• ETRI Journal
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• v.19 no.3
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• pp.228-241
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• 1997

In this paper, we present a design of modem and vocoder digital signal processor (DSP) chips for CDMA mobile station. The modem chip integrates CDMA reverse link modulator, CDMA forward link demodulator and Viterbi decoder. This chip contains 89,000 gates and 29 kbit RAMs, and the chip size is $10 mm{\times}10.1 mm$ which is fabricated using a $0.8{\mu}m$ 2 metal CMOs technology. To carry out the system-level simulation, models of the base station modulator, the fading channel, the automatic gain control loop, and the microcontroller were developed and interfaced with a gate-level description of the modem application specific integrated circuit (ASIC). The Modem chip is now successfully working in the real CDMA mobile station on its first fab-out. A new DSP architecture was designed to implement the Qualcomm code exited linear prediction (QCELP) vocoder algorithm in an efficient way. The 16 bit vocoder DSP chip has an architecture which supports direct and immediate addressing modes in one instruction cycle, combined with a RISC-type instruction set. This turns out to be effective for the implementation of vocoder algorithm in terms of performance and power consumption. The implementation of QCELP algorithm in our DSP requires only 28 million instruction per second (MIPS) of computation and 290 mW of power consumption. The DSP chip contains 32,000 gates, 32K ($2k{\times}16\;bit$) RAM, and 240k ($10k{\times}24\;bit$) ROM. The die size is $8.7\;mm{\times}8.3\;mm$ and chip is fabricated using $0.8\;{\mu}m$ CMOS technology.

• Korean Journal of Computational Design and Engineering
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• v.3 no.3
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• pp.201-209
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• 1998

To develop timely an optimal fan, a design system and a new manufacturing process used step by step have to be integrated. A small sized optimal fan for refrigerators, that was the goal on this project, was developed by the following principal processes. All processes are technologically linked in many directions: The existing fan was measured through reverse engineering. The measured data was used for the basic source of 3D design. The performance tests were carried and used as the data for the evaluation of the existing fan. Flow analysis by FANS-3D/sup [1]/ was performed at the given information (pressure drop and flow rate) to find out the configuration of optimal fan design. The flow patterns were investigated to measure the performance of fan through numerical experiment. The grid point data obtained by the above analysis turned into 3D high efficiency fan model by using CATIA. The product was manufactured by RP process (SLS, SLA) and tested the characteristic curves of the developed fan to compare with the existing fan. The modification of fan design were all examined to see any change in performance and checked to find any deficiency in assembling the fan into a duct. After the plastics flow analysis of the injection molding cycle to ensure acceptable quality fan, an optimal mold was processed by using tool-path for the newly designed fan.

• Clinical and Experimental Reproductive Medicine
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• v.26 no.3
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• pp.377-381
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• 1999

Objectives: Recent studies, including our own, demonstrated that the novel expression of LH gene in rat gonads and uterus, indicating that the local production and action of the LH-like molecule. In the present study, we investigated whether human uterus also expresses the LH gene. Design: Reverse transcription-polymerase chain reaction (RT-PCR) amplified the cDNA fragments coding $LH_{\beta}$ polypeptide from human endometrium but not from myometrium. Presence of the transcripts for the ${\alpha}$-subunit in human endometrium was also confirmed by RT-PCR. Results: Transcripts for $LH_{\beta}$ subunit were detected in endometrial samples from women with endometriosis. The gene for LH/hCG receptor was expressed in both endometrium and myometrium, showing good agreement with previous studies. Increased level of $LH_{\beta}$ transcript was determined in the endometrium from follicular phase compared to that from luteal phase. Conclusion: Taken together, our findings demonstrated that 1) the genes for LH subunits and LH/hCG receptor are expressed in human uterus, 2) the uterine LH expression was changed during menstrual cycle, suggesting that the uterine LH may playa local role in the control of uterine physiology and function(s).

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2001.11b
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• pp.676-681
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• 2001

We usually divide the noise of exhaust system into pulsation noise and flow noise. Pulsation noise is the shock wave to occur when the burning gas of low pressure emits and include harmonic having basic frequency as the exhaust cycle of engine. Flow noise is the noise that is produced when gas flow emits into the atmosphere through the pipe and has the character of frequency like pink noise which has the high level of high frequency component. A muffler is divided into reflective type and absorptive type. We usually use the muffler compounding the property of them. In this study, it is the case of transfer matrix method that a muffler is compounded to analyze the elements of each section according to sound wave's proceed direction. But we use simple model. So, we use finite element method that takes short time to analyze. Acoustic analysis gives us transfer matrix to use FEA of SYSNOISE and we use STAR-CD for fluid analysis. We made database that is based on analytical results about the muffler of expansion type, extended type, offset type, reverse type, and perforated type and developed the muffler design system to perform work efficiently.

• The Transactions of the Korean Institute of Power Electronics
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• v.27 no.2
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• pp.85-91
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• 2022

This study proposes a high efficiency bridgeless Power Factor Correction (PFC) converter with improved common mode noise characteristics. Conventional PFC has limitations due to low efficiency and enlarged heat sink from considerable conduction loss of bridge diode. By applying a Common Mode (CM) coupled inductor, the proposed bridgeless PFC converter generates less conduction loss as only a small magnetizing current of the CM coupled inductor flows through the input diode, thereby reducing or removing heat sink. The input diode is alternately conducted every half cycle of 60 Hz AC input voltage while a negative node of AC input voltage is always connected to the ground, thus improving common mode noise characteristics. With the aim to improve switching loss and reverse recovery of output diode, the proposed circuit employs Critical Conduction Mode (CrM) operation and it features a simple Zero Current Detection (ZCD) circuit for the CrM. In addition, the input current sensing is possible with the shunt resistor instead of the expensive current sensor. Experimental results through 480 W prototype are presented to verify the validity of the proposed circuit.

• Journal of the Korean Society for Precision Engineering
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• v.14 no.10
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• pp.35-43
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• 1997

In this paper, we perform a mechanism analysis and optimal design of the feeding system in a industrial sewing machine. Sewing machines are classified by the transfer mechanism as (1) transferred by feeddog only (2) transferred by feeddog and needle (3) transferred by feeddog, needle and pressure bar. The sewing machine classified as (2) is studied which is more efficient in transferring fabrics than the machine classified as (1). In analyzing the mechanism, we divide the feeding mechanism as feeddog mechanism and needle bar mechanism. The two mechanisms are conneted with each other kinematically because fabrics are transferred by two needles and a feeddog simultaneously and stitched by two needles which pass through the feeddog in every stitch cycle. We define good stitch as coincidence of stitch between the forward and reverse motion of feeding. We optimize the feeding mechanism for that purpose. It is illustrated that stitching performance of the optimized mechanism is compared to original feeding mechanism.

• Journal of Bio-Environment Control
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• v.17 no.4
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• pp.247-251
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• 2008

During a 35-day growth cycle, N, P, and K uptake was determined by measuring changes in their contents in culture solutions. At harvest, plants were separated into the roots, base organs and shoot, and dried for tissue analysis for N, P, and K. The uptake rates of N, P, and K followed cyclical patterns that was related to shoot development and harvest, but were independent of the transpiration rate. Uptake of N declined from 5.6 mmol $plant^{-1}$ $day^{-1}$ just prior to the cycle initiation to 4.0 mmol $plant^{-1}$ $day^{-1}$ at day 15. Uptake rate steadily increased as flower stems reached maturity up to 10.3 mmol $plant^{-1}$ $day^{-1}$ day 35. Uptakes rates of P and K followed similar patterns of N uptake. Tissue concentrations of N and P steadily decreased since day 15. Content of K was the lowest at day 20 and steadily increased thereafter. In the root tissue, N and K contents were the lowest at day 15, increased to day 30, and then decreased at day 35. Tissue P content was just a reverse of those of N and K.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5437-5442
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• 2014

Esophageal squamous cell carcinoma (ESCC) is one of the most malignancies with a poor prognosis. The phospholipase $C{\varepsilon}$ gene (PLCE1) encodes a novel ras-related protein effector mediating the effects of R-Ras on the actin cytoskeleton and membrane protrusion. However, molecular mechanisms pertinent to ESCC are unclear. We therefore designed PLCE1-special small interfering RNA and transfected to esophageal squamous cell (EC) 9706 cells to investigat the effects of PLCE1 gene silencing on the cell cycle and apoptosis of ESCC and indicate its important role in the development of ESCC. Esophageal cancer tissue specimens and normal esophageal mucosa were obtained and assayed by immunohistochemical staining to confirm overexpression of PLCE1 in neoplasias. Fluorescence microscopy was used to examine transfection efficiency, while the result of PLCE1 silencing was examined by reverse transcription (RT-PCR). Flow cytometry and annexin V apoptosis assays were used to assess the cell cycle and apoptosis, respectively. Expression of cyclin D1 and caspase-3 was detected by Western-blotting. The level of PLCE1 protein in esophageal cancer tissue was significantly higher than that in normal tissue. After transfection, the expression of PLCE1 mRNA in EC 9706 was significantly reduced, compared with the control group. Furthermore, flow cytometry results suggested that the PLCE1 gene silencing arrested the cell cycle in the G0/G1 phase; apoptosis was significantly higher than in the negative control group and mock group. PLCE1 gene silencing by RNAi resulted in decreased expression of cyclin D1 and increased expression of caspase-3. Our study suggests that PLCE1 may be an oncogene and play an important role in esophageal carcinogenesis through regulating proteins which control cell cycling and apoptosis.

• Herbal Formula Science
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• v.23 no.2
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• pp.199-208
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• 2015

Objectives : In the present study, we investigated the effects of ethanol extract of Scutellaria baicalensis (EESB) on the progression of cell cycle in human renal cell carcinoma Caki-1 cells. Methods : The effects of EESB on cell growth and apoptosis induction were evaluated by trypan blue dye exclusion assay and flow cytometry, respectively. The mRNA and protein levels were determined by Western blot analysis and reverse transcription-polymerase chain reaction, respectively. Results : It was found that EESB treatment on Caki-1 cells resulted in a dose-dependent inhibition of cell growth and induced apoptotic cell death as detected by Annexin V-FITC staining. The flow cytometric analysis indicated that EESB resulted in G2/M arrest in cell cycle progression which was associated with the down-regulation of cyclin A expression. Our results also revealed that treatment with EESB increased the mRNA and proteins expression of tumor suppressor p53 and cyclin-dependent kinase (Cdk) inhibitor p21(WAF1/CIP1), without any noticeable changes in cyclin B1, Cdk2 and Cdc2. In addition, the incubation of cells with EESB resulted in a significant increase in the binding of p21 and Cdk2 and Cdc2. These findings suggest that EESB-induced G2/M arrest and apoptosis in Caki-1 cells is mediated through the p53-mediated upregulation of Cdk inhibitor p21. Conclusions : Taken together, these findings suggest that EESB may be a potential chemotherapeutic agent and further studies will be needed to identify the biological active compounds that confer the anti-cancer activity of S. baicalensis.

• Journal of Applied Biological Chemistry
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• v.57 no.2
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• pp.103-111
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• 2014

A1E is an extract from traditional Asian medicinal plants that has therapeutic activities against cancers, metabolic disease, and other intractable conditions. However, its mechanism of action on cervical cancer has not been studied. In order to ascertain if A1E would have pronounced anti-cervical cancer effect, cervical cancer cells were incubated with A1E and apoptosis was detected by nuclear morphological changes, annexin V-FITC/PI staining, cell cycle analysis, western blotting, Reverse-transcription polymerase chain reaction, and measurement of mitochondrial membrane potential. Expression of human papiloma virus E6 and E7 oncogenes was down-regulated in A1E-treated cervical cancer cells, while p53 and retinoblastoma protein levels were enhanced. A1E also perturbed cell cycle progression at sub-G1 and altered cell cycle regulatory factors in SiHa cervical cancer cells. A1E activated apoptotic intrinsic pathway markers such as caspase-9, caspase-3 and poly ADP-ribose polymerase, and down-regulated expression of Bcl-2 and Bcl-xl. A1E induced mitochondrial membrane potential collapse and cytochrome c release, and inhibited phosphatidylinositol 3-kinase (PI3K)/Akt, key factors involved in cell survival signaling. Taken all these results, A1E induced apoptosis via activation of the intrinsic pathway and inhibition of the PI3K/Akt survival-signaling pathway in SiHa cervical cancer cells. In conclusion, A1E exerts anti-proliferative action growth inhibition on cervical cancer cells through apoptosis which demonstrates its anti-cervical cancer properties.