• 한방안이비인후피부과학회지
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• 제10권1호
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• pp.185-208
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• 1997

A Literatual Study on the external treatment of eye diseases, the result were as follows. 1. The external treatment of eye diseases used eyedrops(點,滴), steam bath(熏), washing(洗), plaster(敷). 2. Eyedrops used filterated decoction. 3. Eye diseases used Bomeolum(永片), Coptidis Rhiwma(黃連), Angelicae gigantis Radix(當歸) with clearing away heat and toxic materials, clearing away swelling, pain, ithing and convulsion, clearing away nebula 4. Eye diseases used B-1(晴明), B-2(찬竹), Tae-Yang(太陽), S-1(承泣), G-1(瞳子료), S-2(四白), TE-23(絲竹空), Eo-Yo(魚腰), G-14(陽白), Gu-Hu(球後), G-20(風池), B-18(肝兪), LI-4(合谷), Liv-3(太衡, B-23(腎兪), G-37(光明), Liv-2(行間), GV-23(上星), and S-36(足三里).

• 대한수학회보
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• 제46권1호
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• pp.25-33
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• 2009

Let ${\pi}:E{\rightarrow}B$ be a Serre fibration with fibre F. We prove that if the inclusion map $i:F{\rightarrow}E$ has a left homotopy inverse r and ${\pi}:E{\rightarrow}B$ admits a cross section ${\rho}:B{\rightarrow}E$, then $G_n(E,F){\cong}{\pi}_n(B){\oplus}G_n(F)$. This is a generalization of the case of trivial fibration which has been proved by Lee and Woo in [8]. Using this result, we will prove that ${\pi}_n(X^A){\cong}{\pi}_n(X){\oplus}G_n(F)$ for the function space $X^A$ from a space A to a weak $H_*$-space X where the evaluation map ${\omega}:X^A{\rightarrow}X$ is regarded as a fibration.

• 대한화학회지
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• 제40권7호
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• pp.519-525
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• 1996

3-Carbomethoxy-1(3H)-isobenzofuraneme(9)과 .alpha., .beta.-불포화 에스테르 화합물 3a-b를 각각 반응시켜서 naphthacene-6, 7-dione 11a-b를 좋은 수율로 얻었다. 이들 중 C-9 위치에 에틸기가 없는 11a는 산화시켰을 때 naphthacene-5, 12-dione 13a가 생성되는 반면, 에틸기를 갖고 있는 11b는 naphthacene-5, 7, 12-trione 12b와 naphthacene-5, 12-dione 13b가 3:2로 생성되어졌다.

• KSBB Journal
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• 제23권1호
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• pp.44-47
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• 2008

Streptomyces peucetius가 생산하는 anthracycline 계열의 doxorubicin은 치료목적으로 사용되는 중요한 항암제 중 하나이다. Doxorubicin은 rhodomycin D에서부터 몇 단계의 생합성 과정을 더 거쳐 생산되는데, 생물학적 활성을 갖기 위해서는 deoxy-sugar의 전이가 반드시 일어나야 한다. 본 논문에서는 이종균주인 Streptomyces venezuelae에 11개의 유전자를 형질 전환하여 TDP-L-daunosamine를 생산하고 이것을 ${\varepsilon}$-rhodomycinone에 전이하여 rhodomycin D를 생산하는 연구를 수행하였다. S. peucetius 유래의 7개 유전자 dnmU, T, J, V, Z, Q, S.를 당 합성 및 전이를 위해 plasmid 형태로 전이하였으며, S. venezuelae의 desIII, IV와 doxorubicin 내성 유전자인 drrA, B는 chromosomal DNA에 삽입하였다. Aglycone 기질인 ${\varepsilon}$-rhodomycinone을 확보하기 위하여 6L의 고체 배지에 S. peucetius를 배양하여 유기용매로 추출하고 preparative HPLC로 분리 정제하였다. 결과적으로 이종균주인 S. venezuelae에서 ${\varepsilon}$-rhodomycinone에 당 전이가 일어난 생산물을 확인함으로써 deoxy-sugar의 생합성 및 전이에 필요한 최소한의 유전적 정보를 확인할 수 있었다. 또한, 유사서열 단백질 모델링을 통하여, 최초로 당 전이 반응에 필수적인 도움효소 DnrQ의 구조를 예측하였다.

• Journal of Radiation Protection and Research
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• 제43권2호
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• pp.75-84
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• 2018

Background: Gamma-ray spectrometry helps in radiation shielding problems and different applications of radioisotopes. Experimental arrangements including broad beam geometries are widely used. The aim is to investigate and evaluate the ${\gamma}-ray$ spectra via attenuation by environmental materials. Materials and Methods: The photo peak to nominated parts in the ${\gamma}-ray$ spectra and the attenuation coefficients ${\mu}_b/{\rho}$ from broad beam geometries are measured for the materials water, soil, sand and cement at the energies 0.662, 1.25, and 1.332 MeV with a $3{^{\prime}^{\prime}}{\times}3{^{\prime}^{\prime}}$ NaI(Tl) detector. Results and Discussion: The ${\gamma}-ray$ spectra vary according to changes in the effective atomic number $Z_{eff}$ of the attenuator, the photon energy and the solid angle. The peak to total ratios are the most sensitive parts to variations in the experimental conditions and overturn in the region 0.663 MeV to 1.332 MeV. This is indicated as inversion trend. The results are discussed in view of $Z_{eff}$ and the experimental conditions. The intensity build-up is larger at the lower energy and larger scattering angles in agreement with Klein-Nishina formula and other results. The build-up factor B is$${\sim_=}$$1 at high ${\gamma}-energies$ and small scattering angles. Conclusion: The sensitivity to material characteristics decrease gradually from peak: to total, to Compton valley, to Compton plateau ratios. Rigorous collimation is necessary at small energies. Cement, of the largest $Z_{eff}$, is characterized by the maximum broad beam mass attenuation coefficients ${\mu}_b/{\rho}$. The obtained results provide information to decide for the suitable experimental set-up based on aim of the work.

• IEIE Transactions on Smart Processing and Computing
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• 제4권3호
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• pp.189-193
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• 2015

This paper provides the design techniques of a successive approximation register (SAR) type 12b analog-to-digital converter (ADC) for distributed maximum power point tracking (DMPPT) control in a photovoltaic system. Both a top-plate sampling technique and a $V_{CM}$-based switching technique are applied to the 12b capacitor digital-to-analog converter (CDAC). With these techniques, we can implement a 12b SAR ADC with a 10b capacitor array digital-to-analog converter (DAC). To enhance the accuracy of the ADC, a single-to-differential converted DAC is exploited with the dual sampling technique during top-plate sampling. Simulation results show that the proposed ADC can achieve a signal-to-noise plus distortion ratio (SNDR) of 70.8dB, a spurious free dynamic range (SFDR) of 83.3dB and an effective number of bits (ENOB) of 11.5b with bipolar CMOS LDMOD (BCDMOS) $0.35{\mu}m$ technology. Total power consumption is 115uW under a supply voltage of 3.3V at a sampling frequency of 1.25MHz. And the figure of merit (FoM) is 32.68fJ/conversion-step.

• Elastomers and Composites
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• 제33권1호
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• pp.27-36
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• 1998

The surface of wiper blade(W/B) rubber was chlorinated by chemical treatment method using the hydrochloric acid(HCI) and sodium hypochlorite(NaOCl). From the results of contact angle measurement, friction coefficient measurement, and ATR-IR spectra, the surface characteristics of chlorinated W/B rubber with time of chlorination were studied. Contact angles for W/B rubber with increasing time of chlorination and chlorine concentration were measured for the water and ethylene glycol. From the results, contact angle fell rapidly with increasing time of chlorination and chlorine concentration, reaching a constant value after about 10min. And the wettability of W/B rubber surface by means of chlorination has been improved. For an unchlorinated W/B rubber, the friction coefficient with time of chlorination decreased from 1.27 to 0.20~0.23 on full chlorination. As the results it was considered that abrasion resistance of W/B rubber surface has been also improved. The values of pH and $Cl^-$ ion concentration in a chlorine treatment solution decreased as the extent of chlorination of W/B rubber surface increased. From the results of ATR-IR spectra, it was observed that C=C double band of W/B rubber surface transformed into C-Cl band, but quantitative determination of the extent of chlorination was not feasible because of the complexity of chlorination reactions.

• 한국식품영양학회지
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• 제22권3호
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• pp.402-408
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• 2009

The study assessed the quality characteristics of Sulgiddeok with self-made and commercially-available rice flours during a 1-day storage at ambient temperature($20\sim22^{\circ}C$). The nutritional components, color value, physical tests, internal structure as revealed by scanning electron microscopy SEM, and sensory evaluation of Sulgiddeok were determined. Sulgiddeok prepared with self-made rice flour and two commercial rice flour were designated as sample A, B, and C, respectively. Moisture content, crude protein, crude lipid, and pH did not differ significantly among the preparations. Sweetness was highest in sample B(p<0.01) and crude ash was highest in sample A(p<0.001). L color, a value, and b value was highest in sample B, C, and C, respectively. Texture property analysis showed that hardness, gumminess, and chewiness tended to decrease during the 1-day storage, while adhesiveness, springiness, and cohesiveness tended to increase. Sensory characteristics of color, flavor, chewiness, gumminess, externals, and overall quality of sample A were superior to samples B and C. However, softness was highest in sample B. The internal structure of Sulgiddeok was preserved in sample A. It is concluded that rice flour B can make Sulgiddeok comparable to that prepared using self-made rice flour.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.330-339
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• 2023

Liver kinase B1 (LKB1) is a crucial tumor suppressor involved in various cellular processes, including embryonic development, tumor initiation and progression, cell adhesion, apoptosis, and metabolism. However, the precise mechanisms underlying its functions remain elusive. In this study, we demonstrate that LKB1 interacts directly with malic enzyme 3 (ME3) through the N-terminus of the enzyme and identified the binding regions necessary for this interaction. The binding activity was confirmed to promote the expression of ME3 in an LKB1-dependent manner and was also shown to induce apoptosis activity. Furthermore, LKB1 and ME3 overexpression upregulated the expression of tumour suppressor proteins (p53 and p21) and downregulated the expression of antiapoptotic proteins (nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and B-cell lymphoma 2 (Bcl-2)). Additionally, LKB1 and ME3 enhanced the transcription of p21 and p53 and inhibited the transcription of NF-κB. Moreover, LKB1 and ME3 suppressed the phosphorylation of various components of the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B signaling pathway. Overall, these results suggest that LKB1 promotes pro-apoptotic activities by inducing ME3 expression.

• 대한전자공학회논문지
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• 제5권3호
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• pp.1-8
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• 1968

이 열전발전기는 Bi계화합물 반도체 Sb2Te3 및 소량의 불순물을 함유한 ZnSb를 사용하여 실험한 것으로 열기전력 α, 비저항ρ, 열전도율k 및 고온부의 온도차를 측정하였다. 특성은 다른 재료를 사용한 열전발전기보다 Sb2Te3+Bi2Se3와 Bi3Te2+Sb2Te3를 소자로 사용한 경우 효율이 우수하였으며 이의 효율은 1.42%였다.