• Korean Chemical Engineering Research
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• v.60 no.1
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• pp.70-79
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• 2022

Biodiesel production has attracted attention as a sustainable source of fuel and is a competitive alternate to diesel engines. The glycerol that is produced as a by-product is generally discarded as waste and can be converted to green chemicals such as acetins to increase bio-diesel profitability. Acetins find application in fuel, food, pharmaceutical and leather industries. Batch experiments and analysis have been previously conducted for synthesis of acetins using glycerol esterification reaction aided by sulfated metal oxide catalysts (SO₄^2-/CeO₂-ZrO₂). The aim of this study was to optimize process parameters: effects of mole ratio of reactants (glycerol and acetic acid), catalyst concentration and reaction temperature to maximize glycerol conversion/acetin selectivity. The optimum conditions for this reaction were determined using response surface methodology (RSM) designed as per a five-level-three-factor central composite design (CCD). Statistica software 10 was used to analyze the experimental data obtained. The optimized conditions obtained were molar ratio - 1:12, catalyst concentration - 6 wt.% and temperature -90 ℃. A packed bed reactor was fabricated and column studies were performed using the optimized conditions. The breakthrough curve was analyzed.

• Journal of Korea Water Resources Association
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• v.55 no.10
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• pp.843-854
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• 2022

For the rip current warning system to reduce rip-current accidents, the implementation method producing the risk index was modified. To produce fast response from the warning system based on real-time observations, the method employed the numerical results (i.e., rip current likelihoods according to the possible scenario) obtained in advance. In this study, instead of using the empirical curve-fitting functions of the previous method, the present modification utilized two-dimensional distributions (i.e., wave height and period, wave height and tidal elevation, wave height and direction, wave height and spreading of frequency-directional spectrum) of rip current likelihoods stacked in a database of the system. The wave and tidal observations in 2021 at the Haeundae coast were applied to the modified system, and its performances at several real events recorded in CCTV images were presented.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.49 no.5
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• pp.355-363
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• 2021

Heat resistance performance evaluation and thermal analysis were performed to confirm the applicability of the lyocell-based carbon/phenolic composite material for heat-resistant parts for aerospace. Heat resistance performance evaluation of carbon/phenolic was conducted by Thermal Protection Evaluation Motor (TPEM). In this paper, boundary layer integration code considering the boundary layer analysis of combustion gas and MSC-Marc 2018 considering ablation and thermal pyrolysis were used for the thermal analysis. The ablation and thermal insulation performance were analyzed by the pressure curve of test motor and the cut carbon/phenolic specimens. The thermal response of the lyocell-based carbon/phenolic material was similar to that of the rayon-based carbon/phenolic material. Based on the results through the combustion test, the applicability of heat-resistant parts for aerospace to which domestic lyocell-based carbon fibers were applied was confirmed.

• Journal of Sasang Constitutional Medicine
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• v.34 no.4
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• pp.27-37
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• 2022

Objectives The purpose of this study is to propose a method to more specifically identify Sasang constitutional risk factors of metabolic syndromes by adjusting the cut-off value of Korea Sasang Constitutional Diagnostic Questionnaire (KS-15). Methods Data of 1997 participants in Korean medicine Daejeon Citizen Cohort study (KDCC) were analyzed. Metabolic syndrome was defined according to the NCEP-ATP III, lifestyle information, and hematologic information including KS-15 and demographic characteristics were used as covariates. Results The 179 subjects with metabolic syndrome accounted for 9.0% of the total. As a result of determining the Sasang constitution for the KS-15 response based on the cut-off values (approximate 0.33), 0.5, and 0.6 of the constitutional score, when performed at the 0.6 cut-off model, the odds ratio of TE was 2.46 which showed a statistically significantly higher risk than the borderline group. For the accuracy of the model and the Area under the curve (AUC), the model accuracy based on the original cut-off of the KS-15 was 0.902 and AUC was 0.737. The accuracy of the model with cut-off of 0.5 and with of 0.6 were 0.904 and 0.902, respectively, and the AUCs were 0.687 and 0.741, respectively. Conclusion In this study, we confirmed that it is effective to increase the cut-off value of KS-15 to 0.6 in the metabolic syndrome risk model. It is expected that this could increase the accuracy of identifying high-risk groups for metabolic syndrome.

• Analytical Science and Technology
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• v.36 no.4
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• pp.180-190
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• 2023

The presence of process related impurities in any drug or the drug product was associated with its safety, stability and efficacy. The overall literature survey proved that there is no method published on the assessment of process related impurities in brigatinib. In this study, a simple, reliable and stable HPLC qualitative method was reported for quantification of process related impurities with easy and quick extraction procedure. The impurities along with standard brigatinib was resolved on Lichrospher^® C18 (250 mm × 4.6 mm; 5 ㎛ particle size) column in room temperature using methanol, acetonitrile, pH 4.5 phosphate buffer in 55:25:20 (v/v) at 1.0 mL/min as mobile phase and UV detection at 261 nm. The method produces well resolved peaks at retention time of 4.60 min, 12.28 min, 3.37 min, 7.34 min and 8.39 min respectively for brigatinib, impurity A, B, C and D. The method produces a very sensitive detection limit of 0.0065 ㎍/mL, 0.0068 ㎍/mL, 0.0053 ㎍/mL and 0.0058 ㎍/mL for impurity A, B, C and D respectively with calibration curve linear in the concentration range of 22.5-135 ㎍/mL for brigatinib and 0.0225-0.135 ㎍/mL for impurities. The method produces all the validation parameters under the acceptable level and doesn't produces any considerable changes in peak area response while minor changes in the developed method conditions. The method can effectively resolve the unknown stress degradation products along with known impurities with less % degradation. The method can efficiently resolve and quantify the impurities in formulation and hence can suitable for the routine quality analysis of brigatinib in raw material and formulation.

• Animal Bioscience
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• v.36 no.4
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• pp.584-590
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• 2023

Objective: This research aimed to explore the changes in the observed abdominal sagging index (ASI) and reproductive performance of Roman male and female geese during the breeding period. Methods: The 339 six-month-old breeding geese (109 male; 230 female) were used in this study, in which five male and five female geese were slaughtered on a monthly basis to record the ASI. Results: The short diameter of the testes of the male goose when the female goose lays eggs and in the second, third, and fourth months was significantly wider than in the fifth months (19.0, 20.8, 21.4, and 19.6 vs 12.7 and 14.0 mm/bird; p = 0.0105). On the other hand, the testicular weight of the male goose in the second and third months after the female goose lays eggs was significantly higher than that in the second and fifth months after laying (0.33% and 0.37% vs 0.11% and 0.19%; p = 0.0212). During the exploring period, the length and weight of the fallopian tube, the weight of the ovary, the number of follicles in 2 to 3 cm, the number of follicles in 3 to 4 cm, the fallopian tube weight in the carcass weight percentage, and the ovary weight in the carcass weight percentage all demonstrated a significant curve response. Further, female ASI was positively correlated with reproductive tract length (r = 0.815; p<0.05) and egg production per female (r = 0.790; p<0.05). Conclusion: The ASI classification method is more objective and easy to distinguish. This scoring method has a high correlation with the number of eggs laid by each goose and the length of the reproductive tract, inferring that the goose observation could take advantage of ASI during egg-laying and can predict the reproductive system development during the laying period and determine when the breeding goose begins to lay eggs.

• Journal of the Earthquake Engineering Society of Korea
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• v.27 no.3
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• pp.129-137
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• 2023

This study presents a dry precast concrete (PC) beam-column connection, and its target seismic performance level is set to be emulative to the reinforced concrete (RC) intermediate moment resisting frame system specified in ACI 318 and ASCE 7. The key features include self-sustaining ability during construction with the dry mechanical splicing method, enabling emulative connection performances and better constructability. Test specimens with code-compliant seismic details were fabricated and tested under reversed cyclic loading, which included a PC beam-column connection specimen with dry connections and an RC control specimen. The test results showed that all the specimens failed in a similar failure mode due to plastic deformations in beam members, while the hysteretic response curve of the PC specimen showed comparable and emulative performances compared to the RC specimen. Seismic performance evaluation was quantitatively addressed, and on this basis, it confirmed that the presented system can fully satisfy all the required performance for the intermediate RC moment resisting frame.

• Journal of the Korean Geotechnical Society
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• v.25 no.10
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• pp.55-65
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• 2009

It has been well known that the infiltration of rainfall causes major surfacial slope failures in Korea. However, the hydrological and mechanical behaviors in unsaturated slopes are somewhat complex. When an analysis on unsaturated slope problems is performed, soil-water characteristics curves (SWCC) are considered as major parameters to apply. Since the weathered soil slopes are layered and stressed by overburden pressures, the response of SWCCs should account for its overburden pressure. To deal with this situation, in this study, laboratory testings were conducted to evaluate the SWCC under various overburden stress. In addition, the unsaturated shear strength was estimated using SWCC. Then the performance of unsaturated weathered soil slopes was evaluated under various conditions after applying the effect of overburden pressure on SWCCs. The results demonstrated that the effect of overburden pressure on SWCC could be substantial and the proper application to analysis is very important to enhance the prediction of slope stability.

• Journal of the Korean Geotechnical Society
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• v.23 no.3
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• pp.141-147
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• 2007

Various approaches have been developed for the dynamic response analysis of piles. In one of the approaches, the soil-pile interaction is approximated by using parallel nonlinear springs, namely the p-y curves. Currently available p-y curve recommendations are based on static and cyclic lateral load tests. Other researchers have attempted to extend the p-y curves by incorporating the effects of liquefaction on soil-pile interaction and derived scaling factors of p-y curves to account fur the liquefaction. However, opinions on the scaling factors vary. In this study, the sealing factors, which reflect the variation of the elastic moduli of surrounding soils, were established combining the relationship between excess pore pressures and the natural frequencies of a soil-pile system obtained from Ig shaking table tests and the relationship between the elastic moduli of surrounding soils and the natural frequencies of a soil-pile system obtained from numerical analyses. As a result, the scaling factors were presented in an exponential function.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.36 no.2
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• pp.137-145
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• 2023

This paper presents the effects of fire-resistant materials on the temperature and vertical deflection of a composite beam exposed to fire through nonlinear thermo-mechanical analysis. The fire was modeled using the standard fire curve proposed in American Society for Testing and Materials (ASTM) E119. Fire-resistant materials were modeled by reducing the heat transfer coefficient from the air layer to the beam. The temperature and vertical deflection of the uncoated composite beam were measured using a laboratory fire test, and the results of the structural fire analysis were verified through comparison with experimental results. By introducing the fire-resistance effect, the reduction in the temperature and deflection of the beam for the ASTM E119 standard fire can be reasonably estimated. Based on a case study of the heat transfer coefficient, the fire-resistant effect on the thermo-mechanical response of a composite beam in the event of a fire is presented.