• Journal of Advanced Marine Engineering and Technology
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• v.26 no.1
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• pp.116-124
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• 2002

The bubble model by Keller and Prosperetti is adapted to solve the nonlinear oscillation of a gas bubble. This formulation leads to accurate results since it introduces the energy equation instead of the polytropic assumption for the bubble interior. The numerical method used in this study is stable enough to handle large amplitude of bubble oscillation. The numerical results show some interesting nonlinear phenomena fur the bubble oscillator. The excitation changes the natural frequency of the bubble and makes some harmonic resonances at $f/f_0=1/2, 1/3$ and so on. The natural frequency of a bubble oscillator decreases compared with the linear case result, which means that the nonlinear bubble oscillation system is a "softening"system. In addition, the frequency response curve jumps up or down at a certain frequency. It is also found that there exist multi-valued regions in the frequency response curve depending on the initial conditions of bubble. The dependency of the bubble motion on the initial condition can generate extremely large pressure and temperature which might be the cause of the acoustic cavitation and the sonoluminescence.inescence.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.32 no.2
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• pp.122-128
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• 2019

Porcelain insulators have been used mainly for power line fixing and electrical insulation in transmission towers. Porcelain insulators have generally a 30 years desired life, but over 50% exceed their life expectancy. Since the damage to porcelain insulators is usually accompanied by enormous loss of human resource material, their efficient maintenance has emerged as an important issue. In this regard, this study applied a frequency response function (FRF) for integrity assessment of the insulator. The characteristics of the FRF according to damage types were identified and analyzed by the change in natural frequencies, curve shape, attenuation, and Nyquist diagram stability. The results showed significant differences in the FRF according to damage types, which can be used as basic data for the effective integrity assessment of porcelain insulators.

• Earthquakes and Structures
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• v.16 no.6
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• pp.705-714
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• 2019

Seismic assessment of underground structures is one of the challenging problems in engineering design. This is because there are usually many sources of uncertainties in rocks and probable earthquake characteristics. Therefore, for decreasing of the uncertainties, seismic response of underground structures should be evaluated by sufficient number of earthquake records which is scarcely possible in common seismic assessment of underground structures. In the present study, a practical risk-based approach was performed for seismic risk assessment of an unsupported tunnel. For this purpose, Incremental Dynamic Analysis (IDA) was used to evaluate the seismic response of a tunnel in south-west railway of Iran and different analyses were conducted using 15 real records of earthquakes which were chosen from the PEER ground motion database. All of the selected records were scaled to different intensity levels (PGA=0.1-1.7 g) and applied to the numerical models. Based on the numerical modeling results, seismic fragility curves of the tunnel under study were derived from the IDA curves. In the next, seismic risk curve of the tunnel were determined by convolving the hazard and fragility curves. On the basis of the tunnel fragility curves, an earthquake with PGA equal to 0.35 g may lead to severe damage or collapse of the tunnel with only 3% probability and the probability of moderate damage to the tunnel is 12%.

• Journal of Korea Port Economic Association
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• v.27 no.3
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• pp.1-12
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• 2011

The effect of real exchange rate changes on trade balance is called the J-curve effect. That is, after real depreciation, the trade balance will deteriorate in the short run and improve in the long run. Specially, import and export prices respond with little or no decline in volume. Assuming a zero initial trade balance and dominance of the exporter currency in invoicing trade contracts, the trade balance continues to deteriorate in the medium term. Over time, the relative price-induced volume effect comes to dominate the price effect and the trade balance improves. This pattern of the trade balance adjustment is commonly referred to as the J-curve effect. This study examines the effects of changes in the exchange rate on the Korean port trade balance to China. The empirical results indicate that whilst there is J-curve effect in the short-run, but in the long-run, the real depreciation of the Korean won has positive impact on port trade balance to China.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.301-301
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• 1994

〔$^3$H〕Ouabain binding parameters(K$\_$D/ and B$\_$max/,) in homogenates prepared fpom control rat ventricular strip and Langendorff preparations which were not previously exposed to ouabain were compared to those in homogenates from ventricular strip and Langendorff preparations that had been first exposed to a complete ouabain dose-response curve(10$\^$-7/M to 10$\^$-4/ M). In rat ventricular strips and Langendorff perfused rat heart preparations, cumulative dose-response cruves of ouabain revealed biphasic positive inotropic effects, a "low-dose" and a "high-dose" effect with ED$\_$50/ values of 0.5${\mu}$M and 35${\mu}$M ouabain, respectively- The "low-dose" effect in rat ventricular strips disappeared or was diminished significantly when the ouabain dose-response curve wag repeated after the washout of the effects of the first curve, whereas the maximal "high-dose" effect was identical in both exposures to oubain. However, there was no change in the "low-dose" effects in both sets of the Langendorff perfused hearts. The contractile activity of the pre-exposed strips did not indicate the presence of residual ouabain since their basal contractile force was decreased 10% compared to initial control. 〔$^3$H〕Ouabain binding parameters, K$\_$D/ and B$\_$max/, were not changed comparing homogenate of control ventricular strips with that of strips pre-exposed to ouabain. These results suggest that digitalis receptor desensitization in the rat ventricular strip may due to the change of post-receptor events induced by ouabain binding to a high affinity site(${\alpha}$$_2$ isoform).

• Journal of the Korean Data and Information Science Society
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• v.25 no.5
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• pp.987-998
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• 2014

The primary purpose of this paper is to derive a benchmark dose lower limit (BMDL) of lead for the attention deficit/hyperactive disorder (ADHD) based on a longitudinal cohort data set which is referred to as CHEER data set. The CHEER data were recently recruited from the Ministry of Environment of S. Korea to investigate the effect of environment on children's health We first confirm the correlation of ADHD with the blood lead level using a linear mixed effect model. We report from the longitudinal characteristic of CHEER data that ADHD scores tend to have "regression to the mean". A dose-response curve of blood lead level with ADHD being the end point is derived and from this dose-response curve a few BMDLs are derived based on corresponding assumptions on the benchmark region.

• Journal of Korean Society of Environmental Engineers
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• v.28 no.11
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• pp.1148-1153
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• 2006

Signal measuring system to analyze ion concentrations in biofilm was constructed with ion selective microeleclrode and electrometer. In order to evaluate the performance and applicability of signal measuring system, the following characteristics, such as slope of calibration curve, detection limit, variation of response according to the time, and potentiometric selectivity coefficient, were investigated. The slope of calibration curve showed high degree of association for primary ion concentration. The response of the system was log-linear in standard solution down to $10{\mu}M$ and signal measuring system was not sensitive for interfering ions. In comparison with commercial electrometer, the fabricated electrometer system had similar tendencies for the slope of calibration curve, detection limit, and response time. Therefore the signal measuring system could be used to investigate ion profiles in biofilm as a cost effective and reliable measuring system.

• Communications for Statistical Applications and Methods
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• v.15 no.3
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• pp.465-481
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• 2008

Item response theory(IRT) estimates latent ability of a subject based on the property of item and item parameters using item characteristics curve(ICC) of each item case. The initial value and another problems occurs when we try to estimate item parameters of IRT(e.g. the maximum likelihood estimate). Thus, we propose the asymptotic approximation method(AAM) to solve the above mentioned problems. We notice that the proposed method can be thought as an alternative to estimate item parameters when we have small size of data or need to estimate items with local fluctuations. We developed 'Any Assess' and tested reliability of the system result by simulating a practical use possibility.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.1
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• pp.16-22
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• 2017

In order to reduce costs of electricity energy at periods of peak demand, there has been an exponential interest in Demand Response (DR). This paper discusses the effect on the participants' behavior in response to DR. Under the assumption of perfect competition, the equilibrium point of the electricity market with DR is derived by modeling a DR curve, which is suitable for microeconomic analysis. Cournot model is used to analyze the electricity market of imperfect competition that includes strategic behavior of the generation companies. Strategic behavior with DR makes it harder to compute equilibrium point due to the non-differential function of payoff distribution. This paper presents a solution method for achieving the equilibrium point using the best response function of the strategic players. The effect of DR on the electricity market is illustrated using a test system.

• Toxicological Research
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• v.6 no.2
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• pp.205-213
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• 1990

The regulation of neurotoxicants has usually been based upon setting reference doses by dividing a no observed adverse effect level (NOAEL) by uncertainty factors that theoretically account for interspecies and intraspecies extraploation of experimental results in animals to humans. Recently, we have proposed a four-step alternative procedure which provides quantitative estimates of risk as a function of dose. The first step is to establish a mathematical relationship between a biological effect or biomarker and the dose of chemical administered. The second step is to determine the distribution (variability) of individual measurements of biological effects or their biomarkers about the dose response curve. The third step is to define an adverse or abnormal level of a biological effect or biomarker in an untreated population. The fourth and final step is to combine the information from the first three steps to estimate the risk (proportion of individuals exceeding on adverse or abnormal level of a biological effect or biomarker) as a function of dose. The primary purpose of this report is to enhance the certainty of the first step of this procedure by improving our understanding of the relationship between a biomarker and dose of administered chemical. Several factors which need to be considered include: 1) the pharmacokinetics of the parent chemical, 2) the target tissue concentrations of the parent chemical or its bioactivated proximate toxicant, 3) the uptake kinetics of the parent chemical or metabolite into the target cell(s) and/or membrane interactions, and 4) the interaction of the chemical or metabolite with presumed receptor site(s). Because these theoretical factors each contain a saturable step due to definitive amounts of required enzyme, reuptake or receptor site(s), a nonlinear, saturable dose-response curve would be predicted. In order to exemplify this process, effects of the neurotoxicant, methlenedioxymethamphetamine (MDMA), were reviewed and analyzed. Our results and those of others indicate that: 1) peak concentrations of MDMA and metabolites are ochieved in rat brain by 30 min and are negligible by 24 hr, 2) a metabolite of MDMA is probably responsible for its neurotoxic effects, and 3) pretreatment with monoamine uptake blockers prevents MDMA neurotoxicity. When data generated from rats administerde MDMA were plotted as bilolgical effect (decreases in hippocampal serotonin concentrations) versus dose, a saturation curve best described the observed relationship. These results support the hypothesis that at least one saturable step is involved in MDMA neurotoxicity. We conclude that the mathematical relationship between biological effect and dose of MDMA, the first step of our quantitative neurotoxicity risk assessment procedure, should reflect this biological model information generated from the whole of the dose-response curve.