• The Plant Pathology Journal
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• 제37권4호
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• pp.339-346
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• 2021

Prevalence of tan spot of wheat caused by the fungus Pyrenophora tritici-repentis has become more prevalent in Oklahoma as no-till cultivation in wheat has increased. Hence, developing wheat varieties resistant to tan spot has been emphasized, and selecting pathogen isolates to screen for resistance to this disease is critical. Twelve isolates of P. tritici-repentis were used to inoculate 11 wheat cultivars in a greenhouse study in splitplot experiments. Virulence of isolates and cultivar resistance were measured in percent leaf area infection for all possible isolate x cultivar interactions. Isolates differed significantly (P < 0.01) in virulence on wheat cultivars, and cultivars differed significantly in disease reaction to isolates. Increased virulence of isolates detected increased variability in cultivar response (percent leaf area infection) (r = 0.56, P < 0.05) while increased susceptibility in cultivars detected increased variance in virulence of the isolates (r = 0.76, P < 0.01). A significant isolate × cultivar interaction indicated specificity between isolates and cultivars, however, cluster analysis indicated low to moderate physiological specialization. Similarity in wheat cultivars in response to pathogen isolates also was determined by cluster analysis. The use of diverse isolates of the fungus would facilitate evaluation of resistance in wheat cultivars to tan spot.

• Geomechanics and Engineering
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• 제17권6호
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• pp.583-595
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• 2019

In this paper, a comprehensive investigation of the dynamic response of a long-bridge subjected to spatially varying earthquake ground motions (SVEGM) is performed based on a proposed analytical model which includes the effect of soil-structure interaction (SSI). The spatial variability of ground motions is simulated by the powerful record generator, SIMQKE II. Modeling of the SSI in the system is simplified by replacing the pile foundations and soil with sets of independent equivalent linear springs and dashpots along the pile groups. One of the most fundamental objectives of this study is to examine how well the proposed model simulates the dynamic response of a bridge system. For this purpose, the baseline data required for the evaluation process is derived from analyzing a 3D numerical model of the bridge system which is validated in this paper. To emphasize the importance of the SVEGM and SSI, bridge responses are also determined for the uniform ground motion and fixed base cases. This study proposing a compatible analytical model concerns the relative importance of the SSI and SVEGM and shows that these effects cannot be neglected in the seismic analysis of long-bridges.

• 한국지진공학회논문집
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• 제27권4호
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• pp.187-192
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• 2023

An elastic bearing must be strong against vertical loads and flexible against horizontal loads. However, due to the material characteristics of rubber, it may show variability due to the manufacturing process and environmental factors. If the value applied in the bridge design stage and the actual measured value have different values or if the performance during operation changes, the performance required in the design stage may not be achieved. In this paper, the seismic response of bridges was compared and analyzed by assuming a case where quality deviation occurs during construction compared to the design value for elastic bearings, which have not only always served as traditional bearings but also have had many applications in recent seismic reinforcement. The bearing's vertical stiffness and shear stiffness deviation were considered separately for the quality deviation. In order to investigate the seismic response, a time history analysis was performed using artificial seismic waves. The results confirmed that the change in the bearing's shear stiffness affects the natural period and response of the structure.

• 약학회지
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• 제60권3호
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• pp.118-127
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• 2016

A growing number of studies have demonstrated that ABCB1 gene polymorphisms are associated with the variability of responses to imatinib. However, the effects of ABCB1 polymorphisms on imatinib response in chronic myeloid leukemia (CML) are inconsistent. The aim of the present study was to clarify the associations between ABCB1 polymorphisms and imatinib response in CML. A systematic literature review was performed. The databases of PubMed, Embase, and Cochrane Library were searched for all published studies from inception to December 2015. The following terms were used with functions of 'AND' and 'OR': 'chronic myeloid leukemia', 'CML', 'ABCB1', 'MDR1', 'polymorphism', 'SNP', and 'imatinib'. Using the Review Manager 5, odds ratios (ORs) were pooled to estimate the effect of ABCB1 polymorphisms on imatinib response in CML. The pooled analysis showed that ABCB1 2677 G allele was significantly associated with poor response to imatinib in African and Asian patients (GG vs TT, OR: 0.32, p<0.0001; GG+GT vs TT, OR: 0.44, p=0.0005). In subgroup analyses, African patients carrying ABCB1 1236 C allele exhibited higher risk for worse response, whereas Asian patients with 1236 C allele showed better response (CC+CT vs TT, OR: 0.41, p=0.008 for African; OR: 1.65, p=0.03 for Asian). There was no association between C3435T polymorphisms and imatinib response in African, Asian, and Caucasian CML patients.

• Earthquakes and Structures
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• 제3권6호
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• pp.805-820
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• 2012

An enhanced and efficient methodology is proposed for evaluating the robustness of an uncertain structure with passive dampers. Although the structural performance for seismic loads is an important design criterion in earthquake-prone countries, the structural parameters such as storey stiffnesses and damping coefficients of passive dampers are uncertain due to various factors or sources, e.g. initial manufacturing errors, material deterioration, temperature dependence. The concept of robust building design under such uncertain structural-parameter environment may be one of the most challenging issues to be tackled recently. By applying the proposed method of interval analysis and robustness evaluation for predicting the response variability accurately, the robustness of a passively controlled structure can be evaluated efficiently in terms of the so-called robustness function. An application is presented of the robustness function to the design and evaluation of passive damper systems.

• 한국시뮬레이션학회논문지
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• 제9권4호
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• pp.67-75
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• 2000

Often system analysts are interested in the estimation of percentile for system performance. For instance, in PERT network system, the percentile that the project. Typically the control variate method is used to reduce the variability of mean response using the correlation between the response and the control variates with a little additional cost during the course of simulation. In the same spirit, we apply this method to estimate the percentile of project completion time in PERT system, and evaluate the efficiency of the controlled estimator for its percentile.1 Simulation results indicate that the controlled estimators are more effective in reducing the variances of estimators than the simple estimators, however those tend to a little underestimate the percentiles for some critical values. We need more simulation experiments to examine such a kind of bias problem. We expect this research presents a step forward in the area of variance reduction techniques of stochastic simulation.

• 대한산업공학회지
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• 제22권4호
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• pp.633-649
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• 1996

An interactive multicriteria method, which is called the Modified Pairwise Comparison Stochastic Cutting Plane (MPCSCP) method, is proposed for determining the best levels of the integer decision variables needed to optimize a stochastic computer simulation with multiple response functions. MPCSCP combines good features from interactive tradeoff cutting plane methods and response surface methodologies. The proposed method uses a simple pairwise man-machine interaction and searches an integer space uniformly by using the experimental design which evaluates the decision space centering around an integer center point. The characteristics of the proposed method are investigated through an extensive computational study. The parameter configurations examined in the study are (1) variability of the sampling errors, (2) the size of experimental design, (3) the relaxation of cutting planes, and (4) the levels of decision maker's inconsistency.

• Parasites, Hosts and Diseases
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• 제30권4호
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• pp.323-328
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• 1992

질트리코모나스의 항원 분석을 시행하기 위하여 병원성이 화인된 질트리코모나스(Trichamonas vaginnlis) 6개주(HY-1,2,3,9,10,13)의 항일을 sodium dodecyl sulfate - polyacrlyamide gel electrophoresis(SDS-PAGE) 한 결과 Coomassie brilliant blue 염색상에서 peptide의 밀도 차이를 제외하고는 주간에 동일한 단백질 분포양상을 보였으며, 12kDa에서 170kDa까지 약 35개 정도의 분획이 관찰되었다. 또한 질트리코모나스 HY월주를 항원으로 하고 질트리코모나스 6개주에 대해 면역된 마우스의 항혈청을 이용하여 enzyme-linked immunoelectrotransfer blot(EITB)을 시행한 결과 각 주마다 서로 다른 반응양상을 보였으며, 51kDa과 96kDa에서 질트리코모나스의 특이한 공통 반응대가 관찰되었고, 각기 다른 6개주의 항원에 대해 HY-1주의 항혈청으로 ETTB한 결과 HY-1 함원(homologous antigen)과의 반응 양상과 타항친(heterologous antigen)과의 반응 양상간의 특이한 차이는 관찰할 수 없었다. 이상의 결과로 보아 질트리코모나스 각 주의 항원은 항인-항체 반응에서 주간에 이종(antigenic heterogeneity)을 형성하고 있는 것으로 보였으며, 41, 47, 55, 74 및 94kDa에서 질트리코모나스애 특이한 공통반응대를 보었으며, 이 부분이 숙주-기생충의 상 호관계에 있어서 중요한 의의를 내포하고 있을 것으로 생각된다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2000년도 추계 학술대회지
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• pp.3-11
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• 2000

The Asian summer monsoon has a profound social and economic impact in East Asia and its surrounding countries. The monsoon is basically a response of the atmosphere to the differential heating between the land mass of the Asian continent and the adjacent oceans. The atmospheric response, however, is quite complicated due to the interactions between the atmospheric heat sources, land-sea contrast, and topography, The occurrence of extreme summertime floods in Korea, Japan, and China in 1998 and 1999 has highlighted the range of variability of the East Asian summertime monsoon circulation and spurred interest in investigating the cause of such extreme variability. While ENSO is often considered a prime mechanism responsible for the unusual hydrological disasters in East Asia, understanding of the connection between ENSO and the East Asian monsoon is hampered by their dynamic complexities. Along with a recent phenomenon of weather abnormalities observed in many parts of the globe, Korea has seen its share of increased weather abnormalities such as the record-breaking heavy rainfalls due to a series of flash floods in the summers of 1998 and 1999, following devastating Yangtze river floods in China. A clear regime shift is found in the tropospheric mean temperature in the northern hemisphere middle latitudes and the surface temperature over the Asian continent during the summer with a sudden warming since 1977. Either decadal climate variation or climate regime shift in the Asian continent is evident and may have altered the characteristics of the East Asian summer monsoon. Considering the summertime rainfall amount in Korea is overall increased lately, the 1998/99 heavy rainfalls may not be isolated episodes related only to ENSO, but could be a part of long-term climate variation. The record-breaking heavy summer rainfalls in Korea may not be direct impact of ENSO. Instead, the effects of decadal climate variation and ENSO may be coupled to each other and also to the East Asian summer monsoon system, while their individual impacts are difficult to separate.

• 동의신경정신과학회지
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• 제18권2호
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• pp.25-34
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• 2007

Objective : This study was done to investigate the differences of HRV(Heart Rate Variability) change as the response to the emotional stimulus in each Sasang constitutions. Method : We investigated 44 healthy volunteers consisted of 10 Soyangin, 14 Soeumin and 20 Taeumin. After diagnosing the Sasang constitution by specialist of Sasang medicine, we measured the baseline emotional state(100 sec) before the stimulus, the changing emotional state(100 sec) while fearful film was being played. And we rechecked the emotional state(100 sec) while taking a rest. At last, volunteers checked the questionnaire for emotional response. We analysed ECG data with HRV-time domain and frequency domain analysis. Results : (1) There were no significant difference in Mean-RR , SDNN between each groups. (2) LF of Taeumin group significantly increased by the emotional stimulation compared with other groups. (3) There was no significant difference in TP, HF, normalized LF, normalized HF, but the variation of each period in Taeumin group was bigger than those of other groups. (4) Soeumin group reported that they felt significant disgust-emotion in the questionnaire compared with other groups. Conclusion : Taeumin group showed significant emotional changes on HRV by fear stimulus film.