• Genomics & Informatics
• /
• v.17 no.2
• /
• pp.18.1-18.10
• /
• 2019

Prediction of the relations among drug and other molecular or social entities is the main knowledge discovery pattern for the purpose of drug-related knowledge discovery. Computational approaches have combined the information from different sources and levels for drug-related knowledge discovery, which provides a sophisticated comprehension of the relationship among drugs, targets, diseases, and targeted genes, at the molecular level, or relationships among drugs, usage, side effect, safety, and user preference, at a social level. In this research, previous work from the BioNLP community and matrix or matrix decomposition was reviewed, compared, and concluded, and eventually, the BioNLP open-shared task was introduced as a promising case study representing this area.

• Korea Trade Review
• /
• v.44 no.4
• /
• pp.101-114
• /
• 2019

E-business enables SMEs to reduce transaction costs and maintain export competitiveness in rapidly changing overseas markets. It is required to raise the entrepreneurial awareness of e-business of exporting SMEs. This study examines the characteristics of enterprises that play an important role in the introduction and utilization of e-business by domestic export SMEs. It explores the mechanisms that search and exploit these opportunities in an entrepreneurial way, and examines the process leading to export performance. We conducted a survey for empirical analysis and analyzed the data from 316 companies using e-business in Korea. As a result, both the international entrepreneurial orientation and the IT competence tended to be significant for the perception of e-business entrepreneurs and showed a different pattern in terms of size of influence. In addition, cooperation and operation among e-business entrepreneurs' perceptions have a direct impact on the export performance of SMEs.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
• /
• v.32 no.3
• /
• pp.150-152
• /
• 2021

Lobular capillary hemangioma (LCH) is a type of benign vascular tumor. It arises from vascular endothelial cells and contains capillaries arranged in a lobular pattern. In the head and neck, the most common presenting location of LCH is the lips, and presentation in the larynx is very rare. LCH might not be distinct from granuloma in macroscopic views. We report a 71-year-old female with LCH of the larynx that was totally resected via laryngeal microsurgery with a CO₂ laser and briefly review the literature.

• Journal of Gastric Cancer
• /
• v.23 no.1
• /
• pp.171-181
• /
• 2023

Currently, the prevalence of gastroesophageal junction adenocarcinoma (GEJAC) is increasing in both Asian and Western countries, although the increasing rate in Asian countries is much slower than in Western countries. With these current trends, concerns regarding the surgical treatment method are also increasing among gastrointestinal surgeons. However, the surgical treatment for GEJAC has been a controversial issue for a long time due to the relative scarcity of this tumor and its characteristics from its borderline location. Recently, a large-scale prospective study of this tumor has been conducted in Japan, and the results are now available. The results of this study will be helpful for understanding this tumor. In this article, the pattern of lymph node metastasis of GEJAC is reviewed, and the extent and method of lymph node dissection for this tumor are discussed and proposed based on the review.

• International Journal of Computer Science & Network Security
• /
• v.23 no.1
• /
• pp.125-139
• /
• 2023

Facial expression recognition, a topical problem in the field of computer vision and pattern recognition, is a direct means of recognizing human emotions and behaviors. This paper first summarizes the datasets commonly used for expression recognition and their associated characteristics and presents traditional machine learning algorithms and their benefits and drawbacks from three key techniques of face expression; image pre-processing, feature extraction, and expression classification. Deep learning-oriented expression recognition methods and various algorithmic framework performances are also analyzed and compared. Finally, the current barriers to facial expression recognition and potential developments are highlighted.

• Biomolecules & Therapeutics
• /
• v.31 no.4
• /
• pp.395-401
• /
• 2023

Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.

• Journal of Digestive Cancer Research
• /
• v.5 no.1
• /
• pp.5-15
• /
• 2017

Hepatocellular carcinoma (HCC) is the sixth most common cancer and second leading cause of cancer-related death in the world. The aggressive but not always predictable pattern of HCC causes the limited treatment option and poorer outcome. Many researches had already proven the heterogeneity of HCC is one of the major challenges for treatment option and prognosis prediction. Molecular subtyping of HCC and selection of patient based on molecular profile can provide the optimization in the treatment and prognosis prediction. In this review, we have tried to summarize the molecular classification of HCC proposed by different valuable researches presented in the logistic way.

• Journal of Digestive Cancer Research
• /
• v.1 no.2
• /
• pp.89-94
• /
• 2013

The dramatic increase in colorectal cancer incidence in the population of East Asia indicates that diet and lifestyle play a role in colorectal cancer risk. Colorectal cancer prevention and etiologic studies have long provided dietary modification strategies for colorectal cancer prevention. In this review, we provide an overview of the epidemiologic evidence on the association between diet and colorectal cancer risk. Several cohort studies and a few intervention studies, most conducted in Western countries, have shown a possible link between red and processed meat, alcoholic beverages, calcium, vitamin D, vitamin B and the Western dietary pattern with colorectal cancer development. For colorectal cancer prevention in both Western and Asian populations, dietary modification is a key component of colorectal cancer prevention.

• IMMUNE NETWORK
• /
• v.16 no.1
• /
• pp.52-60
• /
• 2016

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that bridge innate and adaptive immune responses, thereby leading to immune activation. DCs have been known to recognize pathogen-associated molecular patterns such as lipopolysaccharides (LPS) and nucleic acids via their pattern recognition receptors, which trigger signaling of their maturation and effector functions. Furthermore, DCs take up and process antigens as a form of peptide loaded on the major histocompatibility complex (MHC) and present them to T cells, which are responsible for the adaptive immune response. Conversely, DCs can also play a role in inducing immune suppression under specific circumstances. From this perspective, the role of DCs is related to tolerance rather than immunity. Immunologists refer to these special DCs as tolerogenic DCs (tolDCs). However, the definition of tolDCs is controversial, and there is limited information on their development and characteristics. In this review, we discuss the current concept of tolDCs, cutting-edge methods for generating tolDCs in vitro, and future applications of tolDCs, including clinical use.