• 경영과학
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• 제21권1호
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• pp.39-55
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• 2004

Efficient crew scheduling for cockpit crew is important in airline industry due to operational safety and cost associated with the flight duty time. Because of complexity of regulations imposed to the cockpit crew. it is complicated to generate an efficient schedule. Schedule of cockpit crew can be generated through two steps; selecting of flight patterns. and scheduling of them to the specific time horizon. Heuristic method is developed and applied with massive data in a limited time of computation. A set of flight patterns is selected from all possible flight patterns. which are generated by composing the flight leg based on regulations. by using the set partitioning problem with objective function of oversea stay cost. The selected set of flight patterns found at the first step is allocated to 4 week crew schedule to minimize the variance of total fight time assigned to each crew. The crew schedules obtained are evaluated and compared with the ones currently used in one of major airline company.

• Reproductive and Developmental Biology
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• 제38권1호
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• pp.35-40
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• 2014

Beta-catenin (CTNNB1, catenin (cadherin-associated protein), beta 1) is involved in various biological processes, including embryogenesis, tumorigenesis, angiogenesis and progression of metastasis. CTNNB1, as a multifunctional and oncogenic protein, has important roles in adhesion between Sertoli cells through an N-cadherin-dependent manner and in various cancer types through its over-activation. In addition, CTNNB1 can interact with estrogen/estrogen receptor alpha complex, which regulates the transcription of WNT (wingless-type MMTV integration site family)/CTNNB1 target genes. Recently, we investigated the functional roles and expression pattern of CTNNB1 during the morphological changes of embryonic gonads of chickens and the estrogen-dependent regulation of CTNNB1 in oviduct development and potential functions as a biomarker of CTNNB1 in human epithelial ovarian cancer using the chicken as a biological research model. Therefore, in this review, we provide a new insight of potential role of CTNNB1 in the development of the female reproductive tract during early embryogenesis and ovarian carcinogenesis of laying hen models.

• Journal of Yeungnam Medical Science
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• 제3권1호
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• pp.333-337
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• 1986

저자들은 증세 발현된 회맹판 주위 장관 지방 종 3예를 치험하였으며 특히 회장의 구역 지방 종증은 아주 희귀하여 문헌고찰과 함께 보고하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제58권6호
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• pp.554-556
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• 2015

Primary intracranial malignant melanoma is a very rare and highly aggressive tumor with poor prognosis. A 66-year-old female patient presented a headache that had been slowly progressing for several months. A large benign pigmented skin lesion was found on her back. A brain MRI showed multiple linear signal changes with branching pattern and strong enhancement in the temporal lobe. The cytological and immunohiostochemical cerebrospinal fluid examination confirmed malignant melanoma. A biopsy confirmed that the pigmented skin lesion on the back and the conjunctiva were benign nevi. We report a case of primary intracranial malignant melanoma and review relevant literatures.

• Journal of Acupuncture Research
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• 제20권2호
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• pp.18-28
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• 2003

Objective : To research the trends of study related to osteoarthritis with acupuncture in PubMed, and to establish he hereafter direction of acupuncture for osteoarthritis. Methods : We searthed in PubMed, with osteoarthritis and acupuncture limited by abstract, human, English. Results : 1. The pattern of study was as follow: Review article(2), Clinical Trials(13), randomized controlled trials(13). bee venom acupuncture(1), electroacupuncture(1). We further estimated 15 articles. 2. The lesion of osteoarthritis & kinds of acupuncture were as follows: knee(12), hip(2), cervical vertebral(1), bee venom acupuncture(1), electroacupuncture(1). 3. Most clinical trials are related to decrease of pain, functional improvement. 4. 10 of clinical studies provide affirmative result. And they recommend acupuncture for osteoarthritis. 5. 4 of clinical studies provide negative result. And these studies are designed by sham acupuncture method.

• 대한간호학회지
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• 제28권3호
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• pp.563-572
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• 1998

The purpose of study was to develop and validate Korean Sleep Scale A which can be easily administrated by nurses for a wide range of adult subjects. Dimensions of sleep concept were derived by literature review. Previously developed sleep sclaes were also analyzed in order to develop scale items. The Korean sleep scale A was structured as a 15 item, 4 point likert type scale. The Scale was tested an 298 female and male adult subjects after pilottest and content validation. The results showed reliability by internal consistency of Cronbach's α=.75 Construct validity was tested by factor analysis and known group technique. Factor analysis showed 4 factors-sleep pattern, sleep evaluation, sleep result, and cause of sleep disturbance. These four factors explained 55.9% of total variance. Correlations between factors ranged from .15-.32. There was correlation among Korean Sleep ScaleA score, Verran and Snyder-Halpern(VSH) Sleep Scale score, and sleep satisfaction scale score, r=.71(p=.00), r=.51(p=.03), respectively, These study results partially support reliability, construct validity, and criterion related validity of Korean Sleep Scale A. Further validation study is required with other subjects and other settings.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8041-8045
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• 2016

Cervical cancer is one of the most common cancers in women worldwide. During their life time the vast majority of women become infected with human papillomavirus (HPV), but interestingly only a small portion develop cervical cancer and in the remainder infection regresses to a normal healthy state. Beyond HPV status, associated molecular characterization of disease has to be established. However, initial work suggests the existence of several different molecular classes, based on the biological features of differentially expressed genes in each subtype. This suggests that additional risk factors play an important role in the outcome of infection. Host genomic factors play an important role in the outcome of such complex or multifactor diseases such as cervical cancer and are also known to regulate the rate of disease progression. The aim of this review was to compile advances in the field of host genomics of HPV positive and negative cervical cancer and their association with clinical response.

• 통상정보연구
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• 제8권4호
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• pp.277-300
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• 2006

In the initial stage of a national economic development of China, the family business takes enterprise's organizational form ruling position. The private enterprise of China is mainly family business; the family makes the mainly proprietorship in other words. Even in the private enterprise after developing, 70 percents are managed as a family This paper start to study the Transferring Power Patterns in family business using the Company's Life Circle Theory and some other correlative theories. Based on the Transporting Power Model, the paper gives a comprehensive explanation for the choice of transferring power pattern in the family business of China.

• Animal cells and systems
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• 제13권1호
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• pp.1-8
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• 2009

Toll-like receptor (TLR) family proteins, type I transmembrane proteins, play a central role in human innate immune response by recognizing common structural patterns in diverse molecules from bacteria, viruses and fungi. Recently four structures of the TLR and ligand complexes have been determined by high resolution x-ray crystallographic technique. In this review we summarize reported structures of TLRs and their proposed activation mechanisms. The structures demonstrate that binding of agonistic ligands to the extracellular domains of TLRs induces homo- or heterodimerization of the receptors. Dimerization of the TLR extracellular domains brings their two C-termini into close proximity. This suggests a plausible mechanism of TLR activation: ligand induces dimerization of the extracellular domains, which enforces juxtaposition of intracellular signaling domains for recruitment of intracellular adaptor proteins for signal initiation.

• 대한가정학회지
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• 제19권3호
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• pp.1-9
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• 1981

The object of this study lies in reviewing of the western costume history in the light of the negative regulations concerning costumes and adornments. Readings related with the subject lead to the following findings; 1. the principal purpose of the sumptuary laws has relationship with the social stratification of the feudalism and the frequency of their occurrence is related with the formation of feudal system, its decline, the appearance of imperial regimes and the start of civil revolutions. 2. Sumptuary regulations spread westward with the flow of civilization, eg., in the sequence of Italy, swiss, France, Britain and new world. 3. Sumptuary laws are also found in abundance in the english colonies of America, and their object seems to be rather of the moral concern than class distinction of economical restriction.4. The reviewed sumptuary regulations are concerned with : A. Material gold or silver clothes, silks, ermine, marten or miniver furs, velvets, laces and embroies. B. Colors-Purple, scarlet and red. Other colors do not show consistent pattern of color-status symbol; C. Form-Length and width of headdresses, shoes, collars, trains or hoops. E. numbers of dresses allowed to be worn.