• Journal of Korean Society for Quality Management
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• v.46 no.1
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• pp.39-74
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• 2018

Purpose: For more than 30 years, robust parameter design (RPD), which attempts to minimize the process bias (i.e., deviation between the mean and the target) and its variability simultaneously, has received consistent attention from researchers in academia and industry. Based on Taguchi's philosophy, a number of RPD methodologies have been developed to improve the quality of products and processes. The primary purpose of this paper is to review and discuss existing RPD methodologies in terms of the three sequential RPD procedures of experimental design, parameter estimation, and optimization. Methods: This literature study composes three review aspects including experimental design, estimation modeling, and optimization methods. Results: To analyze the benefits and weaknesses of conventional RPD methods and investigate the requirements of future research, we first analyze a variety of experimental formats associated with input control and noise factors, output responses and replication, and estimation approaches. Secondly, existing estimation methods are categorized according to their implementation of least-squares, maximum likelihood estimation, generalized linear models, Bayesian techniques, or the response surface methodology. Thirdly, optimization models for single and multiple responses problems are analyzed within their historical and functional framework. Conclusion: This study identifies the current RPD foundations and unresolved problems, including ample discussion of further directions of study.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.6 no.3
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• pp.309-325
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• 1994

Ocean circulation in the Gulf of Alaska is remarkably constant throughout the year despite of being forced by one of the largest seasonal wind stresses in the world. To explain the small seasonal changes in the transport of Alaska Stream. a set of numerical models is employed. First a diagnostic approach is applied to reproduce circulation from the observed density structure. The results reveals the very small seasonal changes in the Alaska Stream transport. Next a series of the prognostic models is used: a barotropic model. a flat bottom baroclinic model, and baroclinic model with topography. These models reveal the influence of topography and baroclinicity on the ocean's response to the seasonal wind forcing. The intercomparisons of the various model results suggest that the seasonal response of the baroclinic ocean is primary barotropic and the resultant barotropic circulation is weakened by the scattering effect of the bottom topography.

• Journal of Korean Society of Steel Construction
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• v.19 no.2
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• pp.223-231
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• 2007

Considering wind speed uncertainty, reliability analysis of the LNG unloading arm at Tongyoung Production Site was performed. Extreme distribution of wind speed was estimated from the data collected at the weather center and wind load was calculated using wind velocities and coefficients of wind pressure. The unloading arm was modeled with plate and solid elements. Contact elements were used to describe the interface between base of structure andground. Response surface for maximum effective stress was found for reliability analysis and then reliability functions was defined and used to determine exceeding probability of allowable and yield stresses. In addition, sensitivity analysis was also performed to estimate the effect of possible material deterioration in the future.

• Journal of Korean Society for Quality Management
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• v.30 no.4
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• pp.58-67
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• 2002

Since the inception of off-line quality control, it has drawn a particular attention from research community and it has been implemented in a wide variety of industries mainly due to its extensive applicability to numerous real situations. Emphasizing design issues rather than control issues related to manufacturing processes, off-line quality control has been recognized as a cost-effective approach to quality improvement. It mainly consists of three design stages: system design, parameter design, and tolerance design which are implemented in a sequential manner. Utilizing experimental designs and optimization techniques, off-line quality control is aimed at achieving product performance insensitive to external noises by reducing process variability. In spite of its conceptual soundness and practical significance, however, off-line quality control has also been criticized to a great extent due to its heuristic nature of investigation. In addition, it has also been pointed out that the process optimization procedures are inefficient. To enhance the current practice of off-line quality control, this study proposes an integrated optimization model by utilizing a well-established statistical tool, so called response surface methodology (RSM), and a tolerance - cost relationship.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.100-100
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• 2015

자연유역은 주어진 강우에 대해 다양한 형태의 유출반응을 나타내는데, 이는 순간반응함수(Instantaneous Response Function; IRF)로 표현될 수 있다. IRF는 유역의 DEM(Digital Elevation Model)으로부터 지표수 흐름방향을 추출한 뒤 지형분석을 통하여 구한 인자를 이용해 구하는 것이 일반적인 이론이다. 여기서 DEM의 모든 셀에 대해 흐름방향을 부여할 수 있지만, 모든 셀이 하천에 해당하지는 않는다. 따라서 최상류의 셀들은 사면으로, 하류의 셀은 하천으로 구분하여 IRF모의에 적용하게 된다. 사면과 하천은 지표수이송에 전혀 다른 경향을 보이므로 전체적인 유역의 유출반응에 큰 영향을 미친다. 예를 들어 사면과 하천에서의 유속 차이는 IRF의 왜도(skewness)에 주된 영향을 미치는 것으로 알려져 있다 (Botter and Rinaldo, 2003). 하지만, DEM에서 사면과 하천을 정확하게 구분하는 것은 매우 어렵기 때문에 하천시점을 정의하는 데에는 불확실성이 내재되어 있으며, 이러한 점은 추정된 IRF의 불확실성으로 연결된다. 본 연구에서는 하천시점의 불확실성으로 인한 IRF의 불확실성을 정량화하고, 그것의 유의수준을 평가하고자 한다. 이를 위해 다양한 유원면적 기준에 대해 IRF를 계산하고, 그 결과를 심도 있게 고찰한다.

• Nuclear Engineering and Technology
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• v.51 no.3
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• pp.894-903
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• 2019

An approach for collapse risk assessment is proposed to evaluate the vulnerability of electric cabinet in nuclear power plants. The lognormal approaches, namely maximum likelihood estimation and linear regression, are introduced to establish the fragility curves. These two fragility analyses are applied for the numerical models of cabinets considering various boundary conditions, which are expressed by representing restrained and anchored models at the base. The models have been built and verified using the system identification (SI) technique. The fundamental frequency of the electric cabinet is sensitive because of many attached devices. To bypass this complex problem, the average spectral acceleration $S_{\bar{a}}$ in the range of period that cover the first mode period is chosen as an intensity measure on the fragility function. The nonlinear time history analyses for cabinet are conducted using a suite of 40 ground motions. The obtained curves with different approaches are compared, and the variability of risk assessment is evaluated for restrained and anchored models. The fragility curves obtained for anchored model are found to be closer each other, compared to the fragility curves for restrained model. It is also found that the support boundary conditions played a significant role in acceleration response of cabinet.

• Geomechanics and Engineering
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• v.28 no.3
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• pp.313-324
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• 2022

Rock properties are important in the design of mines and civil engineering excavations to prevent the imminent failure of slopes and collapse of underground excavations. However, the time, cost, and expertise required to perform experiments to determine those properties are high. Therefore, empirical models have been developed for estimating the mechanical properties of rock that are difficult to determine experimentally from properties that are less difficult to measure. However, the inherent variability in rock properties makes the accurate performance of the empirical models unrealistic and therefore necessitate the use of soft computing models. In this study, Gaussian process regression (GPR), artificial neural network (ANN) and response surface method (RSM) have been proposed to predict the static and dynamic rock properties from the P-wave and rock density. The outcome of the study showed that GPR produced more accurate results than the ANN and RSM models. GPR gave the correlation coefficient of above 99% for all the three properties predicted and RMSE of less than 5. The detailed sensitivity analysis is also conducted using the RSM and the P-wave velocity is found to be the most influencing parameter in the rock mechanical properties predictions. The proposed models can give reasonable predictions of important mechanical properties of sedimentary rock.

• Animal Bioscience
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• v.36 no.11
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• pp.1619-1631
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• 2023

The objective of this review was to provide an overview of the effects of dietary fiber (DF) on reproductive performance in gestating sows. Dietary fibers have been suggested to modulate microbiota in the intestine and the immune system of gestating sows and to improve gut health. Thus, DF may help alleviate the adverse effects of the stressful production cycle of gestating sows. These benefits may subsequently result in improved reproductive performance of sows. Previous studies have reported changes in microbiota by providing gestating sows with DF, and the responses of microbiota varied depending on the source of DF. The responses by providing DF to gestating sows were inconsistent for antioxidative capacity, hormonal response, and inflammatory response among the studies. The effects of DF on reproductive performance were also inconsistent among the previous studies. Potential reasons contributing to these inconsistent results would include variability in reproductive performance data, insufficient replication, influence of other nutrients contained in the DF diets, characteristics of DF, and experimental periods. The present meta-analysis suggests that increasing the total DF concentration by 10 percentage units (e.g., 12% to 22% as-fed basis) in gestating sow diets compared to the control group improves the litter born alive by 0.49 pigs per litter. However, based on the present review, questions remain regarding the benefits of fibers in gestating sow diets. Further research is warranted to clarify the mode of action of fibers and the association with subsequent reproductive performance in gestating sows.

• Archives of Pharmacal Research
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• v.16 no.1
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• pp.57-61
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• 1993

Based on the turbidimetric response of protein with 50% trichloroacetic acid (TCA), this study aims to introduce an assay method for protein in solution. The standard procedure consists of mixing equal volume of sample solution (standard or unknown) with 50%-TCA solution and measuring the absorbance at 450 nm after 20 min. The absorbances of the solutions were almost stable over 120 min at room temperature. This assy method is simple, reproducible, and tolerant to many interfering substances. It can detect less amount than $10\mu$g/ml of bovin serum albumin. The assay method has low protein-to-protein variability over wide range of molecular weight.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.11a
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• pp.51-66
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• 2006

The field of cytochrome P450 pharmacogenomics has progressed rapidly during the past 25 years. Recently, conjugating enzymes including sulfotransferase, acetyltransferase, glucuronosyltransferase and glutathione transferase have been also extensively studied. All the major human drug-metabolizing P450 enzymes and some conjugating enzymes have been identified and cloned, and the major gene variants that cause inter-individual variability in drug response and are related to adverse drug reactions have been identified. This information now provides the basis for the use of predictive pharmacogenomics to yield drug therapies that are more efficient and safer. Today, we understand which drugs warrant dosing based on pharmacogenomics to improve drug treatment. It is anticipated that genotyping could be used to personalize drug treatment for vast numbers of subjects, decreasing the cost of drug treatment and increasing the efficacy of drugs and health in general. It is assumed that such personalized P450 gene-based treatment which is so-called tailor(order)-made drug therapy would be relevant for 10-20% of all drug therapy in the future.