• Mycobiology
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• 제45권2호
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• pp.90-96
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• 2017

Different endophytes isolated from the seeds of Sophora flavescens were tested for their ability to produce matrine production. Response surface methodology (RSM) was applied to optimize the medium components for the endophytic fungus. Results indicated that endophyte Aspergillus terreus had the ability to produce matrine. The single factor tests demonstrated that potato starch was the best carbon source and the combination of peptone and $NH_4NO_3$ was the optimal nitrogen source for A. terreus. The model of RSM predicted to gain the maximal matrine production at $20.67{\mu}g/L$, when the potato starch was 160.68 g/L, peptone was 24.96 g/L and $NH_4NO_3$ was 2.11 g/L. When cultured in the optimal medium, the matrine yield was an average of $20.63{\pm}0.11{\mu}g/L$, which was consistent with the model prediction. This study offered an alternative source for the matrine production by endophytic fungus fermentation and may have far-reaching prospect and value.

• Environmental Engineering Research
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• 제20권3호
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• pp.223-229
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• 2015

The application of coagulation for feed water pretreatment prior to microfiltration (MF) process has been widely adopted to alleviate fouling due to particles and organic matters in feed water. However, the efficiency of coagulation pretreatment for MF is sensitive to its operation conditions such as pH and coagulant dose. Moreover, the optimum coagulation condition for MF process is different from that for rapid sand filtration in conventional drinking water treatment. In this study, the use of response surface methodology (RSM) was attempted to determine coagulation conditions optimized for pretreatment of MF. The center-united experimental design was used to quantify the effects of coagulant dose and pH on the control of fouling control as well as the removal organic matters. A MF membrane (SDI Samsung, Korea) made of polyvinylidene fluoride (PVDF) was used for the filtration experiments. Poly aluminum chloride (PAC) was used as the coagulant and a series of jar tests were conducted under various conditions. The flux was $90L/m^2-h$ and the fouling rate were calculated in each condition. As a result of this study, an empirical model was derived to explore the optimized conditions for coagulant dose and pH for minimization of the fouling rate. This model also allowed the prediction of the efficiency of the coagulation efficiency. The experimental results were in good agreement with the predictions, suggesting that RSM has potential as a practical method for modeling the coagulation pretreatment for MF.

• 한국자기학회지
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• 제20권6호
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• pp.239-243
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• 2010

본 논문은 반응표면법(Respone Surface Methodology)과 유한요소법(Finite Element Method)을 이용하여 250 kW급 견인 유도 전동기의 효율 향상을 위한 최적설계기준에 대해서 다루었다. 본 논문의 주 관점은 첫째, 회전자 형상 및 치수변화에 따른 토크 비교를 통해 설계 해를 찾는 것이다. 둘째, 중심합성법(Central Composite Design)과 결합된 해석방법이 도입되었고, 추정된 회귀모델의 적합성을 결정하기 위해 분산분석(Analysis Of Variance)이 수행되었다. 이렇게 제안된 실험 절차는 기존의 초기 모델로 부터 시작하여 회전자 형상 및 치수를 최적설계 하였다.

• 한국식품영양과학회지
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• 제40권3호
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• pp.458-465
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• 2011

본 연구는 반응표면분석법(response surface methodology, RSM)을 적용하여 소맥 글루텐 산 가수분해물의 염 농도와 기질인 ribose와 소맥 글루텐 산 가수분해물의 농도가 MRP의 갈변도와 항산화 활성, 기호도에 미치는 영향을 분석하여 기질조건을 최적화 하고자 하였다. 종속변수 회귀식의 결정 계수($R^2$)는 각각 0.975, 0.960, 0.854로 나타났으며 반응모형에서 갈변도와 항산화 활성은 모두 ribose와 소맥 글루텐산 가수분해물의 농도가 증가함에 따라 증가하여 두 기질 농도에 영향을 크게 받았다. 그러나 갈변도는 소맥 글루텐산 가수분해물의 염 농도가 높아짐에 따라 감소하는 경향을 보였고 DPPH radical 소거활성은 염 농도의 영향을 받지 않았다. 관능적 기호도로 평가된 고기향미에 대한 향 특성은 소맥 글루텐의 염 농도가 낮으며 ribose의 농도에 비해 소맥글루텐 산 가수분해물의 농도가 높을 때 발현되었다. 본 실험에서 ribose와 소맥 글루텐 산 가수분해물을 이용한 MRP의 높은 DPPH radical 소거활성과 관능적으로 고기향미에 근접한 향 특성을 나타내는 최적조건으로서, 소맥 글루텐산 가수분해물의 염 농도가 3%, ribose 농도 6.2%와 소맥글루텐 산 가수분해물의 농도 13.27%로 나타났다. 이때 DPPH radical 소거활성은 700(DF)과 관능점수 8.42점을 만족시킬 수 있는 MRP를 얻을 수 있었다. 따라서 ribose와 소맥 글루텐 산 가수분해물로 제조된 MRP의 저염화에 따른 갈변도와 항산화 효과 및 관능적 기호도에 대하여 두 기질의 농도를 조절하여 최적화함으로써 이를 향상시킬 수 있을 것으로 판단된다.

• Composites Research
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• 제23권2호
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• pp.40-47
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• 2010

본 논문에서는 복합 반응면 기법을 제안하고 성능을 고찰하였다. 복합 반응면 기법은 MPP의 좌표를 기준으로 하여 근사모델을 반복 계산하는 기법이다. 성능을 검증하기 위해 비선형 함수와 복합재 적층판에 대하여 신뢰성 해석 기법을 적용하여 파괴확률, MPP(Most Probable failure Point), 신뢰도 지수를 계산하고 일반적인 반응면 기법의 결과와 비교하였다. 파괴확률은 비선형 한계상태식을 가정하고 임의의 파괴 기준을 정의하여 계산하였다. 제안한 복합 반응면 기법을 이용하여 파괴확률을 계산한 결과 일반적인 반응면 기법보다 향상된 성능을 나타내었다.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2005년도 추계 학술대회논문집
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• pp.163-167
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• 2005

A research to evaluate efficiency of design optimization was performed for aerodynamic design optimization problem in distributed computing environment. The aerodynamic analyses which take most of computational work during design optimization were divided into several jobs and allocated to associated PC clients through network. This is not a parallel process based on domain decomposition rather than a simultaneous distributed-analyses process using network-distributed computers. GBOM(gradient-based optimization method), SAO(Sequential Approximate Optimization) and RSM(Response Surface Method) were implemented to perform design optimization of transonic airfoil and to evaluate their efficiencies. One dimensional minimization followed by direction search involved in the GBOM was found an obstacle against improving efficiency of the design process in distributed computing environment. The SAO was found quite suitable for the distributed computing environment even it has a handicap of local search. The RSM is apparently the fittest for distributed computing environment, but additional trial and error works needed to enhance the reliability of the approximation model are annoying and time-consuming so that they often impair the automatic capability of design optimization and also deteriorate efficiency from the practical point of view.

• 한국전산유체공학회지
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• 제11권2호
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• pp.19-24
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• 2006

A research to evaluate the efficiency of design optimization was carried out for aerodynamic design optimization problem in distributed computing environment. The aerodynamic analyses which take most of computational work during design optimization were divided into several jobs and allocated to associated PC clients through network. This is not a parallel process based on domain decomposition in a single analysis rather than a simultaneous distributed-analyses using network-distributed computers. GBOM(gradient-based optimization method), SAO(Sequential Approximate Optimization) and RSM(Response Surface Method) were implemented to perform design optimization of transonic airfoils and evaluate their efficiencies. dimensional minimization followed by direction search involved in the GBOM was found an obstacle against improving efficiency of the design process in the present distributed computing system. The SAO was found fairly suitable for the distributed computing environment even it has a handicap of local search. The RSM is apparently the most efficient algorithm in the present distributed computing environment, but additional trial and error works needed to enhance the reliability of the approximation model deteriorate its efficiency from the practical point of view.

• Journal of Microbiology and Biotechnology
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• 제18권1호
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• pp.138-144
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• 2008

The production of the entomopathogenic and phytotoxic cyclic depsipeptide beauvericin (BEA) was studied in submerged cultures of Fusarium oxysporum KFCC 11363P isolated in Korea. The influences of various factors on mycelia growth and BEA production were examined in both complete and chemically defined culture media. The mycelia growth and BEA production were highest in Fusarium defined medium. The optimal carbon and nitrogen sources for maximizing BEA production were glucose and $NaNO_3$, respectively. The carbon/nitrogen ratio for maximal production of BEA was investigated using response surface methodology (RSM). Equations derived by differentiation of the RSM model revealed that the production of BEA was maximal when using 108 mM glucose and 25 mM $NaNO_3$.

• Korean Chemical Engineering Research
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• 제53권2호
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• pp.199-204
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• 2015

지방산 생산을 위한 돈지의 아임계수 가수분해 공정을 최적화하기 위하여 17-run 중심합성법(central composite design)에 기초한 반응표면법(response surface methodology)이 사용되었다. 반응 온도, 오일 대비 물의 몰 비, 반응 시간과 같은 변수 및 이들의 상관관계가 지방산 함량에 미치는 영향을 조사하였으며, 지방산 함량을 예측하기 위하여 2차 다항 회귀방정식이 제안되었다. 최대 지방산 함량을 얻을 수 있는 반응 조건은 $288.5^{\circ}C$, 39.5몰 비, 29.5분이었으며, 이 조건에서의 예측 및 실제 지방산 함량은 각각 97.06% 및 96.99%였다.

• Journal of Microbiology and Biotechnology
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• 제28권6호
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• pp.902-908
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• 2018

Optimization of the culture medium to maximize menaquinone-7 (MK-7) production by Bacillus subtilis strain KCTC 12392BP in static culture was carried out using statistical experimental methods, including one factor at a time, fractional factorial design, and response surface methodology (RSM). Maltose (carbon source), tryptone (nitrogen source), and glycerol (activator) were identified as the key medium components for MK-7 synthesis by the fractional factorial design, and were selected for statistical optimization by RSM. The statistical analysis indicated that, in the range that was studied, maltose, tryptone, and glycerol were all critical factors having profound effects on the production of MK-7, with their coefficients for linear and quadratic all significant at the p < 0.05 level. The established model was efficient and feasible, with a determination coefficient ($R^2$) of 0.9419. The predicted concentrations of maltose, tryptone, and glycerol in the optimal medium were determined as 36.78, 62.76, and 58.90 g/l, respectively. In this optimized medium, the maximum yield of MK-7 reached a remarkably high level of $71.95{\pm}1.00{\mu}g/ml$ after 9 days of static fermentation, which further verified the practicability of this optimized strategy.