• 전기의세계
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• 제31권1호
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• pp.50-58
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• 1982

As a method for improving the power factor and the waveform of ac line current drawn by ac to dc converters, converters of pulse-width control type with forced commutation circuits have been developed in recent years. However, these converters have rather complex commutation circuits which contain auxiliary thyristors in addition to the main thyristors, and their performance is not satisfactory. This paper proposes a new pulse-width controlled ac to dc converter, and analyses its commutation mechanism and its input and output characteristics. The proposed converter circuit consists of a usual thyristor bridge circuit with series diodes to which reactors and diodes are added. This circuit dose not contain auxiliary thyristors, and in this sense it is simpler than the previous converter circuits of pulse-width control type. Since the main thyristors of the converter can be forcedly turned off several times in a half cycle of source voltage, a pulse-width modulation control is possible in order to improve the current waveform as well as the power factor on ac line side. As to dc output side it is shown that the adjustable range of output voltage is wide and the voltage regulation is good due to a rapid reversal of voltage across the commutating capacitors by LC resonance during commutation period. It is also shown that the regenerative operation of the converter is possible.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2311-2314
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• 2016

Pistagremic acid (PA) is a bioactive triterpenoid isolated from various parts of Pistacia integerrima plants. The aim of this research was to investigate PA for reversion of multidrug resistant (MDR) mediated by P-glycoprotein using rhodamine-123 exclusion study on a multidrug resistant human ABCB1 (ATP-binding cassette, sub-family B, member 1) gene-transfected mouse T-lymphoma cell line in vitro. Results were similar to those with verapamil as a positive control. Docking studies of PA and standard Rhodamine123 were carried out against a P-gp crystal structure which showed satisfactory results. Actually, PA cannot bind exactly where co-crystallized ligand of P-gp is already present. However, the docking study predicted that if a compound gives a lesser score then it may have some potency. The docking scores of PA and Rhodamine were similar. Therefore, we can conclude that there are certain important chemical features of PA which are responsible for the inhibiting potency of P-gp.

• 한국음향학회지
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• 제38권6호
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• pp.678-686
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• 2019

수중에서는 다중 경로로 인한 인접 심볼 간 간섭의 영향으로 통신 성능이 저하되며, 수동형 시역전 처리는 다중 경로를 완화하기 위한 가장 효율적인 기법이다. 수동형 시역전 처리의 성능을 향상시키기 위해 다이버시티 결합기법이 이용되고 있으며, 본 논문에서는 여러 각도로의 빔 조향을 통해 획득한 신호들을 결합하는 빔 다이버시티 결합기법을 이용하여 통신 성능을 분석하였다. 수직 선 배열 센서에 수신된 탐침 신호로부터 추정한 빔-시간 그래프를 통해 음파의 전달 각도들을 추정하였으며, 추정된 각도 중 결합 개수 및 방식에 따른 통신 성능을 분석하였다. 분석을 위해 2018년 10월 포항 동방 해역에서 수행된 Biomimetic Long range Acoustic Communications 2018(BLAC18) 실험 데이터를 활용하였으며, 통신 성능 지표로써 출력 신호 대 잡음비를 이용하였다.

• 한국음향학회지
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• 제40권5호
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• pp.428-438
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• 2021

심해 장거리 통신에서는 전달 손실이 적은 낮은 반송 주파수가 효율적이지만, 좁은 대역폭을 가지는 제약이 따른다. 대역폭의 감소는 전송률의 감소를 의미하며, 제한된 대역폭을 가진 환경에서 전송률을 증가시키기 위해서는 고차 변조 기법으로 설계될 필요가 있다. 본 논문은 고차 변조 기법으로 설계된 장거리 수중음향통신 데이터 분석 결과를 제시한다. 2020년 10월 동해에서 예인 음원을 이용한 장거리 해상실험 (23 km ~)이 수행되었고, 수직 선 배열을 통해 데이터를 획득하였다. 본 연구팀은 위상 변조 방식이 적용된 Phase Shift Keying (PSK) 계열 신호와 위상 및 진폭 변조 방식이 적용된 Quadrature Amplitude Modulation (QAM) 계열의 신호를 송신하였으며, 구체적으로 각 계열별 두 종류의 신호를 설계하였다; 1) PSK : quadrature PSK and 8PSK, 2) QAM : 8QAM and 16QAM. 데이터 분석을 위해 수신 신호와 채널 임펄스 응답 사이의 상관성을 활용하여 심볼 간 간섭을 완화시키는 시역전 처리가 적용되었다. 23 km 거리 데이터에 대해 모든 변조 방식이 성공적으로 복조됨으로써 장거리 환경에서 고차 변조 기법의 활용 가능성을 실험적으로 확인하였다.

• 전자공학회논문지A
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• 제31A권7호
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• pp.69-75
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• 1994

A very fine pattern formation process using double exposure is investigated, which can overcome the resolution limit of optical wafer stepper. The very fine pattern can be obtained by moving the edge profile of large pattern by means of moving the stepper stage. The simulation results show that the light transmittance decrease bellow 9%, and the contrast increase to 16.6% for the 0.3$\mu$m photoresist pattern exposeed by the double exposure using i-line wafer stepper. And the experimental results show that fine photoresist pattern as short as 0.2$\mu$m can be obtained without a loss of photoresist thickness. Also, it proves that the depth of focus for 0.3$\mu$m pattern is longer than $1.5\mu$m. And, the very fine negative photoresist pattern was formmed by using the double exposure technique and the image reversal process.

• Journal of Microbiology and Biotechnology
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• 제5권1호
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• pp.31-35
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• 1995

An antitumor antibiotic named YS-1649 was isolated from the culture filtrate of a newly isolated fungus identified as Penicillium sp.. The fermentation yield reached about 40 mg per liter of the broth. YS-1649, a $\gamma$-Iactone - structured antibiotic, has the molecular fomular of $C_7H_6O_4$, Its structure was determined to be patulin by spectral analysis. It is active against some bacteria and showed cytotoxic effect on the proliferation of human breast cancer cell line, MCF-7, at concentrations of more than 0.048 $mu g/ml$. This compound also showed strong cytotoxic effect on the proliferation of human cancer cell lines, A549 and ACHN.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2015년도 전력전자학술대회 논문집
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• pp.189-190
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• 2015

This paper investigates an economic and highly efficient power converter topology and its modulation scheme for 60kW rapid EV charger system. The target system consists of three-phase three-switch buck-type rectifier topology. A new Carrier Based PWM scheme along with its simple implementation using logic gates is introduced in this paper. This PWM scheme replaces the diode rectifier equivalent switching state with an active switching state producing the effectively same current flowing path. As a result, the distortion of input current during the polarity reversal of capacitor line voltage can be mitigated. The proposed modulation technique is confirmed through simulation verification. The proposed modulation technique and its implementation scheme can expand the operation range of the three-phase three-switch buck-type rectifier having ac input and capacitor ripple current of high quality.

• Applied Microscopy
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• 제32권3호
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• pp.265-273
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• 2002

본 연구는 전자현미경을 이용하여 음용 불소가 발생중인 경골의 성장변화와 골모세포의 조직학적 특성에 미치는 영향을 관찰하고 에너지분광분석기를 사용하여 불소의 투여 농도에 따른 골기질 성분변화를 알아보고자 하였다. 전자현미경 관찰 결과, 대조군에서는 입방형의 전형적인 골모세포가 관찰되었다. 100 ppm 불소투여군의 경우, 활성이 강한 골모세포에 의해 생성된 여러층의 반전선과 새로 형성된 골성조직이 관찰되었다. 또한 골모세포의 세포질은 잘 발달된 조면세포체와 미토콘드리아가 관찰되었고 세포막 주위에는 많은 분비소포들이 관찰되었으며, 일부는 세포막과 융합되어 분비물질이 세포 밖으로 방출되었다. 200 ppm 불소투여군에서는 활성이 저하된 골모세포가 관찰되었는데, 세포질내에는 미토콘드리아가 팽창되어 있었고 수조의 형태가 파괴되어 나타났다. 또한, 조면소포체의 표면에는 리보솜이 탈락되어 관찰되었다. 300 ppm의 고농도 불소투여군에서는 골내막과 인접한 골모세포는 불규칙하게 배열되어 있었고, 세포막은 파괴되어 세포성분이 세포 밖으로 용출되어 관찰되었다. 한편, 에너지분산분광분석 결과는 대조군에 비해 100 ppm 불소투여군에서 골기질 성분인 인과 칼슘이 증가하였으나 200 ppm 및 300 ppm 불소투여군에서는 더 이상 증가하지 않았다. 따라서 본 연구결과, 투여된 불소에 의해 골모세포의 활동이 활발해지고 왕성한 골기질 합성이 관찰되었으나, 고농도의 불소 투여는 골모세포를 파괴하고 활동을 억제한다는 것을 확인하였다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2015년도 제49회 하계 정기학술대회 초록집
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• pp.233-233
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• 2015

We report on a simple method for inducing physical and chemical property-gradient on nanoimprinted patterns by intensity-regulated plasma treatment under caved sample stage. As for the size gradient, a line pattern having a linewidth of 294.9 nm was etched to have gradually varying width from 277.4 nm to 147.9 nm. Modified pattern was proven to be adaptable to replica stamp for reversal patterning. To investigate the wettability gradient, imprinted nanopatterns were coated with fluoroalkylsilane to increase the hydrophobicity, and the surface was modified to have gradually varying wettability from hydrophobic to hydrophilic (contact angle was ${\sim}160^{\circ}$ to ${\sim}5^{\circ}$ on a single chip). This method is expected to be applicable to the selective adsorption of biological entities and hydrodynamic manipulation of liquid droplets for the pumpless microfluidics.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1403-1410
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• 2014

Epigenetic regulators like histone deacetylases (1 and 2), and viral onco-proteins (E6/E7) are known to be overexpressed in cervical cancer cells. The present study was designed to investigate the effect of curcumin on HDACs (1 and 2) and HPV E6/E7 in the cervical cancer cell line SiHa and a drug resistant clone $SiHa^R$ (derived from SiHa). It was further intended to investigate whether curcumin could sensitize the cells towards cisplatin induced cell killing by modulation of multi drug resistant proteins like MRP1 and Pgp1. Curcumin inhibited HDACs, HPV expression and differentially increased acetylation and up-regulation of p53 in SiHa and $SiHa^R$, leading to cell cycle arrest at G1-S phase. Up-regulation of pRb, p21, p27 and corresponding inhibition of cyclin D1 and CDK4 were observed. Cisplatin resistance in $SiHa^R$ due to over-expression of MRP1 and Pgp1 was overcome by curcumin. Curcumin also sensitized both the cervical cancer cells towards cisplatin induced cell killing. Inhibition of HDACs and HPVs led to cell cycle arrest at G1/S phase by alteration of cell cycle regulatory proteins. Suppression of MRP1 and Pgp1 by curcumin resulted in sensitization of cervical cancer cells, lowering the chemotherapeutic dose of the drug cisplatin.