• 제목/요약/키워드: Rheumatoid arthritis

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기침 및 호흡곤란을 호소하는 폐 이식 환자의 복합 한방 치험 1례 (A Case Report of Patient Suffering from Cough and Dyspnea after Lung Transplantation Treated with Complex Korean Medicine)

  • 이세연;구기범;김마리아;남이랑;김민화;한창우;이인;홍진우;권정남;김소연;윤영주;박소정;최준용
    • 대한한방내과학회지
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    • 제44권5호
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    • pp.1101-1108
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    • 2023
  • We report the case of a lung transplantation patient whose cough and dyspnea symptoms improved after receiving complex Korean medicine treatment. Lung transplantation provides a solution to many end-stage patients with lung disease who are refractory to conventional treatment, but the five-year survival rate of lung transplantation remains around 50%, and even surviving patients suffer from side effects, including infection, respiratory difficulty, and gastrointestinal problems. A 66-year-old woman with rheumatoid arthritis-interstitial lung disease was advised to undergo lung transplantation surgery when she suffered from dyspnea and failing respiratory symptoms after being diagnosed with COVID-19 and contracting pneumonia. Approximately five months after receiving a bilateral lung transplantation operation, she experienced acute pulmonary thromboembolism, and even after receiving anticoagulation therapy, she still struggled with cough and respiratory difficulty. After she received complex Korean medicine treatments, including herbal medicine, cupping therapy, and electrical moxibustion, we observed a decrease in inflammation, alleviation of symptoms such as cough and dyspnea, and improvement of pulmonary function and exercise capacity.

염증성 질환에 대한 Crocin의 치료 효과 (Therapeutic Effect of Crocin in Inflammatory Diseases)

  • 김영희
    • 생명과학회지
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    • 제34권2호
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    • pp.138-144
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    • 2024
  • Crocin은 여러 가지 요리에 향미와 색깔을 주는 치자 열매나 사프란에 함유되어 있는 적노란색의 수용성 색소이다. 사프란과 치자는 전통의학 분야에서 부종, 해열, 해독 작용이 있어 바이러스성 간염, 식도염, 관상동맥심장병, 신경쇠약, 불면증, 퇴행성 신경질환, 호흡기 질환, 비뇨기 질환 등을 치료하는데 사용되어 왔다. Crocin (C44H64O24)은 카로테노이드의 복합체로, dicarboxylic acid crocetin과 disaccharide gentiobiose로 이루어진 diester이다. Crocin은 혈액학적인, 병리학적인 독성이나 유전독성이 없다. 현재까지 수많은 생체 내 및 생체 외 연구들을 통해 Crocin의 생물학적인 약리작용이 밝혀지고 있다. 본 총설에서는 염증성 장질환, 위염, 천식, 동맥경화, 류머티스 관절염, 다발성 경화증, 당뇨, 알츠하이머병, 파킨슨병, 우울증 등의 염증 관련 질환에서 Crocin의 보호 효과를 요약한다. Crocin은 다양한 작용 기전을 통해 항염, 항산화, 세포 자살 방지 기능을 함으로써 이들 질환을 개선하는 것으로 추론된다.

CORRIGENDUM : Korean treatment recommendations for patients with axial spondyloarthritis

  • Mi Ryoung Seo;Jina Yeo;Jun Won Park;Yeon-Ah Lee;Ju Ho Lee;Eun Ha Kang;Seon Mi Ji;Seong-Ryul Kwon;Seong-Kyu Kim;Tae-Jong Kim;Tae-Hwan Kim;Hye Won Kim;Min-Chan Park;Kichul Shin;Sang-Hoon Lee;Eun Young Lee;Hoon Suk Cha;Seung Cheol Shim;Youngim Yoon;Seung Ho Lee;Jun Hong Lim;Han Joo Baek;Korean Society of Spondyloarthritis Research
    • The Korean journal of internal medicine
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    • 제39권1호
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    • pp.200-200
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    • 2024

Reverse total shoulder replacement for patients with "weight-bearing" shoulders

  • Ofer Levy;Georgios Arealis;Oren Tsvieli;Paolo Consigliere;Omri Lubovsky
    • Clinics in Shoulder and Elbow
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    • 제27권2호
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    • pp.183-195
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    • 2024
  • Background: Reverse total shoulder arthroplasty (rTSA) has gained popularity in recent years and is indicated for a wide variety of shoulder pathologies. However, use of rTSA in patients with "weight-bearing" shoulders that support wheelchair use or crutches has higher risk. The aim of this study was to assess the results of rTSA in such patients. Methods: Between 2005 and 2014, 24 patients (30 shoulders) with weight-bearing shoulders were treated with rTSA at our unit. Patients had cuff arthropathy (n=21), rheumatoid arthritis (n=3), osteoarthritis (n=1), acute fracture (n=3), or fracture sequela (n=2). Postoperatively, patients were advised not to push themselves up and out of their wheelchair for 6 weeks. This study was performed in 2016, and 21 patients (27 shoulders) were available for a mean follow-up of 5.6 years (range, 2-10 years). The mean age at surgery was 78 years (range, 54-90 years). Results: Constant-Murley score improved from 9.4 preoperatively to 59.8 at the final follow-up (P=0.001). Pain score improved from 2/15 to 13.8/15 (P=0.001). Patient satisfaction (Subjective Shoulder Value) improved from 0.6/10 to 8.7/10 (P=0.001). Significant improvement in mean range of motion from 46° to 130° of elevation, 14° to 35° of external rotation, and 29° to 78° internal rotation was recorded (P=0.001). Final mean Activities of Daily Living External and Internal Rotation was 32.4/36. Only three patients showed Sirveaux-Nerot grade-1 (10%) glenoid notching and three grade 2 (10%). Conclusions: rTSA can be used for treatment of patients with weight-bearing shoulders. Such patients reported pain free movement, resumed daily activities, and high satisfaction rates.

구강 미생물이 치주질환 및 전신건강에 미치는 영향에 관한 연구 현황 고찰 (Review of Research Status on the Impact of Oral Microorganisms on Periodontal Disease and Systemic Health)

  • 김선미;권은자;최에스더
    • 보건의료생명과학 논문지
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    • 제11권2호
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    • pp.393-405
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    • 2023
  • 구강질환은 전 세계적으로 약 35억 명의 인구에 영향을 미치는 것으로 보고되었고, 국내에서 치은염 및 치주질환이 2019년부터 2021년까지 다빈도 상병 1위를 차지하였다. 구강질환을 일으키는 대표적인 박테리아로 Streptococcus mutans, Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus gordonii, Leptotrichia buccalis, Prevotella, Treponema 등이 있고, 진균류로는 Candida albicans, 고세균으로 Methanobrevibacter oralis 등이 있다. 구강 미생물이 치주질환을 일으키는 과정을 살펴보면, Streptococcus mutans 와 같은 박테리아가 먼저 증식하여 바이오필름을 형성하고, 이어서 절대혐기성 미생물, 기회감염균 및 병원균이 부착하여 증식하면서 숙주의 치은연하에 치태를 형성하며 정착하게 된다. 이처럼 마이크로바이옴 군집 내 다양한 상호작용이 구강질환 발생에 중요하다. 나아가서 구강 미생물과 구강질환으로 인하여 생성된 물질 및 염증이 소화기질환, 당뇨병, 심혈관질환, 인지기능, 류마티스 관절염, 조산, 암과 같은 질환 발생과 밀접한 관련성이 있으며, 한편으로 이러한 질환들이 구강질환을 일으키는 원인이 된다.

만성통증 환자의 통증 조절 (Chronic pain control in patients with rheumatoid arthritis)

  • 은영
    • 근관절건강학회지
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    • 제2권1호
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    • pp.17-40
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    • 1995
  • Rheumatoid arthritis is the one of the chronic diseases, one of its major symptoms is a chronic pain. Despite developing medical treatment and surgical techniques, it is suggested that to control the pain is the goal of the treatment. But pain is an inner experience and even those closest to the patient cannot truly observe its progress or share in its suffering. The National Academy of Sciences Institute of Medicine's report on Pain and Disability concluded that there is no objective measure of pain-(exactly) no pain thermometer-nor can there ever be one, because the experience of pain is inseparable from personal perception and social influence such as culture. To explore chronic pain experience is to understand the process and property of the patient's perception of pain through the response to pain, the coping with pain, and the adaptation to pain. Therefore a qualitative study was conducted in order to gain an understanding of pain experience of patients with RA in korea. I used naturalistic inquiry as a research methodology, which had 5 axioms, the first is that realities are multiple, constructed, and holistic, the second is that knower and known are interactive, inseparable, the third is only time and context bound working hypotheses(idiographic statements) are possible, the forth is all entities are in a state of mutual simultaneous shaping, so that it is impossible to distinguish causes from effects and the last is that inquiry is value-bound. Purposive sampling was conducted as a sampling. 20 subjects who experienced pain over 10 years, lived in middle-sized city and big city in Korea, and 17 women and 3 men. The subject's age was from 32 to 62 (average 48.8), all were married, living with their spouse and children, except two-one divorced and the other widow before they became ill. I collected data using In depth structured interview. I had interviews two or three times with each subject, and the interviews were conducted at each subject's home. Each interview lasted about two hours an average. A recording was taken with the consent of the subject. I used inductive data analysis-such as unitizing and categorizing. unitizing is a process of coding, whereby raw data are systematically transformed and aggregated into units. Categorizing is a process wherby previously unitized data are organized into categories that provide descriptive or inferential information about the context or setting from which the units were derived. This process is used constant comparative method. The pain controlling process is composed of behavior of pain control. The behaviors of pain control are rearranging of ADL, hiddening role conflict, balancing treatment, and changing social relation. Rearranging of ADL includes diet management, sleep management, and the adjustment of daily life activities. The subjects try to rearrange their daily activities by modified style of motions, rearranging time span & range of activities, using auxillary facilities, and getting help in order to keep on the pace of daily life. Hiddening role conflict means to reduce conflicts between sick role and their role as a family member. In this process, the subjects use two modes, one is to control the pain complaints, and the other is to internalize the value which is to stay home is good for caring her children and being a good mother. To control pain complaints is done by 'enduring', 'understanding' the other family members, or making them undersood in order to reduce pain. Balancing treatment is composed of two aspects. One is to keep the pain within the endurable level, the other is to keep in touch with medical personnel in order to get the information of treatment and emotional support. Changing social relation is made by information seeking and sharing, formation of mutual support relation, and finally simplification of social relationships. The subjects simplify their social relationships by refraining from relations with someone who makes them physically and psychologically strained. In particular the subjects are apt to avoid contact with in-laws, and the change of relation to in-laws results in lessening the family boundary. In the course of this process, they confront the crisis of family confict result in family dissolution. This crisis is related to the threat of self-existence. Findings from this study contribute to understanding the chronic pain experience. To advance this study, we should compare this result with other cases in different cultural contexts. I think to interpret these results, korean cultural background should be considered. Especially the different family concept, more broader family members and kinship network, and the traditional medical knowledge influences patients' behavior.

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식품안정성 수준에 따른 한국노인의 건강상태와 영양섭취현황: 제7기 (2016-2018) 국민건강영양조사 자료 활용 (Health and nutrition intake status of the Korean elderly according to their food security level: data from the 7th Korea National Health and Nutrition Examination Survey (KNHANES VII), 2016-2018)

  • 맹아름;이지현;윤은주
    • Journal of Nutrition and Health
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    • 제54권2호
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    • pp.179-198
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    • 2021
  • 본 연구는 제7기 (2016-2018년) 국민건강영양조사 자료를 활용하여 노인의 식품안정성에 따른 건강과 영양섭취 현황을 분석하고자 하였다. 식품불안정 그룹일수록 직장건강보험 가입자 비율이 유의적으로 낮았으며, 자신의 건강상태에 대한 주관적 평가 점수가 낮았다. 질환과의 상관관계에서 식품불안정 그룹일수록 남자는 류마티스성 관절염, 골다공증에서 여자는 고혈압과 뇌졸중 진단 비율이 높았으며, 관절염과 골관절염은 남녀 노인 모두에서 질환보유 비율이 유의적으로 높게 나타났다. 의료이용실태에서는 식품안정성이 낮을수록 필요한 의료를 받지 못한 것으로 나타났고, 의료서비스를 이용하지 못한 이유를 분석해본 결과, 경제적인 이유라고 답한 비율이 식품안정성이 낮은 그룹에서 높았다. 또한 남녀 노인 모두 유의하게 나타나는 변수를 보정한 후, 건강관련 삶의 질 저하에 대해 식품안정성에 따라 분석한 결과, 성별에 따라 세부 항목에 차이는 나타났지만 전반적으로 식품불안정 그룹일수록 안정한 그룹에 비해 더욱 삶의 질이 저하되는 위험이 컸다. 한 번에 마시는 음주량이 7잔 이상인 비율이 식품안정성이 낮을수록 남녀 노인 모두 유의적으로 높았으며, 특히, 남자 노인에서는 식품안정성이 낮을수록 가족이나 의사로부터 금주를 권유 받거나, 조사 시점 직전 1년 동안 음주 상담을 받은 경험이 유의적으로 더 높았다. 에너지 필요추정량 (EER)보다 낮게 섭취하는 비율이 남녀 노인 모두 식품불안정 그룹에서 유의적으로 높았으며, 단백질, 비타민 A, 비타민 B1, 비타민 B2, 나이아신, 비타민 C, 칼슘, 철분을 낮게 섭취하는 비율 또한 이 그룹에서 유의적으로 높았다. 식품안정성에 따른 영양소의 에너지 섭취비율 및 주요 영양소의 밀도를 분석한 결과, 남녀 모두 단백질, 지방에서의 에너지섭취 비율과 비타민 B2, 나이아신, 칼슘, 칼륨, 인의 영양밀도가 식품불안정 그룹에서 유의하게 낮게 나타났으며, 식품불안정군 남자노인은 비타민 A, 여자 노인은 철분의 영양밀도가 유의하게 낮은 것으로 나타났다. 결론적으로 식품안정성은 사회경제적인 특성, 건강 상태, 삶의 질, 영양과 밀접하게 서로 연계되어 있는 것으로, 고령화 사회에서 취약 계층인 노인의 식품안정성 영향 요인을 확인하여 식품안정성을 확보하는 것과 함께 이들의 식품안정성과 관련한 건강 문제를 개선함으로써 추후 막대한 사회적 비용이 될 노인 의료비를 줄일 수 있는 영양지원 프로그램을 개발하기 위한 방향성을 설정하는데 있어 본 연구가 도움이 될 것으로 사료된다.

인체폐암세포에서 봉독에 의한 prostagladin E2 생성 및 telomerase 활성 저하 (Bee Venom-induced Growth Inhibition of Human Lung Cancer Cells was Associated with Inhibition of Prostagladin E2 Production and Telomerase Activity.)

  • 김종환;황원덕;김병우;최영현
    • 생명과학회지
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    • 제19권4호
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    • pp.502-507
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    • 2009
  • 본 연구에서는 봉독의 처리에 따른 A549 폐암세포의 증식억제에서 $PGE_2$ 생성 및 telomerase 활성의 변화 관련성을 조사하였다. A549 세포의 증식은 봉독 처리에 의하여 유의적으로 감소되었으며, 이는 apoptosis 유발과 연관성이 있음을 알 수 있었다. 봉독 처리 농도의 증가에 따라 COX-2의 발현이 전사 및 번역 수준에서 모두 감소되었으며 이에 따른 $PGE_2$의 생성이 현저하게 감소되었으나, COX-1의 발현에는 큰 변화가 없었다. 또한 봉독 처리에 따라 telomere 조절인자들 중, hTERT, hTR 및 c-myc의 발현이 억제되었으며, telomerase의 활성도 매우 감소되었다. 본 연구의 결과는 $PGE_2$ 생성과 telomerase 활성 저하가 봉독의 항암 작용 표적인자로서 작용될 수 있음을 보여준다.

백하수오(白何首烏) 물 추출물의 파골세포 분화에 미치는 영향 (Effect of Water Extract of Cynanchi Wilfordii Radix in RANKL-induced Osteoclast Differentiation)

  • 안용환;오재민;이명수;정종혁;채수욱;문서영;전병훈;최민규
    • 동의생리병리학회지
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    • 제26권2호
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    • pp.160-165
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    • 2012
  • Osteoporotic fracture became a serious social problem, which related with mortality and morbidity in old age population. Osteoclast which is responsible for bone resorption is originated from hematopoietic cell line and plays a key role osteoporotic bone loss. Cynanchum wilfordii (Asclepiadaceae) roots have been used in Korean folk medicine for the treatment of diabetes mellitus and aging progression. Also, recent studies have shown that the extract and fractions of Cynanchi Wilfordii Radix have various pharmacological actions including scavenging free radicals, enhancing immunity, reducing high serum cholesterol, and anti-tumor activity. However, the effect of extract of Cynanchi Wilfordii Radix in osteoclast differentiation had not been reported. Thus, we evaluated the effect of Cynanchi Wilfordii Radix on receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation. Through our study, we found that Cynanchi Wilfordii Radix significantly inhibited osteoclast differentiation induced by RANKL. Cynanchi Wilfordii Radix suppressed the activation of p38 pathway and $NF{\kappa}B$ in bone marrow macrophages (BMMs) treated with RANKL. Also, Cynanchi Wilfordii Radix significantly inhibited the mRNA expression of c-Fos, tartrate-resistant acid phosphatase (TRAP), osteoclast-associated receptor (OSCAR), nuclear factor of activated T cells (NFAT)c1 and cathepsin K in BMMs treated with RANKL. Particularly, Cynanchi Wilfordii Radix inhibited the protein expression of c-fos and NFATc1. Taken together, our results demonstrated that Cynanchi Wilfordii Radix may be useful treatment option of bone-related disease such as osteoporosis leads to fracture of bone and rheumatoid arthritis.

진교의 파골세포 분화 및 골 흡수 유전자 억제기전 연구 (Gentianae Macrophyllae Radix Water Extract Inhibits RANKL-Induced Osteoclastogenesis and Osteoclast Specific Genes)

  • 양규진;김재현;김민선;류광현;문진호;이혜인;정혁상;손영주
    • Korean Journal of Acupuncture
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    • 제37권2호
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    • pp.63-75
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    • 2020
  • Objectives : Osteoporosis is the most common bone disease and osteoporosis fracture is the leading cause of decreased life. Bisphosphonate and selective estrogen receptor modulators are the best choice of treatment for osteoporosis. However, when used for a long time, they increase the probability of side effect such as osteonecrosis of the jaw. Thus, it is crucial to develop alternative medicine to treat osteoporosis. Gentianae Macrophyllae Radix, a herbal medicine, is mainly to treat rheumatoid arthritis. However, the effect of the water extract of Gentianae Macrophyllae Radix (w-GM) on osteoporosis has not been investigated. Thus, we examine whether w-GM can inhibit osteoclast differentiation and bone resorption on receptor activator of nuclear factor kappa-B (NF-κB) ligand (RANKL)-treated RAW 264.7 cells. In this study, RAW 264.7 cells were used as an osteoclast differentiation model by treating them with RANKL. Methods : RAW 264.7 cells were used to determine the effect of w-GM on osteoclast differentiation and bone resorption. The number of tartrate-resistant acid phosphatase (TRAP)-positive cells, TRAP activity and pit formation assay were examined. In addition, protein expressions were measured by western blot and mRNA expressions were analyzed by reverse transcription polymerase chain reaction. Results : Treatment with w-GM inhibited the number of TRAP-positive cells, TRAP activity and pit area. In addition, w-GM decreased protein expression such as mitogen-activated protein kinase, NF-κB, c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1). It also inhibited the mRNA levels such as c-Fos, NFATc1, TRAP, NF-κB, calcitonin receptor and cathepsin K in RANKL-treated RAW 264.7 cells. Conclusions : These results suggest that w-GM has inhibitory effects via osteoclast differentiation, thus it could be a new medication for osteoporosis.