• The Korean Journal of Physiology and Pharmacology
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• 제23권6호
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• pp.493-499
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• 2019

Macrophage-associated inflammation is crucial for the pathogenesis of diverse diseases including metabolic disorders. Rhodanthpyrone (Rho) is an active component of Gentiana rhodantha, which has been used in traditional Chinese medicine to treat inflammation. Although synthesis procedures of RhoA and RhoB were reported, the biological effects of the specific compounds have never been explored. In this study, the anti-inflammatory activity and mechanisms of action of RhoA and RhoB were studied in lipopolysaccharide (LPS)-stimulated macrophages. Pretreatment with RhoA and RhoB decreased inducible nitric oxide synthase and cyclooxygenase-2 expressions in RAW 264.7 cells and in thioglycollate-elicited mouse peritoneal macrophages. In addition, it downregulated transcript levels of several inflammatory genes in LPS-stimulated RAW 264.7 cells, including inflammatory cytokines/chemokines (Tnfa, Il6, and Ccl2) and inflammatory mediators (Nos2 and Ptgs2). Macrophage chemotaxis was also inhibited by treatment with the compounds. Mechanistic studies revealed that RhoA and RhoB suppressed the nuclear factor $(NF)-{\kappa}B$ pathway, but not the canonical mitogen activated protein kinase pathway, in LPS-stimulated condition. Moreover, the inhibitory effect of RhoA and RhoB on inflammatory gene expressions was attenuated by treatment with an $NF-{\kappa}B$ inhibitor. Our findings suggest that RhoA and RhoB play an anti-inflammatory role at least in part by suppressing the $NF-{\kappa}B$ pathway during macrophage-mediated inflammation.

• Structural Engineering and Mechanics
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• 제48권6호
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• pp.833-848
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• 2013

Nine rectangular-section of High Strength Concrete(HSC) beams were designed and casted based on the American Concrete Institute (ACI) code provisons with varying of tensile reinforcement ratio as (${\rho}_{min}$, $0.2_{{\rho}b}$, $0.3_{{\rho}b}$, $0.4_{{\rho}b}$, $0.5_{{\rho}b}$, $0.75_{{\rho}b}$, $0.85_{{\rho}b}$, $_{{\rho}b}$, $1.2_{{\rho}b}$). Steel and concrete strains and deflections were measured at different points of the beam's length for every incremental load up to failure. The ductility ratios were calculated and the moment-curvature and load-deflection curves were drawn. The results showed that the ductility ratio reduced to less than 2 when the tensile reinforcement ratio increased to $0.5_{{\rho}b}$. Comparison of the theoretical ductility coefficient from CSA94, NZS95 and ACI with the experimental ones shows that the three mentioned codes exhibit conservative values for low reinforced HSC beams. For over-reinforced HSC beams, only the CSA94 provision is more valid. ACI bending provision is 10 percent conservative for assessing of ultimate bending moment in low-reinforced HSC section while its results are valid for over-reinforced HSC sections. The ACI code provision is non-conservative for the modulus of rupture and needs to be reviewed.

• 콘크리트학회지
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• 제8권6호
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• pp.141-149
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• 1996

동일한 인장철근배근상태($\rho$/$\rho_b$=constant)에서 휨을 받는 고강도 철근 콘크리트 보는 보통강도의 철근 콘크리트보에 비해 더욱 취성적인 거동을 하게 된다. 본 실험결과 연성적인 파괴를 유도하기 위하여 콘크리트의 강도가 830kg/$cm^2$이상일 경우 철근비를 $0.6\rho_b$이하로 배근하여야 할 것으로 나타났다. 또한 콘크리트 강도가 830kg/$cm^2$ 이상일 경우 사각형응력 블록을 사용한 ACI 휨강도식의 안전율이 감소하였으며, 삼각형에 가까운 압축응력 분포를 나타내었다. 이는 콘크리트 강도가 증가할수록 응력-변형률 곡선이 거의 선형적으로 증가하는 재료적 성질에 기인하는 것으로 사료된다.

• 한국컴퓨터정보학회논문지
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• 제20권8호
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• pp.29-33
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• 2015

This paper proposes a discrete logarithm algorithm that remarkably reduces the execution time of Pollard's Rho algorithm. Pollard's Rho algorithm computes congruence or collision of ${\alpha}^a{\beta}^b{\equiv}{\alpha}^A{\beta}^B$ (modp) from the initial value a = b = 0, only to derive ${\gamma}$ from $(a+b{\gamma})=(A+B{\gamma})$, ${\gamma}(B-b)=(a-A)$. The basic Pollard's Rho algorithm computes $x_i=(x_{i-1})^2,{\alpha}x_{i-1},{\beta}x_{i-1}$ given ${\alpha}^a{\beta}^b{\equiv}x$(modp), and the general algorithm computes $x_i=(x_{i-1})^2$, $Mx_{i-1}$, $Nx_{i-1}$ for randomly selected $M={\alpha}^m$, $N={\beta}^n$. This paper proposes 4-model Pollard Rho algorithm that seeks ${\beta}_{\gamma}={\alpha}^{\gamma},{\beta}_{\gamma}={\alpha}^{(p-1)/2+{\gamma}}$, and ${\beta}_{{\gamma}^{-1}}={\alpha}^{(p-1)-{\gamma}}$) from $m=n={\lceil}{\sqrt{n}{\rceil}$, (a,b) = (0,0), (1,1). The proposed algorithm has proven to improve the performance of the (0,0)-basic Pollard's Rho algorithm by 71.70%.

• 대한수학회지
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• 제50권4호
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• pp.727-753
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• 2013

In this paper, we introduce three new broad classes of second-order generalized convex functions, namely, ($\mathcal{F}$, $b$, ${\phi}$, ${\rho}$, ${\theta}$)-sounivex functions, ($\mathcal{F}$, $b$, ${\phi}$, ${\rho}$, ${\theta}$)-pseudosounivex functions, and ($\mathcal{F}$, $b$, ${\phi}$, ${\rho}$, ${\theta}$)-quasisounivex functions; formulate eight general second-order duality models; and prove appropriate duality theorems under various generalized ($\mathcal{F}$, $b$, ${\phi}$, ${\rho}$, ${\theta}$)-sounivexity assumptions for a multiobjective programming problem containing arbitrary norms.

• The Korean Journal of Ecology
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• 제27권1호
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• pp.27-33
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• 2004

Cryptomeria japonica plantation was monitored every year during 15 years from 1983 to 1997 for stem diameter and volume. The reciprocal equation, 1/Y = A + B/N, was applied to the relationship between cumulative volume Y and cumulative number N from the largest tree in the stand each year. The parameters A and B, which means respectively the reciprocal of an asymptotic value of total stand stem volume and the reciprocal of the maximum stem volume, are related by a power function. The power functional relationship between A and B derived a linear relationship of B-points ( $N_{B}$, $V_{B}$; $N_{B}$ = B/A, $Y_{B}$ = 1/2A) of each Y-N curve on log-log coordinates. The gradient of B-point line was so steep that the Y-N curve moved parallel upward year by year. The time trajectory of mean stem volume (W) and density ($\rho$) provided evidence in favor of the 3/2 power law of self-thinning, because the gradient of W - $\rho$ trajectory on log-log coordinates approximated to -3/2 at the final stage of stand development. On the basis of the results of Y-N curves and W - $\rho$ trajectory, the time trajectory of maximum stem volume $W_{max obs}$ and $\rho$ was derived theoretically. The gradient of $W_{max obs}$ - $\rho$ trajectory on log-log coordinates is calculated to be -0.6105 at the final stage. The gradient of $W_{max obs}$ - $\rho$ trajectory was steeper than that of W - $\rho$ trajectory at the early stage, while the former is gentler than the latter at the later stage.stage.e.age.e.

• Korean Journal of Mathematics
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• 제6권1호
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• pp.127-135
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• 1998

Let ${\rho}(A)$ and ${\rho}(B)$ denote the orders of entire functions $A(z)$ and $B(z)$ respectively. Suppose that ${\rho}(A)$ > 1 and 0 < ${\rho}(B){\leq}\frac{1}{2}$, and that ${\rho}$(A) is not an integer. Then it is shown that every nonconstant solution $f$ of $f^{{\prime}{\prime}}+A(z)f^{\prime}+B(z)f=0$ is of infinite order if all the zeros of $A(z)$ lie in a certain angular sector depending on its genus. In addition, we investigate some growth properties of $A(z)$.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1997년도 봄 학술발표회 논문집
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• pp.475-482
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• 1997

This study reports the results of flexural test on 6 specimens for maximum reinforcement ratio and 4 specimens for minmum reinforcement ratio with concrete compressive strength 1,000, 1,200 kg/$\textrm{cm}^2$ . The major test variables for the reinforcement ratio designed 0.55$\rho_b$, 0.65$\rho_b$, 0.75$\rho_b$ for maximurm reinforcement ratio test 14/fy $\sqrt[0.72]{\rho}\acute{f}_c$ / $f_y$ for minimum reinforcement ratio test. The test results were compared with ACI 318-95 Code. In the Ultra High Strength Concrete beam, the maximum reinforcement ration should be less than 0.6$\rho_b$ for ductile behavior and the existing minimum reinforcement ratio by ACI Building Code is Sufficiently safe.

• Journal of Welding and Joining
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• 제13권4호
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• pp.147-154
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• 1995

In order to study the bonding mechanism of Ni/B/Ni transient liquid phase bonding system, width of liquid layers were calculated, where in this system melting point of insert material(B) is higher than bonding temperature and melting point of base metal(Ni). Caclulated values were compared with experimental ones which were measured by bonding Ni/B/Ni system at 1433-1474K under vacuum atmosphere. As results, the width of initial liquid layer of Ni/B/Ni system was calculated as $W_{IL}$ = $W_{o}$[1 + {2.100..rho.$_{S/}$ ( $X_{3}$ + $X_{4}$)..rho.$_{Ni}$ }-.rho.$_{S/}$.rho. Ni/], and it was nearly same with experimental values. Maximum width of liquid layer, width of liquid layer during isothermal solidification and isothermal solidification time were calculated also.o.o.o.

• 한국자기공명학회논문지
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• 제17권1호
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• pp.24-29
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• 2013

The structural characteristics of 4-coordinate $BO_4$ [B(1)] and 3-coordinate $BO_3$ [B(2)] groups in $BiB_3O_6$ were studied by $^{11}B$ magic angle spinning (MAS) and single-crystal nuclear magnetic resonance (NMR) spectroscopy. The spin-lattice relaxation time in the laboratory frame, $T_1$, for $^{11}B$ decreased slowly with increasing temperature, whereas the spin-lattice relaxation times in the rotating frame, $T_{1{\rho}}$, for B(1) and B(2), which differed from $T_1$, were nearly constant. Further, $T_{1{\rho}}$ for B(1) and B(2) showed very similar trends, although the $T_{1{\rho}}$ value of B(2) was shorter than that of B(1). The 3-coordinate $BO_3$ and 4-coordinate $BO_4$ were distinguished by $^{11}B$ MAS NMR spectrum and $T_{1{\rho}}$.