• Molecules and Cells
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• v.26 no.1
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• pp.41-47
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• 2008

Mitogen-activated protein kinase (MAPK) signaling is a crucial component of eukaryotic cells; it plays an important role in responses to extracelluar stimuli and in the regulation of various cellular activities. The signaling cascade is evolutionarily conserved in the eukaryotic kingdom from yeast to human. In response to a variety of extracellular signals, MAPK activity is known to be regulated via phosphorylation of a conserved $T{\times}Y$ motif at the activation loop in which both threonine and tyrosine residues are phosphorylated by the upstream kinase. However, the mechanism by which both residues are phosphorylated continues to remain elusive. In the budding yeast, Saccharomyces cerevisiae, Fus3 MAPK is involved in the mating signaling pathway. In order to elucidate the functional mechanism of MAPK activation, we quantitatively profiled phosphorylation of the $T{\times}Y$ motif in Fus3 using mass spectrometry (MS). We used synthetic heavy stable isotope-labeled phosphopeptides and nonphosphopeptides corresponding to the proteolytic $T{\times}Y$ motif of Fus3 and accompanying data-dependent tandem MS to quantitatively monitor dynamic changes in the phosphorylation events of MAPK. Phosphospecific immunoblotting and the MS data suggested that the tyrosine residue is dynamically phosphorylated upon stimulation and that this leads to dual phosphorylation. In contrast, the magnitude of threonine phosphorylation did not change significantly. However, the absence of a threonine residue leads to hyperphosphorylation of the tyrosine residue in the unstimulated condition, suggesting that the threonine residue contributes to the control of signaling noise.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.6
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• pp.50-56
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• 2015

An efficient fast response hysteretic buck converter suitable for mobile application is propoesed. The problems of large output ripple and difficulty in using of small power inductor that conventional hysteretic converter has are improved by adding ramp generator. and the changeable switching frequency with load current is fixed by adding a delay time control circuit composed of PLL structure resulting in decrease of EMI noise. The circuits are implemented by using BCDMOS 0.35um 2-polt 4-metal process. Measurement results show that the converter operates with a switching frequency of 1.85MHz when drives 80mA load current. As the converter drives over 170mA load current, the switching frequency is fixed on 2MHz. The converter has output ripple voltage of less 20mV and more than efficiency 85% with 50~500mA laod current condition.

• Journal of the Korean Institute of Intelligent Systems
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• v.24 no.6
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• pp.609-614
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• 2014

Cerebellar ataxia is a steadily progressive neurodegenerative disease associated with loss of motor control, leaving patients unable to walk, talk, or perform activities of daily living. Direct motor instruction in cerebella ataxia patients has limited effectiveness, presumably because an inappropriate closed-loop cerebellar response to the inevitable observed error confounds motor learning mechanisms. Recent studies have validated the age-old technique of employing motor imagery training (mental rehearsal of a movement) to boost motor performance in athletes, much as a champion downhill skier visualizes the course prior to embarking on a run. Could the use of EEG based BCI provide advanced biofeedback to improve motor imagery and provide a "backdoor" to improving motor performance in ataxia patients? In order to determine the feasibility of using EEG-based BCI control in this population, we compare the ability to modulate mu-band power (8-12 Hz) by performing a cued motor imagery task in an ataxia patient and healthy control.

• Journal of IKEEE
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• v.5 no.1 s.8
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• pp.16-23
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• 2001

Passive noise reduction is a classical approach to attenuate industrial noise, and an active noise cancellation has several advantages over the passive noise cancellation. The active noise reduction system offers a better low frequency performance with a smaller and lighter system. This paper presents a simple active closed loop control system which consists of an controller for inverting and compensating the phase delay, a microphone for picking up the external noise, and a loudspeaker for radiating the acoustic out of phase signal to reduce the external noise, and external noise can be reduced after compensating the phase difference to be $180^{\circ}$ in the frequency of maximum value in the amplitude response. The noise of the phase delay covered from $50^{\circ}\;to\;310^{\circ}$ tends to be reduced in the active noise control system and it is possible to obtain a noise cancelling of up to approximately 20[dB] at the ears in the enclosurer.

• The Transactions of the Korean Institute of Power Electronics
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• v.20 no.6
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• pp.517-525
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• 2015

A grid connected inverter must be operated as the main electricity source under an isolated condition caused by the grid problem. Conventionally, the dual loop controller is used for the grid inverter, and the controller is used for control under the stand-alone mode. Generally, the PI(Proportional - Integral) controller is highly efficient under a synchronous reference frame, and stable control can be available. However, in this synchronous frame-based control, high-quality DSP is required because many sinusoidal calculations are necessary. When the PI control is conducted under a stationary frame, the controller constructions are made simple so that they work even with a low-price micro controller. However, given the characteristics of the PI controller, it should be designed with the phase of reference voltage considered. Otherwise, the phase delay of the output voltage can occur. Although the current controller also has a higher bandwidth than the voltage controller, distortion of the voltage is difficult to avoid only by the rapid response of the PI controller, as a sudden load change can occur in the nonlinear load. In this study, a new control method that solves the voltage controller bandwidth problem and rapidly copes with it even in the nonlinear load situation is proposed. The validity of the proposed method is proved by simulation and experimental results.

• Journal of the Korea Society of Computer and Information
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• v.8 no.3
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• pp.179-187
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• 2003

This study investigate the reasons of organizational failure in detection and appropriate response to risk signal. The Crisis does not come true suddenly, there is some risk signals in crisis. If Organization detect the risk signals the crisis is come true opportunities, if not the crisis is come true disastrous outcome. This is use the system dynamics approach. System Dynamics assume the system as a collection of causal feedback loop, so we understand the dynamics around the problems. This investigate suggest that, the focus on growth is the a kind of promotional pressure and the pressure drive the organization to less attention the risk signal, so the risk is underestimate In proportion to real risk. Ultimate, the organization entrap the promotional climate and insensible to security. This study is a kind of hypothesis-discovering research, in the further study, the discovered hypothesis will be empirically tested.

• The Transactions of the Korean Institute of Power Electronics
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• v.10 no.2
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• pp.109-116
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• 2005

The high performance drives of the slotless Permanent Magnet Brushless DC(PM BLDC) motor can be achieved by the current control, where the currents flow according to the rotor position and the current phase is suitably controlled according to the operational condition. Rotor position information can be provided by Hall-IC or sensorless algorithm. So, the Hall-ICs are set up in this motor to detect the main flux from the rotor. Instead of using three Hall-ICs and encoder, this paper uses only two Hall-ICs for the permanent magnet rotor position and the speed feedback signals, and uses a micro-controller of 16-bit type (80C196KC). Also because of low resolution obtained by using Hall-IC even low-cost and simple structure, to improve the wide range of speed response characteristic more exactly, we propose the rotor position signal synthesizer using PLL circuit based on two Hall-ICs.

• Smart Structures and Systems
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• v.13 no.2
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• pp.219-233
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• 2014

In a companion paper, Pasala and Nagarajaiah analytically and experimentally validate the Adaptive Length Pendulum Smart Tuned Mass Damper (ALP-STMD) on a primary structure (2 story steel structure) whose frequencies are time invariant (Pasala and Nagarajaiah 2012). In this paper, the ALP-STMD effectiveness on a primary structure whose frequencies are time varying is studied experimentally. This study experimentally validates the ability of an ALP-STMD to adequately control a structural system in the presence of real time changes in primary stiffness that are detected by a real time observer based system identification. The experiments implement the newly developed Adaptive Length Pendulum Smart Tuned Mass Damper (ALP-STMD) which was first introduced and developed by Nagarajaiah (2009), Nagarajaiah and Pasala (2010) and Nagarajaiah et al. (2010). The ALP-STMD employs a mass pendulum of variable length which can be tuned in real time to the parameters of the system using sensor feedback. The tuning action is made possible by applying a current to a shape memory alloy wire changing the effective length that supports the damper mass assembly in real time. Once a stiffness change in the structural system is detected by an open loop observer, the ALP-STMD is re-tuned to the modified system parameters which successfully reduce the response of the primary system. Significant performance improvement is illustrated for the stiffness modified system, which undergoes the re-tuning adaptation, when compared to the stiffness modified system without adaptive re-tuning.

• Journal of Korean language education
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• v.25 no.1
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• pp.53-82
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• 2014

This study aims to find the method to promote interaction in L2 classrooms. Active interaction between learner-to-learner and learner-to-teacher in L2 classroom plays an important role in language acquisition. In light of this, L2 classroom would benefit with the help of learning tools such as Clickers which helps learners to express their level of understanding during the process of learning itself. This is because the anonymity of Clickers allows learners to express their needs without the social risks associated with speaking up in the class. It allows for an evaluative feedback loop where both learners and teachers understand the level of progress of the learners, better enabling classrooms to adapt to the learners' needs. Eventually this tool promotes participation from learners, This is in turn, believed to be effective in fostering classroom interaction, allowing learning to take place in a more comfortable yet vibrant way. This study is finalized by presenting the result of an experiment conducted to verify the effectiveness of this approach when teaching pragmatic aspect of the Korean expressions with similar semantic functions. As a result of the research, the learning achievement of learners in the experimental group was found higher than the learners' in a control group. Analyzing the data collected from a questionnaire given to the learners, the study presented data suggesting that this approach increased the scope of interactivity in the classroom, thus enhancing more active participation among learners. This active participation in turn led to a marked improvement in their communicative abilities.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.49 no.9
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• pp.749-757
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• 2021

In transportation missions using quadrotor, the payload may change the model parameters, such as mass, moment of inertia, and center of gravity. Moreover, if position of the payload is constantly changing during flight, the effect can adversely affect the control performances. To handle this issue, we suggest Model Reference Adaptive Control based on Linear Quadratic Regulator(LQR+MRAC) to compensate the uncertainty caused by payload. Firstly, the mathematical modeling with the fixed payload is derived. Second, Linear Quadratic Regulator (LQR) is used to design the reference model and baseline controller. Also, through the Stability method, Adaptive law is derived to estimate the model parameters. To verify the performance of proposed control scheme, we compared LQR and LQR+MRAC in situations where uncertainties exist. And, when the disturbance exist, the classic MRAC and proposed controller is compared to analyze the transient response and robustness.