Journal of the Korean Data and Information Science Society

The Korean Data and Information Science Society (한국데이터정보과학회)
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Derivation of benchmark dose lower limit of lead for ADHD based on a longitudinal cohort data set

동집단 자료의 주의력 결핍 과잉행동 장애를 종점으로 한 납의 벤치마크 용량 하한 도출

  • Kim, Byung Soo (Department of Applied Statistics, Yonsei University) ;
  • Kim, Daehee (Department of Applied Statistics, Yonsei University) ;
  • Ha, Mina (Department of Preventive Medicine, Dankook University) ;
  • Kwon, Ho-Jang (Department of Preventive Medicine, Dankook University)
  • 김병수 (연세대학교 응용통계학과) ;
  • 김대희 (연세대학교 응용통계학과) ;
  • 하미나 (단국대학교 예방의학교실) ;
  • 권호장 (단국대학교 예방의학교실)
  • Received : 2014.06.29
  • Accepted : 2014.08.01
  • Published : 2014.09.30
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Abstract

The primary purpose of this paper is to derive a benchmark dose lower limit (BMDL) of lead for the attention deficit/hyperactive disorder (ADHD) based on a longitudinal cohort data set which is referred to as CHEER data set. The CHEER data were recently recruited from the Ministry of Environment of S. Korea to investigate the effect of environment on children's health We first confirm the correlation of ADHD with the blood lead level using a linear mixed effect model. We report from the longitudinal characteristic of CHEER data that ADHD scores tend to have "regression to the mean". A dose-response curve of blood lead level with ADHD being the end point is derived and from this dose-response curve a few BMDLs are derived based on corresponding assumptions on the benchmark region.

본 연구에서는 우리나라 환경부에서 최근에 구축한 아동 동집단 경시적 자료인 아동 건강과 환경 연구 (CHEER) 자료에 기초하여 주의력 결핍 과잉행동 장애 (ADHD)와 혈중 납 농도의 상관을 선형혼합모형을 사용하여 규명하고, CHEER 자료의 경시적 특성으로 나타나는 ADHD 점수의 "평균으로의 회귀" 현상을 보고하고자 한다. 또한 ADHD를 종점으로 한 혈중 납 농도의 용량-반응 곡선을 도출하며, 이렇게 도출된 용량-반응 곡선에 기초하여 몇 가지 상황 하에서 독성기준치인 벤치마크 용량 하한 (BMDL)을 유도한다.

Keywords

References

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