanin synthesis compared with positive control, kojic acid and arbutin. These results suggest that the phenolic compounds from Phragmites communis might be developed as a potent skin whitenting cosmeceuticals.