• Journal of Biomedical Engineering Research
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• v.13 no.4
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• pp.285-298
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• 1992

An analysis of the dynamics in the closing phase of the occluder of a mechanical monoleaflet heart valve prosthesis is presented. The dynamic analysis of the fluid in the vicinity of the occluder was based on the control vo]use approach. The backflow velocity of the fluid was computed by applying the continuity, Bernoulli's and momentum equations in the unsteady state. By considering the fluid pressure and gravity as external forces acting on the occluder, the moment equilibrium on fine occluder was employed to analyze the motion of the occluder during closing and the force of impact between the occluder and the guiding struts. Occluder comes to rest after several oscillations in about 10-18 msec after the Inltiaton of closing. As the aortic pressure increases, the occludes closes faster and comes to the final resting position earlier and the impact force increases also. But backflow is not af footed by the variation of the aortic pressure. With decreasing time delay of the ventricle pressure, the occluder closes faster and impact force Increases. The computed magnitudes of the occluder tiP velocities as well as the backflow of the fluid during the closing phase using this model were in agreement with previously reported experimental measurements.

• The Journal of Korean Physical Therapy
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• v.20 no.3
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• pp.61-68
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• 2008

Purpose: Protein kinase C (PKC) is a member of a family of serine/threonine kinases that are activated by diacylglycerol (DG) and PKC stimulants. PKC play a key role in signal transduction, including muscle contraction, cell migration, apoptosis, cell proliferation and differentiation. However, the mechanism relating mitogen-activated protein kinases (MAPKs) and PKC, especially in the volume-dependent hypertensive state, remains unclear. Methods: In the present study, I investigated the relationship between PKC and MAPKs for isometric contraction, PKC translocation, and enzymatic activity from normotensive sham-operated rats (NSR) and aldosterone-analogue deoxycorticosterone acetate (DOCA) hypertensive rats (ADHR). Results: Systolic blood pressure was significantly increased in ADHR than in NSR. Physiological salt solution (PSS)-induced resting tension and the intracellular $Ca^{2+}$ concentration ([$Ca^{2+}{_i}$]) were different in the ADHR and NSR. The expression of PKC$\alpha$, PKC$\beta$II, PKC$\delta$, PKC$\varepsilon$ and PKC$\xi$ were different between the cytoplasmic and membranous fractions. However, expression of the PKC isoforms did not differ for the ADHR and NSR. The use of 12-deoxyphorbol 13-isobutyrate (DPB, a PKC stimulant) induced isometric contraction in $Ca^{2+}$-free medium, which was diminished in muscle strips from ADHR as compared to NSR. Increased vasoconstriction and phosphorylation induced by the use of 1 ${\mu}$M DPB were inhibited by treatment with 10 ${\mu}$M PD098059 and 10 ${\mu}$M SB203580, inhibitors of extracellular-regulated protein kinase 1/2 (ERK1/2) and p38 MAPK from ADHR, respectively. Conclusion: These results suggest that the development of aldosterone analogue-induced hypertension is associated with an altered blood pressure, resting tension, [$Ca^{2+}{_i}$], and that the $Ca^{2+}$-independent contraction evoked by PKC stimulants is due to the activation of ERK1/2 and p38 MAPK in volume-dependent hypertension. Therefore, it is suggested that PKC activity affects volume-dependent hypertension and the need to develop cardiovascular disease-specialized physical therapy.

• Journal of Korean Academy of Nursing
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• v.26 no.2
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• pp.372-386
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• 1996

Recently, the ratio of elderly in the population are fast growing due to socio-economical development and the better medical service. Proportionally, the health problems in elderly are increasing, too. Medical professionals must try so that the elderly have the better life through health promotion and disease prevention as well as disease treatment. This study evaluated the effect of walking exercise program on the cardiorespiratory function and the flexibility in the elderly women. The design of research was one group pretest-posttest design. The subjects were eleven elderly women over sixty years old to live in K-city, Kyonggi-do. The type of exercise was walking, which was the most popular exercise in questionnaire. The exercise intensity was 40％∼60％ of the target heart-rate by Karvonen's method and maintained by the heart-rate monitor. The exercise period was five weeks and the exercise frequency was three times per week. The exercise duration was forty minutes at first and gradually increased up to an hour. In order to evaluate the effect of walking exercise, we measured VO/sub₂ max, resting heart -rate, systolic/diastolic blood pressure, FVC, FEV/sub₁, the flexibility before and after the five week's exercise program. The data are analyzed by the paired t-test and Wilcoxon signed rank test using SAS package. The results are as follows : 1) The hypothesis that cardiorespiratory function will be improved was partly supported. In VO/sub₂ max（p＝0.0001）, resting heart-rate（p＝0.0030）, systolic/diastolic blood-pressure（p＝0.0387／ p＝0.0024）, there was significant difference. FVC and FEV/sub₁ were increased after the exercise, but there were no significant difference. 2) The hypothesis that the flexibility will be improved was supported. There was significant difference in the flexibility（p＝0.0140）. As the further study, it is necessary to reevaluate the effect with more refined design. We also need to try meta-analysis about the results of previous studies obtained in the experimental setting and compare our result obtained in the field setting with them.

• Membrane Journal
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• v.24 no.3
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• pp.249-257
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• 2014

This experiment was carried out for a laboratory scale activated sludge bioreactor equipped with submerged flat sheet membrane using the synthetic wastewater. The membrane system for the activated sludge solution of MLSS 5,000 mg/L was operated with constant permeate flux by continuously permeating and periodically 10 minute-permeating/2 minute-resting modes, respectively. The transmembrane pressure was measured as the permeate flux increased from 10 to $25L/m^2{\cdot}hr$ under the constant air flowrate 0.25 L/min. Also, the complete blocking, standard blocking, intermediate blocking, incompressible cake and linear compressible cake fouling models were retrofitted for the experimental data in order to determine the state of the membrane fouling. Because the transmembrane pressure fluctuated as a pulse shape for every period of 10 minute-permeating/2-minute resting mode, the membrane fouling models were separately applied for the maximum and minimum connecting lines. The linear compressible cake fouling model for the activated sludge cakes was the best fitted with the experimental results from the above five models.

• Coupled systems mechanics
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• v.3 no.2
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• pp.233-245
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• 2014

Coupled finite element analysis is carried out to study the effect of degree of saturation on the vertical displacements and pore water pressures simultaneously by developing a FORTRAN90 code. The finite element formulation adopted in the present study is based upon Biot's consolidation theory to include partially saturated soils. Numerical methods are applied to a two-dimensional plane strain strip footing (flexible) problem and the effect of variable degree of saturation on the response of excess pore water pressure dissipation and settlement of the footing is studied. The immediate settlement in the case of partly saturated soils is larger than that of a fully saturated soil, the reason being the presence of pore air in partially saturated soils. On the other hand, the excess pore water pressure for partially saturated soil are smaller than those for fully saturated soil.

• Journal of Chest Surgery
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• v.18 no.4
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• pp.663-666
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• 1985

Whatever a surgeon choose aortic prosthesis in aortic stenosis, it will always provoke some degree of obstruction to flow due to its smaller effective orifice area to tissue annulus. Occasionally, we meet small aortic annulus to his or her body surface area in aortic valve replacement. The small annulus remains a problem in that both tissue and mechanical prosthesis have significant pressure gradients between LV and aorta in resting or exercising states. In these circumstances, diverse surgical procedures, such as tilting disc prosthesis, supraannular position of aortic prosthesis, and enlargement of aortic root [including aortoventriculoplasty, translocation of aortic valve, & double outlet of LV by valved conduit], were applied. We experienced one case of aortic stenosis with small aortic annulus. Systolic pressure gradients between LV & aorta were 90 mmHg. Diameter of annulus was 19 mm. So we performed patch enlargement of aortic root by Manouguian and AVR with St. Jude medical valve 23 mm.

• Journal of Life Science
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• v.21 no.9
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• pp.1336-1345
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• 2011

The purpose of this study was to analyze and compare the effects of exercise science of shoes for Aged' health promotion. Kinematic and kinetic data were collected using cinematography and the Zebris system (Zebris Emed Sensor Platform, GR-DVL9800) to analyze pressure of foot and ground reaction force. Subjects recruited were 20 healthy elderly men. They walked at 1.36m/sec velocity wearing type A (domestic), type B (foreign) and walking shoes (A company). One-way ANOVA was used to analyze statistics. The results were as following: no significant differences were observed in gait variables among the three groups (p<0.05). There was a significant difference in max pronation angle of heels examined among the three groups (p<0.05). There were no significant differences in kinetic variables (ground reaction force and max pressure) among the three groups (p<0.05). A physiology study was performed to analyze the effects of walking with shoes with silver added to them on percent body fat, resting metabolic rate and energy expenditure. Sixty adults males were recruited from the public health center. They were divided into four groups. C: control group (n=20), EY: elderly Y group (n=20), and EO: elderly O group (n=20). The results of this study were as follows: percent body fat was decreased following each exercise period, however, not all the groups showed a significant difference. The change of resting metabolic rate was significantly increased in HI (high intensity) and LI (low intensity) periods in the C and EY groups. However, there was no significant difference in the EO group. The mean energy expenditure during and after exercise were significantly lowered in all periods compared to the control group.

• Korean Journal of Clinical Laboratory Science
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• v.46 no.4
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• pp.143-149
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• 2014

Pulse wave velocity (PWV) is used to non-invasively estimate the severity of arteriosclerosis by measuring the patient's arterial stiffness comparing with each normal reference range according to their ages. Increased arterial stiffness is closely related to both atherosclerosis and arteriosclerosis, which have been known for causes of cardiovascular disease and stroke, also negatively affects the prognosis and the re-occurrence in patients with stroke. The study is focused on how brachial-ankle pulse wave velocity (baPWV) is related to cardiovascular disease risk factors in patients with acute stroke. There were 114 subjects, 69 males and 45 females, all in their 60's and had PWV test for acute stroke. The results are as follows: the group with increased arterial stiffness showed significant increase in HbAlc, total cholesterol, RSBP (resting systolic blood pressure), CSBP (central systolic blood pressure) and CDBP (central diastolic blood pressure). Cross tabulation test showed that there was a significant relationship only between the group with increased arterial stiffness and diabetes mellitus (DM). Therefore, it might be useful for preventing re-occurrence and making a favorable prognosis to promptly adjust DM and hypertension-related risk factors in patients with acute stroke.

• Geomechanics and Engineering
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• v.7 no.4
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• pp.355-374
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• 2014

An analytical solution of the fully coupled system of equations governing the plane strain deformation of a poroelastic medium with anisotropic permeability and compressible fluid and solid constituents is obtained. This solution is used to study the consolidation of a poroelastic clay layer with free permeable surface resting on a rough-rigid permeable or impermeable base. The stresses and the pore pressure are taken as the basic state variables. Displacements are obtained by integrating the coupled constitutive relations. The case of normal surface loading is discussed in detail. The solution is obtained in the Laplace-Fourier domain. Two integrations are required to obtain the solution in the space-time domain which are evaluated numerically for normal strip loading. Consolidation of the clay layer and diffusion of pore pressure is studied for both the bases. It is found that the time settlement is accelerated by the permeability of the base. Initially, the pore pressure is not affected by the permeability of the base, but has a significant effect, as we move towards the bottom of the layer. Also, anisotropy in permeability and compressibilities of constituents of the poroelastic medium have a significant effect on the consolidation of the clay layer.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.04a
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• pp.121-127
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• 2007

Direct acting pressure relief valve applicable to propellant tank of launch vehicle is modeled in this study The flow resistance of the partially opened valve is modeled as a function of the distance of the valve stem from the resting position. The position of the valve varies transiently as a function of its mass, the spring force, sliding friction, and the pressure differential. Choking at valve throat and compressibility are considered for the analysis. This study presents systematic analysis method for pressure relief valve applicable to propellant tank of liquid rocket. The results shows transient flow resistance caused by stem motion and the importance of choking at valve throat for pressure relief valve design.